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Protein

LIM/homeobox protein Lhx8

Gene

Lhx8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor involved in differentiation of certain neurons and mesenchymal cells.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi246 – 305HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • female gonad development Source: MGI
  • forebrain neuron development Source: MGI
  • forebrain neuron differentiation Source: MGI
  • learning or memory Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx8
Short name:
LIM homeobox protein 8
Alternative name(s):
L3
LIM/homeobox protein Lhx7
Short name:
LIM homeobox protein 7
Gene namesi
Name:Lhx8
Synonyms:Lhx7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1096343. Lhx8.

Subcellular locationi

GO - Cellular componenti

  • female germ cell nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757971 – 367LIM/homeobox protein Lhx8Add BLAST367

Proteomic databases

PaxDbiO35652.
PRIDEiO35652.

Expressioni

Developmental stagei

Limited spatially to the medical ganglionic eminence and the mesenchyme surrounding the oral cavity and temporally from middle embryonic to early postnatal development.

Gene expression databases

BgeeiENSMUSG00000096225.
CleanExiMM_LHX8.
ExpressionAtlasiO35652. baseline and differential.
GenevisibleiO35652. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136047.

Structurei

3D structure databases

ProteinModelPortaliO35652.
SMRiO35652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 148LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST53
Domaini157 – 210LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST54

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000038965.
HOVERGENiHBG006261.
InParanoidiO35652.
KOiK09375.
OMAiPGKCVCS.
OrthoDBiEOG091G0EXT.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYWKSDQMFV CKLEGKEVPE LAVPREKCPG LMSEECGRPA ALAAGRTRKG
60 70 80 90 100
AGEEGLVNPE GAGDEDSCSS SAPLSPSSSP QSMASGSVCP PGKCVCSSCG
110 120 130 140 150
LEIVDKYLLK VNDLCWHVRC LSCSVCRTSL GRHTSCYIKD KDIFCKLDYF
160 170 180 190 200
RRYGTRCSRC GRHIHSTDWV RRAKGNVYHL ACFACFSCKR QLSTGEEFAL
210 220 230 240 250
VEEKVLCRVH FDCMLDNLKR EVENGNGISV EGALLTEQDV NHPKPAKRAR
260 270 280 290 300
TSFTADQLQV MQAQFAQDNN PDAQTLQKLA ERTGLSRRVI QVWFQNCRAR
310 320 330 340 350
HKKHVSPNHS SSAPVTAVPS SRLSPPMLEE MAYSAYVPQD GTMLTALHSY
360
MDAHQQLLDS SPCYPIQ
Length:367
Mass (Da):40,710
Last modified:July 27, 2011 - v4
Checksum:i1F8E3756D14DB43E
GO

Sequence cautioni

The sequence BAA21649 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18V → M in CAA04012 (PubMed:9570771).Curated1
Sequence conflicti27K → M in CAA04012 (PubMed:9570771).Curated1
Sequence conflicti42 – 43LA → G in CAA04012 (PubMed:9570771).Curated2
Sequence conflicti51A → S in CAA04012 (PubMed:9570771).Curated1
Sequence conflicti72A → G in BAA21649 (PubMed:8929991).Curated1
Sequence conflicti72A → G in CAA04012 (PubMed:9570771).Curated1
Sequence conflicti87 – 88SV → PM in CAA04012 (PubMed:9570771).Curated2
Sequence conflicti327M → I in CAA04012 (PubMed:9570771).Curated1
Sequence conflicti337V → D in CAA04012 (PubMed:9570771).Curated1
Sequence conflicti341 – 342GT → DG in CAA04012 (PubMed:9570771).Curated2
Sequence conflicti347Missing in CAA04012 (PubMed:9570771).Curated1
Sequence conflicti351M → L in CAA04012 (PubMed:9570771).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49658 mRNA. Translation: BAA21649.1. Different initiation.
AB007596 Genomic DNA. Translation: BAA28628.1.
AJ000338 mRNA. Translation: CAA04012.1.
AK165733 mRNA. Translation: BAE38359.1.
CH466532 Genomic DNA. Translation: EDL11894.1.
BC125281 mRNA. Translation: AAI25282.1.
BC125283 mRNA. Translation: AAI25284.1.
BC144768 mRNA. Translation: AAI44769.1.
CCDSiCCDS17926.1.
RefSeqiNP_034843.2. NM_010713.2.
UniGeneiMm.15530.

Genome annotation databases

EnsembliENSMUST00000177846; ENSMUSP00000136047; ENSMUSG00000096225.
GeneIDi16875.
KEGGimmu:16875.
UCSCiuc008rum.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49658 mRNA. Translation: BAA21649.1. Different initiation.
AB007596 Genomic DNA. Translation: BAA28628.1.
AJ000338 mRNA. Translation: CAA04012.1.
AK165733 mRNA. Translation: BAE38359.1.
CH466532 Genomic DNA. Translation: EDL11894.1.
BC125281 mRNA. Translation: AAI25282.1.
BC125283 mRNA. Translation: AAI25284.1.
BC144768 mRNA. Translation: AAI44769.1.
CCDSiCCDS17926.1.
RefSeqiNP_034843.2. NM_010713.2.
UniGeneiMm.15530.

3D structure databases

ProteinModelPortaliO35652.
SMRiO35652.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136047.

Proteomic databases

PaxDbiO35652.
PRIDEiO35652.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000177846; ENSMUSP00000136047; ENSMUSG00000096225.
GeneIDi16875.
KEGGimmu:16875.
UCSCiuc008rum.1. mouse.

Organism-specific databases

CTDi431707.
MGIiMGI:1096343. Lhx8.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000038965.
HOVERGENiHBG006261.
InParanoidiO35652.
KOiK09375.
OMAiPGKCVCS.
OrthoDBiEOG091G0EXT.
TreeFamiTF315442.

Miscellaneous databases

PROiO35652.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000096225.
CleanExiMM_LHX8.
ExpressionAtlasiO35652. baseline and differential.
GenevisibleiO35652. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLHX8_MOUSE
AccessioniPrimary (citable) accession number: O35652
Secondary accession number(s): O70163, O88707, Q3TMT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 136 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.