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Protein

Centrin-3

Gene

Cetn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a fundamental role in microtubule-organizing center structure and function.
Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi38 – 491PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi147 – 1582CuratedAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • G-protein beta/gamma-subunit complex binding Source: MGI
  • microtubule binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Centrin-3
Gene namesi
Name:Cetn3
Synonyms:Cen3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1097706. Cetn3.

Subcellular locationi

  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
  • Nucleusnucleolus By similarity
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity

  • Note: Centrosome of interphase and mitotic cells. Localizes to centriole distal lumen.By similarity

GO - Cellular componenti

  • centriole Source: MGI
  • centrosome Source: MGI
  • ciliary basal body Source: MGI
  • ciliary transition zone Source: MGI
  • nucleolus Source: UniProtKB-SubCell
  • photoreceptor connecting cilium Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735641 – 167Centrin-3Add BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei135PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO35648.
PaxDbiO35648.
PeptideAtlasiO35648.
PRIDEiO35648.

PTM databases

iPTMnetiO35648.
PhosphoSitePlusiO35648.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021537.
CleanExiMM_CETN3.
ExpressionAtlasiO35648. baseline and differential.
GenevisibleiO35648. MM.

Interactioni

Subunit structurei

Monomer (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3.By similarity

GO - Molecular functioni

  • G-protein beta/gamma-subunit complex binding Source: MGI
  • microtubule binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022009.

Structurei

3D structure databases

ProteinModelPortaliO35648.
SMRiO35648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 60EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini61 – 96EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini98 – 133EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini134 – 167EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the centrin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0028. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiO35648.
KOiK16466.
OMAiEFFAIMT.
OrthoDBiEOG091G0RLZ.
PhylomeDBiO35648.
TreeFamiTF101141.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLALRGELV VDKTKRKKRR ELSEEQKQEI KDAFELFDTD KDQAIDYHEL
60 70 80 90 100
KVAMRALGFD VKKADVLKIL KDYDREATGK ITFEDFNEVV TDWILERDPH
110 120 130 140 150
EEILKAFKLF DDDDSGKISL RNLRRVAREL GENMSDEELR AMIEEFDKDG
160
DGEINQEEFI AIMTGDI
Length:167
Mass (Da):19,519
Last modified:January 1, 1998 - v1
Checksum:i562FF752E56C2E9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12474 mRNA. Translation: CAA73078.1.
BC002162 mRNA. Translation: AAH02162.1.
BC054097 mRNA. Translation: AAH54097.1.
CCDSiCCDS26663.1.
RefSeqiNP_031710.1. NM_007684.3.
UniGeneiMm.12481.

Genome annotation databases

EnsembliENSMUST00000022009; ENSMUSP00000022009; ENSMUSG00000021537.
GeneIDi12626.
KEGGimmu:12626.
UCSCiuc007rid.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12474 mRNA. Translation: CAA73078.1.
BC002162 mRNA. Translation: AAH02162.1.
BC054097 mRNA. Translation: AAH54097.1.
CCDSiCCDS26663.1.
RefSeqiNP_031710.1. NM_007684.3.
UniGeneiMm.12481.

3D structure databases

ProteinModelPortaliO35648.
SMRiO35648.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022009.

PTM databases

iPTMnetiO35648.
PhosphoSitePlusiO35648.

Proteomic databases

EPDiO35648.
PaxDbiO35648.
PeptideAtlasiO35648.
PRIDEiO35648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022009; ENSMUSP00000022009; ENSMUSG00000021537.
GeneIDi12626.
KEGGimmu:12626.
UCSCiuc007rid.1. mouse.

Organism-specific databases

CTDi1070.
MGIiMGI:1097706. Cetn3.

Phylogenomic databases

eggNOGiKOG0028. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00670000097718.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiO35648.
KOiK16466.
OMAiEFFAIMT.
OrthoDBiEOG091G0RLZ.
PhylomeDBiO35648.
TreeFamiTF101141.

Miscellaneous databases

PROiO35648.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021537.
CleanExiMM_CETN3.
ExpressionAtlasiO35648. baseline and differential.
GenevisibleiO35648. MM.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCETN3_MOUSE
AccessioniPrimary (citable) accession number: O35648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.