Reviewed,
UniProtKB/Swiss-Prot O35643 (AP1B1_MOUSE)
Last modified
March 2, 2010.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: AP-1 complex subunit beta-1 Alternative name(s): Adapter-related protein complex 1 subunit beta-1 Adaptor protein complex AP-1 subunit beta-1 Beta-adaptin 1 Beta-1-adaptin Golgi adaptor HA1/AP1 adaptin beta subunit Clathrin assembly protein complex 1 beta large chain | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 943 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. |
| Subunit structure | Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). |
| Subcellular location | Golgi apparatus. Cytoplasmic vesicle › clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Golgi apparatus By similarity. Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex By similarity. |
| Tissue specificity | Widely expressed. |
| Sequence similarities | Belongs to the adaptor complexes large subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Endocytosis Protein transport Transport |
| Cellular component | Cytoplasmic vesicle Golgi apparatus Membrane |
| PTM | Acetylation Nitration Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | endocytosis Inferred from electronic annotation. Source: UniProtKB-KW intracellular protein transportTraceable author statement. Source: MGI |
| Cellular component | clathrin adaptor complex Inferred from electronic annotation. Source: InterPro clathrin coated vesicle membraneInferred from electronic annotation. Source: UniProtKB-SubCell trans-Golgi networkTraceable author statement. Source: MGI |
| Molecular function | protein binding Inferred from physical interaction. Source: UniProtKB protein transporter activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 943 | 943 | AP-1 complex subunit beta-1 | PRO_0000193739 | |||||
Regions | |||||||||
| Compositional bias | 576 – 722 | 147 | Pro-rich (stalk region) | ||||||
Amino acid modifications | |||||||||
| Modified residue | 318 | 1 | N6-acetyllysine By similarity | ||||||
| Modified residue | 574 | 1 | Nitrated tyrosine Ref.3 | ||||||
| Modified residue | 894 | 1 | Phosphotyrosine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 227 | 1 | D → A in AAH08513. Ref.2 | ||||||
| Sequence conflict | 288 | 1 | L → P in AAH08513. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of the mouse beta-prime adaptin gene; cDNA sequence, genomic structure, and chromosomal localization." Guilbaud C., Peyrard M., Fransson I., Clifton S.W., Roe B.A., Carter N.P., Dumanski J.P. Mamm. Genome 8:651-656(1997) [PubMed: 9271666] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Embryonic brain. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland. |
| [3] | "Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease." Sacksteder C.A., Qian W.-J., Knyushko T.V., Wang H., Chin M.H., Lacan G., Melega W.P., Camp D.G. II, Smith R.D., Smith D.J., Squier T.C., Bigelow D.J. Biochemistry 45:8009-8022(2006) [PubMed: 16800626] [Abstract] Cited for: NITRATION [LARGE SCALE ANALYSIS] AT TYR-574, MASS SPECTROMETRY. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Y07919 mRNA. Translation: CAA69224.1. BC008513 mRNA. Translation: AAH08513.1. |
| IPI | IPI00648683. |
| UniGene | Mm.274816 |
3D structure databases | |
| SMR | O35643. Positions 2-583, 711-943. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O35643. |
PTM databases | |
| PhosphoSite | O35643. |
Proteomic databases | |
| PRIDE | O35643. |
Genome annotation databases | |
| Ensembl | ENSMUST00000009234; ENSMUSP00000009234; ENSMUSG00000009090; Mus musculus. [Genome view] |
Organism-specific databases | |
| MGI | MGI:1096368. Ap1b1. |
Phylogenomic databases | |
| eggNOG | roNOG10896. |
| HOVERGEN | HBG050515. |
| PhylomeDB | O35643. |
Gene expression databases | |
| ArrayExpress | O35643. |
| Bgee | O35643. |
| CleanEx | MM_AP1B1. |
| Genevestigator | O35643. |
Family and domain databases | |
| InterPro | IPR016342. AP_complex_bsu. IPR016024. ARM-type_fold. IPR012295. b_Adaptin_TBP_C. IPR009028. Calthrin/coatomer_app_sub_C. IPR002553. Clathrin/coatomer_adapt-like_N. IPR013041. Clathrin/coatomer_app_Ig-like. IPR008152. Clathrin_a/b/g-adaptin_app_Ig. IPR013037. Clathrin_b-adaptin_app_Ig-like. IPR015151. Clathrin_b-adaptin_app_sub_C. [Graphical view] |
| Gene3D | G3DSA:3.30.310.10. b_Adaptin_TBP_C. 1 hit. G3DSA:2.60.40.1150. Clathrin_b-adaptin_app_Ig-like. 1 hit. |
| Pfam | PF01602. Adaptin_N. 1 hit. PF02883. Alpha_adaptinC2. 1 hit. PF09066. B2-adapt-app_C. 1 hit. [Graphical view] |
| PIRSF | PIRSF002291. AP_complex_beta. 1 hit. |
| SMART | SM00809. Alpha_adaptinC2. 1 hit. [Graphical view] |
| SUPFAM | SSF55711. AP2_adap_app. 1 hit. SSF48371. ARM-type_fold. 1 hit. SSF49348. Clath_adapt. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | AP1B1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: O35643 Secondary accession number(s): Q922E2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


