Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O35643

- AP1B1_MOUSE

UniProt

O35643 - AP1B1_MOUSE

Protein

AP-1 complex subunit beta-1

Gene

Ap1b1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein kinase binding Source: ParkinsonsUK-UCL
    3. protein transporter activity Source: InterPro

    GO - Biological processi

    1. intracellular protein transport Source: MGI
    2. vesicle-mediated transport Source: MGI

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AP-1 complex subunit beta-1
    Alternative name(s):
    Adaptor protein complex AP-1 subunit beta-1
    Adaptor-related protein complex 1 subunit beta-1
    Beta-1-adaptin
    Beta-adaptin 1
    Clathrin assembly protein complex 1 beta large chain
    Golgi adaptor HA1/AP1 adaptin beta subunit
    Gene namesi
    Name:Ap1b1
    Synonyms:Adtb1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1096368. Ap1b1.

    Subcellular locationi

    Cytoplasmic vesicleclathrin-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Golgi apparatus By similarity
    Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.By similarity

    GO - Cellular componenti

    1. clathrin adaptor complex Source: InterPro
    2. clathrin-coated vesicle membrane Source: UniProtKB-SubCell
    3. trans-Golgi network Source: MGI

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 943942AP-1 complex subunit beta-1PRO_0000193739Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylthreonineBy similarity
    Modified residuei265 – 2651N6-acetyllysineBy similarity
    Modified residuei318 – 3181N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO35643.
    PaxDbiO35643.
    PRIDEiO35643.

    PTM databases

    PhosphoSiteiO35643.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    BgeeiO35643.
    CleanExiMM_AP1B1.
    GenevestigatoriO35643.

    Interactioni

    Subunit structurei

    Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).

    Protein-protein interaction databases

    BioGridi198122. 6 interactions.
    IntActiO35643. 6 interactions.
    MINTiMINT-1870179.

    Structurei

    3D structure databases

    ProteinModelPortaliO35643.
    SMRiO35643. Positions 12-574, 711-943.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi576 – 722147Pro-rich (stalk region)Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5096.
    GeneTreeiENSGT00530000063138.
    HOGENOMiHOG000163270.
    HOVERGENiHBG050515.
    KOiK12392.
    OMAiQPGNPSC.
    TreeFamiTF300318.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    2.60.40.1150. 1 hit.
    3.30.310.10. 1 hit.
    InterProiIPR026739. AP_beta.
    IPR016342. AP_complex_bsu_1_2_4.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR015151. B-adaptin_app_sub_C.
    IPR012295. Beta2_adaptin/TBP_C_dom.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR013037. Clathrin_b-adaptin_app_Ig-like.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view]
    PANTHERiPTHR11134. PTHR11134. 1 hit.
    PfamiPF01602. Adaptin_N. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    PF09066. B2-adapt-app_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002291. AP_complex_beta. 1 hit.
    SMARTiSM00809. Alpha_adaptinC2. 1 hit.
    SM01020. B2-adapt-app_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35643-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL    50
    FPDVVNCMQT DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP 100
    LIRALAVRTM GCIRVDKITE YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD 150
    INAQLVEDQG FLDTLKDLIS DSNPMVVANA VAALSEIAES HPSSNLLDLN 200
    PQSINKLLTA LNECTEWGQI FILDCLANYM PKDDREAQSI CERVTPRLSH 250
    ANSAVVLSAV KVLMKFMEML SKDLDYYATL LKKLAPPLVT LLSAEPELQY 300
    VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN 350
    IAQVLAELKE YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ 400
    TKVNYVVQEA IVVIKDIFRK YPNKYESVIA TLCENLDSLD EPEARAAMIW 450
    IVGEYAERID NADELLESFL EGFHDESTQV QLQLLTAIVK LFLKKPTETQ 500
    ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV VLAEKPLISE 550
    ETDLIEPTLL DELICYIGTL ASVYHKPPNA FVEGGRGVVH KSLPPRTASS 600
    ESTESPETAP AGAPAGDQPD VIPAQGDLLG DLLNLDLGPP VSGPPLAASS 650
    VQMGAVDLLG GGLDSLIGDS NFGAPSASVA AAPAPARLGA PISSGLSDLF 700
    DLTSGVGTLS GSYVAPKAVW LPAMKAKGLE ISGTFTRQAG SISMDLQLTN 750
    KALQVMTDFA IQFNRNSFGL APAAPLQVHV PLSPNQTVEI SLPLNTVGSV 800
    LKMEPLNNLQ VAVKNNIDVF YFSTLYPLHV LFVEDGKMDR QMFLATWKDI 850
    ANENEAQFQI RDCPLNTEAA SNKLQSSNIF TVAKRNVEGQ DMLYQSLKLT 900
    NGIWVLAELR IQPGNPSFTL SLKCRAPEVS QHVYQAYETI LKN 943
    Length:943
    Mass (Da):103,935
    Last modified:July 27, 2011 - v2
    Checksum:i5DD1951EAAC20225
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti227 – 2271A → D in CAA69224. (PubMed:9271666)Curated
    Sequence conflicti288 – 2881L → P in AAH08513. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07919 mRNA. Translation: CAA69224.1.
    AK159273 mRNA. Translation: BAE34952.1.
    CH466574 Genomic DNA. Translation: EDL40509.1.
    BC008513 mRNA. Translation: AAH08513.1.
    CCDSiCCDS36100.1.
    RefSeqiNP_031480.2. NM_007454.3.
    UniGeneiMm.274816.

    Genome annotation databases

    EnsembliENSMUST00000009234; ENSMUSP00000009234; ENSMUSG00000009090.
    GeneIDi11764.
    KEGGimmu:11764.
    UCSCiuc007hvo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07919 mRNA. Translation: CAA69224.1 .
    AK159273 mRNA. Translation: BAE34952.1 .
    CH466574 Genomic DNA. Translation: EDL40509.1 .
    BC008513 mRNA. Translation: AAH08513.1 .
    CCDSi CCDS36100.1.
    RefSeqi NP_031480.2. NM_007454.3.
    UniGenei Mm.274816.

    3D structure databases

    ProteinModelPortali O35643.
    SMRi O35643. Positions 12-574, 711-943.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198122. 6 interactions.
    IntActi O35643. 6 interactions.
    MINTi MINT-1870179.

    PTM databases

    PhosphoSitei O35643.

    Proteomic databases

    MaxQBi O35643.
    PaxDbi O35643.
    PRIDEi O35643.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000009234 ; ENSMUSP00000009234 ; ENSMUSG00000009090 .
    GeneIDi 11764.
    KEGGi mmu:11764.
    UCSCi uc007hvo.2. mouse.

    Organism-specific databases

    CTDi 162.
    MGIi MGI:1096368. Ap1b1.

    Phylogenomic databases

    eggNOGi COG5096.
    GeneTreei ENSGT00530000063138.
    HOGENOMi HOG000163270.
    HOVERGENi HBG050515.
    KOi K12392.
    OMAi QPGNPSC.
    TreeFami TF300318.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.

    Miscellaneous databases

    ChiTaRSi AP1B1. mouse.
    NextBioi 279521.
    PROi O35643.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35643.
    CleanExi MM_AP1B1.
    Genevestigatori O35643.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    2.60.40.1150. 1 hit.
    3.30.310.10. 1 hit.
    InterProi IPR026739. AP_beta.
    IPR016342. AP_complex_bsu_1_2_4.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR015151. B-adaptin_app_sub_C.
    IPR012295. Beta2_adaptin/TBP_C_dom.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR008152. Clathrin_a/b/g-adaptin_app_Ig.
    IPR013037. Clathrin_b-adaptin_app_Ig-like.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    [Graphical view ]
    PANTHERi PTHR11134. PTHR11134. 1 hit.
    Pfami PF01602. Adaptin_N. 1 hit.
    PF02883. Alpha_adaptinC2. 1 hit.
    PF09066. B2-adapt-app_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002291. AP_complex_beta. 1 hit.
    SMARTi SM00809. Alpha_adaptinC2. 1 hit.
    SM01020. B2-adapt-app_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the mouse beta-prime adaptin gene; cDNA sequence, genomic structure, and chromosomal localization."
      Guilbaud C., Peyrard M., Fransson I., Clifton S.W., Roe B.A., Carter N.P., Dumanski J.P.
      Mamm. Genome 8:651-656(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Embryonic brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiAP1B1_MOUSE
    AccessioniPrimary (citable) accession number: O35643
    Secondary accession number(s): Q3TXG4, Q922E2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3