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Protein

Annexin A8

Gene

Anxa8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi266Calcium; via carbonyl oxygenBy similarity1
Metal bindingi268Calcium; via carbonyl oxygenBy similarity1
Metal bindingi270Calcium; via carbonyl oxygenBy similarity1
Metal bindingi310CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A8
Alternative name(s):
Annexin VIII
Annexin-8
Gene namesi
Name:Anxa8
Synonyms:Anx8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1201374. Anxa8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000675041 – 327Annexin A8Add BLAST327

Proteomic databases

MaxQBiO35640.
PaxDbiO35640.
PeptideAtlasiO35640.
PRIDEiO35640.

PTM databases

PhosphoSitePlusiO35640.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021950.
CleanExiMM_ANXA8.
ExpressionAtlasiO35640. baseline and differential.
GenevisibleiO35640. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022519.

Structurei

3D structure databases

ProteinModelPortaliO35640.
SMRiO35640.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati38 – 90Annexin 1Add BLAST53
Repeati110 – 162Annexin 2Add BLAST53
Repeati195 – 247Annexin 3Add BLAST53
Repeati270 – 322Annexin 4Add BLAST53

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiO35640.
KOiK17096.
OMAiPHFNPDP.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009115. AnnexinVIII.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01808. ANNEXINVIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWWKAWVEQ EGVSVKGSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK
60 70 80 90 100
RSNVQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYSYEAK
110 120 130 140 150
ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG STLEEDIQGD
160 170 180 190 200
TSGYLERILV CLLQGSRDDV SGFVDPGLVL QDAQALHEAG EKIMGTDEMK
210 220 230 240 250
FITILCTRSA THLMRVFEEY EKIANKCIED SIKSETHGSL EEAMLTVVKC
260 270 280 290 300
TRNVHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKGQFKKMYG
310 320
KTLSSMIMAD TSGYYKTALL NLVGTDL
Length:327
Mass (Da):36,724
Last modified:July 27, 2011 - v2
Checksum:i56DB9CFAFA8C2B21
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14S → T in CAA05364 (PubMed:9434938).Curated1
Sequence conflicti210A → L in CAA05364 (PubMed:9434938).Curated1
Sequence conflicti225N → D in CAA05364 (PubMed:9434938).Curated1
Sequence conflicti232I → F in CAA05364 (PubMed:9434938).Curated1
Sequence conflicti296K → R in CAA05364 (PubMed:9434938).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002390 mRNA. Translation: CAA05364.1.
BC030407 mRNA. Translation: AAH30407.1.
CCDSiCCDS26932.1.
RefSeqiNP_001268774.1. NM_001281845.1.
NP_038501.2. NM_013473.4.
UniGeneiMm.3267.

Genome annotation databases

EnsembliENSMUST00000022519; ENSMUSP00000022519; ENSMUSG00000021950.
GeneIDi11752.
KEGGimmu:11752.
UCSCiuc007taj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002390 mRNA. Translation: CAA05364.1.
BC030407 mRNA. Translation: AAH30407.1.
CCDSiCCDS26932.1.
RefSeqiNP_001268774.1. NM_001281845.1.
NP_038501.2. NM_013473.4.
UniGeneiMm.3267.

3D structure databases

ProteinModelPortaliO35640.
SMRiO35640.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022519.

PTM databases

PhosphoSitePlusiO35640.

Proteomic databases

MaxQBiO35640.
PaxDbiO35640.
PeptideAtlasiO35640.
PRIDEiO35640.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022519; ENSMUSP00000022519; ENSMUSG00000021950.
GeneIDi11752.
KEGGimmu:11752.
UCSCiuc007taj.2. mouse.

Organism-specific databases

CTDi653145.
MGIiMGI:1201374. Anxa8.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiO35640.
KOiK17096.
OMAiPHFNPDP.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Miscellaneous databases

PROiO35640.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021950.
CleanExiMM_ANXA8.
ExpressionAtlasiO35640. baseline and differential.
GenevisibleiO35640. MM.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009115. AnnexinVIII.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01808. ANNEXINVIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA8_MOUSE
AccessioniPrimary (citable) accession number: O35640
Secondary accession number(s): Q8K2N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.