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O35640 (ANXA8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Annexin A8
Alternative name(s):
Annexin VIII
Annexin-8
Gene names
Name:Anxa8
Synonyms:Anx8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade By similarity.

Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similarities

Belongs to the annexin family.

Contains 4 annexin repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Annexin A8
PRO_0000067504

Regions

Repeat38 – 9053Annexin 1
Repeat110 – 16253Annexin 2
Repeat195 – 24753Annexin 3
Repeat270 – 32253Annexin 4

Sites

Metal binding2661Calcium; via carbonyl oxygen By similarity
Metal binding2681Calcium; via carbonyl oxygen By similarity
Metal binding2701Calcium; via carbonyl oxygen By similarity
Metal binding3101Calcium By similarity

Experimental info

Sequence conflict141S → T in CAA05364. Ref.1
Sequence conflict2101A → L in CAA05364. Ref.1
Sequence conflict2251N → D in CAA05364. Ref.1
Sequence conflict2321I → F in CAA05364. Ref.1
Sequence conflict2961K → R in CAA05364. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35640 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 56DB9CFAFA8C2B21

FASTA32736,724
        10         20         30         40         50         60 
MAWWKAWVEQ EGVSVKGSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK RSNVQRQQIA 

        70         80         90        100        110        120 
KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYSYEAK ELHDAMKGLG TKEGVIIEIL 

       130        140        150        160        170        180 
ASRTKNQLRE IMKAYEEDYG STLEEDIQGD TSGYLERILV CLLQGSRDDV SGFVDPGLVL 

       190        200        210        220        230        240 
QDAQALHEAG EKIMGTDEMK FITILCTRSA THLMRVFEEY EKIANKCIED SIKSETHGSL 

       250        260        270        280        290        300 
EEAMLTVVKC TRNVHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKGQFKKMYG 

       310        320 
KTLSSMIMAD TSGYYKTALL NLVGTDL 

« Hide

References

« Hide 'large scale' references
[1]"The genetic origin of mouse annexin VIII."
Fernandez M.-P., Copeland N.G., Gilbert D.J., Jenkins N.A., Morgan R.O.
Mamm. Genome 9:8-14(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Fetus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ002390 mRNA. Translation: CAA05364.1.
BC030407 mRNA. Translation: AAH30407.1.
RefSeqNP_001268774.1. NM_001281845.1.
NP_038501.2. NM_013473.4.
UniGeneMm.3267.

3D structure databases

ProteinModelPortalO35640.
SMRO35640. Positions 18-326.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO35640.

Proteomic databases

PaxDbO35640.
PRIDEO35640.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022519; ENSMUSP00000022519; ENSMUSG00000021950.
GeneID11752.
KEGGmmu:11752.
UCSCuc007taj.1. mouse.

Organism-specific databases

CTD653145.
MGIMGI:1201374. Anxa8.

Phylogenomic databases

eggNOGNOG267770.
GeneTreeENSGT00740000115434.
HOGENOMHOG000158803.
HOVERGENHBG061815.
InParanoidQ8K2N9.
KOK17096.
OMAPHFNPDP.
OrthoDBEOG74XS72.
TreeFamTF105452.

Gene expression databases

BgeeO35640.
CleanExMM_ANXA8.
GenevestigatorO35640.

Family and domain databases

Gene3D1.10.220.10. 4 hits.
InterProIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009115. AnnexinVIII.
[Graphical view]
PfamPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSPR00196. ANNEXIN.
PR01808. ANNEXINVIII.
SMARTSM00335. ANX. 4 hits.
[Graphical view]
PROSITEPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio279497.
PROO35640.
SOURCESearch...

Entry information

Entry nameANXA8_MOUSE
AccessionPrimary (citable) accession number: O35640
Secondary accession number(s): Q8K2N9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot