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O35640

- ANXA8_MOUSE

UniProt

O35640 - ANXA8_MOUSE

Protein

Annexin A8

Gene

Anxa8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi266 – 2661Calcium; via carbonyl oxygenBy similarity
    Metal bindingi268 – 2681Calcium; via carbonyl oxygenBy similarity
    Metal bindingi270 – 2701Calcium; via carbonyl oxygenBy similarity
    Metal bindingi310 – 3101CalciumBy similarity

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro

    GO - Biological processi

    1. blood coagulation Source: UniProtKB-KW

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A8
    Alternative name(s):
    Annexin VIII
    Annexin-8
    Gene namesi
    Name:Anxa8
    Synonyms:Anx8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1201374. Anxa8.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Annexin A8PRO_0000067504Add
    BLAST

    Proteomic databases

    MaxQBiO35640.
    PaxDbiO35640.
    PRIDEiO35640.

    PTM databases

    PhosphoSiteiO35640.

    Expressioni

    Gene expression databases

    BgeeiO35640.
    CleanExiMM_ANXA8.
    GenevestigatoriO35640.

    Structurei

    3D structure databases

    ProteinModelPortaliO35640.
    SMRiO35640. Positions 18-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati38 – 9053Annexin 1Add
    BLAST
    Repeati110 – 16253Annexin 2Add
    BLAST
    Repeati195 – 24753Annexin 3Add
    BLAST
    Repeati270 – 32253Annexin 4Add
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 4 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    eggNOGiNOG267770.
    GeneTreeiENSGT00740000115434.
    HOGENOMiHOG000158803.
    HOVERGENiHBG061815.
    InParanoidiQ8K2N9.
    KOiK17096.
    OMAiPHFNPDP.
    OrthoDBiEOG74XS72.
    TreeFamiTF105452.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR009115. AnnexinVIII.
    [Graphical view]
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR01808. ANNEXINVIII.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35640-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWWKAWVEQ EGVSVKGSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK    50
    RSNVQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYSYEAK 100
    ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG STLEEDIQGD 150
    TSGYLERILV CLLQGSRDDV SGFVDPGLVL QDAQALHEAG EKIMGTDEMK 200
    FITILCTRSA THLMRVFEEY EKIANKCIED SIKSETHGSL EEAMLTVVKC 250
    TRNVHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKGQFKKMYG 300
    KTLSSMIMAD TSGYYKTALL NLVGTDL 327
    Length:327
    Mass (Da):36,724
    Last modified:July 27, 2011 - v2
    Checksum:i56DB9CFAFA8C2B21
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141S → T in CAA05364. (PubMed:9434938)Curated
    Sequence conflicti210 – 2101A → L in CAA05364. (PubMed:9434938)Curated
    Sequence conflicti225 – 2251N → D in CAA05364. (PubMed:9434938)Curated
    Sequence conflicti232 – 2321I → F in CAA05364. (PubMed:9434938)Curated
    Sequence conflicti296 – 2961K → R in CAA05364. (PubMed:9434938)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ002390 mRNA. Translation: CAA05364.1.
    BC030407 mRNA. Translation: AAH30407.1.
    CCDSiCCDS26932.1.
    RefSeqiNP_001268774.1. NM_001281845.1.
    NP_038501.2. NM_013473.4.
    UniGeneiMm.3267.

    Genome annotation databases

    EnsembliENSMUST00000022519; ENSMUSP00000022519; ENSMUSG00000021950.
    GeneIDi11752.
    KEGGimmu:11752.
    UCSCiuc007taj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ002390 mRNA. Translation: CAA05364.1 .
    BC030407 mRNA. Translation: AAH30407.1 .
    CCDSi CCDS26932.1.
    RefSeqi NP_001268774.1. NM_001281845.1.
    NP_038501.2. NM_013473.4.
    UniGenei Mm.3267.

    3D structure databases

    ProteinModelPortali O35640.
    SMRi O35640. Positions 18-326.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O35640.

    Proteomic databases

    MaxQBi O35640.
    PaxDbi O35640.
    PRIDEi O35640.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022519 ; ENSMUSP00000022519 ; ENSMUSG00000021950 .
    GeneIDi 11752.
    KEGGi mmu:11752.
    UCSCi uc007taj.1. mouse.

    Organism-specific databases

    CTDi 653145.
    MGIi MGI:1201374. Anxa8.

    Phylogenomic databases

    eggNOGi NOG267770.
    GeneTreei ENSGT00740000115434.
    HOGENOMi HOG000158803.
    HOVERGENi HBG061815.
    InParanoidi Q8K2N9.
    KOi K17096.
    OMAi PHFNPDP.
    OrthoDBi EOG74XS72.
    TreeFami TF105452.

    Miscellaneous databases

    NextBioi 279497.
    PROi O35640.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35640.
    CleanExi MM_ANXA8.
    Genevestigatori O35640.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR009115. AnnexinVIII.
    [Graphical view ]
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR01808. ANNEXINVIII.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Fetus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiANXA8_MOUSE
    AccessioniPrimary (citable) accession number: O35640
    Secondary accession number(s): Q8K2N9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3