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O35640

- ANXA8_MOUSE

UniProt

O35640 - ANXA8_MOUSE

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Protein

Annexin A8

Gene

Anxa8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi266 – 2661Calcium; via carbonyl oxygenBy similarity
Metal bindingi268 – 2681Calcium; via carbonyl oxygenBy similarity
Metal bindingi270 – 2701Calcium; via carbonyl oxygenBy similarity
Metal bindingi310 – 3101CalciumBy similarity

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A8
Alternative name(s):
Annexin VIII
Annexin-8
Gene namesi
Name:Anxa8
Synonyms:Anx8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1201374. Anxa8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Annexin A8PRO_0000067504Add
BLAST

Proteomic databases

MaxQBiO35640.
PaxDbiO35640.
PRIDEiO35640.

PTM databases

PhosphoSiteiO35640.

Expressioni

Gene expression databases

BgeeiO35640.
CleanExiMM_ANXA8.
ExpressionAtlasiO35640. baseline and differential.
GenevestigatoriO35640.

Structurei

3D structure databases

ProteinModelPortaliO35640.
SMRiO35640. Positions 18-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati38 – 9053Annexin 1Add
BLAST
Repeati110 – 16253Annexin 2Add
BLAST
Repeati195 – 24753Annexin 3Add
BLAST
Repeati270 – 32253Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG267770.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiO35640.
KOiK17096.
OMAiPHFNPDP.
OrthoDBiEOG74XS72.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009115. AnnexinVIII.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01808. ANNEXINVIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35640-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAWWKAWVEQ EGVSVKGSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK
60 70 80 90 100
RSNVQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYSYEAK
110 120 130 140 150
ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG STLEEDIQGD
160 170 180 190 200
TSGYLERILV CLLQGSRDDV SGFVDPGLVL QDAQALHEAG EKIMGTDEMK
210 220 230 240 250
FITILCTRSA THLMRVFEEY EKIANKCIED SIKSETHGSL EEAMLTVVKC
260 270 280 290 300
TRNVHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKGQFKKMYG
310 320
KTLSSMIMAD TSGYYKTALL NLVGTDL
Length:327
Mass (Da):36,724
Last modified:July 27, 2011 - v2
Checksum:i56DB9CFAFA8C2B21
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141S → T in CAA05364. (PubMed:9434938)Curated
Sequence conflicti210 – 2101A → L in CAA05364. (PubMed:9434938)Curated
Sequence conflicti225 – 2251N → D in CAA05364. (PubMed:9434938)Curated
Sequence conflicti232 – 2321I → F in CAA05364. (PubMed:9434938)Curated
Sequence conflicti296 – 2961K → R in CAA05364. (PubMed:9434938)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ002390 mRNA. Translation: CAA05364.1.
BC030407 mRNA. Translation: AAH30407.1.
CCDSiCCDS26932.1.
RefSeqiNP_001268774.1. NM_001281845.1.
NP_038501.2. NM_013473.4.
UniGeneiMm.3267.

Genome annotation databases

EnsembliENSMUST00000022519; ENSMUSP00000022519; ENSMUSG00000021950.
GeneIDi11752.
KEGGimmu:11752.
UCSCiuc007taj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ002390 mRNA. Translation: CAA05364.1 .
BC030407 mRNA. Translation: AAH30407.1 .
CCDSi CCDS26932.1.
RefSeqi NP_001268774.1. NM_001281845.1.
NP_038501.2. NM_013473.4.
UniGenei Mm.3267.

3D structure databases

ProteinModelPortali O35640.
SMRi O35640. Positions 18-326.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O35640.

Proteomic databases

MaxQBi O35640.
PaxDbi O35640.
PRIDEi O35640.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022519 ; ENSMUSP00000022519 ; ENSMUSG00000021950 .
GeneIDi 11752.
KEGGi mmu:11752.
UCSCi uc007taj.1. mouse.

Organism-specific databases

CTDi 653145.
MGIi MGI:1201374. Anxa8.

Phylogenomic databases

eggNOGi NOG267770.
GeneTreei ENSGT00760000118972.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.
InParanoidi O35640.
KOi K17096.
OMAi PHFNPDP.
OrthoDBi EOG74XS72.
TreeFami TF105452.

Miscellaneous databases

NextBioi 279497.
PROi O35640.
SOURCEi Search...

Gene expression databases

Bgeei O35640.
CleanExi MM_ANXA8.
ExpressionAtlasi O35640. baseline and differential.
Genevestigatori O35640.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009115. AnnexinVIII.
[Graphical view ]
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR01808. ANNEXINVIII.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Fetus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiANXA8_MOUSE
AccessioniPrimary (citable) accession number: O35640
Secondary accession number(s): Q8K2N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3