Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Annexin A8

Gene

Anxa8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi266 – 2661Calcium; via carbonyl oxygenBy similarity
Metal bindingi268 – 2681Calcium; via carbonyl oxygenBy similarity
Metal bindingi270 – 2701Calcium; via carbonyl oxygenBy similarity
Metal bindingi310 – 3101CalciumBy similarity

GO - Molecular functioni

  1. actin filament binding Source: MGI
  2. calcium-dependent phospholipid binding Source: MGI
  3. calcium ion binding Source: MGI
  4. phosphatidylinositol-3,4,5-trisphosphate binding Source: MGI
  5. phosphatidylinositol-3,4-bisphosphate binding Source: MGI
  6. phosphatidylinositol-4,5-bisphosphate binding Source: MGI

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A8
Alternative name(s):
Annexin VIII
Annexin-8
Gene namesi
Name:Anxa8
Synonyms:Anx8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1201374. Anxa8.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: MGI
  2. late endosome membrane Source: MGI
  3. plasma membrane Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Annexin A8PRO_0000067504Add
BLAST

Proteomic databases

MaxQBiO35640.
PaxDbiO35640.
PRIDEiO35640.

PTM databases

PhosphoSiteiO35640.

Expressioni

Gene expression databases

BgeeiO35640.
CleanExiMM_ANXA8.
ExpressionAtlasiO35640. baseline and differential.
GenevestigatoriO35640.

Structurei

3D structure databases

ProteinModelPortaliO35640.
SMRiO35640. Positions 18-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati38 – 9053Annexin 1Add
BLAST
Repeati110 – 16253Annexin 2Add
BLAST
Repeati195 – 24753Annexin 3Add
BLAST
Repeati270 – 32253Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG267770.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiO35640.
KOiK17096.
OMAiPHFNPDP.
OrthoDBiEOG74XS72.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009115. AnnexinVIII.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01808. ANNEXINVIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWWKAWVEQ EGVSVKGSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK
60 70 80 90 100
RSNVQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYSYEAK
110 120 130 140 150
ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG STLEEDIQGD
160 170 180 190 200
TSGYLERILV CLLQGSRDDV SGFVDPGLVL QDAQALHEAG EKIMGTDEMK
210 220 230 240 250
FITILCTRSA THLMRVFEEY EKIANKCIED SIKSETHGSL EEAMLTVVKC
260 270 280 290 300
TRNVHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKGQFKKMYG
310 320
KTLSSMIMAD TSGYYKTALL NLVGTDL
Length:327
Mass (Da):36,724
Last modified:July 26, 2011 - v2
Checksum:i56DB9CFAFA8C2B21
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141S → T in CAA05364 (PubMed:9434938).Curated
Sequence conflicti210 – 2101A → L in CAA05364 (PubMed:9434938).Curated
Sequence conflicti225 – 2251N → D in CAA05364 (PubMed:9434938).Curated
Sequence conflicti232 – 2321I → F in CAA05364 (PubMed:9434938).Curated
Sequence conflicti296 – 2961K → R in CAA05364 (PubMed:9434938).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002390 mRNA. Translation: CAA05364.1.
BC030407 mRNA. Translation: AAH30407.1.
CCDSiCCDS26932.1.
RefSeqiNP_001268774.1. NM_001281845.1.
NP_038501.2. NM_013473.4.
UniGeneiMm.3267.

Genome annotation databases

EnsembliENSMUST00000022519; ENSMUSP00000022519; ENSMUSG00000021950.
GeneIDi11752.
KEGGimmu:11752.
UCSCiuc007taj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002390 mRNA. Translation: CAA05364.1.
BC030407 mRNA. Translation: AAH30407.1.
CCDSiCCDS26932.1.
RefSeqiNP_001268774.1. NM_001281845.1.
NP_038501.2. NM_013473.4.
UniGeneiMm.3267.

3D structure databases

ProteinModelPortaliO35640.
SMRiO35640. Positions 18-326.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiO35640.

Proteomic databases

MaxQBiO35640.
PaxDbiO35640.
PRIDEiO35640.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022519; ENSMUSP00000022519; ENSMUSG00000021950.
GeneIDi11752.
KEGGimmu:11752.
UCSCiuc007taj.1. mouse.

Organism-specific databases

CTDi653145.
MGIiMGI:1201374. Anxa8.

Phylogenomic databases

eggNOGiNOG267770.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiO35640.
KOiK17096.
OMAiPHFNPDP.
OrthoDBiEOG74XS72.
TreeFamiTF105452.

Miscellaneous databases

NextBioi279497.
PROiO35640.
SOURCEiSearch...

Gene expression databases

BgeeiO35640.
CleanExiMM_ANXA8.
ExpressionAtlasiO35640. baseline and differential.
GenevestigatoriO35640.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR009115. AnnexinVIII.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR01808. ANNEXINVIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Fetus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiANXA8_MOUSE
AccessioniPrimary (citable) accession number: O35640
Secondary accession number(s): Q8K2N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2001
Last sequence update: July 26, 2011
Last modified: February 3, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.