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O35639 (ANXA3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Annexin A3
Alternative name(s):
35-alpha calcimedin
Annexin III
Annexin-3
Lipocortin III
Placental anticoagulant protein III
Short name=PAP-III
Gene names
Name:Anxa3
Synonyms:Anx3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibitor of phospholipase A2, also possesses anti-coagulant properties.

Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similarities

Belongs to the annexin family.

Contains 4 annexin repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 323322Annexin A3
PRO_0000067478

Regions

Repeat27 – 8761Annexin 1
Repeat99 – 15961Annexin 2
Repeat183 – 24361Annexin 3
Repeat258 – 31861Annexin 4

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1771N6-acetyllysine Ref.4

Experimental info

Sequence conflict97 – 982KQ → NE in CAA04887. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35639 [UniParc].

Last modified July 27, 2011. Version 4.
Checksum: E869F181A8AC60B9

FASTA32336,384
        10         20         30         40         50         60 
MASIWVGPRG TIKDYPGFSP SVDAEAIRKA IRGLGTDEKT LINILTERSN AQRQLIVKQY 

        70         80         90        100        110        120 
QAAYEQELKD DLKGDLSGHF EHVMVALVTA PALFDAKQLK KSMKGTGTDE DALIEILTTR 

       130        140        150        160        170        180 
SSRQMKEISQ AYYTVYKKSL GDDISSETSG DFRKALLTLA DGRRDESLKV DEHLAKKDAQ 

       190        200        210        220        230        240 
ILYNAGENKW GTDEDKFTEV LCLRSFPQLK LTFDEYRNIS QKDIEDSIKG ELSGHFEDLL 

       250        260        270        280        290        300 
LAIVHCARNT PAFLAERLHQ ALKGAGTDEF TLNRIMVSRS EIDLLDIRHE FKKHYGYSLY 

       310        320 
SAIQSDTSGD YRTVLLKICG EDD 

« Hide

References

« Hide 'large scale' references
[1]"Mouse annexin III cDNA, genetic mapping and evolution."
Fernandez M.-P., Copeland N.G., Gilbert D.J., Jenkins N.A., Morgan R.O.
Gene 207:43-51(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Amnion, Bone marrow and Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Eye.
[4]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ001633 mRNA. Translation: CAA04887.1.
AK150922 mRNA. Translation: BAE29960.1.
AK150951 mRNA. Translation: BAE29984.1.
AK151771 mRNA. Translation: BAE30677.1.
AK152863 mRNA. Translation: BAE31554.1.
AK168396 mRNA. Translation: BAE40320.1.
AK168507 mRNA. Translation: BAE40390.1.
BC090634 mRNA. Translation: AAH90634.1.
CCDSCCDS51568.1.
RefSeqNP_038498.2. NM_013470.2.
XP_006534797.1. XM_006534734.1.
UniGeneMm.7214.

3D structure databases

ProteinModelPortalO35639.
SMRO35639. Positions 2-323.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198109. 1 interaction.
IntActO35639. 3 interactions.
MINTMINT-4996194.

PTM databases

PhosphoSiteO35639.

2D gel databases

COMPLUYEAST-2DPAGEO35639.
REPRODUCTION-2DPAGEO35639.

Proteomic databases

MaxQBO35639.
PaxDbO35639.
PRIDEO35639.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031447; ENSMUSP00000031447; ENSMUSG00000029484.
GeneID11745.
KEGGmmu:11745.
UCSCuc008yfm.2. mouse.

Organism-specific databases

CTD306.
MGIMGI:1201378. Anxa3.

Phylogenomic databases

eggNOGNOG267770.
GeneTreeENSGT00740000115158.
HOGENOMHOG000158803.
HOVERGENHBG061815.
InParanoidQ3UBI0.
KOK17089.
OMAHRGTVRD.
OrthoDBEOG74XS72.
TreeFamTF105452.

Gene expression databases

BgeeO35639.
CleanExMM_ANXA3.
GenevestigatorO35639.

Family and domain databases

Gene3D1.10.220.10. 4 hits.
InterProIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002390. AnnexinIII.
[Graphical view]
PANTHERPTHR10502:SF25. PTHR10502:SF25. 1 hit.
PfamPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSPR00196. ANNEXIN.
PR00199. ANNEXINIII.
SMARTSM00335. ANX. 4 hits.
[Graphical view]
PROSITEPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio279477.
PROO35639.
SOURCESearch...

Entry information

Entry nameANXA3_MOUSE
AccessionPrimary (citable) accession number: O35639
Secondary accession number(s): Q3UBI0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 110 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot