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O35639

- ANXA3_MOUSE

UniProt

O35639 - ANXA3_MOUSE

Protein

Annexin A3

Gene

Anxa3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 4 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Inhibitor of phospholipase A2, also possesses anti-coagulant properties.

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro
    3. phospholipase A2 inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. defense response to bacterium Source: Ensembl
    2. neutrophil degranulation Source: Ensembl
    3. phagocytosis Source: Ensembl
    4. positive regulation of angiogenesis Source: Ensembl
    5. positive regulation of endothelial cell migration Source: Ensembl
    6. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl

    Keywords - Molecular functioni

    Phospholipase A2 inhibitor

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A3
    Alternative name(s):
    35-alpha calcimedin
    Annexin III
    Annexin-3
    Lipocortin III
    Placental anticoagulant protein III
    Short name:
    PAP-III
    Gene namesi
    Name:Anxa3
    Synonyms:Anx3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1201378. Anxa3.

    Subcellular locationi

    GO - Cellular componenti

    1. phagocytic vesicle membrane Source: Ensembl
    2. plasma membrane Source: Ensembl
    3. specific granule Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 323322Annexin A3PRO_0000067478Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei177 – 1771N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO35639.
    PaxDbiO35639.
    PRIDEiO35639.

    2D gel databases

    COMPLUYEAST-2DPAGEO35639.
    REPRODUCTION-2DPAGEO35639.

    PTM databases

    PhosphoSiteiO35639.

    Expressioni

    Gene expression databases

    BgeeiO35639.
    CleanExiMM_ANXA3.
    GenevestigatoriO35639.

    Interactioni

    Protein-protein interaction databases

    BioGridi198109. 1 interaction.
    IntActiO35639. 3 interactions.
    MINTiMINT-4996194.

    Structurei

    3D structure databases

    ProteinModelPortaliO35639.
    SMRiO35639. Positions 2-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati27 – 8761Annexin 1Add
    BLAST
    Repeati99 – 15961Annexin 2Add
    BLAST
    Repeati183 – 24361Annexin 3Add
    BLAST
    Repeati258 – 31861Annexin 4Add
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 4 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    eggNOGiNOG267770.
    GeneTreeiENSGT00740000115158.
    HOGENOMiHOG000158803.
    HOVERGENiHBG061815.
    InParanoidiQ3UBI0.
    KOiK17089.
    OMAiHRGTVRD.
    OrthoDBiEOG74XS72.
    TreeFamiTF105452.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002390. AnnexinIII.
    [Graphical view]
    PANTHERiPTHR10502:SF25. PTHR10502:SF25. 1 hit.
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR00199. ANNEXINIII.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35639-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASIWVGPRG TIKDYPGFSP SVDAEAIRKA IRGLGTDEKT LINILTERSN    50
    AQRQLIVKQY QAAYEQELKD DLKGDLSGHF EHVMVALVTA PALFDAKQLK 100
    KSMKGTGTDE DALIEILTTR SSRQMKEISQ AYYTVYKKSL GDDISSETSG 150
    DFRKALLTLA DGRRDESLKV DEHLAKKDAQ ILYNAGENKW GTDEDKFTEV 200
    LCLRSFPQLK LTFDEYRNIS QKDIEDSIKG ELSGHFEDLL LAIVHCARNT 250
    PAFLAERLHQ ALKGAGTDEF TLNRIMVSRS EIDLLDIRHE FKKHYGYSLY 300
    SAIQSDTSGD YRTVLLKICG EDD 323
    Length:323
    Mass (Da):36,384
    Last modified:July 27, 2011 - v4
    Checksum:iE869F181A8AC60B9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 982KQ → NE in CAA04887. (PubMed:9511742)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001633 mRNA. Translation: CAA04887.1.
    AK150922 mRNA. Translation: BAE29960.1.
    AK150951 mRNA. Translation: BAE29984.1.
    AK151771 mRNA. Translation: BAE30677.1.
    AK152863 mRNA. Translation: BAE31554.1.
    AK168396 mRNA. Translation: BAE40320.1.
    AK168507 mRNA. Translation: BAE40390.1.
    BC090634 mRNA. Translation: AAH90634.1.
    CCDSiCCDS51568.1.
    RefSeqiNP_038498.2. NM_013470.2.
    XP_006534797.1. XM_006534734.1.
    UniGeneiMm.7214.

    Genome annotation databases

    EnsembliENSMUST00000031447; ENSMUSP00000031447; ENSMUSG00000029484.
    GeneIDi11745.
    KEGGimmu:11745.
    UCSCiuc008yfm.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001633 mRNA. Translation: CAA04887.1 .
    AK150922 mRNA. Translation: BAE29960.1 .
    AK150951 mRNA. Translation: BAE29984.1 .
    AK151771 mRNA. Translation: BAE30677.1 .
    AK152863 mRNA. Translation: BAE31554.1 .
    AK168396 mRNA. Translation: BAE40320.1 .
    AK168507 mRNA. Translation: BAE40390.1 .
    BC090634 mRNA. Translation: AAH90634.1 .
    CCDSi CCDS51568.1.
    RefSeqi NP_038498.2. NM_013470.2.
    XP_006534797.1. XM_006534734.1.
    UniGenei Mm.7214.

    3D structure databases

    ProteinModelPortali O35639.
    SMRi O35639. Positions 2-323.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198109. 1 interaction.
    IntActi O35639. 3 interactions.
    MINTi MINT-4996194.

    PTM databases

    PhosphoSitei O35639.

    2D gel databases

    COMPLUYEAST-2DPAGE O35639.
    REPRODUCTION-2DPAGE O35639.

    Proteomic databases

    MaxQBi O35639.
    PaxDbi O35639.
    PRIDEi O35639.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031447 ; ENSMUSP00000031447 ; ENSMUSG00000029484 .
    GeneIDi 11745.
    KEGGi mmu:11745.
    UCSCi uc008yfm.2. mouse.

    Organism-specific databases

    CTDi 306.
    MGIi MGI:1201378. Anxa3.

    Phylogenomic databases

    eggNOGi NOG267770.
    GeneTreei ENSGT00740000115158.
    HOGENOMi HOG000158803.
    HOVERGENi HBG061815.
    InParanoidi Q3UBI0.
    KOi K17089.
    OMAi HRGTVRD.
    OrthoDBi EOG74XS72.
    TreeFami TF105452.

    Miscellaneous databases

    NextBioi 279477.
    PROi O35639.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35639.
    CleanExi MM_ANXA3.
    Genevestigatori O35639.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002390. AnnexinIII.
    [Graphical view ]
    PANTHERi PTHR10502:SF25. PTHR10502:SF25. 1 hit.
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR00199. ANNEXINIII.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse annexin III cDNA, genetic mapping and evolution."
      Fernandez M.-P., Copeland N.G., Gilbert D.J., Jenkins N.A., Morgan R.O.
      Gene 207:43-51(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Amnion, Bone marrow and Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiANXA3_MOUSE
    AccessioniPrimary (citable) accession number: O35639
    Secondary accession number(s): Q3UBI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 111 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3