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Protein

Dexamethasone-induced Ras-related protein 1

Gene

Rasd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 388GTPBy similarity
Nucleotide bindingi78 – 825GTPBy similarity
Nucleotide bindingi145 – 1484GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dexamethasone-induced Ras-related protein 1
Gene namesi
Name:Rasd1
Synonyms:Dexras1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1270848. Rasd1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB-SubCell
  • sarcoplasmic reticulum Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Dexamethasone-induced Ras-related protein 1PRO_0000082718Add
BLAST
Propeptidei278 – 2803Removed in mature formBy similarityPRO_0000281373

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei11 – 111S-nitrosocysteineBy similarity
Modified residuei277 – 2771Cysteine methyl esterBy similarity
Lipidationi277 – 2771S-farnesyl cysteineBy similarity

Post-translational modificationi

S-nitrosylation stimulates guanine-nucleotide exchange activity.1 Publication

Keywords - PTMi

Lipoprotein, Methylation, Prenylation, S-nitrosylation

Proteomic databases

PaxDbiO35626.
PRIDEiO35626.

PTM databases

iPTMnetiO35626.
PhosphoSiteiO35626.

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney and liver.1 Publication

Inductioni

By dexamethasone.1 Publication

Gene expression databases

BgeeiO35626.
CleanExiMM_RASD1.
ExpressionAtlasiO35626. baseline and differential.
GenevisibleiO35626. MM.

Interactioni

Subunit structurei

Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts with APBB1/FE65 (By similarity). Forms a ternary complex with CAPON and NOS1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Nr2f6P431365EBI-4319979,EBI-4319956

Protein-protein interaction databases

IntActiO35626. 8 interactions.
STRINGi10090.ENSMUSP00000051959.

Structurei

3D structure databases

ProteinModelPortaliO35626.
SMRiO35626. Positions 23-219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi53 – 619Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. RasD family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO35626.
KOiK07843.
OMAiFYREVEQ.
OrthoDBiEOG7M0NSN.
PhylomeDBiO35626.
TreeFamiTF316238.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35626-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLAAMIKKM CPSDSELSIP AKNCYRMVIL GSSKVGKTAI VSRFLTGRFE
60 70 80 90 100
DAYTPTIEDF HRKFYSIRGE VYQLDILDTS GNHPFPAMRR LSILTGDVFI
110 120 130 140 150
LVFSLDNRDS FEEVQRLKQQ ILDTKSCLKN KTKENVDVPL VICGNKGDRD
160 170 180 190 200
FYREVEQREI EQLVGDDPQR CAYFEISAKK NSSLDQMFRA LFAMAKLPSE
210 220 230 240 250
MSPDLHRKVS VQYCDVLHKK ALRNKKLLRA GSGGGGDHGD AFGILAPFAR
260 270 280
RPSVHSDLMY IREKTSVGSQ AKDKERCVIS
Length:280
Mass (Da):31,684
Last modified:January 1, 1998 - v1
Checksum:iE551203197FCF9D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009246 mRNA. Translation: AAC53538.1.
AK038932 mRNA. Translation: BAC30173.1.
BC034166 mRNA. Translation: AAH34166.1.
CCDSiCCDS24781.1.
RefSeqiNP_033052.1. NM_009026.5.
UniGeneiMm.3903.

Genome annotation databases

EnsembliENSMUST00000062405; ENSMUSP00000051959; ENSMUSG00000049892.
GeneIDi19416.
KEGGimmu:19416.
UCSCiuc007jfh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009246 mRNA. Translation: AAC53538.1.
AK038932 mRNA. Translation: BAC30173.1.
BC034166 mRNA. Translation: AAH34166.1.
CCDSiCCDS24781.1.
RefSeqiNP_033052.1. NM_009026.5.
UniGeneiMm.3903.

3D structure databases

ProteinModelPortaliO35626.
SMRiO35626. Positions 23-219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35626. 8 interactions.
STRINGi10090.ENSMUSP00000051959.

PTM databases

iPTMnetiO35626.
PhosphoSiteiO35626.

Proteomic databases

PaxDbiO35626.
PRIDEiO35626.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062405; ENSMUSP00000051959; ENSMUSG00000049892.
GeneIDi19416.
KEGGimmu:19416.
UCSCiuc007jfh.2. mouse.

Organism-specific databases

CTDi51655.
MGIiMGI:1270848. Rasd1.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiO35626.
KOiK07843.
OMAiFYREVEQ.
OrthoDBiEOG7M0NSN.
PhylomeDBiO35626.
TreeFamiTF316238.

Miscellaneous databases

ChiTaRSiRasd1. mouse.
PROiO35626.
SOURCEiSearch...

Gene expression databases

BgeeiO35626.
CleanExiMM_RASD1.
ExpressionAtlasiO35626. baseline and differential.
GenevisibleiO35626. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells."
    Kemppainen R.J., Behrend E.N.
    J. Biol. Chem. 273:3129-3131(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hypothalamus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. "Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON."
    Fang M., Jaffrey S.R., Sawa A., Ye K., Luo X., Snyder S.H.
    Neuron 28:183-193(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CAPON AND NOS1, S-NITROSYLATION.

Entry informationi

Entry nameiRASD1_MOUSE
AccessioniPrimary (citable) accession number: O35626
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.