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O35625

- AXIN1_MOUSE

UniProt

O35625 - AXIN1_MOUSE

Protein

Axin-1

Gene

Axin1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 3 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling By similarity. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 By similarity. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.By similarity3 Publications

    GO - Molecular functioni

    1. armadillo repeat domain binding Source: RefGenome
    2. beta-catenin binding Source: MGI
    3. GTPase activator activity Source: RefGenome
    4. identical protein binding Source: MGI
    5. I-SMAD binding Source: BHF-UCL
    6. p53 binding Source: MGI
    7. protein binding Source: UniProtKB
    8. protein complex scaffold Source: BHF-UCL
    9. protein C-terminus binding Source: MGI
    10. protein domain specific binding Source: MGI
    11. protein homodimerization activity Source: UniProtKB
    12. protein kinase binding Source: MGI
    13. protein self-association Source: MGI
    14. R-SMAD binding Source: MGI
    15. signal transducer activity Source: Ensembl
    16. ubiquitin protein ligase binding Source: BHF-UCL

    GO - Biological processi

    1. activation of JUN kinase activity Source: RefGenome
    2. apoptotic process Source: UniProtKB-KW
    3. axial mesoderm development Source: MGI
    4. axial mesoderm formation Source: MGI
    5. canonical Wnt signaling pathway Source: MGI
    6. canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation Source: RefGenome
    7. cell death Source: RefGenome
    8. cellular protein complex assembly Source: Ensembl
    9. cellular response to organic cyclic compound Source: RefGenome
    10. cytoplasmic microtubule organization Source: MGI
    11. determination of left/right symmetry Source: RefGenome
    12. dorsal/ventral axis specification Source: MGI
    13. dorsal/ventral pattern formation Source: MGI
    14. embryonic eye morphogenesis Source: RefGenome
    15. forebrain anterior/posterior pattern specification Source: RefGenome
    16. genetic imprinting Source: MGI
    17. in utero embryonic development Source: MGI
    18. muscle cell development Source: RefGenome
    19. negative regulation of canonical Wnt signaling pathway Source: MGI
    20. negative regulation of fat cell differentiation Source: MGI
    21. negative regulation of protein metabolic process Source: MGI
    22. negative regulation of transcription elongation from RNA polymerase II promoter Source: MGI
    23. negative regulation of Wnt signaling pathway Source: MGI
    24. nucleocytoplasmic transport Source: MGI
    25. olfactory placode formation Source: RefGenome
    26. optic placode formation Source: RefGenome
    27. positive regulation of GTPase activity Source: GOC
    28. positive regulation of JNK cascade Source: UniProtKB
    29. positive regulation of JUN kinase activity Source: MGI
    30. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    31. positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
    32. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
    33. positive regulation of protein phosphorylation Source: MGI
    34. positive regulation of protein ubiquitination Source: MGI
    35. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
    36. positive regulation of transcription, DNA-templated Source: BHF-UCL
    37. positive regulation of transforming growth factor beta receptor signaling pathway Source: MGI
    38. positive regulation of ubiquitin-protein transferase activity Source: BHF-UCL
    39. post-anal tail morphogenesis Source: MGI
    40. protein catabolic process Source: MGI
    41. protein homooligomerization Source: MGI
    42. protein polyubiquitination Source: MGI
    43. regulation of catenin import into nucleus Source: MGI
    44. regulation of protein phosphorylation Source: MGI
    45. sensory perception of sound Source: MGI
    46. termination of G-protein coupled receptor signaling pathway Source: InterPro
    47. Wnt-activated signaling pathway involved in forebrain neuron fate commitment Source: RefGenome
    48. Wnt signaling pathway Source: MGI
    49. Wnt signaling pathway involved in somitogenesis Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Apoptosis, Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_203336. Degradation of beta-catenin by the destruction complex.
    REACT_207044. TCF dependent signaling in response to WNT.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_218396. Beta-catenin phosphorylation cascade.
    REACT_219129. degradation of AXIN.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Axin-1
    Alternative name(s):
    Axis inhibition protein 1
    Protein Fused
    Gene namesi
    Name:Axin1
    Synonyms:Axin, Fu
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1096327. Axin1.

    Subcellular locationi

    Cytoplasm. Nucleus By similarity. Cell membrane. Membrane
    Note: On UV irradiation, translocates to the nucleus and colocalizes with DAAX By similarity. MACF1 is required for its translocation to cell membrane.By similarity

    GO - Cellular componenti

    1. beta-catenin destruction complex Source: MGI
    2. cell cortex Source: MGI
    3. cytoplasm Source: BHF-UCL
    4. cytoplasmic membrane-bounded vesicle Source: MGI
    5. Golgi apparatus Source: Ensembl
    6. lateral plasma membrane Source: Ensembl
    7. nucleus Source: UniProtKB-SubCell
    8. perinuclear region of cytoplasm Source: Ensembl
    9. plasma membrane Source: UniProtKB
    10. postsynaptic density Source: RefGenome
    11. protein complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi480 – 4801T → A: Greatly reduced GSK3B-mediated phosphorylation; when associated with A-485 and A-492. 2 Publications
    Mutagenesisi485 – 4851S → A: Greatly reduced GSK3B-mediated phosphorylation and large effect on the inhibitory activity in Wnt-signaling; when associated with A-480 and A-492. 2 Publications
    Mutagenesisi492 – 4921S → A: Greatly reduced GSK3B-mediated phosphorylation; when associated with A-480 and A-485. 2 Publications
    Mutagenesisi492 – 4921S → I: Little effect on inhibitory activity on Wnt-signaling. 2 Publications
    Mutagenesisi495 – 4951S → A: No effect on phosphorylation. Little effect on inhibitory activity on Wnt-signaling. 2 Publications
    Mutagenesisi858 – 8636Missing: Abolishes binding of PIAS1 and PIAS2. Dramatically reduces sumoylation and abolishes AXIN1-mediated JNK activation. No effect on homodimerization nor on Wnt-signaling. 2 Publications
    Mutagenesisi858 – 8581K → A: Decreased sumoylation followed by increased ubiquitination; when associated with A-861. 2 Publications
    Mutagenesisi861 – 8611K → A: Decreased sumoylation followed by increased ubiquitination; when associated with A-858. 2 Publications

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 863863Axin-1PRO_0000220889Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei75 – 751Phosphoserine; by CK1By similarity
    Modified residuei77 – 771Phosphoserine; by CK1By similarity
    Modified residuei217 – 2171Phosphoserine; by CK1By similarity
    Modified residuei468 – 4681Phosphoserine; by CK1By similarity
    Modified residuei480 – 4801Phosphothreonine; by GSK3-beta2 Publications
    Modified residuei485 – 4851Phosphoserine; by GSK3-beta2 Publications
    Modified residuei492 – 4921Phosphoserine2 Publications
    Cross-linki858 – 858Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
    Cross-linki861 – 861Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

    Post-translational modificationi

    Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1 By similarity. Also phosphorylated by CDK2 which regulates interaction with CTNBB1.By similarity2 Publications
    ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway By similarity.By similarity
    Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important for nuclear accumulation during Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription By similarity. Sumoylation at Lys-858 and Lys-861 prevents ubiquitination and degradation. Sumoylation is required for AXIN1-mediated JNK activation.By similarity2 Publications

    Keywords - PTMi

    ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiO35625.
    PRIDEiO35625.

    PTM databases

    PhosphoSiteiO35625.

    Expressioni

    Tissue specificityi

    Expressed in embryonic stem cells.

    Developmental stagei

    Widely expressed at E10.5 to E16.5 day.

    Gene expression databases

    CleanExiMM_AXIN1.
    GenevestigatoriO35625.

    Interactioni

    Subunit structurei

    Homodimer. Component of the beta-catenin destruction complex, containing at least CTNNB1, an axin and GSK3B, that regulates CTNNB1 protein levels through phosphorylation and ubiquitination By similarity. Interacts with GSK3B; the interaction hyperphosphorylates CTNNB1 leading to its ubiquitination and destruction. Interacts with DAXX; the interaction stimulates the interaction of DAXX with TP53, stimulates 'Ser-46' phosphorylation of TP53 and induces cell death on UV irradiation. Also interacts with APC, RNF111, SMAD6 and SMAD7. Interacts (via the C-terminal) with PPP1CA; the interaction dephosphorylates AXIN1 and regulates interaction with GSK3B. Interacts with PPP2CA; the interaction dephosphorylates AXIN1. Interacts with MDFI; the interaction decreases AXIN1-mediated JUN N-terminal kinase (JNK) activation. Interacts with MDFIC; the interaction inhibits beta-cateninin-mediated signaling and AXIN1-mediated JUN N-terminal kinase (JNK) activation By similarity. Binds ANKRD6, PIAS1, PIAS2, PIAS4, SUMO1, MAP3K1 and MAP3K4. Component of the AXIN1-HIPK2-TP53 complex. Interacts directly in the complex with TP53 and HIPK2. Interacts with DIXDC1; the interaction prevents interaction with MAP3K1. Interacts with AIDA; the interaction blocks the AXIN1-mediated JNK activation through disrupting AXIN1 homodimerization and Wnt signaling. Interacts with LRP5 (via its phosphorylated PPPSP motifs); the interaction is stimulated by WNT1 and GSK3B and activates beta-catenin signaling. Interacts with CTNNB1 (via the armadillo repeats 2-7). Interacts with MACF1 By similarity. Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B By similarity. Interacts with TNKS By similarity. Interacts with DAB2; the interaction is mutually exclusive with the AXIN1:PPP1CA interaction. Interacts with ZBED3 (via PPPSP motif); the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations.By similarity10 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTNNB1P352224EBI-2365912,EBI-491549From a different organism.
    Dab2P980784EBI-2365912,EBI-1391846
    Dvl3Q610622EBI-2365912,EBI-1538450
    GSK3BP498415EBI-2365912,EBI-373586From a different organism.
    LRP6O755812EBI-2365912,EBI-910915From a different organism.
    Ppp1caP621372EBI-2365912,EBI-357187
    Rnf111Q99ML94EBI-2365912,EBI-646015
    Smad3Q8BUN52EBI-2365912,EBI-2337983
    Smad6O351822EBI-2365912,EBI-4321242
    Smad7O352532EBI-2365912,EBI-5274835
    TNKSO952714EBI-2365912,EBI-1105254From a different organism.

    Protein-protein interaction databases

    BioGridi198287. 33 interactions.
    DIPiDIP-42637N.
    IntActiO35625. 21 interactions.
    MINTiMINT-1543084.

    Structurei

    Secondary structure

    1
    863
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi64 – 663

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3UTMX-ray2.00C1-80[»]
    ProteinModelPortaliO35625.
    SMRiO35625. Positions 74-220, 780-863.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini88 – 211124RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini781 – 86383DIXPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni209 – 338130Interaction with TP53Add
    BLAST
    Regioni348 – 43285Interaction with GSK3BBy similarityAdd
    BLAST
    Regioni433 – 50169Interaction with beta-cateninBy similarityAdd
    BLAST
    Regioni505 – 758254Interaction with RNF111By similarityAdd
    BLAST
    Regioni572 – 790219Interaction with PPP2CABy similarityAdd
    BLAST
    Regioni678 – 75376Interaction with HIPK2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi20 – 2910Tankyrase-binding motif

    Domaini

    The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.By similarity

    Sequence similaritiesi

    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG238205.
    HOVERGENiHBG004324.
    InParanoidiO35625.
    KOiK02157.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O35625-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNVQEQGFPL DLGASFTEDA PRPPVPGEEG ELVSTDSRPV NHSFCSGKGT    50
    SIKSETSTAT PRRSDLDLGY EPEGSASPTP PYLRWAESLH SLLDDQDGIS 100
    LFRTFLKQEG CADLLDFWFA CSGFRKLEPC DSNEEKRLKL ARAIYRKYIL 150
    DSNGIVSRQT KPATKSFIKD CVMKQQIDPA MFDQAQTEIQ STMEENTYPS 200
    FLKSDIYLEY TRTGSESPKV CSDQSSGSGT GKGMSGYLPT LNEDEEWKCD 250
    QDADEDDGRD PLPPSRLTQK LLLETAAPRA PSSRRYNEGR ELRYGSWREP 300
    VNPYYVNSGY ALAPATSAND SEQQSLSSDA DTLSLTDSSV DGIPPYRIRK 350
    QHRREMQESI QVNGRVPLPH IPRTYRMPKE IRVEPQKFAE ELIHRLEAVQ 400
    RTREAEEKLE ERLKRVRMEE EGEDGEMPSG PMASHKLPSV PAWHHFPPRY 450
    VDMGCSGLRD AHEENPESIL DEHVQRVMRT PGCQSPGPGH RSPDSGHVAK 500
    TAVLGGTASG HGKHVPKLGL KLDTAGLHHH RHVHHHVHHN SARPKEQMEA 550
    EVARRVQSSF SWGPETHGHA KPRSYSENAG TTLSAGDLAF GGKTSAPSKR 600
    NTKKAESGKN ANAEVPSTTE DAEKNQKIMQ WIIEGEKEIS RHRKAGHGSS 650
    GLRKQQAHES SRPLSIERPG AVHPWVSAQL RNSVQPSHLF IQDPTMPPNP 700
    APNPLTQLEE ARRRLEEEEK RANKLPSKQR YVQAVMQRGR TCVRPACAPV 750
    LSVVPAVSDL ELSETETKSQ RKAGGGSAPP CDSIVVAYYF CGEPIPYRTL 800
    VRGRAVTLGQ FKELLTKKGS YRYYFKKVSD EFDCGVVFEE VREDEAVLPV 850
    FEEKIIGKVE KVD 863
    Length:863
    Mass (Da):96,276
    Last modified:October 3, 2012 - v3
    Checksum:i2216D66E92387B81
    GO
    Isoform 2 (identifier: O35625-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         731-766: Missing.

    Show »
    Length:827
    Mass (Da):92,418
    Checksum:i0D99A235EEDC597E
    GO

    Sequence cautioni

    The sequence AAC53285.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti589 – 5891A → P in AAC53285. (PubMed:9230313)Curated
    Sequence conflicti787 – 7871A → G in AAC53285. (PubMed:9230313)Curated
    Sequence conflicti846 – 8461A → P in AAC53285. (PubMed:9230313)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei731 – 76636Missing in isoform 2. 1 PublicationVSP_000452Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF009011 mRNA. Translation: AAC53285.1. Different initiation.
    AC126438 Genomic DNA. No translation available.
    AC140047 Genomic DNA. No translation available.
    RefSeqiNP_033863.2. NM_009733.2.
    UniGeneiMm.23684.

    Genome annotation databases

    GeneIDi12005.
    KEGGimmu:12005.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF009011 mRNA. Translation: AAC53285.1 . Different initiation.
    AC126438 Genomic DNA. No translation available.
    AC140047 Genomic DNA. No translation available.
    RefSeqi NP_033863.2. NM_009733.2.
    UniGenei Mm.23684.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3UTM X-ray 2.00 C 1-80 [» ]
    ProteinModelPortali O35625.
    SMRi O35625. Positions 74-220, 780-863.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198287. 33 interactions.
    DIPi DIP-42637N.
    IntActi O35625. 21 interactions.
    MINTi MINT-1543084.

    PTM databases

    PhosphoSitei O35625.

    Proteomic databases

    PaxDbi O35625.
    PRIDEi O35625.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 12005.
    KEGGi mmu:12005.

    Organism-specific databases

    CTDi 8312.
    MGIi MGI:1096327. Axin1.

    Phylogenomic databases

    eggNOGi NOG238205.
    HOVERGENi HBG004324.
    InParanoidi O35625.
    KOi K02157.

    Enzyme and pathway databases

    Reactomei REACT_203336. Degradation of beta-catenin by the destruction complex.
    REACT_207044. TCF dependent signaling in response to WNT.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_218396. Beta-catenin phosphorylation cascade.
    REACT_219129. degradation of AXIN.

    Miscellaneous databases

    NextBioi 280195.
    PROi O35625.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_AXIN1.
    Genevestigatori O35625.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation."
      Zeng L., Fagotto F., Zhang T., Hsu W., Vasicek T.J., Perry W.L. III, Lee J.J., Tilghman S.M., Gumbiner B.M., Costantini F.
      Cell 90:181-192(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression."
      Jho E., Lomvardas S., Costantini F.
      Biochem. Biophys. Res. Commun. 266:28-35(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-480; SER-485 AND SER-492, INTERACTION WITH CTNNB1, MUTAGENESIS OF THR-480; SER-485; SER-492 AND SER-495.
    4. "Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway."
      Mao J., Wang J., Liu B., Pan W., Farr G.H. III, Flynn C., Yuan H., Takada S., Kimelman D., Li L., Wu D.
      Mol. Cell 7:801-809(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LRP5.
    5. "The ankyrin repeat protein diversin recruits casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling."
      Schwarz-Romond T., Asbrand C., Bakkers J., Kuehl M., Schaeffer H.J., Huelsken J., Behrens J., Hammerschmidt M., Birchmeier W.
      Genes Dev. 16:2073-2084(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ANKRD6.
    6. "SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling."
      Rui H.L., Fan E., Zhou H.M., Xu Z., Zhang Y., Lin S.C.
      J. Biol. Chem. 277:42981-42986(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUMOYLATION AT LYS-858 AND LYS-861, INTERACTION WITH MAP3K1; SUMO1; PIAS1; PIAS2 AND PIAS4, FUNCTION, HOMODIMERIZATION, MUTAGENESIS OF 858-LYS--ASP-863.
    7. "Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin."
      Kim S.I., Park C.S., Lee M.S., Kwon M.S., Jho E.H., Song W.K.
      Biochem. Biophys. Res. Commun. 317:478-483(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, INTERACTION WITH CTNNB1.
    8. "Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation."
      Rui Y., Xu Z., Lin S., Li Q., Rui H., Luo W., Zhou H.-M., Cheung P.-Y., Wu Z., Ye Z., Li P., Han J., Lin S.-C.
      EMBO J. 23:4583-4594(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TP53 AND HIPK2, IDENTIFICATION IN A COMPLEX WITH TP53 AND HIPK2.
    9. "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."
      Wong C.K., Luo W., Deng Y., Zou H., Ye Z., Lin S.-C.
      J. Biol. Chem. 279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DIXDC1; MAP3K1 AND MAP3K4.
    10. "The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway."
      Chen H.J., Lin C.M., Lin C.S., Perez-Olle R., Leung C.L., Liem R.K.
      Genes Dev. 20:1933-1945(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    11. "A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida."
      Rui Y., Xu Z., Xiong B., Cao Y., Lin S., Zhang M., Chan S.-C., Luo W., Han Y., Lu Z., Ye Z., Zhou H.-M., Han J., Meng A., Lin S.-C.
      Dev. Cell 13:268-282(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, HOMODIMERIZATION, INTERACTION WITH AIDA.
    12. "SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability."
      Kim M.J., Chia I.V., Costantini F.
      FASEB J. 22:3785-3794(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUMOYLATION AT LYS-858 AND LYS-861, MUTAGENESIS OF LYS-858 AND LYS-861.
    13. "Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling."
      Chen T., Li M., Ding Y., Zhang L.S., Xi Y., Pan W.J., Tao D.L., Wang J.Y., Li L.
      J. Biol. Chem. 284:6683-6689(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZBED3, SUBCELLULAR LOCATION.
    14. "Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions."
      Jiang Y., Luo W., Howe P.H.
      Oncogene 28:2999-3007(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DAB2.

    Entry informationi

    Entry nameiAXIN1_MOUSE
    AccessioniPrimary (citable) accession number: O35625
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 142 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3