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O35625

- AXIN1_MOUSE

UniProt

O35625 - AXIN1_MOUSE

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Protein

Axin-1

Gene

Axin1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.By similarity3 Publications

GO - Molecular functioni

  1. armadillo repeat domain binding Source: RefGenome
  2. beta-catenin binding Source: MGI
  3. GTPase activator activity Source: RefGenome
  4. identical protein binding Source: MGI
  5. I-SMAD binding Source: BHF-UCL
  6. p53 binding Source: MGI
  7. protein complex scaffold Source: BHF-UCL
  8. protein C-terminus binding Source: MGI
  9. protein domain specific binding Source: MGI
  10. protein homodimerization activity Source: UniProtKB
  11. protein kinase binding Source: MGI
  12. protein self-association Source: MGI
  13. R-SMAD binding Source: MGI
  14. signal transducer activity Source: Ensembl
  15. ubiquitin protein ligase binding Source: BHF-UCL

GO - Biological processi

  1. activation of JUN kinase activity Source: RefGenome
  2. apoptotic process Source: UniProtKB-KW
  3. axial mesoderm development Source: MGI
  4. axial mesoderm formation Source: MGI
  5. canonical Wnt signaling pathway Source: MGI
  6. canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation Source: RefGenome
  7. cell death Source: RefGenome
  8. cellular protein complex assembly Source: Ensembl
  9. cellular response to organic cyclic compound Source: RefGenome
  10. cytoplasmic microtubule organization Source: MGI
  11. determination of left/right symmetry Source: RefGenome
  12. dorsal/ventral axis specification Source: MGI
  13. dorsal/ventral pattern formation Source: MGI
  14. embryonic eye morphogenesis Source: RefGenome
  15. forebrain anterior/posterior pattern specification Source: RefGenome
  16. genetic imprinting Source: MGI
  17. in utero embryonic development Source: MGI
  18. muscle cell development Source: RefGenome
  19. negative regulation of canonical Wnt signaling pathway Source: MGI
  20. negative regulation of fat cell differentiation Source: MGI
  21. negative regulation of protein metabolic process Source: MGI
  22. negative regulation of transcription elongation from RNA polymerase II promoter Source: MGI
  23. negative regulation of Wnt signaling pathway Source: MGI
  24. nucleocytoplasmic transport Source: MGI
  25. olfactory placode formation Source: RefGenome
  26. optic placode formation Source: RefGenome
  27. positive regulation of GTPase activity Source: GOC
  28. positive regulation of JNK cascade Source: UniProtKB
  29. positive regulation of JUN kinase activity Source: MGI
  30. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  31. positive regulation of protein phosphorylation Source: MGI
  32. positive regulation of protein ubiquitination Source: MGI
  33. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
  34. positive regulation of transcription, DNA-templated Source: BHF-UCL
  35. positive regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  36. positive regulation of ubiquitin-protein transferase activity Source: BHF-UCL
  37. post-anal tail morphogenesis Source: MGI
  38. protein catabolic process Source: MGI
  39. protein homooligomerization Source: MGI
  40. protein polyubiquitination Source: MGI
  41. regulation of catenin import into nucleus Source: MGI
  42. regulation of protein phosphorylation Source: MGI
  43. sensory perception of sound Source: MGI
  44. termination of G-protein coupled receptor signaling pathway Source: InterPro
  45. Wnt-activated signaling pathway involved in forebrain neuron fate commitment Source: RefGenome
  46. Wnt signaling pathway Source: MGI
  47. Wnt signaling pathway involved in somitogenesis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Apoptosis, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_203336. Degradation of beta-catenin by the destruction complex.
REACT_207044. TCF dependent signaling in response to WNT.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_218396. Beta-catenin phosphorylation cascade.
REACT_219129. degradation of AXIN.
REACT_230286. APC truncation mutants have impaired AXIN binding.
REACT_234076. S37 mutants of beta-catenin aren't phosphorylated.
REACT_248000. S45 mutants of beta-catenin aren't phosphorylated.
REACT_250714. truncations of AMER1 destabilize the destruction complex.
REACT_252458. AXIN missense mutants destabilize the destruction complex.
REACT_258576. T41 mutants of beta-catenin aren't phosphorylated.
REACT_260752. S33 mutants of beta-catenin aren't phosphorylated.
REACT_261276. misspliced GSK3beta mutants stabilize beta-catenin.

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-1
Alternative name(s):
Axis inhibition protein 1
Protein Fused
Gene namesi
Name:Axin1
Synonyms:Axin, Fu
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1096327. Axin1.

Subcellular locationi

Cytoplasm. Nucleus By similarity. Cell membrane. Membrane
Note: On UV irradiation, translocates to the nucleus and colocalizes with DAAX (By similarity). MACF1 is required for its translocation to cell membrane.By similarity

GO - Cellular componenti

  1. beta-catenin destruction complex Source: MGI
  2. cell cortex Source: MGI
  3. cytoplasm Source: BHF-UCL
  4. cytoplasmic membrane-bounded vesicle Source: MGI
  5. Golgi apparatus Source: Ensembl
  6. lateral plasma membrane Source: Ensembl
  7. nucleus Source: UniProtKB-KW
  8. perinuclear region of cytoplasm Source: Ensembl
  9. plasma membrane Source: UniProtKB
  10. postsynaptic density Source: RefGenome
  11. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi480 – 4801T → A: Greatly reduced GSK3B-mediated phosphorylation; when associated with A-485 and A-492. 1 Publication
Mutagenesisi485 – 4851S → A: Greatly reduced GSK3B-mediated phosphorylation and large effect on the inhibitory activity in Wnt-signaling; when associated with A-480 and A-492. 1 Publication
Mutagenesisi492 – 4921S → A: Greatly reduced GSK3B-mediated phosphorylation; when associated with A-480 and A-485. 1 Publication
Mutagenesisi492 – 4921S → I: Little effect on inhibitory activity on Wnt-signaling. 1 Publication
Mutagenesisi495 – 4951S → A: No effect on phosphorylation. Little effect on inhibitory activity on Wnt-signaling. 1 Publication
Mutagenesisi858 – 8636Missing: Abolishes binding of PIAS1 and PIAS2. Dramatically reduces sumoylation and abolishes AXIN1-mediated JNK activation. No effect on homodimerization nor on Wnt-signaling. 1 Publication
Mutagenesisi858 – 8581K → A: Decreased sumoylation followed by increased ubiquitination; when associated with A-861. 1 Publication
Mutagenesisi861 – 8611K → A: Decreased sumoylation followed by increased ubiquitination; when associated with A-858. 1 Publication

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Axin-1PRO_0000220889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751Phosphoserine; by CK1By similarity
Modified residuei77 – 771Phosphoserine; by CK1By similarity
Modified residuei217 – 2171Phosphoserine; by CK1By similarity
Modified residuei468 – 4681Phosphoserine; by CK1By similarity
Modified residuei480 – 4801Phosphothreonine; by GSK3-beta1 Publication
Modified residuei485 – 4851Phosphoserine; by GSK3-beta1 Publication
Modified residuei492 – 4921Phosphoserine1 Publication
Cross-linki858 – 858Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linki861 – 861Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationi

Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1 (By similarity). Also phosphorylated by CDK2 which regulates interaction with CTNBB1.By similarity2 Publications
ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway (By similarity).By similarity
Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important for nuclear accumulation during Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription (By similarity). Sumoylation at Lys-858 and Lys-861 prevents ubiquitination and degradation. Sumoylation is required for AXIN1-mediated JNK activation.By similarity2 Publications

Keywords - PTMi

ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO35625.
PRIDEiO35625.

PTM databases

PhosphoSiteiO35625.

Expressioni

Tissue specificityi

Expressed in embryonic stem cells.

Developmental stagei

Widely expressed at E10.5 to E16.5 day.

Gene expression databases

CleanExiMM_AXIN1.
ExpressionAtlasiO35625. baseline and differential.
GenevestigatoriO35625.

Interactioni

Subunit structurei

Homodimer. Component of the beta-catenin destruction complex, containing at least CTNNB1, an axin and GSK3B, that regulates CTNNB1 protein levels through phosphorylation and ubiquitination (By similarity). Interacts with GSK3B; the interaction hyperphosphorylates CTNNB1 leading to its ubiquitination and destruction. Interacts with DAXX; the interaction stimulates the interaction of DAXX with TP53, stimulates 'Ser-46' phosphorylation of TP53 and induces cell death on UV irradiation. Also interacts with APC, RNF111, SMAD6 and SMAD7. Interacts (via the C-terminal) with PPP1CA; the interaction dephosphorylates AXIN1 and regulates interaction with GSK3B. Interacts with PPP2CA; the interaction dephosphorylates AXIN1. Interacts with MDFI; the interaction decreases AXIN1-mediated JUN N-terminal kinase (JNK) activation. Interacts with MDFIC; the interaction inhibits beta-cateninin-mediated signaling and AXIN1-mediated JUN N-terminal kinase (JNK) activation (By similarity). Binds ANKRD6, PIAS1, PIAS2, PIAS4, SUMO1, MAP3K1 and MAP3K4. Component of the AXIN1-HIPK2-TP53 complex. Interacts directly in the complex with TP53 and HIPK2. Interacts with DIXDC1; the interaction prevents interaction with MAP3K1. Interacts with AIDA; the interaction blocks the AXIN1-mediated JNK activation through disrupting AXIN1 homodimerization and Wnt signaling. Interacts with LRP5 (via its phosphorylated PPPSP motifs); the interaction is stimulated by WNT1 and GSK3B and activates beta-catenin signaling. Interacts with CTNNB1 (via the armadillo repeats 2-7). Interacts with MACF1 (By similarity). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Interacts with TNKS (By similarity). Interacts with DAB2; the interaction is mutually exclusive with the AXIN1:PPP1CA interaction. Interacts with ZBED3 (via PPPSP motif); the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations.By similarity10 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTNNB1P352224EBI-2365912,EBI-491549From a different organism.
Dab2P980784EBI-2365912,EBI-1391846
Dvl3Q610622EBI-2365912,EBI-1538450
GSK3BP498415EBI-2365912,EBI-373586From a different organism.
LRP6O755812EBI-2365912,EBI-910915From a different organism.
Ppp1caP621372EBI-2365912,EBI-357187
Rnf111Q99ML94EBI-2365912,EBI-646015
Smad3Q8BUN52EBI-2365912,EBI-2337983
Smad6O351822EBI-2365912,EBI-4321242
Smad7O352532EBI-2365912,EBI-5274835
TNKSO952714EBI-2365912,EBI-1105254From a different organism.

Protein-protein interaction databases

BioGridi198287. 33 interactions.
DIPiDIP-42637N.
IntActiO35625. 22 interactions.
MINTiMINT-1543084.

Structurei

Secondary structure

1
863
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi64 – 663Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UTMX-ray2.00C1-80[»]
ProteinModelPortaliO35625.
SMRiO35625. Positions 74-220, 780-863.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 211124RGSPROSITE-ProRule annotationAdd
BLAST
Domaini781 – 86383DIXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni209 – 338130Interaction with TP53Add
BLAST
Regioni348 – 43285Interaction with GSK3BBy similarityAdd
BLAST
Regioni433 – 50169Interaction with beta-cateninBy similarityAdd
BLAST
Regioni505 – 758254Interaction with RNF111By similarityAdd
BLAST
Regioni572 – 790219Interaction with PPP2CABy similarityAdd
BLAST
Regioni678 – 75376Interaction with HIPK2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi20 – 2910Tankyrase-binding motif

Domaini

The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.By similarity

Sequence similaritiesi

Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG238205.
HOVERGENiHBG004324.
InParanoidiO35625.
KOiK02157.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O35625-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNVQEQGFPL DLGASFTEDA PRPPVPGEEG ELVSTDSRPV NHSFCSGKGT
60 70 80 90 100
SIKSETSTAT PRRSDLDLGY EPEGSASPTP PYLRWAESLH SLLDDQDGIS
110 120 130 140 150
LFRTFLKQEG CADLLDFWFA CSGFRKLEPC DSNEEKRLKL ARAIYRKYIL
160 170 180 190 200
DSNGIVSRQT KPATKSFIKD CVMKQQIDPA MFDQAQTEIQ STMEENTYPS
210 220 230 240 250
FLKSDIYLEY TRTGSESPKV CSDQSSGSGT GKGMSGYLPT LNEDEEWKCD
260 270 280 290 300
QDADEDDGRD PLPPSRLTQK LLLETAAPRA PSSRRYNEGR ELRYGSWREP
310 320 330 340 350
VNPYYVNSGY ALAPATSAND SEQQSLSSDA DTLSLTDSSV DGIPPYRIRK
360 370 380 390 400
QHRREMQESI QVNGRVPLPH IPRTYRMPKE IRVEPQKFAE ELIHRLEAVQ
410 420 430 440 450
RTREAEEKLE ERLKRVRMEE EGEDGEMPSG PMASHKLPSV PAWHHFPPRY
460 470 480 490 500
VDMGCSGLRD AHEENPESIL DEHVQRVMRT PGCQSPGPGH RSPDSGHVAK
510 520 530 540 550
TAVLGGTASG HGKHVPKLGL KLDTAGLHHH RHVHHHVHHN SARPKEQMEA
560 570 580 590 600
EVARRVQSSF SWGPETHGHA KPRSYSENAG TTLSAGDLAF GGKTSAPSKR
610 620 630 640 650
NTKKAESGKN ANAEVPSTTE DAEKNQKIMQ WIIEGEKEIS RHRKAGHGSS
660 670 680 690 700
GLRKQQAHES SRPLSIERPG AVHPWVSAQL RNSVQPSHLF IQDPTMPPNP
710 720 730 740 750
APNPLTQLEE ARRRLEEEEK RANKLPSKQR YVQAVMQRGR TCVRPACAPV
760 770 780 790 800
LSVVPAVSDL ELSETETKSQ RKAGGGSAPP CDSIVVAYYF CGEPIPYRTL
810 820 830 840 850
VRGRAVTLGQ FKELLTKKGS YRYYFKKVSD EFDCGVVFEE VREDEAVLPV
860
FEEKIIGKVE KVD
Length:863
Mass (Da):96,276
Last modified:October 3, 2012 - v3
Checksum:i2216D66E92387B81
GO
Isoform 2 (identifier: O35625-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     731-766: Missing.

Show »
Length:827
Mass (Da):92,418
Checksum:i0D99A235EEDC597E
GO

Sequence cautioni

The sequence AAC53285.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti589 – 5891A → P in AAC53285. (PubMed:9230313)Curated
Sequence conflicti787 – 7871A → G in AAC53285. (PubMed:9230313)Curated
Sequence conflicti846 – 8461A → P in AAC53285. (PubMed:9230313)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei731 – 76636Missing in isoform 2. 1 PublicationVSP_000452Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009011 mRNA. Translation: AAC53285.1. Different initiation.
AC126438 Genomic DNA. No translation available.
AC140047 Genomic DNA. No translation available.
RefSeqiNP_033863.2. NM_009733.2.
UniGeneiMm.23684.

Genome annotation databases

GeneIDi12005.
KEGGimmu:12005.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009011 mRNA. Translation: AAC53285.1 . Different initiation.
AC126438 Genomic DNA. No translation available.
AC140047 Genomic DNA. No translation available.
RefSeqi NP_033863.2. NM_009733.2.
UniGenei Mm.23684.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UTM X-ray 2.00 C 1-80 [» ]
ProteinModelPortali O35625.
SMRi O35625. Positions 74-220, 780-863.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198287. 33 interactions.
DIPi DIP-42637N.
IntActi O35625. 22 interactions.
MINTi MINT-1543084.

PTM databases

PhosphoSitei O35625.

Proteomic databases

PaxDbi O35625.
PRIDEi O35625.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 12005.
KEGGi mmu:12005.

Organism-specific databases

CTDi 8312.
MGIi MGI:1096327. Axin1.

Phylogenomic databases

eggNOGi NOG238205.
HOVERGENi HBG004324.
InParanoidi O35625.
KOi K02157.

Enzyme and pathway databases

Reactomei REACT_203336. Degradation of beta-catenin by the destruction complex.
REACT_207044. TCF dependent signaling in response to WNT.
REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_218396. Beta-catenin phosphorylation cascade.
REACT_219129. degradation of AXIN.
REACT_230286. APC truncation mutants have impaired AXIN binding.
REACT_234076. S37 mutants of beta-catenin aren't phosphorylated.
REACT_248000. S45 mutants of beta-catenin aren't phosphorylated.
REACT_250714. truncations of AMER1 destabilize the destruction complex.
REACT_252458. AXIN missense mutants destabilize the destruction complex.
REACT_258576. T41 mutants of beta-catenin aren't phosphorylated.
REACT_260752. S33 mutants of beta-catenin aren't phosphorylated.
REACT_261276. misspliced GSK3beta mutants stabilize beta-catenin.

Miscellaneous databases

ChiTaRSi Axin1. mouse.
NextBioi 280195.
PROi O35625.
SOURCEi Search...

Gene expression databases

CleanExi MM_AXIN1.
ExpressionAtlasi O35625. baseline and differential.
Genevestigatori O35625.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation."
    Zeng L., Fagotto F., Zhang T., Hsu W., Vasicek T.J., Perry W.L. III, Lee J.J., Tilghman S.M., Gumbiner B.M., Costantini F.
    Cell 90:181-192(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression."
    Jho E., Lomvardas S., Costantini F.
    Biochem. Biophys. Res. Commun. 266:28-35(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-480; SER-485 AND SER-492, INTERACTION WITH CTNNB1, MUTAGENESIS OF THR-480; SER-485; SER-492 AND SER-495.
  4. "Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway."
    Mao J., Wang J., Liu B., Pan W., Farr G.H. III, Flynn C., Yuan H., Takada S., Kimelman D., Li L., Wu D.
    Mol. Cell 7:801-809(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LRP5.
  5. "The ankyrin repeat protein diversin recruits casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling."
    Schwarz-Romond T., Asbrand C., Bakkers J., Kuehl M., Schaeffer H.J., Huelsken J., Behrens J., Hammerschmidt M., Birchmeier W.
    Genes Dev. 16:2073-2084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ANKRD6.
  6. "SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling."
    Rui H.L., Fan E., Zhou H.M., Xu Z., Zhang Y., Lin S.C.
    J. Biol. Chem. 277:42981-42986(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION AT LYS-858 AND LYS-861, INTERACTION WITH MAP3K1; SUMO1; PIAS1; PIAS2 AND PIAS4, FUNCTION, HOMODIMERIZATION, MUTAGENESIS OF 858-LYS--ASP-863.
  7. "Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin."
    Kim S.I., Park C.S., Lee M.S., Kwon M.S., Jho E.H., Song W.K.
    Biochem. Biophys. Res. Commun. 317:478-483(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, INTERACTION WITH CTNNB1.
  8. "Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation."
    Rui Y., Xu Z., Lin S., Li Q., Rui H., Luo W., Zhou H.-M., Cheung P.-Y., Wu Z., Ye Z., Li P., Han J., Lin S.-C.
    EMBO J. 23:4583-4594(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TP53 AND HIPK2, IDENTIFICATION IN A COMPLEX WITH TP53 AND HIPK2.
  9. "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."
    Wong C.K., Luo W., Deng Y., Zou H., Ye Z., Lin S.-C.
    J. Biol. Chem. 279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DIXDC1; MAP3K1 AND MAP3K4.
  10. "The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway."
    Chen H.J., Lin C.M., Lin C.S., Perez-Olle R., Leung C.L., Liem R.K.
    Genes Dev. 20:1933-1945(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  11. "A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida."
    Rui Y., Xu Z., Xiong B., Cao Y., Lin S., Zhang M., Chan S.-C., Luo W., Han Y., Lu Z., Ye Z., Zhou H.-M., Han J., Meng A., Lin S.-C.
    Dev. Cell 13:268-282(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, HOMODIMERIZATION, INTERACTION WITH AIDA.
  12. "SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability."
    Kim M.J., Chia I.V., Costantini F.
    FASEB J. 22:3785-3794(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION AT LYS-858 AND LYS-861, MUTAGENESIS OF LYS-858 AND LYS-861.
  13. "Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling."
    Chen T., Li M., Ding Y., Zhang L.S., Xi Y., Pan W.J., Tao D.L., Wang J.Y., Li L.
    J. Biol. Chem. 284:6683-6689(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZBED3, SUBCELLULAR LOCATION.
  14. "Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions."
    Jiang Y., Luo W., Howe P.H.
    Oncogene 28:2999-3007(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DAB2.

Entry informationi

Entry nameiAXIN1_MOUSE
AccessioniPrimary (citable) accession number: O35625
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3