ID   FGF15_MOUSE             Reviewed;         218 AA.
AC   O35622;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-NOV-2011, entry version 89.
DE   RecName: Full=Fibroblast growth factor 15;
DE            Short=FGF-15;
DE   Flags: Precursor;
GN   Name=Fgf15;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=97454242; PubMed=9310317;
RA   McWhirter J.R., Goulding M., Weiner J.A., Chun J., Murre C.;
RT   "A novel fibroblast growth factor gene expressed in the developing
RT   nervous system is a downstream target of the chimeric homeodomain
RT   oncoprotein E2A-Pbx1.";
RL   Development 124:3221-3232(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=16213224; DOI=10.1016/j.cmet.2005.09.001;
RA   Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L.,
RA   McDonald J.G., Luo G., Jones S.A., Goodwin B., Richardson J.A.,
RA   Gerard R.D., Repa J.J., Mangelsdorf D.J., Kliewer S.A.;
RT   "Fibroblast growth factor 15 functions as an enterohepatic signal to
RT   regulate bile acid homeostasis.";
RL   Cell Metab. 2:217-225(2005).
CC   -!- FUNCTION: Involved in the suppression of bile acid biosynthesis
CC       through down-regulation of CYP7A1 expression.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in the developing brain.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
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DR   EMBL; AF007268; AAB63197.1; -; mRNA.
DR   EMBL; AK017829; BAB30961.1; -; mRNA.
DR   EMBL; BC021328; AAH21328.1; -; mRNA.
DR   IPI; IPI00132684; -.
DR   RefSeq; NP_032029.1; NM_008003.2.
DR   UniGene; Mm.3904; -.
DR   ProteinModelPortal; O35622; -.
DR   SMR; O35622; 48-179.
DR   STRING; O35622; -.
DR   PRIDE; O35622; -.
DR   Ensembl; ENSMUST00000033389; ENSMUSP00000033389; ENSMUSG00000031073.
DR   GeneID; 14170; -.
DR   KEGG; mmu:14170; -.
DR   CTD; 14170; -.
DR   MGI; MGI:1096383; Fgf15.
DR   eggNOG; roNOG17577; -.
DR   HOGENOM; HBG446834; -.
DR   HOVERGEN; HBG051611; -.
DR   InParanoid; O35622; -.
DR   OMA; DGYNVYR; -.
DR   OrthoDB; EOG45X7X5; -.
DR   PhylomeDB; O35622; -.
DR   NextBio; 285330; -.
DR   ArrayExpress; O35622; -.
DR   Bgee; O35622; -.
DR   CleanEx; MM_FGF15; -.
DR   Genevestigator; O35622; -.
DR   GermOnline; ENSMUSG00000031073; Mus musculus.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007507; P:heart development; IMP:MGI.
DR   GO; GO:0001755; P:neural crest cell migration; IMP:MGI.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR017338; Fibroblast_GF_15/19/21.
DR   InterPro; IPR002348; IL1_HBGF.
DR   KO; K04358; -.
DR   PANTHER; PTHR11486; IL1_HBGF; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PIRSF; PIRSF037961; FGF-19_FGF-21; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; Cytok_IL1_like; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Growth factor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL        1     25       Potential.
FT   CHAIN        26    218       Fibroblast growth factor 15.
FT                                /FTId=PRO_0000008984.
SQ   SEQUENCE   218 AA;  25236 MW;  A96B0D771FE125A5 CRC64;
     MARKWNGRAV ARALVLATLW LAVSGRPLAQ QSQSVSDEDP LFLYGWGKIT RLQYLYSAGP
     YVSNCFLRIR SDGSVDCEED QNERNLLEFR AVALKTIAIK DVSSVRYLCM SADGKIYGLI
     RYSEEDCTFR EEMDCLGYNQ YRSMKHHLHI IFIQAKPREQ LQDQKPSNFI PVFHRSFFET
     GDQLRSKMFS LPLESDSMDP FRMVEDVDHL VKSPSFQK
//