ID   FGF15_MOUSE             Reviewed;         218 AA.
AC   O35622;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   24-JAN-2024, entry version 169.
DE   RecName: Full=Fibroblast growth factor 15;
DE            Short=FGF-15;
DE   Flags: Precursor;
GN   Name=Fgf15;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9310317; DOI=10.1242/dev.124.17.3221;
RA   McWhirter J.R., Goulding M., Weiner J.A., Chun J., Murre C.;
RT   "A novel fibroblast growth factor gene expressed in the developing nervous
RT   system is a downstream target of the chimeric homeodomain oncoprotein E2A-
RT   Pbx1.";
RL   Development 124:3221-3232(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=16213224; DOI=10.1016/j.cmet.2005.09.001;
RA   Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G.,
RA   Luo G., Jones S.A., Goodwin B., Richardson J.A., Gerard R.D., Repa J.J.,
RA   Mangelsdorf D.J., Kliewer S.A.;
RT   "Fibroblast growth factor 15 functions as an enterohepatic signal to
RT   regulate bile acid homeostasis.";
RL   Cell Metab. 2:217-225(2005).
RN   [5]
RP   FUNCTION, AND INTERACTION WITH MALRD1.
RX   PubMed=23747249; DOI=10.1016/j.cmet.2013.04.007;
RA   Vergnes L., Lee J.M., Chin R.G., Auwerx J., Reue K.;
RT   "Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate
RT   bile acid and lipid levels.";
RL   Cell Metab. 17:916-928(2013).
CC   -!- FUNCTION: Involved in the suppression of bile acid biosynthesis through
CC       down-regulation of CYP7A1 expression. {ECO:0000269|PubMed:16213224,
CC       ECO:0000269|PubMed:23747249}.
CC   -!- SUBUNIT: Interacts with MALRD1. {ECO:0000269|PubMed:23747249}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in the developing brain.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; AF007268; AAB63197.1; -; mRNA.
DR   EMBL; AK017829; BAB30961.1; -; mRNA.
DR   EMBL; BC021328; AAH21328.1; -; mRNA.
DR   CCDS; CCDS22053.1; -.
DR   RefSeq; NP_032029.1; NM_008003.2.
DR   AlphaFoldDB; O35622; -.
DR   SMR; O35622; -.
DR   STRING; 10090.ENSMUSP00000033389; -.
DR   PhosphoSitePlus; O35622; -.
DR   PaxDb; 10090-ENSMUSP00000033389; -.
DR   Antibodypedia; 30654; 490 antibodies from 34 providers.
DR   DNASU; 14170; -.
DR   Ensembl; ENSMUST00000033389.7; ENSMUSP00000033389.6; ENSMUSG00000031073.7.
DR   GeneID; 14170; -.
DR   KEGG; mmu:14170; -.
DR   UCSC; uc009kqr.1; mouse.
DR   AGR; MGI:1096383; -.
DR   CTD; 14170; -.
DR   MGI; MGI:1096383; Fgf15.
DR   VEuPathDB; HostDB:ENSMUSG00000031073; -.
DR   eggNOG; KOG3885; Eukaryota.
DR   GeneTree; ENSGT00940000160601; -.
DR   HOGENOM; CLU_094251_1_0_1; -.
DR   InParanoid; O35622; -.
DR   OMA; PGCVVIR; -.
DR   OrthoDB; 3092220at2759; -.
DR   PhylomeDB; O35622; -.
DR   TreeFam; TF335872; -.
DR   Reactome; R-MMU-109704; PI3K Cascade.
DR   Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
DR   Reactome; R-MMU-1307965; betaKlotho-mediated ligand binding.
DR   Reactome; R-MMU-190322; FGFR4 ligand binding and activation.
DR   Reactome; R-MMU-5654228; Phospholipase C-mediated cascade, FGFR4.
DR   Reactome; R-MMU-5654712; FRS-mediated FGFR4 signaling.
DR   Reactome; R-MMU-5654719; SHC-mediated cascade:FGFR4.
DR   Reactome; R-MMU-5654720; PI-3K cascade:FGFR4.
DR   Reactome; R-MMU-5654733; Negative regulation of FGFR4 signaling.
DR   Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR   BioGRID-ORCS; 14170; 3 hits in 80 CRISPR screens.
DR   ChiTaRS; Fgf15; mouse.
DR   PRO; PR:O35622; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; O35622; Protein.
DR   Bgee; ENSMUSG00000031073; Expressed in roof plate of midbrain and 111 other cell types or tissues.
DR   ExpressionAtlas; O35622; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; ISO:MGI.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0015721; P:bile acid and bile salt transport; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISO:MGI.
DR   GO; GO:0007507; P:heart development; IMP:MGI.
DR   GO; GO:0070858; P:negative regulation of bile acid biosynthetic process; IGI:MGI.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
DR   GO; GO:0001755; P:neural crest cell migration; IMP:MGI.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR   GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0046326; P:positive regulation of glucose import; ISO:MGI.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; ISO:MGI.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
DR   GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR   GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR   GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR   GO; GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.
DR   CDD; cd00058; FGF; 1.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR035444; FGF15/19/21.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; FIBROBLAST GROWTH FACTOR; 1.
DR   PANTHER; PTHR11486:SF74; FIBROBLAST GROWTH FACTOR 19; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PIRSF; PIRSF037961; FGF-19_FGF-21; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; Cytokine; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
DR   Genevisible; O35622; MM.
PE   1: Evidence at protein level;
KW   Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..218
FT                   /note="Fibroblast growth factor 15"
FT                   /id="PRO_0000008984"
SQ   SEQUENCE   218 AA;  25236 MW;  A96B0D771FE125A5 CRC64;
     MARKWNGRAV ARALVLATLW LAVSGRPLAQ QSQSVSDEDP LFLYGWGKIT RLQYLYSAGP
     YVSNCFLRIR SDGSVDCEED QNERNLLEFR AVALKTIAIK DVSSVRYLCM SADGKIYGLI
     RYSEEDCTFR EEMDCLGYNQ YRSMKHHLHI IFIQAKPREQ LQDQKPSNFI PVFHRSFFET
     GDQLRSKMFS LPLESDSMDP FRMVEDVDHL VKSPSFQK
//