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O35622

- FGF15_MOUSE

UniProt

O35622 - FGF15_MOUSE

Protein

Fibroblast growth factor 15

Gene

Fgf15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.1 Publication

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. fibroblast growth factor receptor signaling pathway Source: Ensembl
    2. heart development Source: MGI
    3. negative regulation of bile acid biosynthetic process Source: MGI
    4. neural crest cell migration Source: MGI
    5. positive regulation of cell proliferation Source: Ensembl
    6. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    7. positive regulation of glucose import Source: Ensembl
    8. positive regulation of JNK cascade Source: Ensembl

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_199063. betaKlotho-mediated ligand binding.
    REACT_206694. FGFR4 ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 15
    Short name:
    FGF-15
    Gene namesi
    Name:Fgf15
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1096383. Fgf15.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 218193Fibroblast growth factor 15PRO_0000008984Add
    BLAST

    Proteomic databases

    PRIDEiO35622.

    PTM databases

    PhosphoSiteiO35622.

    Expressioni

    Tissue specificityi

    Expressed in the developing brain.

    Gene expression databases

    ArrayExpressiO35622.
    BgeeiO35622.
    CleanExiMM_FGF15.
    GenevestigatoriO35622.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000033389.

    Structurei

    3D structure databases

    ProteinModelPortaliO35622.
    SMRiO35622. Positions 51-150.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG294039.
    HOGENOMiHOG000112572.
    HOVERGENiHBG051611.
    InParanoidiO35622.
    KOiK04358.
    OMAiQYSAGDC.
    OrthoDBiEOG7BS4C1.
    PhylomeDBiO35622.
    TreeFamiTF335872.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028303. FGF15/FGF19.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF74. PTHR11486:SF74. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35622-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARKWNGRAV ARALVLATLW LAVSGRPLAQ QSQSVSDEDP LFLYGWGKIT    50
    RLQYLYSAGP YVSNCFLRIR SDGSVDCEED QNERNLLEFR AVALKTIAIK 100
    DVSSVRYLCM SADGKIYGLI RYSEEDCTFR EEMDCLGYNQ YRSMKHHLHI 150
    IFIQAKPREQ LQDQKPSNFI PVFHRSFFET GDQLRSKMFS LPLESDSMDP 200
    FRMVEDVDHL VKSPSFQK 218
    Length:218
    Mass (Da):25,236
    Last modified:January 1, 1998 - v1
    Checksum:iA96B0D771FE125A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007268 mRNA. Translation: AAB63197.1.
    AK017829 mRNA. Translation: BAB30961.1.
    BC021328 mRNA. Translation: AAH21328.1.
    CCDSiCCDS22053.1.
    RefSeqiNP_032029.1. NM_008003.2.
    UniGeneiMm.3904.

    Genome annotation databases

    EnsembliENSMUST00000033389; ENSMUSP00000033389; ENSMUSG00000031073.
    GeneIDi14170.
    KEGGimmu:14170.
    UCSCiuc009kqr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007268 mRNA. Translation: AAB63197.1 .
    AK017829 mRNA. Translation: BAB30961.1 .
    BC021328 mRNA. Translation: AAH21328.1 .
    CCDSi CCDS22053.1.
    RefSeqi NP_032029.1. NM_008003.2.
    UniGenei Mm.3904.

    3D structure databases

    ProteinModelPortali O35622.
    SMRi O35622. Positions 51-150.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000033389.

    PTM databases

    PhosphoSitei O35622.

    Proteomic databases

    PRIDEi O35622.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033389 ; ENSMUSP00000033389 ; ENSMUSG00000031073 .
    GeneIDi 14170.
    KEGGi mmu:14170.
    UCSCi uc009kqr.1. mouse.

    Organism-specific databases

    CTDi 14170.
    MGIi MGI:1096383. Fgf15.

    Phylogenomic databases

    eggNOGi NOG294039.
    HOGENOMi HOG000112572.
    HOVERGENi HBG051611.
    InParanoidi O35622.
    KOi K04358.
    OMAi QYSAGDC.
    OrthoDBi EOG7BS4C1.
    PhylomeDBi O35622.
    TreeFami TF335872.

    Enzyme and pathway databases

    Reactomei REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_199063. betaKlotho-mediated ligand binding.
    REACT_206694. FGFR4 ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    NextBioi 285330.
    PROi O35622.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35622.
    Bgeei O35622.
    CleanExi MM_FGF15.
    Genevestigatori O35622.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028303. FGF15/FGF19.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF74. PTHR11486:SF74. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1."
      McWhirter J.R., Goulding M., Weiner J.A., Chun J., Murre C.
      Development 124:3221-3232(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis."
      Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G., Luo G., Jones S.A., Goodwin B., Richardson J.A., Gerard R.D., Repa J.J., Mangelsdorf D.J., Kliewer S.A.
      Cell Metab. 2:217-225(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiFGF15_MOUSE
    AccessioniPrimary (citable) accession number: O35622
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3