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Protein

Fibroblast growth factor 15

Gene

Fgf15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-1307965. betaKlotho-mediated ligand binding.
R-MMU-190322. FGFR4 ligand binding and activation.
R-MMU-5654228. Phospholipase C-mediated cascade, FGFR4.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654712. FRS-mediated FGFR4 signaling.
R-MMU-5654719. SHC-mediated cascade:FGFR4.
R-MMU-5654720. PI-3K cascade:FGFR4.
R-MMU-5654733. Negative regulation of FGFR4 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 15
Short name:
FGF-15
Gene namesi
Name:Fgf15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1096383. Fgf15.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000898426 – 218Fibroblast growth factor 15Add BLAST193

Proteomic databases

PaxDbiO35622.
PRIDEiO35622.

PTM databases

PhosphoSitePlusiO35622.

Expressioni

Tissue specificityi

Expressed in the developing brain.

Gene expression databases

BgeeiENSMUSG00000031073.
CleanExiMM_FGF15.
ExpressionAtlasiO35622. baseline and differential.
GenevisibleiO35622. MM.

Interactioni

Subunit structurei

Interacts with MALRD1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033389.

Structurei

3D structure databases

ProteinModelPortaliO35622.
SMRiO35622.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00530000063469.
HOGENOMiHOG000112572.
HOVERGENiHBG051611.
InParanoidiO35622.
KOiK04358.
OMAiHSLMEIR.
OrthoDBiEOG091G0NAY.
PhylomeDBiO35622.
TreeFamiTF335872.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiView protein in InterPro
IPR035444. FGF15/19/21.
IPR028303. FGF15/FGF19.
IPR002209. Fibroblast_GF_fam.
IPR008996. IL1/FGF.
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF111. PTHR11486:SF111. 1 hit.
PfamiView protein in Pfam
PF00167. FGF. 1 hit.
PIRSFiPIRSF037961. FGF-19_FGF-21. 1 hit.
SMARTiView protein in SMART
SM00442. FGF. 1 hit.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00247. HBGF_FGF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKWNGRAV ARALVLATLW LAVSGRPLAQ QSQSVSDEDP LFLYGWGKIT
60 70 80 90 100
RLQYLYSAGP YVSNCFLRIR SDGSVDCEED QNERNLLEFR AVALKTIAIK
110 120 130 140 150
DVSSVRYLCM SADGKIYGLI RYSEEDCTFR EEMDCLGYNQ YRSMKHHLHI
160 170 180 190 200
IFIQAKPREQ LQDQKPSNFI PVFHRSFFET GDQLRSKMFS LPLESDSMDP
210
FRMVEDVDHL VKSPSFQK
Length:218
Mass (Da):25,236
Last modified:January 1, 1998 - v1
Checksum:iA96B0D771FE125A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007268 mRNA. Translation: AAB63197.1.
AK017829 mRNA. Translation: BAB30961.1.
BC021328 mRNA. Translation: AAH21328.1.
CCDSiCCDS22053.1.
RefSeqiNP_032029.1. NM_008003.2.
UniGeneiMm.3904.

Genome annotation databases

EnsembliENSMUST00000033389; ENSMUSP00000033389; ENSMUSG00000031073.
GeneIDi14170.
KEGGimmu:14170.
UCSCiuc009kqr.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiFGF15_MOUSE
AccessioniPrimary (citable) accession number: O35622
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families