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O35622

- FGF15_MOUSE

UniProt

O35622 - FGF15_MOUSE

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Protein

Fibroblast growth factor 15

Gene
Fgf15
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.1 Publication

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. fibroblast growth factor receptor signaling pathway Source: Ensembl
  2. heart development Source: MGI
  3. negative regulation of bile acid biosynthetic process Source: MGI
  4. neural crest cell migration Source: MGI
  5. positive regulation of cell proliferation Source: Ensembl
  6. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  7. positive regulation of glucose import Source: Ensembl
  8. positive regulation of JNK cascade Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_199063. betaKlotho-mediated ligand binding.
REACT_206694. FGFR4 ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_226341. PIP3 activates AKT signaling.
REACT_94437. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 15
Short name:
FGF-15
Gene namesi
Name:Fgf15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1096383. Fgf15.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 218193Fibroblast growth factor 15PRO_0000008984Add
BLAST

Proteomic databases

PRIDEiO35622.

PTM databases

PhosphoSiteiO35622.

Expressioni

Tissue specificityi

Expressed in the developing brain.

Gene expression databases

ArrayExpressiO35622.
BgeeiO35622.
CleanExiMM_FGF15.
GenevestigatoriO35622.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033389.

Structurei

3D structure databases

ProteinModelPortaliO35622.
SMRiO35622. Positions 51-150.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG294039.
HOGENOMiHOG000112572.
HOVERGENiHBG051611.
InParanoidiO35622.
KOiK04358.
OMAiQYSAGDC.
OrthoDBiEOG7BS4C1.
PhylomeDBiO35622.
TreeFamiTF335872.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028303. FGF15/FGF19.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF74. PTHR11486:SF74. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35622-1 [UniParc]FASTAAdd to Basket

« Hide

MARKWNGRAV ARALVLATLW LAVSGRPLAQ QSQSVSDEDP LFLYGWGKIT    50
RLQYLYSAGP YVSNCFLRIR SDGSVDCEED QNERNLLEFR AVALKTIAIK 100
DVSSVRYLCM SADGKIYGLI RYSEEDCTFR EEMDCLGYNQ YRSMKHHLHI 150
IFIQAKPREQ LQDQKPSNFI PVFHRSFFET GDQLRSKMFS LPLESDSMDP 200
FRMVEDVDHL VKSPSFQK 218
Length:218
Mass (Da):25,236
Last modified:January 1, 1998 - v1
Checksum:iA96B0D771FE125A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007268 mRNA. Translation: AAB63197.1.
AK017829 mRNA. Translation: BAB30961.1.
BC021328 mRNA. Translation: AAH21328.1.
CCDSiCCDS22053.1.
RefSeqiNP_032029.1. NM_008003.2.
UniGeneiMm.3904.

Genome annotation databases

EnsembliENSMUST00000033389; ENSMUSP00000033389; ENSMUSG00000031073.
GeneIDi14170.
KEGGimmu:14170.
UCSCiuc009kqr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007268 mRNA. Translation: AAB63197.1 .
AK017829 mRNA. Translation: BAB30961.1 .
BC021328 mRNA. Translation: AAH21328.1 .
CCDSi CCDS22053.1.
RefSeqi NP_032029.1. NM_008003.2.
UniGenei Mm.3904.

3D structure databases

ProteinModelPortali O35622.
SMRi O35622. Positions 51-150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000033389.

PTM databases

PhosphoSitei O35622.

Proteomic databases

PRIDEi O35622.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033389 ; ENSMUSP00000033389 ; ENSMUSG00000031073 .
GeneIDi 14170.
KEGGi mmu:14170.
UCSCi uc009kqr.1. mouse.

Organism-specific databases

CTDi 14170.
MGIi MGI:1096383. Fgf15.

Phylogenomic databases

eggNOGi NOG294039.
HOGENOMi HOG000112572.
HOVERGENi HBG051611.
InParanoidi O35622.
KOi K04358.
OMAi QYSAGDC.
OrthoDBi EOG7BS4C1.
PhylomeDBi O35622.
TreeFami TF335872.

Enzyme and pathway databases

Reactomei REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_199063. betaKlotho-mediated ligand binding.
REACT_206694. FGFR4 ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_226341. PIP3 activates AKT signaling.
REACT_94437. SHC-mediated cascade.

Miscellaneous databases

NextBioi 285330.
PROi O35622.
SOURCEi Search...

Gene expression databases

ArrayExpressi O35622.
Bgeei O35622.
CleanExi MM_FGF15.
Genevestigatori O35622.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028303. FGF15/FGF19.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF74. PTHR11486:SF74. 1 hit.
Pfami PF00167. FGF. 1 hit.
[Graphical view ]
PRINTSi PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1."
    McWhirter J.R., Goulding M., Weiner J.A., Chun J., Murre C.
    Development 124:3221-3232(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis."
    Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G., Luo G., Jones S.A., Goodwin B., Richardson J.A., Gerard R.D., Repa J.J., Mangelsdorf D.J., Kliewer S.A.
    Cell Metab. 2:217-225(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiFGF15_MOUSE
AccessioniPrimary (citable) accession number: O35622
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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