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Protein

Fibroblast growth factor 15

Gene

Fgf15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_276236. FGFR4 ligand binding and activation.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_354060. betaKlotho-mediated ligand binding.
REACT_358477. Negative regulation of FGFR4 signaling.
REACT_358906. SHC-mediated cascade:FGFR4.
REACT_360720. Phospholipase C-mediated cascade, FGFR4.
REACT_361038. PI-3K cascade:FGFR4.
REACT_361658. FRS2-mediated FGFR4 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 15
Short name:
FGF-15
Gene namesi
Name:Fgf15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1096383. Fgf15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 218193Fibroblast growth factor 15PRO_0000008984Add
BLAST

Proteomic databases

PRIDEiO35622.

PTM databases

PhosphoSiteiO35622.

Expressioni

Tissue specificityi

Expressed in the developing brain.

Gene expression databases

BgeeiO35622.
CleanExiMM_FGF15.
ExpressionAtlasiO35622. baseline and differential.
GenevisibleiO35622. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033389.

Structurei

3D structure databases

ProteinModelPortaliO35622.
SMRiO35622. Positions 51-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG294039.
HOGENOMiHOG000112572.
HOVERGENiHBG051611.
InParanoidiO35622.
KOiK04358.
OMAiSEEDCAF.
OrthoDBiEOG7BS4C1.
PhylomeDBiO35622.
TreeFamiTF335872.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028303. FGF15/FGF19.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF74. PTHR11486:SF74. 1 hit.
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKWNGRAV ARALVLATLW LAVSGRPLAQ QSQSVSDEDP LFLYGWGKIT
60 70 80 90 100
RLQYLYSAGP YVSNCFLRIR SDGSVDCEED QNERNLLEFR AVALKTIAIK
110 120 130 140 150
DVSSVRYLCM SADGKIYGLI RYSEEDCTFR EEMDCLGYNQ YRSMKHHLHI
160 170 180 190 200
IFIQAKPREQ LQDQKPSNFI PVFHRSFFET GDQLRSKMFS LPLESDSMDP
210
FRMVEDVDHL VKSPSFQK
Length:218
Mass (Da):25,236
Last modified:January 1, 1998 - v1
Checksum:iA96B0D771FE125A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007268 mRNA. Translation: AAB63197.1.
AK017829 mRNA. Translation: BAB30961.1.
BC021328 mRNA. Translation: AAH21328.1.
CCDSiCCDS22053.1.
RefSeqiNP_032029.1. NM_008003.2.
UniGeneiMm.3904.

Genome annotation databases

EnsembliENSMUST00000033389; ENSMUSP00000033389; ENSMUSG00000031073.
GeneIDi14170.
KEGGimmu:14170.
UCSCiuc009kqr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007268 mRNA. Translation: AAB63197.1.
AK017829 mRNA. Translation: BAB30961.1.
BC021328 mRNA. Translation: AAH21328.1.
CCDSiCCDS22053.1.
RefSeqiNP_032029.1. NM_008003.2.
UniGeneiMm.3904.

3D structure databases

ProteinModelPortaliO35622.
SMRiO35622. Positions 51-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033389.

PTM databases

PhosphoSiteiO35622.

Proteomic databases

PRIDEiO35622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033389; ENSMUSP00000033389; ENSMUSG00000031073.
GeneIDi14170.
KEGGimmu:14170.
UCSCiuc009kqr.1. mouse.

Organism-specific databases

CTDi14170.
MGIiMGI:1096383. Fgf15.

Phylogenomic databases

eggNOGiNOG294039.
HOGENOMiHOG000112572.
HOVERGENiHBG051611.
InParanoidiO35622.
KOiK04358.
OMAiSEEDCAF.
OrthoDBiEOG7BS4C1.
PhylomeDBiO35622.
TreeFamiTF335872.

Enzyme and pathway databases

ReactomeiREACT_276236. FGFR4 ligand binding and activation.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_354060. betaKlotho-mediated ligand binding.
REACT_358477. Negative regulation of FGFR4 signaling.
REACT_358906. SHC-mediated cascade:FGFR4.
REACT_360720. Phospholipase C-mediated cascade, FGFR4.
REACT_361038. PI-3K cascade:FGFR4.
REACT_361658. FRS2-mediated FGFR4 signaling.

Miscellaneous databases

NextBioi285330.
PROiO35622.
SOURCEiSearch...

Gene expression databases

BgeeiO35622.
CleanExiMM_FGF15.
ExpressionAtlasiO35622. baseline and differential.
GenevisibleiO35622. MM.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028303. FGF15/FGF19.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF74. PTHR11486:SF74. 1 hit.
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1."
    McWhirter J.R., Goulding M., Weiner J.A., Chun J., Murre C.
    Development 124:3221-3232(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis."
    Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G., Luo G., Jones S.A., Goodwin B., Richardson J.A., Gerard R.D., Repa J.J., Mangelsdorf D.J., Kliewer S.A.
    Cell Metab. 2:217-225(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiFGF15_MOUSE
AccessioniPrimary (citable) accession number: O35622
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: June 24, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.