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O35615

- FOG1_MOUSE

UniProt

O35615 - FOG1_MOUSE

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Protein

Zinc finger protein ZFPM1

Gene

Zfpm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.7 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri255 – 27824C2HC-type 1Add
BLAST
Zinc fingeri303 – 32725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38424C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri590 – 61324C2HC-type 2Add
BLAST
Zinc fingeri696 – 71924C2HC-type 3Add
BLAST
Zinc fingeri836 – 85924C2HC-type 4Add
BLAST
Zinc fingeri868 – 89124C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri963 – 98624C2HC-type 5Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. RNA polymerase II activating transcription factor binding Source: MGI
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  5. transcription corepressor activity Source: MGI

GO - Biological processi

  1. atrial septum morphogenesis Source: BHF-UCL
  2. atrioventricular valve morphogenesis Source: BHF-UCL
  3. cardiac muscle tissue morphogenesis Source: BHF-UCL
  4. definitive erythrocyte differentiation Source: MGI
  5. embryonic hemopoiesis Source: BHF-UCL
  6. erythrocyte differentiation Source: MGI
  7. granulocyte differentiation Source: MGI
  8. heart development Source: MGI
  9. homeostasis of number of cells Source: MGI
  10. megakaryocyte development Source: MGI
  11. megakaryocyte differentiation Source: MGI
  12. mitral valve formation Source: BHF-UCL
  13. negative regulation of fat cell differentiation Source: UniProtKB
  14. negative regulation of interleukin-4 biosynthetic process Source: Ensembl
  15. negative regulation of mast cell differentiation Source: BHF-UCL
  16. negative regulation of protein binding Source: BHF-UCL
  17. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  18. outflow tract morphogenesis Source: BHF-UCL
  19. platelet formation Source: Ensembl
  20. positive regulation of interferon-gamma biosynthetic process Source: Ensembl
  21. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  22. primitive erythrocyte differentiation Source: MGI
  23. regulation of chemokine production Source: MGI
  24. regulation of definitive erythrocyte differentiation Source: Ensembl
  25. transcriptional activation by promoter-enhancer looping Source: BHF-UCL
  26. tricuspid valve formation Source: BHF-UCL
  27. ventricular septum morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFPM1
Alternative name(s):
Friend of GATA protein 1
Short name:
FOG-1
Short name:
Friend of GATA 1
Zinc finger protein multitype 1
Gene namesi
Name:Zfpm1
Synonyms:Fog, Fog1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1095400. Zfpm1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
  3. transcriptional repressor complex Source: Ensembl
  4. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi254 – 2541V → A: Does not affect the interaction with GATA1. 1 Publication
Mutagenesisi255 – 2551F → A: Impairs interaction with GATA1. 1 Publication
Mutagenesisi256 – 2561P → A: Does not affect the interaction with GATA1. 1 Publication
Mutagenesisi258 – 2581K → A: Does not affect the interaction with GATA1. 1 Publication
Mutagenesisi259 – 2591D → A: Does not affect the interaction with GATA1. 1 Publication
Mutagenesisi261 – 2611G → A: Slightly affects the interaction with GATA1. 1 Publication
Mutagenesisi262 – 2621I → A: Impairs interaction with GATA1. 1 Publication
Mutagenesisi263 – 2631W → A: Does not affect the interaction with GATA1. 1 Publication
Mutagenesisi265 – 2651R → A: Slightly affects the interaction with GATA1. 1 Publication
Mutagenesisi266 – 2661S → A: Does not affect the interaction with GATA1. 1 Publication
Mutagenesisi267 – 2671E → A: Slightly affects the interaction with GATA1. 1 Publication
Mutagenesisi268 – 2681R → A: Does not affect the interaction with GATA1. 1 Publication
Mutagenesisi269 – 2691N → A: Impairs interaction with GATA1. 1 Publication
Mutagenesisi271 – 2711Q → A: Does not affect the interaction with GATA1. 1 Publication
Mutagenesisi274 – 2741L → A: Slightly affects the interaction with GATA1. 1 Publication
Mutagenesisi275 – 2751L → A: Does not affect the interaction with GATA1. 1 Publication
Mutagenesisi276 – 2761Y → A: Slightly affects the interaction with GATA1. 1 Publication
Mutagenesisi277 – 2771Y → A: Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-612; A-718 and/or A-985. 1 Publication
Mutagenesisi280 – 2801S → A: Does not affect the interaction with GATA1. 1 Publication
Mutagenesisi281 – 2811R → A: Does not affect the interaction with GATA1. 1 Publication
Mutagenesisi334 – 3341V → A: No effect on interaction with TACC3. 1 Publication
Mutagenesisi336 – 3361L → A: No effect on interaction with TACC3. 1 Publication
Mutagenesisi339 – 3391L → A: No effect on interaction with TACC3. 1 Publication
Mutagenesisi340 – 3401S → A: No effect on interaction with TACC3. 1 Publication
Mutagenesisi343 – 3431T → A: Impairs interaction with TACC3. 1 Publication
Mutagenesisi344 – 3441T → A: Abolishes interaction with TACC3. 1 Publication
Mutagenesisi345 – 3451K → A: No effect on interaction with TACC3. 1 Publication
Mutagenesisi346 – 3461A → D: No effect on interaction with TACC3. 1 Publication
Mutagenesisi347 – 3471N → A: Abolishes interaction with TACC3. 1 Publication
Mutagenesisi349 – 3491E → A: No effect on interaction with TACC3. 1 Publication
Mutagenesisi350 – 3501R → A: Abolishes interaction with TACC3. 1 Publication
Mutagenesisi352 – 3521L → A: No effect on interaction with TACC3. 1 Publication
Mutagenesisi353 – 3531K → A: No effect on interaction with TACC3. 1 Publication
Mutagenesisi354 – 3541V → A: Abolishes interaction with TACC3. 1 Publication
Mutagenesisi356 – 3561T → A: No effect on interaction with TACC3. 1 Publication
Mutagenesisi357 – 3571D → A: No effect on interaction with TACC3. 1 Publication
Mutagenesisi612 – 6121Y → A: Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-718 and/or A-985. 1 Publication
Mutagenesisi698 – 6981C → A: Abolishes interaction with GATA1. 1 Publication
Mutagenesisi706 – 7061S → R: Able to partially restore the interaction with the G-205 GATA1 mutant, which is usually unable to interact with ZFPM1. 1 Publication
Mutagenesisi718 – 7181Y → A: Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-612 and/or A-985. 1 Publication
Mutagenesisi719 – 7191C → A: Abolishes interaction with GATA1. 1 Publication
Mutagenesisi719 – 7191C → H: Transforms the C2HC-type zinc finger into a C2H2-type, leading to abolition of interaction with GATA1. 1 Publication
Mutagenesisi811 – 8144PIDL → AIAA: Abolishes interaction with CTBP2. 1 Publication
Mutagenesisi813 – 8142DL → AS: Abolishes interaction with CTBP2; it however does not abolish the corepressor activity in erythropoiesis. 1 Publication
Mutagenesisi985 – 9851Y → A: Slightly affects the interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-612 and/or A-718. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 995995Zinc finger protein ZFPM1PRO_0000221042Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei803 – 8031PhosphoserineBy similarity
Modified residuei925 – 9251Phosphoserine1 Publication
Modified residuei927 – 9271Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO35615.
PaxDbiO35615.
PRIDEiO35615.

PTM databases

PhosphoSiteiO35615.

Expressioni

Tissue specificityi

Mainly expressed in hematopoietic tissues. Expressed in the spleen, a primary site of hematopoiesis in the adult mouse, as well as in the liver and testis, but not in the heart, brain, lung, kidney, or skeletal muscle. Among hematopoietic cell lines, it is strongly expressed in erythroid and megakaryocytic cell lines. Expressed at low level in several lymphoid and early myeloid cell lines. Not expressed in mast cell and macrophage lines. Expressed in the heart, where it colocalizes with GATA4, GATA5 and GATA6.2 Publications

Developmental stagei

First expressed in two extraembryonic mesodermal derivatives, the yolk sac and the allantois in E8.5 embryos. Localized to the embryonic red blood cells within the yolk sac blood islands.1 Publication

Gene expression databases

BgeeiO35615.
CleanExiMM_ZFPM1.
ExpressionAtlasiO35615. differential.
GenevestigatoriO35615.

Interactioni

Subunit structurei

Interacts with the N-terminal zinc-finger of GATA1, GATA2 and GATA3. Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity in erythropoiesis. Interacts with TACC3.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Tacc3Q9JJ117EBI-4394596,EBI-2553611

Protein-protein interaction databases

BioGridi204687. 11 interactions.
DIPiDIP-48414N.
IntActiO35615. 3 interactions.
MINTiMINT-6613139.
STRINGi10090.ENSMUSP00000058037.

Structurei

Secondary structure

1
995
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi336 – 3383Combined sources
Beta strandi341 – 3444Combined sources
Helixi345 – 3528Combined sources
Helixi353 – 3553Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SRKNMR-A328-360[»]
ProteinModelPortaliO35615.
SMRiO35615. Positions 251-383, 591-616, 696-722, 837-863, 960-989.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35615.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni343 – 35412Interaction with TACC3Add
BLAST
Regioni811 – 8177Interaction with CTBP2

Domaini

The CCHC-type zinc fingers 1, 5, 6 and 9 bind directly to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.

Sequence similaritiesi

Belongs to the FOG (Friend of GATA) family.Curated
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 5 C2HC-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri255 – 27824C2HC-type 1Add
BLAST
Zinc fingeri303 – 32725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38424C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri590 – 61324C2HC-type 2Add
BLAST
Zinc fingeri696 – 71924C2HC-type 3Add
BLAST
Zinc fingeri836 – 85924C2HC-type 4Add
BLAST
Zinc fingeri868 – 89124C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri963 – 98624C2HC-type 5Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG146797.
GeneTreeiENSGT00530000063823.
HOGENOMiHOG000112626.
HOVERGENiHBG101018.
InParanoidiO35615.
KOiK17441.
OMAiKLYELHA.
OrthoDBiEOG74TWXR.
PhylomeDBiO35615.
TreeFamiTF331342.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35615-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRRKQSNPR QIKRSLRDME AGEEAKAMDS SPKEQEAPDP EAPAIEEPPS
60 70 80 90 100
PPREDVSPPA VPAPPESPED PEDMEGQELE MRPQDEEKEE KEEEAAMASP
110 120 130 140 150
WSGPEELELA LQDGQRCVRA RLSLTEGLSW GPFYGSIQTR ALSPEREEPG
160 170 180 190 200
PAVTLMVDES CWLRMLPQVL TEEAANSEIY RKDDALWCRV TKVVPSGGLL
210 220 230 240 250
YVRLVTEPHG APRHPVQEPV EPGGLAPVHT DIQLLPQQAG MASILATAVI
260 270 280 290 300
NKDVFPCKDC GIWYRSERNL QAHLLYYCAS RQRAGSPVSA TEEKPKETYP
310 320 330 340 350
NERVCPFPQC RKSCPSASSL EIHMRSHSGE RPFVCLICLS AFTTKANCER
360 370 380 390 400
HLKVHTDTLS GVCHNCGFIS TTRDILYSHL VTNHMVCQPG SKGEIYSPGA
410 420 430 440 450
GHPAAKLPPD SLAGFQQHSL MHSPLVPADK APTPSSGLDS KAEVTNGETR
460 470 480 490 500
VPPQNGGSSE SPAAPRTIKV EAAEEPEATR ASGPGEPGPQ APSRTPSPHS
510 520 530 540 550
PNPVRVKTEL SSPTPGSSPG PGELTMAGTL FLPQYVFSPD AGTTTVPTAP
560 570 580 590 600
QASEILAKMS ELVHNRLQQG AGSSGAAGTP TGLFSGTKGA TCFECEITFN
610 620 630 640 650
NINNFYVHKR LYCSGRRAPE DPPTVRRPKA ATGPARAPAG AAAEPDPSRS
660 670 680 690 700
SPGPGPREEE ASGTTTPEAE AAGRGSEGSQ SPGSSVDDAE DDPSRTLCEA
710 720 730 740 750
CNIRFSRHET YTVHKRYYCA SRHDPPPRRP PAPTTAPGPA APALTAPPVR
760 770 780 790 800
TRRRRKLYEL PAAGAPPPAA GPAPVPVVPS PTAELPSSPR PGSASAGPAP
810 820 830 840 850
ALSPSPVPDG PIDLSKRPRR QSPDAPTALP ALADYHECTA CRVSFHSLEA
860 870 880 890 900
YLAHKKYSCP AAPLRTTALC PYCPPNGRVR GDLVEHLRQA HGLQVAKPAA
910 920 930 940 950
SPGAEPRTPA ERAPRDSPDG RAPRSPSPAP ENTPSDPADQ GARTPSKGPP
960 970 980 990
APAPAPGGGG GHRYCRLCNI RFSSLSTFIA HKKYYCSSHA AEHVK
Length:995
Mass (Da):105,984
Last modified:January 1, 1998 - v1
Checksum:i293255B28151ECB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006492 mRNA. Translation: AAC53292.1.
CCDSiCCDS22733.1.
RefSeqiNP_033595.1. NM_009569.3.
XP_006530914.1. XM_006530851.1.
UniGeneiMm.3105.
Mm.390068.

Genome annotation databases

EnsembliENSMUST00000054052; ENSMUSP00000058037; ENSMUSG00000049577.
GeneIDi22761.
KEGGimmu:22761.
UCSCiuc009nsj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006492 mRNA. Translation: AAC53292.1 .
CCDSi CCDS22733.1.
RefSeqi NP_033595.1. NM_009569.3.
XP_006530914.1. XM_006530851.1.
UniGenei Mm.3105.
Mm.390068.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1SRK NMR - A 328-360 [» ]
ProteinModelPortali O35615.
SMRi O35615. Positions 251-383, 591-616, 696-722, 837-863, 960-989.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204687. 11 interactions.
DIPi DIP-48414N.
IntActi O35615. 3 interactions.
MINTi MINT-6613139.
STRINGi 10090.ENSMUSP00000058037.

PTM databases

PhosphoSitei O35615.

Proteomic databases

MaxQBi O35615.
PaxDbi O35615.
PRIDEi O35615.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000054052 ; ENSMUSP00000058037 ; ENSMUSG00000049577 .
GeneIDi 22761.
KEGGi mmu:22761.
UCSCi uc009nsj.1. mouse.

Organism-specific databases

CTDi 161882.
MGIi MGI:1095400. Zfpm1.

Phylogenomic databases

eggNOGi NOG146797.
GeneTreei ENSGT00530000063823.
HOGENOMi HOG000112626.
HOVERGENi HBG101018.
InParanoidi O35615.
KOi K17441.
OMAi KLYELHA.
OrthoDBi EOG74TWXR.
PhylomeDBi O35615.
TreeFami TF331342.

Enzyme and pathway databases

Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

EvolutionaryTracei O35615.
NextBioi 303277.
PROi O35615.
SOURCEi Search...

Gene expression databases

Bgeei O35615.
CleanExi MM_ZFPM1.
ExpressionAtlasi O35615. differential.
Genevestigatori O35615.

Family and domain databases

Gene3Di 3.30.160.60. 2 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation."
    Tsang A.P., Visvader J.E., Turner C.A., Fujiwara Y., Yu C., Weiss M.J., Crossley M., Orkin S.H.
    Cell 90:109-119(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH GATA1; GATA2 AND GATA3.
    Tissue: Erythroleukemia.
  2. "Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG."
    Tsang A.P., Fujiwara Y., Hom D.B., Orkin S.H.
    Genes Dev. 12:1176-1188(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Key residues characteristic of GATA N-fingers are recognized by FOG."
    Fox A.H., Kowalski K., King G.F., Mackay J.P., Crossley M.
    J. Biol. Chem. 273:33595-33603(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GATA1, MUTAGENESIS OF CYS-698 AND CYS-719.
  4. "Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex."
    Crispino J.D., Lodish M.B., MacKay J.P., Orkin S.H.
    Mol. Cell 3:219-228(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF SER-706.
  5. "Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers."
    Fox A.H., Liew C., Holmes M., Kowalski K., Mackay J., Crossley M.
    EMBO J. 18:2812-2822(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GATA1 AND CTBP2, MUTAGENESIS OF VAL-254; PHE-255; PRO-256; LYS-258; ASP-259; GLY-261; ILE-262; TRP-263; ARG-265; SER-266; GLU-267; ARG-268; ASN-269; GLN-271; LEU-274; LEU-275; TYR-276; TYR-277; SER-280; ARG-281; 811-PRO--LEU-814; TYR-612; TYR-718 AND TYR-985.
  6. "Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo."
    Katz S.G., Cantor A.B., Orkin S.H.
    Mol. Cell. Biol. 22:3121-3128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CTBP2, MUTAGENESIS OF 813-ASP-LEU-814.
  7. "Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors."
    Wang X., Crispino J.D., Letting D.L., Nakazawa M., Poncz M., Blobel G.A.
    EMBO J. 21:5225-5234(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development."
    Katz S.G., Williams A., Yang J., Fujiwara Y., Tsang A.P., Epstein J.A., Orkin S.H.
    Proc. Natl. Acad. Sci. U.S.A. 100:14030-14035(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-925 AND SER-927, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "A classic zinc finger from Friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3."
    Simpson R.J.Y., Yi Lee S.H., Bartle N., Sum E.Y., Visvader J.E., Matthews J.M., Mackay J.P., Crossley M.
    J. Biol. Chem. 279:39789-39797(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 328-360, INTERACTION WITH TACC3, MUTAGENESIS OF VAL-334; LEU-336; LEU-339; SER-340; THR-343; THR-344; LYS-345; ALA-346; ASN-347; GLU-349; ARG-350; LEU-352; LYS-353; VAL-354; THR-356 AND ASP-357.

Entry informationi

Entry nameiFOG1_MOUSE
AccessioniPrimary (citable) accession number: O35615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3