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O35615

- FOG1_MOUSE

UniProt

O35615 - FOG1_MOUSE

Protein

Zinc finger protein ZFPM1

Gene

Zfpm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.7 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri255 – 27824C2HC-type 1Add
    BLAST
    Zinc fingeri303 – 32725C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 35523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri361 – 38424C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri590 – 61324C2HC-type 2Add
    BLAST
    Zinc fingeri696 – 71924C2HC-type 3Add
    BLAST
    Zinc fingeri836 – 85924C2HC-type 4Add
    BLAST
    Zinc fingeri868 – 89124C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri963 – 98624C2HC-type 5Add
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. RNA polymerase II activating transcription factor binding Source: MGI
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
    6. transcription corepressor activity Source: MGI

    GO - Biological processi

    1. atrial septum morphogenesis Source: BHF-UCL
    2. atrioventricular valve morphogenesis Source: BHF-UCL
    3. cardiac muscle tissue morphogenesis Source: BHF-UCL
    4. definitive erythrocyte differentiation Source: MGI
    5. embryonic hemopoiesis Source: BHF-UCL
    6. erythrocyte differentiation Source: MGI
    7. granulocyte differentiation Source: MGI
    8. heart development Source: MGI
    9. homeostasis of number of cells Source: MGI
    10. megakaryocyte development Source: MGI
    11. megakaryocyte differentiation Source: MGI
    12. mitral valve formation Source: BHF-UCL
    13. negative regulation of fat cell differentiation Source: UniProtKB
    14. negative regulation of interleukin-4 biosynthetic process Source: Ensembl
    15. negative regulation of mast cell differentiation Source: BHF-UCL
    16. negative regulation of protein binding Source: BHF-UCL
    17. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    18. outflow tract morphogenesis Source: BHF-UCL
    19. platelet formation Source: Ensembl
    20. positive regulation of interferon-gamma biosynthetic process Source: Ensembl
    21. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    22. primitive erythrocyte differentiation Source: MGI
    23. regulation of chemokine production Source: MGI
    24. regulation of definitive erythrocyte differentiation Source: Ensembl
    25. transcriptional activation by promoter-enhancer looping Source: BHF-UCL
    26. tricuspid valve formation Source: BHF-UCL
    27. ventricular septum morphogenesis Source: BHF-UCL

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein ZFPM1
    Alternative name(s):
    Friend of GATA protein 1
    Short name:
    FOG-1
    Short name:
    Friend of GATA 1
    Zinc finger protein multitype 1
    Gene namesi
    Name:Zfpm1
    Synonyms:Fog, Fog1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1095400. Zfpm1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI
    3. transcriptional repressor complex Source: Ensembl
    4. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi254 – 2541V → A: Does not affect the interaction with GATA1. 2 Publications
    Mutagenesisi255 – 2551F → A: Impairs interaction with GATA1. 2 Publications
    Mutagenesisi256 – 2561P → A: Does not affect the interaction with GATA1. 2 Publications
    Mutagenesisi258 – 2581K → A: Does not affect the interaction with GATA1. 2 Publications
    Mutagenesisi259 – 2591D → A: Does not affect the interaction with GATA1. 2 Publications
    Mutagenesisi261 – 2611G → A: Slightly affects the interaction with GATA1. 2 Publications
    Mutagenesisi262 – 2621I → A: Impairs interaction with GATA1. 2 Publications
    Mutagenesisi263 – 2631W → A: Does not affect the interaction with GATA1. 2 Publications
    Mutagenesisi265 – 2651R → A: Slightly affects the interaction with GATA1. 2 Publications
    Mutagenesisi266 – 2661S → A: Does not affect the interaction with GATA1. 2 Publications
    Mutagenesisi267 – 2671E → A: Slightly affects the interaction with GATA1. 2 Publications
    Mutagenesisi268 – 2681R → A: Does not affect the interaction with GATA1. 2 Publications
    Mutagenesisi269 – 2691N → A: Impairs interaction with GATA1. 2 Publications
    Mutagenesisi271 – 2711Q → A: Does not affect the interaction with GATA1. 2 Publications
    Mutagenesisi274 – 2741L → A: Slightly affects the interaction with GATA1. 2 Publications
    Mutagenesisi275 – 2751L → A: Does not affect the interaction with GATA1. 2 Publications
    Mutagenesisi276 – 2761Y → A: Slightly affects the interaction with GATA1. 2 Publications
    Mutagenesisi277 – 2771Y → A: Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-612; A-718 and/or A-985. 2 Publications
    Mutagenesisi280 – 2801S → A: Does not affect the interaction with GATA1. 2 Publications
    Mutagenesisi281 – 2811R → A: Does not affect the interaction with GATA1. 2 Publications
    Mutagenesisi334 – 3341V → A: No effect on interaction with TACC3. 2 Publications
    Mutagenesisi336 – 3361L → A: No effect on interaction with TACC3. 2 Publications
    Mutagenesisi339 – 3391L → A: No effect on interaction with TACC3. 2 Publications
    Mutagenesisi340 – 3401S → A: No effect on interaction with TACC3. 2 Publications
    Mutagenesisi343 – 3431T → A: Impairs interaction with TACC3. 2 Publications
    Mutagenesisi344 – 3441T → A: Abolishes interaction with TACC3. 2 Publications
    Mutagenesisi345 – 3451K → A: No effect on interaction with TACC3. 2 Publications
    Mutagenesisi346 – 3461A → D: No effect on interaction with TACC3. 2 Publications
    Mutagenesisi347 – 3471N → A: Abolishes interaction with TACC3. 2 Publications
    Mutagenesisi349 – 3491E → A: No effect on interaction with TACC3. 2 Publications
    Mutagenesisi350 – 3501R → A: Abolishes interaction with TACC3. 2 Publications
    Mutagenesisi352 – 3521L → A: No effect on interaction with TACC3. 2 Publications
    Mutagenesisi353 – 3531K → A: No effect on interaction with TACC3. 2 Publications
    Mutagenesisi354 – 3541V → A: Abolishes interaction with TACC3. 2 Publications
    Mutagenesisi356 – 3561T → A: No effect on interaction with TACC3. 2 Publications
    Mutagenesisi357 – 3571D → A: No effect on interaction with TACC3. 2 Publications
    Mutagenesisi612 – 6121Y → A: Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-718 and/or A-985. 2 Publications
    Mutagenesisi698 – 6981C → A: Abolishes interaction with GATA1. 2 Publications
    Mutagenesisi706 – 7061S → R: Able to partially restore the interaction with the G-205 GATA1 mutant, which is usually unable to interact with ZFPM1. 2 Publications
    Mutagenesisi718 – 7181Y → A: Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-612 and/or A-985. 2 Publications
    Mutagenesisi719 – 7191C → A: Abolishes interaction with GATA1. 2 Publications
    Mutagenesisi719 – 7191C → H: Transforms the C2HC-type zinc finger into a C2H2-type, leading to abolition of interaction with GATA1. 2 Publications
    Mutagenesisi811 – 8144PIDL → AIAA: Abolishes interaction with CTBP2. 1 Publication
    Mutagenesisi813 – 8142DL → AS: Abolishes interaction with CTBP2; it however does not abolish the corepressor activity in erythropoiesis. 1 Publication
    Mutagenesisi985 – 9851Y → A: Slightly affects the interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-612 and/or A-718. 2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 995995Zinc finger protein ZFPM1PRO_0000221042Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei803 – 8031PhosphoserineBy similarity
    Modified residuei925 – 9251Phosphoserine1 Publication
    Modified residuei927 – 9271Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO35615.
    PRIDEiO35615.

    PTM databases

    PhosphoSiteiO35615.

    Expressioni

    Tissue specificityi

    Mainly expressed in hematopoietic tissues. Expressed in the spleen, a primary site of hematopoiesis in the adult mouse, as well as in the liver and testis, but not in the heart, brain, lung, kidney, or skeletal muscle. Among hematopoietic cell lines, it is strongly expressed in erythroid and megakaryocytic cell lines. Expressed at low level in several lymphoid and early myeloid cell lines. Not expressed in mast cell and macrophage lines. Expressed in the heart, where it colocalizes with GATA4, GATA5 and GATA6.2 Publications

    Developmental stagei

    First expressed in two extraembryonic mesodermal derivatives, the yolk sac and the allantois in E8.5 embryos. Localized to the embryonic red blood cells within the yolk sac blood islands.1 Publication

    Gene expression databases

    ArrayExpressiO35615.
    BgeeiO35615.
    CleanExiMM_ZFPM1.
    GenevestigatoriO35615.

    Interactioni

    Subunit structurei

    Interacts with the N-terminal zinc-finger of GATA1, GATA2 and GATA3. Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity in erythropoiesis. Interacts with TACC3.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Tacc3Q9JJ117EBI-4394596,EBI-2553611

    Protein-protein interaction databases

    BioGridi204687. 11 interactions.
    DIPiDIP-48414N.
    IntActiO35615. 3 interactions.
    MINTiMINT-6613139.
    STRINGi10090.ENSMUSP00000058037.

    Structurei

    Secondary structure

    1
    995
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi336 – 3383
    Beta strandi341 – 3444
    Helixi345 – 3528
    Helixi353 – 3553

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1SRKNMR-A328-360[»]
    ProteinModelPortaliO35615.
    SMRiO35615. Positions 251-418, 582-616.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO35615.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni343 – 35412Interaction with TACC3Add
    BLAST
    Regioni811 – 8177Interaction with CTBP2

    Domaini

    The CCHC-type zinc fingers 1, 5, 6 and 9 bind directly to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.

    Sequence similaritiesi

    Belongs to the FOG (Friend of GATA) family.Curated
    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 5 C2HC-type zinc fingers.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri255 – 27824C2HC-type 1Add
    BLAST
    Zinc fingeri303 – 32725C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri333 – 35523C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri361 – 38424C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri590 – 61324C2HC-type 2Add
    BLAST
    Zinc fingeri696 – 71924C2HC-type 3Add
    BLAST
    Zinc fingeri836 – 85924C2HC-type 4Add
    BLAST
    Zinc fingeri868 – 89124C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri963 – 98624C2HC-type 5Add
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG146797.
    GeneTreeiENSGT00530000063823.
    HOGENOMiHOG000112626.
    HOVERGENiHBG101018.
    InParanoidiO35615.
    KOiK17441.
    OMAiKLYELHA.
    OrthoDBiEOG74TWXR.
    PhylomeDBiO35615.
    TreeFamiTF331342.

    Family and domain databases

    Gene3Di3.30.160.60. 2 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 9 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35615-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRRKQSNPR QIKRSLRDME AGEEAKAMDS SPKEQEAPDP EAPAIEEPPS    50
    PPREDVSPPA VPAPPESPED PEDMEGQELE MRPQDEEKEE KEEEAAMASP 100
    WSGPEELELA LQDGQRCVRA RLSLTEGLSW GPFYGSIQTR ALSPEREEPG 150
    PAVTLMVDES CWLRMLPQVL TEEAANSEIY RKDDALWCRV TKVVPSGGLL 200
    YVRLVTEPHG APRHPVQEPV EPGGLAPVHT DIQLLPQQAG MASILATAVI 250
    NKDVFPCKDC GIWYRSERNL QAHLLYYCAS RQRAGSPVSA TEEKPKETYP 300
    NERVCPFPQC RKSCPSASSL EIHMRSHSGE RPFVCLICLS AFTTKANCER 350
    HLKVHTDTLS GVCHNCGFIS TTRDILYSHL VTNHMVCQPG SKGEIYSPGA 400
    GHPAAKLPPD SLAGFQQHSL MHSPLVPADK APTPSSGLDS KAEVTNGETR 450
    VPPQNGGSSE SPAAPRTIKV EAAEEPEATR ASGPGEPGPQ APSRTPSPHS 500
    PNPVRVKTEL SSPTPGSSPG PGELTMAGTL FLPQYVFSPD AGTTTVPTAP 550
    QASEILAKMS ELVHNRLQQG AGSSGAAGTP TGLFSGTKGA TCFECEITFN 600
    NINNFYVHKR LYCSGRRAPE DPPTVRRPKA ATGPARAPAG AAAEPDPSRS 650
    SPGPGPREEE ASGTTTPEAE AAGRGSEGSQ SPGSSVDDAE DDPSRTLCEA 700
    CNIRFSRHET YTVHKRYYCA SRHDPPPRRP PAPTTAPGPA APALTAPPVR 750
    TRRRRKLYEL PAAGAPPPAA GPAPVPVVPS PTAELPSSPR PGSASAGPAP 800
    ALSPSPVPDG PIDLSKRPRR QSPDAPTALP ALADYHECTA CRVSFHSLEA 850
    YLAHKKYSCP AAPLRTTALC PYCPPNGRVR GDLVEHLRQA HGLQVAKPAA 900
    SPGAEPRTPA ERAPRDSPDG RAPRSPSPAP ENTPSDPADQ GARTPSKGPP 950
    APAPAPGGGG GHRYCRLCNI RFSSLSTFIA HKKYYCSSHA AEHVK 995
    Length:995
    Mass (Da):105,984
    Last modified:January 1, 1998 - v1
    Checksum:i293255B28151ECB8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006492 mRNA. Translation: AAC53292.1.
    CCDSiCCDS22733.1.
    RefSeqiNP_033595.1. NM_009569.3.
    XP_006530914.1. XM_006530851.1.
    UniGeneiMm.3105.
    Mm.390068.

    Genome annotation databases

    EnsembliENSMUST00000054052; ENSMUSP00000058037; ENSMUSG00000049577.
    GeneIDi22761.
    KEGGimmu:22761.
    UCSCiuc009nsj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006492 mRNA. Translation: AAC53292.1 .
    CCDSi CCDS22733.1.
    RefSeqi NP_033595.1. NM_009569.3.
    XP_006530914.1. XM_006530851.1.
    UniGenei Mm.3105.
    Mm.390068.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1SRK NMR - A 328-360 [» ]
    ProteinModelPortali O35615.
    SMRi O35615. Positions 251-418, 582-616.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204687. 11 interactions.
    DIPi DIP-48414N.
    IntActi O35615. 3 interactions.
    MINTi MINT-6613139.
    STRINGi 10090.ENSMUSP00000058037.

    PTM databases

    PhosphoSitei O35615.

    Proteomic databases

    PaxDbi O35615.
    PRIDEi O35615.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054052 ; ENSMUSP00000058037 ; ENSMUSG00000049577 .
    GeneIDi 22761.
    KEGGi mmu:22761.
    UCSCi uc009nsj.1. mouse.

    Organism-specific databases

    CTDi 161882.
    MGIi MGI:1095400. Zfpm1.

    Phylogenomic databases

    eggNOGi NOG146797.
    GeneTreei ENSGT00530000063823.
    HOGENOMi HOG000112626.
    HOVERGENi HBG101018.
    InParanoidi O35615.
    KOi K17441.
    OMAi KLYELHA.
    OrthoDBi EOG74TWXR.
    PhylomeDBi O35615.
    TreeFami TF331342.

    Enzyme and pathway databases

    Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    EvolutionaryTracei O35615.
    NextBioi 303277.
    PROi O35615.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35615.
    Bgeei O35615.
    CleanExi MM_ZFPM1.
    Genevestigatori O35615.

    Family and domain databases

    Gene3Di 3.30.160.60. 2 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 9 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation."
      Tsang A.P., Visvader J.E., Turner C.A., Fujiwara Y., Yu C., Weiss M.J., Crossley M., Orkin S.H.
      Cell 90:109-119(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH GATA1; GATA2 AND GATA3.
      Tissue: Erythroleukemia.
    2. "Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG."
      Tsang A.P., Fujiwara Y., Hom D.B., Orkin S.H.
      Genes Dev. 12:1176-1188(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "Key residues characteristic of GATA N-fingers are recognized by FOG."
      Fox A.H., Kowalski K., King G.F., Mackay J.P., Crossley M.
      J. Biol. Chem. 273:33595-33603(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GATA1, MUTAGENESIS OF CYS-698 AND CYS-719.
    4. "Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex."
      Crispino J.D., Lodish M.B., MacKay J.P., Orkin S.H.
      Mol. Cell 3:219-228(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF SER-706.
    5. "Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers."
      Fox A.H., Liew C., Holmes M., Kowalski K., Mackay J., Crossley M.
      EMBO J. 18:2812-2822(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GATA1 AND CTBP2, MUTAGENESIS OF VAL-254; PHE-255; PRO-256; LYS-258; ASP-259; GLY-261; ILE-262; TRP-263; ARG-265; SER-266; GLU-267; ARG-268; ASN-269; GLN-271; LEU-274; LEU-275; TYR-276; TYR-277; SER-280; ARG-281; 811-PRO--LEU-814; TYR-612; TYR-718 AND TYR-985.
    6. "Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo."
      Katz S.G., Cantor A.B., Orkin S.H.
      Mol. Cell. Biol. 22:3121-3128(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CTBP2, MUTAGENESIS OF 813-ASP-LEU-814.
    7. "Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors."
      Wang X., Crispino J.D., Letting D.L., Nakazawa M., Poncz M., Blobel G.A.
      EMBO J. 21:5225-5234(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development."
      Katz S.G., Williams A., Yang J., Fujiwara Y., Tsang A.P., Epstein J.A., Orkin S.H.
      Proc. Natl. Acad. Sci. U.S.A. 100:14030-14035(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-925 AND SER-927, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    10. "A classic zinc finger from Friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3."
      Simpson R.J.Y., Yi Lee S.H., Bartle N., Sum E.Y., Visvader J.E., Matthews J.M., Mackay J.P., Crossley M.
      J. Biol. Chem. 279:39789-39797(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 328-360, INTERACTION WITH TACC3, MUTAGENESIS OF VAL-334; LEU-336; LEU-339; SER-340; THR-343; THR-344; LYS-345; ALA-346; ASN-347; GLU-349; ARG-350; LEU-352; LYS-353; VAL-354; THR-356 AND ASP-357.

    Entry informationi

    Entry nameiFOG1_MOUSE
    AccessioniPrimary (citable) accession number: O35615
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3