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O35615

- FOG1_MOUSE

UniProt

O35615 - FOG1_MOUSE

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Protein
Zinc finger protein ZFPM1
Gene
Zfpm1, Fog, Fog1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.7 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri255 – 27824C2HC-type 1
Add
BLAST
Zinc fingeri303 – 32725C2H2-type 1
Add
BLAST
Zinc fingeri333 – 35523C2H2-type 2
Add
BLAST
Zinc fingeri361 – 38424C2H2-type 3
Add
BLAST
Zinc fingeri590 – 61324C2HC-type 2
Add
BLAST
Zinc fingeri696 – 71924C2HC-type 3
Add
BLAST
Zinc fingeri836 – 85924C2HC-type 4
Add
BLAST
Zinc fingeri868 – 89124C2H2-type 4
Add
BLAST
Zinc fingeri963 – 98624C2HC-type 5
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. RNA polymerase II activating transcription factor binding Source: MGI
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  4. metal ion binding Source: UniProtKB-KW
  5. protein binding Source: IntAct
  6. transcription corepressor activity Source: MGI

GO - Biological processi

  1. atrial septum morphogenesis Source: BHF-UCL
  2. atrioventricular valve morphogenesis Source: BHF-UCL
  3. cardiac muscle tissue morphogenesis Source: BHF-UCL
  4. definitive erythrocyte differentiation Source: MGI
  5. embryonic hemopoiesis Source: BHF-UCL
  6. erythrocyte differentiation Source: MGI
  7. granulocyte differentiation Source: MGI
  8. heart development Source: MGI
  9. homeostasis of number of cells Source: MGI
  10. megakaryocyte development Source: MGI
  11. megakaryocyte differentiation Source: MGI
  12. mitral valve formation Source: BHF-UCL
  13. negative regulation of fat cell differentiation Source: UniProtKB
  14. negative regulation of interleukin-4 biosynthetic process Source: Ensembl
  15. negative regulation of mast cell differentiation Source: BHF-UCL
  16. negative regulation of protein binding Source: BHF-UCL
  17. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  18. outflow tract morphogenesis Source: BHF-UCL
  19. platelet formation Source: Ensembl
  20. positive regulation of interferon-gamma biosynthetic process Source: Ensembl
  21. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  22. primitive erythrocyte differentiation Source: MGI
  23. regulation of chemokine production Source: MGI
  24. regulation of definitive erythrocyte differentiation Source: Ensembl
  25. transcriptional activation by promoter-enhancer looping Source: BHF-UCL
  26. tricuspid valve formation Source: BHF-UCL
  27. ventricular septum morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFPM1
Alternative name(s):
Friend of GATA protein 1
Short name:
FOG-1
Short name:
Friend of GATA 1
Zinc finger protein multitype 1
Gene namesi
Name:Zfpm1
Synonyms:Fog, Fog1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1095400. Zfpm1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
  3. transcription factor complex Source: Ensembl
  4. transcriptional repressor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi254 – 2541V → A: Does not affect the interaction with GATA1. 2 Publications
Mutagenesisi255 – 2551F → A: Impairs interaction with GATA1. 2 Publications
Mutagenesisi256 – 2561P → A: Does not affect the interaction with GATA1. 2 Publications
Mutagenesisi258 – 2581K → A: Does not affect the interaction with GATA1. 2 Publications
Mutagenesisi259 – 2591D → A: Does not affect the interaction with GATA1. 2 Publications
Mutagenesisi261 – 2611G → A: Slightly affects the interaction with GATA1. 2 Publications
Mutagenesisi262 – 2621I → A: Impairs interaction with GATA1. 2 Publications
Mutagenesisi263 – 2631W → A: Does not affect the interaction with GATA1. 2 Publications
Mutagenesisi265 – 2651R → A: Slightly affects the interaction with GATA1. 2 Publications
Mutagenesisi266 – 2661S → A: Does not affect the interaction with GATA1. 2 Publications
Mutagenesisi267 – 2671E → A: Slightly affects the interaction with GATA1. 2 Publications
Mutagenesisi268 – 2681R → A: Does not affect the interaction with GATA1. 2 Publications
Mutagenesisi269 – 2691N → A: Impairs interaction with GATA1. 2 Publications
Mutagenesisi271 – 2711Q → A: Does not affect the interaction with GATA1. 2 Publications
Mutagenesisi274 – 2741L → A: Slightly affects the interaction with GATA1. 2 Publications
Mutagenesisi275 – 2751L → A: Does not affect the interaction with GATA1. 2 Publications
Mutagenesisi276 – 2761Y → A: Slightly affects the interaction with GATA1. 2 Publications
Mutagenesisi277 – 2771Y → A: Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-612; A-718 and/or A-985. 2 Publications
Mutagenesisi280 – 2801S → A: Does not affect the interaction with GATA1. 2 Publications
Mutagenesisi281 – 2811R → A: Does not affect the interaction with GATA1. 2 Publications
Mutagenesisi334 – 3341V → A: No effect on interaction with TACC3. 2 Publications
Mutagenesisi336 – 3361L → A: No effect on interaction with TACC3. 2 Publications
Mutagenesisi339 – 3391L → A: No effect on interaction with TACC3. 2 Publications
Mutagenesisi340 – 3401S → A: No effect on interaction with TACC3. 2 Publications
Mutagenesisi343 – 3431T → A: Impairs interaction with TACC3. 2 Publications
Mutagenesisi344 – 3441T → A: Abolishes interaction with TACC3. 2 Publications
Mutagenesisi345 – 3451K → A: No effect on interaction with TACC3. 2 Publications
Mutagenesisi346 – 3461A → D: No effect on interaction with TACC3. 2 Publications
Mutagenesisi347 – 3471N → A: Abolishes interaction with TACC3. 2 Publications
Mutagenesisi349 – 3491E → A: No effect on interaction with TACC3. 2 Publications
Mutagenesisi350 – 3501R → A: Abolishes interaction with TACC3. 2 Publications
Mutagenesisi352 – 3521L → A: No effect on interaction with TACC3. 2 Publications
Mutagenesisi353 – 3531K → A: No effect on interaction with TACC3. 2 Publications
Mutagenesisi354 – 3541V → A: Abolishes interaction with TACC3. 2 Publications
Mutagenesisi356 – 3561T → A: No effect on interaction with TACC3. 2 Publications
Mutagenesisi357 – 3571D → A: No effect on interaction with TACC3. 2 Publications
Mutagenesisi612 – 6121Y → A: Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-718 and/or A-985. 2 Publications
Mutagenesisi698 – 6981C → A: Abolishes interaction with GATA1. 2 Publications
Mutagenesisi706 – 7061S → R: Able to partially restore the interaction with the G-205 GATA1 mutant, which is usually unable to interact with ZFPM1. 2 Publications
Mutagenesisi718 – 7181Y → A: Impairs interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-612 and/or A-985. 2 Publications
Mutagenesisi719 – 7191C → A: Abolishes interaction with GATA1. 2 Publications
Mutagenesisi719 – 7191C → H: Transforms the C2HC-type zinc finger into a C2H2-type, leading to abolition of interaction with GATA1. 2 Publications
Mutagenesisi811 – 8144PIDL → AIAA: Abolishes interaction with CTBP2. 2 Publications
Mutagenesisi813 – 8142DL → AS: Abolishes interaction with CTBP2; it however does not abolish the corepressor activity in erythropoiesis. 1 Publication
Mutagenesisi985 – 9851Y → A: Slightly affects the interaction with GATA1. Strongly impairs interaction with GATA1; when associated with A-277; A-612 and/or A-718. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 995995Zinc finger protein ZFPM1
PRO_0000221042Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei803 – 8031Phosphoserine By similarity
Modified residuei925 – 9251Phosphoserine1 Publication
Modified residuei927 – 9271Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO35615.
PRIDEiO35615.

PTM databases

PhosphoSiteiO35615.

Expressioni

Tissue specificityi

Mainly expressed in hematopoietic tissues. Expressed in the spleen, a primary site of hematopoiesis in the adult mouse, as well as in the liver and testis, but not in the heart, brain, lung, kidney, or skeletal muscle. Among hematopoietic cell lines, it is strongly expressed in erythroid and megakaryocytic cell lines. Expressed at low level in several lymphoid and early myeloid cell lines. Not expressed in mast cell and macrophage lines. Expressed in the heart, where it colocalizes with GATA4, GATA5 and GATA6.2 Publications

Developmental stagei

First expressed in two extraembryonic mesodermal derivatives, the yolk sac and the allantois in E8.5 embryos. Localized to the embryonic red blood cells within the yolk sac blood islands.1 Publication

Gene expression databases

ArrayExpressiO35615.
BgeeiO35615.
CleanExiMM_ZFPM1.
GenevestigatoriO35615.

Interactioni

Subunit structurei

Interacts with the N-terminal zinc-finger of GATA1, GATA2 and GATA3. Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity in erythropoiesis. Interacts with TACC3.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Tacc3Q9JJ117EBI-4394596,EBI-2553611

Protein-protein interaction databases

BioGridi204687. 11 interactions.
DIPiDIP-48414N.
IntActiO35615. 3 interactions.
MINTiMINT-6613139.
STRINGi10090.ENSMUSP00000058037.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi336 – 3383
Beta strandi341 – 3444
Helixi345 – 3528
Helixi353 – 3553

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SRKNMR-A328-360[»]
ProteinModelPortaliO35615.
SMRiO35615. Positions 251-418, 582-616.

Miscellaneous databases

EvolutionaryTraceiO35615.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni343 – 35412Interaction with TACC3
Add
BLAST
Regioni811 – 8177Interaction with CTBP2

Domaini

The CCHC-type zinc fingers 1, 5, 6 and 9 bind directly to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG146797.
GeneTreeiENSGT00530000063823.
HOGENOMiHOG000112626.
HOVERGENiHBG101018.
InParanoidiO35615.
KOiK17441.
OMAiKLYELHA.
OrthoDBiEOG74TWXR.
PhylomeDBiO35615.
TreeFamiTF331342.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35615-1 [UniParc]FASTAAdd to Basket

« Hide

MSRRKQSNPR QIKRSLRDME AGEEAKAMDS SPKEQEAPDP EAPAIEEPPS    50
PPREDVSPPA VPAPPESPED PEDMEGQELE MRPQDEEKEE KEEEAAMASP 100
WSGPEELELA LQDGQRCVRA RLSLTEGLSW GPFYGSIQTR ALSPEREEPG 150
PAVTLMVDES CWLRMLPQVL TEEAANSEIY RKDDALWCRV TKVVPSGGLL 200
YVRLVTEPHG APRHPVQEPV EPGGLAPVHT DIQLLPQQAG MASILATAVI 250
NKDVFPCKDC GIWYRSERNL QAHLLYYCAS RQRAGSPVSA TEEKPKETYP 300
NERVCPFPQC RKSCPSASSL EIHMRSHSGE RPFVCLICLS AFTTKANCER 350
HLKVHTDTLS GVCHNCGFIS TTRDILYSHL VTNHMVCQPG SKGEIYSPGA 400
GHPAAKLPPD SLAGFQQHSL MHSPLVPADK APTPSSGLDS KAEVTNGETR 450
VPPQNGGSSE SPAAPRTIKV EAAEEPEATR ASGPGEPGPQ APSRTPSPHS 500
PNPVRVKTEL SSPTPGSSPG PGELTMAGTL FLPQYVFSPD AGTTTVPTAP 550
QASEILAKMS ELVHNRLQQG AGSSGAAGTP TGLFSGTKGA TCFECEITFN 600
NINNFYVHKR LYCSGRRAPE DPPTVRRPKA ATGPARAPAG AAAEPDPSRS 650
SPGPGPREEE ASGTTTPEAE AAGRGSEGSQ SPGSSVDDAE DDPSRTLCEA 700
CNIRFSRHET YTVHKRYYCA SRHDPPPRRP PAPTTAPGPA APALTAPPVR 750
TRRRRKLYEL PAAGAPPPAA GPAPVPVVPS PTAELPSSPR PGSASAGPAP 800
ALSPSPVPDG PIDLSKRPRR QSPDAPTALP ALADYHECTA CRVSFHSLEA 850
YLAHKKYSCP AAPLRTTALC PYCPPNGRVR GDLVEHLRQA HGLQVAKPAA 900
SPGAEPRTPA ERAPRDSPDG RAPRSPSPAP ENTPSDPADQ GARTPSKGPP 950
APAPAPGGGG GHRYCRLCNI RFSSLSTFIA HKKYYCSSHA AEHVK 995
Length:995
Mass (Da):105,984
Last modified:January 1, 1998 - v1
Checksum:i293255B28151ECB8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006492 mRNA. Translation: AAC53292.1.
CCDSiCCDS22733.1.
RefSeqiNP_033595.1. NM_009569.3.
XP_006530914.1. XM_006530851.1.
UniGeneiMm.3105.
Mm.390068.

Genome annotation databases

EnsembliENSMUST00000054052; ENSMUSP00000058037; ENSMUSG00000049577.
GeneIDi22761.
KEGGimmu:22761.
UCSCiuc009nsj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006492 mRNA. Translation: AAC53292.1 .
CCDSi CCDS22733.1.
RefSeqi NP_033595.1. NM_009569.3.
XP_006530914.1. XM_006530851.1.
UniGenei Mm.3105.
Mm.390068.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1SRK NMR - A 328-360 [» ]
ProteinModelPortali O35615.
SMRi O35615. Positions 251-418, 582-616.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204687. 11 interactions.
DIPi DIP-48414N.
IntActi O35615. 3 interactions.
MINTi MINT-6613139.
STRINGi 10090.ENSMUSP00000058037.

PTM databases

PhosphoSitei O35615.

Proteomic databases

PaxDbi O35615.
PRIDEi O35615.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000054052 ; ENSMUSP00000058037 ; ENSMUSG00000049577 .
GeneIDi 22761.
KEGGi mmu:22761.
UCSCi uc009nsj.1. mouse.

Organism-specific databases

CTDi 161882.
MGIi MGI:1095400. Zfpm1.

Phylogenomic databases

eggNOGi NOG146797.
GeneTreei ENSGT00530000063823.
HOGENOMi HOG000112626.
HOVERGENi HBG101018.
InParanoidi O35615.
KOi K17441.
OMAi KLYELHA.
OrthoDBi EOG74TWXR.
PhylomeDBi O35615.
TreeFami TF331342.

Enzyme and pathway databases

Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

EvolutionaryTracei O35615.
NextBioi 303277.
PROi O35615.
SOURCEi Search...

Gene expression databases

ArrayExpressi O35615.
Bgeei O35615.
CleanExi MM_ZFPM1.
Genevestigatori O35615.

Family and domain databases

Gene3Di 3.30.160.60. 2 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 9 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation."
    Tsang A.P., Visvader J.E., Turner C.A., Fujiwara Y., Yu C., Weiss M.J., Crossley M., Orkin S.H.
    Cell 90:109-119(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH GATA1; GATA2 AND GATA3.
    Tissue: Erythroleukemia.
  2. "Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG."
    Tsang A.P., Fujiwara Y., Hom D.B., Orkin S.H.
    Genes Dev. 12:1176-1188(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Key residues characteristic of GATA N-fingers are recognized by FOG."
    Fox A.H., Kowalski K., King G.F., Mackay J.P., Crossley M.
    J. Biol. Chem. 273:33595-33603(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GATA1, MUTAGENESIS OF CYS-698 AND CYS-719.
  4. "Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex."
    Crispino J.D., Lodish M.B., MacKay J.P., Orkin S.H.
    Mol. Cell 3:219-228(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF SER-706.
  5. "Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers."
    Fox A.H., Liew C., Holmes M., Kowalski K., Mackay J., Crossley M.
    EMBO J. 18:2812-2822(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GATA1 AND CTBP2, MUTAGENESIS OF VAL-254; PHE-255; PRO-256; LYS-258; ASP-259; GLY-261; ILE-262; TRP-263; ARG-265; SER-266; GLU-267; ARG-268; ASN-269; GLN-271; LEU-274; LEU-275; TYR-276; TYR-277; SER-280; ARG-281; 811-PRO--LEU-814; TYR-612; TYR-718 AND TYR-985.
  6. "Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo."
    Katz S.G., Cantor A.B., Orkin S.H.
    Mol. Cell. Biol. 22:3121-3128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CTBP2, MUTAGENESIS OF 813-ASP-LEU-814.
  7. "Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors."
    Wang X., Crispino J.D., Letting D.L., Nakazawa M., Poncz M., Blobel G.A.
    EMBO J. 21:5225-5234(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development."
    Katz S.G., Williams A., Yang J., Fujiwara Y., Tsang A.P., Epstein J.A., Orkin S.H.
    Proc. Natl. Acad. Sci. U.S.A. 100:14030-14035(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-925 AND SER-927, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  10. "A classic zinc finger from Friend of GATA mediates an interaction with the coiled-coil of transforming acidic coiled-coil 3."
    Simpson R.J.Y., Yi Lee S.H., Bartle N., Sum E.Y., Visvader J.E., Matthews J.M., Mackay J.P., Crossley M.
    J. Biol. Chem. 279:39789-39797(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 328-360, INTERACTION WITH TACC3, MUTAGENESIS OF VAL-334; LEU-336; LEU-339; SER-340; THR-343; THR-344; LYS-345; ALA-346; ASN-347; GLU-349; ARG-350; LEU-352; LYS-353; VAL-354; THR-356 AND ASP-357.

Entry informationi

Entry nameiFOG1_MOUSE
AccessioniPrimary (citable) accession number: O35615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi