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Protein

Secretory carrier-associated membrane protein 3

Gene

Scamp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

GO - Molecular functioni

GO - Biological processi

  • intracellular protein transport Source: MGI
  • response to organic substance Source: MGI
  • response to retinoic acid Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory carrier-associated membrane protein 3
Short name:
Secretory carrier membrane protein 3
Gene namesi
Name:Scamp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1346346. Scamp3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 168CytoplasmicSequence analysisAdd BLAST168
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 349CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912581 – 349Secretory carrier-associated membrane protein 3Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineBy similarity1
Modified residuei37PhosphothreonineBy similarity1
Modified residuei41PhosphotyrosineBy similarity1
Modified residuei53PhosphotyrosineBy similarity1
Modified residuei74PhosphoserineBy similarity1
Modified residuei78PhosphoserineCombined sources1
Modified residuei85PhosphotyrosineCombined sources1
Modified residuei87PhosphoserineBy similarity1
Cross-linki315Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Post-translational modificationi

Monoubiquitinated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO35609.
MaxQBiO35609.
PaxDbiO35609.
PRIDEiO35609.

PTM databases

iPTMnetiO35609.
PhosphoSitePlusiO35609.
SwissPalmiO35609.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028049.
CleanExiMM_SCAMP3.
ExpressionAtlasiO35609. baseline and differential.
GenevisibleiO35609. MM.

Interactioni

Subunit structurei

Interacts with NEDD4 and NEDD4L and TSG101 (By similarity). Interacts with RNF126.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiO35609. 2 interactors.
MINTiMINT-1865874.
STRINGi10090.ENSMUSP00000029684.

Structurei

3D structure databases

ProteinModelPortaliO35609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SCAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3088. Eukaryota.
ENOG410XSJN. LUCA.
GeneTreeiENSGT00390000014393.
HOGENOMiHOG000294221.
HOVERGENiHBG071938.
InParanoidiO35609.
KOiK19995.
TreeFamiTF313797.

Family and domain databases

InterProiIPR007273. SCAMP.
[Graphical view]
PANTHERiPTHR10687. PTHR10687. 1 hit.
PfamiPF04144. SCAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSRDTGNP FPDSGELDNP FQDPAVIQHR PSQQYATLDV YNPFENREPP
60 70 80 90 100
PAYEPPAPAP APLPPPSAPS VQSSRKLSPT EPRNYGSYST QASAAAATAE
110 120 130 140 150
LLKKQEELNR KAEELDRRER ELQHVALGGA GTRQNNWPPL PSFCPVKPCF
160 170 180 190 200
FQDISMEIPQ EFQKTVSTMY YLWMCSTLAL LLNFFACLAR FCVDTGSGSG
210 220 230 240 250
FGLSMLWLLL FTPCSFVCWY RPMYKAFRSD SSFNFFVFFF IFFVQDVFFV
260 270 280 290 300
LQAIGIPGWG FSGWVTALVV VGSKPAVAVL MLLVALLFTG IAVLGIVMLK
310 320 330 340
RIHSLYRQTG ASFQKAQQEF AAGVFSNPAV RTAAANAAAG AAENAFRAP
Length:349
Mass (Da):38,458
Last modified:July 27, 2011 - v3
Checksum:i4963A582F56A560D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11F → S in AAB62721 (PubMed:9378760).Curated1
Sequence conflicti11F → S in AAG22800 (PubMed:11050114).Curated1
Sequence conflicti48E → EQ in AAH02021 (PubMed:16141072).Curated1
Sequence conflicti61A → S in AAH02021 (PubMed:16141072).Curated1
Sequence conflicti111K → T in AAB62721 (PubMed:9378760).Curated1
Sequence conflicti284V → D in AAB62721 (PubMed:9378760).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005036 mRNA. Translation: AAB62721.1.
AF295403 mRNA. Translation: AAG22800.1.
AK160549 mRNA. Translation: BAE35865.1.
CH466547 Genomic DNA. Translation: EDL15232.1.
BC002021 mRNA. Translation: AAH02021.1.
CCDSiCCDS50959.1.
RefSeqiNP_001296838.1. NM_001309909.1.
NP_001296839.1. NM_001309910.1.
NP_036016.2. NM_011886.3.
UniGeneiMm.257052.

Genome annotation databases

EnsembliENSMUST00000029684; ENSMUSP00000029684; ENSMUSG00000028049.
GeneIDi24045.
KEGGimmu:24045.
UCSCiuc008pxw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005036 mRNA. Translation: AAB62721.1.
AF295403 mRNA. Translation: AAG22800.1.
AK160549 mRNA. Translation: BAE35865.1.
CH466547 Genomic DNA. Translation: EDL15232.1.
BC002021 mRNA. Translation: AAH02021.1.
CCDSiCCDS50959.1.
RefSeqiNP_001296838.1. NM_001309909.1.
NP_001296839.1. NM_001309910.1.
NP_036016.2. NM_011886.3.
UniGeneiMm.257052.

3D structure databases

ProteinModelPortaliO35609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35609. 2 interactors.
MINTiMINT-1865874.
STRINGi10090.ENSMUSP00000029684.

PTM databases

iPTMnetiO35609.
PhosphoSitePlusiO35609.
SwissPalmiO35609.

Proteomic databases

EPDiO35609.
MaxQBiO35609.
PaxDbiO35609.
PRIDEiO35609.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029684; ENSMUSP00000029684; ENSMUSG00000028049.
GeneIDi24045.
KEGGimmu:24045.
UCSCiuc008pxw.1. mouse.

Organism-specific databases

CTDi10067.
MGIiMGI:1346346. Scamp3.

Phylogenomic databases

eggNOGiKOG3088. Eukaryota.
ENOG410XSJN. LUCA.
GeneTreeiENSGT00390000014393.
HOGENOMiHOG000294221.
HOVERGENiHBG071938.
InParanoidiO35609.
KOiK19995.
TreeFamiTF313797.

Miscellaneous databases

PROiO35609.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028049.
CleanExiMM_SCAMP3.
ExpressionAtlasiO35609. baseline and differential.
GenevisibleiO35609. MM.

Family and domain databases

InterProiIPR007273. SCAMP.
[Graphical view]
PANTHERiPTHR10687. PTHR10687. 1 hit.
PfamiPF04144. SCAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCAM3_MOUSE
AccessioniPrimary (citable) accession number: O35609
Secondary accession number(s): Q3TUV6, Q99M48, Q9ERM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.