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O35608

- ANGP2_MOUSE

UniProt

O35608 - ANGP2_MOUSE

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Protein
Angiopoietin-2
Gene
Angpt2, Agpt2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi429 – 4291Calcium By similarity
Metal bindingi431 – 4311Calcium By similarity
Metal bindingi433 – 4331Calcium; via carbonyl oxygen By similarity
Metal bindingi435 – 4351Calcium; via carbonyl oxygen By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: MGI
  3. vascular endothelial growth factor receptor binding Source: MGI

GO - Biological processi

  1. Tie signaling pathway Source: DFLAT
  2. angiogenesis Source: MGI
  3. blood vessel morphogenesis Source: MGI
  4. blood vessel remodeling Source: DFLAT
  5. cellular response to growth factor stimulus Source: Ensembl
  6. endoderm development Source: MGI
  7. germ cell development Source: Ensembl
  8. glomerulus vasculature development Source: Ensembl
  9. hemopoiesis Source: DFLAT
  10. maternal process involved in female pregnancy Source: Ensembl
  11. negative regulation of angiogenesis Source: MGI
  12. negative regulation of blood vessel endothelial cell migration Source: Ensembl
  13. negative regulation of cell-substrate adhesion Source: MGI
  14. negative regulation of positive chemotaxis Source: Ensembl
  15. organ regeneration Source: Ensembl
  16. positive regulation of angiogenesis Source: Ensembl
  17. regulation of angiogenesis Source: DFLAT
  18. response to activity Source: Ensembl
  19. response to glucose Source: Ensembl
  20. response to hypoxia Source: Ensembl
  21. response to mechanical stimulus Source: Ensembl
  22. response to organic cyclic compound Source: Ensembl
  23. response to radiation Source: Ensembl
  24. transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_211860. Tie2 Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-2
Short name:
ANG-2
Gene namesi
Name:Angpt2
Synonyms:Agpt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1202890. Angpt2.

Subcellular locationi

GO - Cellular componenti

  1. cell projection Source: Ensembl
  2. extracellular space Source: Ensembl
  3. nucleus Source: Ensembl
  4. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 496478Angiopoietin-2
PRO_0000009114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi240 – 2401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi284 ↔ 313 By similarity
Glycosylationi304 – 3041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi433 ↔ 435 By similarity
Disulfide bondi437 ↔ 450 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO35608.

PTM databases

PhosphoSiteiO35608.

Expressioni

Tissue specificityi

Expressed only at sites of vascular remodeling.

Gene expression databases

ArrayExpressiO35608.
BgeeiO35608.
CleanExiMM_ANGPT2.
GenevestigatoriO35608.

Interactioni

Subunit structurei

Interacts with TEK/TIE2, competing for the same binding site as ANGPT1 By similarity.

Protein-protein interaction databases

DIPiDIP-6049N.
IntActiO35608. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO35608.
SMRiO35608. Positions 148-495.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini275 – 495221Fibrinogen C-terminal
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili159 – 25698 Reviewed prediction
Add
BLAST

Domaini

The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor By similarity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG298026.
GeneTreeiENSGT00720000108441.
HOGENOMiHOG000037128.
HOVERGENiHBG001644.
InParanoidiO35608.
KOiK05466.
OMAiIKAYCDM.
OrthoDBiEOG7X9G60.
PhylomeDBiO35608.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR028844. Ang-2.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERiPTHR19143:SF199. PTHR19143:SF199. 1 hit.
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35608-1 [UniParc]FASTAAdd to Basket

« Hide

MWQIIFLTFG WDLVLASAYS NFRKSVDSTG RRQYQVQNGP CSYTFLLPET    50
DSCRSSSSPY MSNAVQRDAP LDYDDSVQRL QVLENILENN TQWLMKLENY 100
IQDNMKKEMV EIQQNVVQNQ TAVMIEIGTS LLNQTAAQTR KLTDVEAQVL 150
NQTTRLELQL LQHSISTNKL EKQILDQTSE INKLQNKNSF LEQKVLDMEG 200
KHSEQLQSMK EQKDELQVLV SKQSSVIDEL EKKLVTATVN NSLLQKQQHD 250
LMETVNSLLT MMSSPNSKSS VAIRKEEQTT FRDCAEIFKS GLTTSGIYTL 300
TFPNSTEEIK AYCDMDVGGG GWTVIQHRED GSVDFQRTWK EYKEGFGSPL 350
GEYWLGNEFV SQLTGQHRYV LKIQLKDWEG NEAHSLYDHF YLAGEESNYR 400
IHLTGLTGTA GKISSISQPG SDFSTKDSDN DKCICKCSQM LSGGWWFDAC 450
GPSNLNGQYY PQKQNTNKFN GIKWYYWKGS GYSLKATTMM IRPADF 496
Length:496
Mass (Da):56,576
Last modified:April 26, 2004 - v2
Checksum:iE7563B498A0EF331
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti348 – 3481S → N in AAB63189. 1 Publication
Sequence conflicti411 – 4111G → A in AAB63189. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF004326 mRNA. Translation: AAB63189.1.
AK019860 mRNA. Translation: BAB31887.1.
AK048622 mRNA. Translation: BAC33396.1.
AK156132 mRNA. Translation: BAE33599.1.
BC027216 mRNA. Translation: AAH27216.1.
CCDSiCCDS22125.1.
RefSeqiNP_031452.2. NM_007426.4.
UniGeneiMm.439874.

Genome annotation databases

EnsembliENSMUST00000033846; ENSMUSP00000033846; ENSMUSG00000031465.
GeneIDi11601.
KEGGimmu:11601.
UCSCiuc009kzu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF004326 mRNA. Translation: AAB63189.1 .
AK019860 mRNA. Translation: BAB31887.1 .
AK048622 mRNA. Translation: BAC33396.1 .
AK156132 mRNA. Translation: BAE33599.1 .
BC027216 mRNA. Translation: AAH27216.1 .
CCDSi CCDS22125.1.
RefSeqi NP_031452.2. NM_007426.4.
UniGenei Mm.439874.

3D structure databases

ProteinModelPortali O35608.
SMRi O35608. Positions 148-495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-6049N.
IntActi O35608. 1 interaction.

PTM databases

PhosphoSitei O35608.

Proteomic databases

PRIDEi O35608.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033846 ; ENSMUSP00000033846 ; ENSMUSG00000031465 .
GeneIDi 11601.
KEGGi mmu:11601.
UCSCi uc009kzu.1. mouse.

Organism-specific databases

CTDi 285.
MGIi MGI:1202890. Angpt2.

Phylogenomic databases

eggNOGi NOG298026.
GeneTreei ENSGT00720000108441.
HOGENOMi HOG000037128.
HOVERGENi HBG001644.
InParanoidi O35608.
KOi K05466.
OMAi IKAYCDM.
OrthoDBi EOG7X9G60.
PhylomeDBi O35608.
TreeFami TF336658.

Enzyme and pathway databases

Reactomei REACT_211860. Tie2 Signaling.

Miscellaneous databases

NextBioi 279120.
PROi O35608.
SOURCEi Search...

Gene expression databases

ArrayExpressi O35608.
Bgeei O35608.
CleanExi MM_ANGPT2.
Genevestigatori O35608.

Family and domain databases

Gene3Di 3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProi IPR028844. Ang-2.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view ]
PANTHERi PTHR19143:SF199. PTHR19143:SF199. 1 hit.
Pfami PF00147. Fibrinogen_C. 1 hit.
[Graphical view ]
SMARTi SM00186. FBG. 1 hit.
[Graphical view ]
SUPFAMi SSF56496. SSF56496. 1 hit.
PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Uterus.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Head, Ovary, Spleen and Uterus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiANGP2_MOUSE
AccessioniPrimary (citable) accession number: O35608
Secondary accession number(s): Q3U1A1, Q9D2D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: April 26, 2004
Last modified: September 3, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi