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O35607

- BMPR2_MOUSE

UniProt

O35607 - BMPR2_MOUSE

Protein

Bone morphogenetic protein receptor type-2

Gene

Bmpr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei230 – 2301ATPPROSITE-ProRule annotation
    Active sitei333 – 3331Proton acceptorPROSITE-ProRule annotation
    Binding sitei351 – 3511ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi209 – 2179ATPPROSITE-ProRule annotation
    Nucleotide bindingi280 – 2823ATPPROSITE-ProRule annotation
    Nucleotide bindingi337 – 3382ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. receptor signaling protein serine/threonine kinase activity Source: InterPro
    5. transforming growth factor beta-activated receptor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. artery development Source: BHF-UCL
    3. blood vessel remodeling Source: BHF-UCL
    4. BMP signaling pathway Source: MGI
    5. brain development Source: Ensembl
    6. cellular response to starvation Source: Ensembl
    7. limb development Source: MGI
    8. lung alveolus development Source: BHF-UCL
    9. lymphangiogenesis Source: BHF-UCL
    10. lymphatic endothelial cell differentiation Source: BHF-UCL
    11. mesoderm formation Source: MGI
    12. negative regulation of cell growth Source: Ensembl
    13. negative regulation of DNA biosynthetic process Source: Ensembl
    14. negative regulation of systemic arterial blood pressure Source: Ensembl
    15. negative regulation of vasoconstriction Source: BHF-UCL
    16. positive regulation of axon extension involved in axon guidance Source: UniProt
    17. positive regulation of BMP signaling pathway Source: Ensembl
    18. positive regulation of bone mineralization Source: Ensembl
    19. positive regulation of endothelial cell migration Source: Ensembl
    20. positive regulation of endothelial cell proliferation Source: Ensembl
    21. positive regulation of osteoblast differentiation Source: Ensembl
    22. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    23. regulation of lung blood pressure Source: BHF-UCL
    24. retina vasculature development in camera-type eye Source: BHF-UCL
    25. transcription from RNA polymerase II promoter Source: Ensembl
    26. vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
    27. venous blood vessel development Source: BHF-UCL

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 3474.
    ReactomeiREACT_220505. Signaling by BMP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein receptor type-2 (EC:2.7.11.30)
    Short name:
    BMP type-2 receptor
    Short name:
    BMPR-2
    Alternative name(s):
    BRK-3
    Bone morphogenetic protein receptor type II
    Short name:
    BMP type II receptor
    Short name:
    BMPR-II
    Gene namesi
    Name:Bmpr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1095407. Bmpr2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basal plasma membrane Source: Ensembl
    3. caveola Source: Ensembl
    4. cell surface Source: MGI
    5. cytoplasm Source: Ensembl
    6. dendrite Source: Ensembl
    7. integral component of plasma membrane Source: Ensembl
    8. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 10381012Bone morphogenetic protein receptor type-2PRO_0000024416Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 66By similarity
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi94 ↔ 117By similarity
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Modified residuei379 – 3791PhosphothreonineBy similarity
    Modified residuei586 – 5861PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiO35607.
    PRIDEiO35607.

    PTM databases

    PhosphoSiteiO35607.

    Expressioni

    Gene expression databases

    ArrayExpressiO35607.
    BgeeiO35607.
    GenevestigatoriO35607.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Prkg1P0C6054EBI-527224,EBI-6991999

    Protein-protein interaction databases

    BioGridi198373. 4 interactions.
    IntActiO35607. 4 interactions.
    MINTiMINT-1743993.

    Structurei

    3D structure databases

    ProteinModelPortaliO35607.
    SMRiO35607. Positions 33-131, 197-555.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 150124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini172 – 1038867CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini203 – 504302Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi191 – 1944Poly-Ala
    Compositional biasi547 – 5504Poly-Ser
    Compositional biasi610 – 6189Poly-Thr
    Compositional biasi901 – 9088Poly-Asn

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00560000076906.
    HOGENOMiHOG000043088.
    HOVERGENiHBG050705.
    InParanoidiO35607.
    KOiK04671.
    OMAiDHYKPAI.
    OrthoDBiEOG7JHM5B.
    PhylomeDBiO35607.
    TreeFamiTF314724.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR015770. BMPR2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PTHR23255:SF63. PTHR23255:SF63. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35607-1 [UniParc]FASTAAdd to Basket

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    MTSSLHRPFR VPWLLWAVLL VSTTAASQNQ ERLCAFKDPY QQDLGIGESR     50
    ISHENGTILC SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV 100
    VTTTPPSIQN GTYRFCCCST DLCNVNFTEN FPPPDTTPLS PPHSFNRDET 150
    IIIALASVSV LAVLIVALCF GYRMLTGDRK QGLHSMNMME AAAAEPSLDL 200
    DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF INEKNIYRVP 250
    LMEHDNIARF IVGDERLTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS 300
    SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGACVIS 350
    DFGLSMRLTG NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA 400
    LKQVDMYALG LIYWEVFMRC TDLFPGESVP DYQMAFQTEV GNHPTFEDMQ 450
    VLVSREKQRP KFPEAWKENS LAVRSLKETI EDCWDQDAEA RLTAQCAEER 500
    MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI GPYPDYSSSS 550
    YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS 600
    PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETHL HATNVAQSIG 650
    PTPVCLQLTE EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS 700
    STSSSLLYPL IKLAVEVTGQ QDFTQAANGQ ACLIPDVPPA QIYPLPKQQN 750
    LPKRPTSLPL NTKNSTKEPR LKFGNKHKSN LKQVETGVAK MNTINAAEPH 800
    VVTVTMNGVA GRSHNVNSHA ATTQYANGAV PAGQAANIVA HRSQEMLQNQ 850
    FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT 900
    NSNNNNSNPC SEQDILTQGV TSTAADPGPS KPRRAQRPNS LDLSATNILD 950
    GSSIQIGEST QDGKSGSGEK IKRRVKTPYS LKRWRPSTWV ISTEPLDCEV 1000
    NNNGSDRAVH SKSSTAVYLA EGGTATTTVS KDIGMNCL 1038
    Length:1,038
    Mass (Da):115,020
    Last modified:January 1, 1998 - v1
    Checksum:i4106945DC63250E1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF003942 mRNA. Translation: AAB63042.1.
    U78048 mRNA. Translation: AAB87638.1.
    CCDSiCCDS35588.1.
    PIRiJC5527.
    RefSeqiNP_031587.1. NM_007561.4.
    UniGeneiMm.391654.
    Mm.7106.

    Genome annotation databases

    EnsembliENSMUST00000087435; ENSMUSP00000084701; ENSMUSG00000067336.
    GeneIDi12168.
    KEGGimmu:12168.
    UCSCiuc007bdz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF003942 mRNA. Translation: AAB63042.1 .
    U78048 mRNA. Translation: AAB87638.1 .
    CCDSi CCDS35588.1.
    PIRi JC5527.
    RefSeqi NP_031587.1. NM_007561.4.
    UniGenei Mm.391654.
    Mm.7106.

    3D structure databases

    ProteinModelPortali O35607.
    SMRi O35607. Positions 33-131, 197-555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198373. 4 interactions.
    IntActi O35607. 4 interactions.
    MINTi MINT-1743993.

    PTM databases

    PhosphoSitei O35607.

    Proteomic databases

    PaxDbi O35607.
    PRIDEi O35607.

    Protocols and materials databases

    DNASUi 12168.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087435 ; ENSMUSP00000084701 ; ENSMUSG00000067336 .
    GeneIDi 12168.
    KEGGi mmu:12168.
    UCSCi uc007bdz.1. mouse.

    Organism-specific databases

    CTDi 659.
    MGIi MGI:1095407. Bmpr2.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00560000076906.
    HOGENOMi HOG000043088.
    HOVERGENi HBG050705.
    InParanoidi O35607.
    KOi K04671.
    OMAi DHYKPAI.
    OrthoDBi EOG7JHM5B.
    PhylomeDBi O35607.
    TreeFami TF314724.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 3474.
    Reactomei REACT_220505. Signaling by BMP.

    Miscellaneous databases

    ChiTaRSi BMPR2. mouse.
    NextBioi 280539.
    PROi O35607.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35607.
    Bgeei O35607.
    Genevestigatori O35607.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR015770. BMPR2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    PTHR23255:SF63. PTHR23255:SF63. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and genomic organization of the mouse BMP type II receptor."
      Beppu H., Minowa O., Miyazono K., Kawabata M.
      Biochem. Biophys. Res. Commun. 235:499-504(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of BMP receptor complexes with differential signaling properties and ligand binding profiles."
      Whitaker G.B., Koenig B.B., Ting J., Tiesman J.P., Limberg A.L., Grant R.A., Begley K.B., Rosenbaum J.S.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiBMPR2_MOUSE
    AccessioniPrimary (citable) accession number: O35607
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 136 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3