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Protein

Bone morphogenetic protein receptor type-2

Gene

Bmpr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei230 – 2301ATPPROSITE-ProRule annotation
Active sitei333 – 3331Proton acceptorPROSITE-ProRule annotation
Binding sitei351 – 3511ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi209 – 2179ATPPROSITE-ProRule annotation
Nucleotide bindingi280 – 2823ATPPROSITE-ProRule annotation
Nucleotide bindingi337 – 3382ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. artery development Source: BHF-UCL
  3. blood vessel remodeling Source: BHF-UCL
  4. BMP signaling pathway Source: MGI
  5. brain development Source: Ensembl
  6. cellular response to starvation Source: Ensembl
  7. chondrocyte development Source: MGI
  8. endochondral bone morphogenesis Source: AgBase
  9. limb development Source: MGI
  10. lung alveolus development Source: BHF-UCL
  11. lymphangiogenesis Source: BHF-UCL
  12. lymphatic endothelial cell differentiation Source: BHF-UCL
  13. maternal placenta development Source: MGI
  14. mesoderm formation Source: MGI
  15. negative regulation of cell growth Source: MGI
  16. negative regulation of chondrocyte proliferation Source: MGI
  17. negative regulation of DNA biosynthetic process Source: MGI
  18. negative regulation of systemic arterial blood pressure Source: MGI
  19. negative regulation of vasoconstriction Source: BHF-UCL
  20. positive regulation of axon extension involved in axon guidance Source: UniProtKB
  21. positive regulation of BMP signaling pathway Source: MGI
  22. positive regulation of bone mineralization Source: MGI
  23. positive regulation of cartilage development Source: AgBase
  24. positive regulation of endothelial cell migration Source: MGI
  25. positive regulation of endothelial cell proliferation Source: MGI
  26. positive regulation of epithelial cell migration Source: MGI
  27. positive regulation of osteoblast differentiation Source: MGI
  28. positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  29. proteoglycan biosynthetic process Source: AgBase
  30. regulation of cell proliferation Source: MGI
  31. regulation of lung blood pressure Source: BHF-UCL
  32. retina vasculature development in camera-type eye Source: BHF-UCL
  33. transcription from RNA polymerase II promoter Source: MGI
  34. transmembrane receptor protein serine/threonine kinase signaling pathway Source: MGI
  35. vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
  36. venous blood vessel development Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiREACT_220505. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-2 (EC:2.7.11.30)
Short name:
BMP type-2 receptor
Short name:
BMPR-2
Alternative name(s):
BRK-3
Bone morphogenetic protein receptor type II
Short name:
BMP type II receptor
Short name:
BMPR-II
Gene namesi
Name:Bmpr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1095407. Bmpr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 150124ExtracellularSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Topological domaini172 – 1038867CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basal plasma membrane Source: Ensembl
  3. caveola Source: Ensembl
  4. cell surface Source: MGI
  5. cytoplasm Source: Ensembl
  6. dendrite Source: Ensembl
  7. extracellular space Source: MGI
  8. integral component of plasma membrane Source: MGI
  9. neuronal cell body Source: Ensembl
  10. neuronal postsynaptic density Source: MGI
  11. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 10381012Bone morphogenetic protein receptor type-2PRO_0000024416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 66By similarity
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi94 ↔ 117By similarity
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
Modified residuei379 – 3791PhosphothreonineBy similarity
Modified residuei586 – 5861PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO35607.
PaxDbiO35607.
PRIDEiO35607.

PTM databases

PhosphoSiteiO35607.

Expressioni

Gene expression databases

BgeeiO35607.
ExpressionAtlasiO35607. baseline and differential.
GenevestigatoriO35607.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Prkg1P0C6054EBI-527224,EBI-6991999

Protein-protein interaction databases

BioGridi198373. 4 interactions.
IntActiO35607. 4 interactions.
MINTiMINT-1743993.

Structurei

3D structure databases

ProteinModelPortaliO35607.
SMRiO35607. Positions 33-131, 197-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini203 – 504302Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi191 – 1944Poly-Ala
Compositional biasi547 – 5504Poly-Ser
Compositional biasi610 – 6189Poly-Thr
Compositional biasi901 – 9088Poly-Asn

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000043088.
HOVERGENiHBG050705.
InParanoidiO35607.
KOiK04671.
OMAiDHYKPAI.
OrthoDBiEOG7JHM5B.
PhylomeDBiO35607.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR015770. BMPR2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PTHR23255:SF63. PTHR23255:SF63. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSLHRPFR VPWLLWAVLL VSTTAASQNQ ERLCAFKDPY QQDLGIGESR
60 70 80 90 100
ISHENGTILC SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV
110 120 130 140 150
VTTTPPSIQN GTYRFCCCST DLCNVNFTEN FPPPDTTPLS PPHSFNRDET
160 170 180 190 200
IIIALASVSV LAVLIVALCF GYRMLTGDRK QGLHSMNMME AAAAEPSLDL
210 220 230 240 250
DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF INEKNIYRVP
260 270 280 290 300
LMEHDNIARF IVGDERLTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS
310 320 330 340 350
SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGACVIS
360 370 380 390 400
DFGLSMRLTG NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA
410 420 430 440 450
LKQVDMYALG LIYWEVFMRC TDLFPGESVP DYQMAFQTEV GNHPTFEDMQ
460 470 480 490 500
VLVSREKQRP KFPEAWKENS LAVRSLKETI EDCWDQDAEA RLTAQCAEER
510 520 530 540 550
MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI GPYPDYSSSS
560 570 580 590 600
YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS
610 620 630 640 650
PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETHL HATNVAQSIG
660 670 680 690 700
PTPVCLQLTE EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS
710 720 730 740 750
STSSSLLYPL IKLAVEVTGQ QDFTQAANGQ ACLIPDVPPA QIYPLPKQQN
760 770 780 790 800
LPKRPTSLPL NTKNSTKEPR LKFGNKHKSN LKQVETGVAK MNTINAAEPH
810 820 830 840 850
VVTVTMNGVA GRSHNVNSHA ATTQYANGAV PAGQAANIVA HRSQEMLQNQ
860 870 880 890 900
FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT
910 920 930 940 950
NSNNNNSNPC SEQDILTQGV TSTAADPGPS KPRRAQRPNS LDLSATNILD
960 970 980 990 1000
GSSIQIGEST QDGKSGSGEK IKRRVKTPYS LKRWRPSTWV ISTEPLDCEV
1010 1020 1030
NNNGSDRAVH SKSSTAVYLA EGGTATTTVS KDIGMNCL
Length:1,038
Mass (Da):115,020
Last modified:January 1, 1998 - v1
Checksum:i4106945DC63250E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003942 mRNA. Translation: AAB63042.1.
U78048 mRNA. Translation: AAB87638.1.
CCDSiCCDS35588.1.
PIRiJC5527.
RefSeqiNP_031587.1. NM_007561.4.
UniGeneiMm.391654.
Mm.7106.

Genome annotation databases

EnsembliENSMUST00000087435; ENSMUSP00000084701; ENSMUSG00000067336.
GeneIDi12168.
KEGGimmu:12168.
UCSCiuc007bdz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003942 mRNA. Translation: AAB63042.1.
U78048 mRNA. Translation: AAB87638.1.
CCDSiCCDS35588.1.
PIRiJC5527.
RefSeqiNP_031587.1. NM_007561.4.
UniGeneiMm.391654.
Mm.7106.

3D structure databases

ProteinModelPortaliO35607.
SMRiO35607. Positions 33-131, 197-555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198373. 4 interactions.
IntActiO35607. 4 interactions.
MINTiMINT-1743993.

PTM databases

PhosphoSiteiO35607.

Proteomic databases

MaxQBiO35607.
PaxDbiO35607.
PRIDEiO35607.

Protocols and materials databases

DNASUi12168.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087435; ENSMUSP00000084701; ENSMUSG00000067336.
GeneIDi12168.
KEGGimmu:12168.
UCSCiuc007bdz.1. mouse.

Organism-specific databases

CTDi659.
MGIiMGI:1095407. Bmpr2.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000043088.
HOVERGENiHBG050705.
InParanoidiO35607.
KOiK04671.
OMAiDHYKPAI.
OrthoDBiEOG7JHM5B.
PhylomeDBiO35607.
TreeFamiTF314724.

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiREACT_220505. Signaling by BMP.

Miscellaneous databases

NextBioi280539.
PROiO35607.
SOURCEiSearch...

Gene expression databases

BgeeiO35607.
ExpressionAtlasiO35607. baseline and differential.
GenevestigatoriO35607.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR015770. BMPR2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PTHR23255:SF63. PTHR23255:SF63. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning and genomic organization of the mouse BMP type II receptor."
    Beppu H., Minowa O., Miyazono K., Kawabata M.
    Biochem. Biophys. Res. Commun. 235:499-504(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of BMP receptor complexes with differential signaling properties and ligand binding profiles."
    Whitaker G.B., Koenig B.B., Ting J., Tiesman J.P., Limberg A.L., Grant R.A., Begley K.B., Rosenbaum J.S.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiBMPR2_MOUSE
AccessioniPrimary (citable) accession number: O35607
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: March 4, 2015
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.