O35607 (BMPR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein receptor type-2
Short name=BMP type-2 receptor
Short name=BMPR-2
EC=2.7.11.30

Alternative name(s):
BRK-3
Bone morphogenetic protein receptor type II
Short name=BMP type II receptor
Short name=BMPR-II

Gene names

Name:

Bmpr2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1038 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from mutant phenotype PubMed 17472960. Source: MGI anterior/posterior pattern specification Inferred from mutant phenotype PubMed 10772805. Source: MGI artery development Inferred from mutant phenotype PubMed 19903896. Source: BHF-UCL blood vessel remodeling Inferred from mutant phenotype PubMed 19903896. Source: BHF-UCL cellular response to starvation Inferred from electronic annotation. Source: Compara lung alveolus development Inferred from mutant phenotype PubMed 18552156. Source: BHF-UCL lymphangiogenesis Inferred from mutant phenotype PubMed 19903896. Source: BHF-UCL lymphatic endothelial cell differentiation Inferred from mutant phenotype PubMed 19903896. Source: BHF-UCL mesoderm formation Inferred from mutant phenotype PubMed 10772805. Source: MGI negative regulation of DNA biosynthetic process Inferred from electronic annotation. Source: Compara negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of systemic arterial blood pressure Inferred from electronic annotation. Source: Compara negative regulation of vasoconstriction Inferred from mutant phenotype PubMed 18552156. Source: BHF-UCL positive regulation of BMP signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of bone mineralization Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell migration Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell migration Inferred from electronic annotation. Source: Compara positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of protein phosphorylation Inferred from sequence orthology PubMed 17472960. Source: MGI regulation of lung blood pressure Inferred from mutant phenotype PubMed 18552156. Source: BHF-UCL retina vasculature development in camera-type eye Inferred from mutant phenotype PubMed 19903896. Source: BHF-UCL transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara vascular endothelial growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 18552156. Source: BHF-UCL venous blood vessel development Inferred from mutant phenotype PubMed 19903896. Source: BHF-UCL
Cellular_component	caveola Inferred from electronic annotation. Source: Compara cell surface Inferred from direct assay PubMed 12117821. Source: MGI integral to plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta-activated receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 1038	1012	Bone morphogenetic protein receptor type-2		PRO_0000024416
Regions
	Topological domain	27 – 150	124	Extracellular Potential
	Transmembrane	151 – 171	21	Helical; Potential
	Topological domain	172 – 1038	867	Cytoplasmic Potential
	Domain	203 – 504	302	Protein kinase
	Nucleotide binding	209 – 217	9	ATP By similarity
	Nucleotide binding	280 – 282	3	ATP By similarity
	Nucleotide binding	337 – 338	2	ATP By similarity
	Compositional bias	191 – 194	4	Poly-Ala
	Compositional bias	547 – 550	4	Poly-Ser
	Compositional bias	610 – 618	9	Poly-Thr
	Compositional bias	901 – 908	8	Poly-Asn
Sites
	Active site	333	1	Proton acceptor By similarity
	Binding site	230	1	ATP By similarity
	Binding site	351	1	ATP By similarity
Amino acid modifications
	Modified residue	379	1	Phosphothreonine By similarity
	Modified residue	586	1	Phosphoserine By similarity
	Glycosylation	55	1	N-linked (GlcNAc...) Potential
	Glycosylation	110	1	N-linked (GlcNAc...) Potential
	Glycosylation	126	1	N-linked (GlcNAc...) Potential
	Disulfide bond	34 ↔ 66		By similarity
	Disulfide bond	94 ↔ 117		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O35607 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 4106945DC63250E1	FASTA	1,038	115,020
	10 20 30 40 50 60 MTSSLHRPFR VPWLLWAVLL VSTTAASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC 70 80 90 100 110 120 SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV VTTTPPSIQN GTYRFCCCST 130 140 150 160 170 180 DLCNVNFTEN FPPPDTTPLS PPHSFNRDET IIIALASVSV LAVLIVALCF GYRMLTGDRK 190 200 210 220 230 240 QGLHSMNMME AAAAEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF 250 260 270 280 290 300 INEKNIYRVP LMEHDNIARF IVGDERLTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS 310 320 330 340 350 360 SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGACVIS DFGLSMRLTG 370 380 390 400 410 420 NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEVFMRC 430 440 450 460 470 480 TDLFPGESVP DYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI 490 500 510 520 530 540 EDCWDQDAEA RLTAQCAEER MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI 550 560 570 580 590 600 GPYPDYSSSS YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS 610 620 630 640 650 660 PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETHL HATNVAQSIG PTPVCLQLTE 670 680 690 700 710 720 EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS STSSSLLYPL IKLAVEVTGQ 730 740 750 760 770 780 QDFTQAANGQ ACLIPDVPPA QIYPLPKQQN LPKRPTSLPL NTKNSTKEPR LKFGNKHKSN 790 800 810 820 830 840 LKQVETGVAK MNTINAAEPH VVTVTMNGVA GRSHNVNSHA ATTQYANGAV PAGQAANIVA 850 860 870 880 890 900 HRSQEMLQNQ FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT 910 920 930 940 950 960 NSNNNNSNPC SEQDILTQGV TSTAADPGPS KPRRAQRPNS LDLSATNILD GSSIQIGEST 970 980 990 1000 1010 1020 QDGKSGSGEK IKRRVKTPYS LKRWRPSTWV ISTEPLDCEV NNNGSDRAVH SKSSTAVYLA 1030 EGGTATTTVS KDIGMNCL

References

[1]	"cDNA cloning and genomic organization of the mouse BMP type II receptor." Beppu H., Minowa O., Miyazono K., Kawabata M. Biochem. Biophys. Res. Commun. 235:499-504(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of BMP receptor complexes with differential signaling properties and ligand binding profiles." Whitaker G.B., Koenig B.B., Ting J., Tiesman J.P., Limberg A.L., Grant R.A., Begley K.B., Rosenbaum J.S. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF003942 mRNA. Translation: AAB63042.1. U78048 mRNA. Translation: AAB87638.1.
IPI	IPI00338094.
PIR	JC5527.
RefSeq	NP_031587.1. NM_007561.3.
UniGene	Mm.391654. Mm.7106.
3D structure databases
ProteinModelPortal	O35607.
SMR	O35607. Positions 33-131, 197-555.
ModBase	Search...
Protein-protein interaction databases
IntAct	O35607. 2 interactions.
PTM databases
PhosphoSite	O35607.
Proteomic databases
PaxDb	O35607.
PRIDE	O35607.
Protocols and materials databases
DNASU	12168.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000087435; ENSMUSP00000084701; ENSMUSG00000067336.
GeneID	12168.
KEGG	mmu:12168.
UCSC	uc007bdz.1. mouse.
Organism-specific databases
CTD	659.
MGI	MGI:1095407. Bmpr2.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00560000076906.
HOGENOM	HOG000043088.
HOVERGEN	HBG050705.
InParanoid	O35607.
KO	K04671.
OMA	LPRGDHY.
OrthoDB	EOG470TGJ.
Enzyme and pathway databases
BRENDA	2.7.10.2. 3474.
Gene expression databases
ArrayExpress	O35607.
Bgee	O35607.
Genevestigator	O35607.
GermOnline	ENSMUSG00000067336. Mus musculus.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR015770. BMPRII. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. [Graphical view]
PANTHER	PTHR23255:SF12. PTHR23255:SF12. 1 hit.
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	BMPR2. mouse.
NextBio	280539.
SOURCE	Search...

Entry information

Entry name

BMPR2_MOUSE

Accession

Primary (citable) accession number: O35607

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 122 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program