Reviewed,
UniProtKB/Swiss-Prot O35607 (BMPR2_MOUSE)
Last modified
July 22, 2008.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Bone morphogenetic protein receptor type-2 EC=2.7.11.30 Alternative name(s): Bone morphogenetic protein receptor type II BMP type II receptor BMPR-II BRK-3 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 1038 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs. |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Cofactor | Magnesium or manganese By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal Transmembrane |
| Ligand | ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding |
| Molecular function | Kinase Receptor Serine/threonine-protein kinase Transferase |
| PTM | Glycoprotein |
Gene Ontology (GO) | |
| Biological process | BMP signaling pathway Inferred from mutant phenotype. Source: MGI alveolus developmentInferred from mutant phenotype. Source: UniProtKB anterior/posterior pattern formationInferred from mutant phenotype. Source: MGI mesoderm formationInferred from mutant phenotype. Source: MGI negative regulation of vasoconstrictionInferred from mutant phenotype. Source: UniProtKB regulation of lung blood pressureInferred from mutant phenotype. Source: UniProtKB vascular endothelial growth factor receptor signaling pathwayInferred from mutant phenotype. Source: UniProtKB |
| Cellular component | cell surface Inferred from direct assay. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||||
Molecule processing | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 26 | 26 | Potential | |||||||
| Chain | 27 – 1038 | 1012 | Bone morphogenetic protein receptor type-2 | |||||||
Regions | ||||||||||
| Topological domain | 27 – 150 | 124 | Extracellular Potential | |||||||
| Transmembrane | 151 – 171 | 21 | Potential | |||||||
| Topological domain | 172 – 1038 | 867 | Cytoplasmic Potential | |||||||
| Domain | 203 – 504 | 302 | Protein kinase | |||||||
| Nucleotide binding | 209 – 217 | 9 | ATP By similarity | |||||||
| Compositional bias | 191 – 194 | 4 | Poly-Ala | |||||||
| Compositional bias | 547 – 550 | 4 | Poly-Ser | |||||||
| Compositional bias | 610 – 618 | 9 | Poly-Thr | |||||||
| Compositional bias | 901 – 908 | 8 | Poly-Asn | |||||||
Sites | ||||||||||
| Active site | 333 | 1 | Proton acceptor By similarity | |||||||
| Binding site | 230 | 1 | ATP By similarity | |||||||
Amino acid modifications | ||||||||||
| Glycosylation | 55 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Glycosylation | 110 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Glycosylation | 126 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Disulfide bond | 34 ↔ 66 | By similarity | ||||||||
| Disulfide bond | 94 ↔ 117 | By similarity | ||||||||
Sequences
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References
| [1] | "cDNA cloning and genomic organization of the mouse BMP type II receptor." Beppu H., Minowa O., Miyazono K., Kawabata M. Biochem. Biophys. Res. Commun. 235:499-504(1997) [PubMed: 9207184] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Identification of BMP receptor complexes with differential signaling properties and ligand binding profiles." Whitaker G.B., Koenig B.B., Ting J., Tiesman J.P., Limberg A.L., Grant R.A., Begley K.B., Rosenbaum J.S. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF003942 mRNA. Translation: AAB63042.1. U78048 mRNA. Translation: AAB87638.1. | |
| PIR | JC5527. |
| RefSeq | NP_031587.1. |
| UniGene | Mm.391654 Mm.466857 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IAS based on UniProtKB P36897. |
| SMR | O35607. Positions 33-131. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O35607. |
PTM databases | |
| PhosphoSite | O35607. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000067336. Mus musculus. [Contig view] |
| GeneID | 12168. |
| KEGG | mmu:12168. |
Organism-specific databases | |
| MGI | MGI:1095407. Bmpr2. |
Phylogenomic databases | |
| HOGENOM | O35607. |
| HOVERGEN | O35607. |
Gene expression databases | |
| ArrayExpress | O35607. |
| GermOnline | ENSMUSG00000067336. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000472. Activin_rcpt. IPR015770. BMPRII. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view] |
| PANTHER | PTHR23255:SF12. BMPRII. 1 hit. |
| Pfam | PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. False negative. [Graphical view] |
| BLOCKS | Search... |
Other Resources | |
| SOURCE | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | BMPR2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: O35607 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


