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O35607

- BMPR2_MOUSE

UniProt

O35607 - BMPR2_MOUSE

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Protein

Bone morphogenetic protein receptor type-2

Gene

Bmpr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei230 – 2301ATPPROSITE-ProRule annotation
Active sitei333 – 3331Proton acceptorPROSITE-ProRule annotation
Binding sitei351 – 3511ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi209 – 2179ATPPROSITE-ProRule annotation
Nucleotide bindingi280 – 2823ATPPROSITE-ProRule annotation
Nucleotide bindingi337 – 3382ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. receptor signaling protein serine/threonine kinase activity Source: InterPro
  4. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. artery development Source: BHF-UCL
  3. blood vessel remodeling Source: BHF-UCL
  4. BMP signaling pathway Source: MGI
  5. brain development Source: Ensembl
  6. cellular response to starvation Source: Ensembl
  7. chondrocyte development Source: Ensembl
  8. limb development Source: MGI
  9. lung alveolus development Source: BHF-UCL
  10. lymphangiogenesis Source: BHF-UCL
  11. lymphatic endothelial cell differentiation Source: BHF-UCL
  12. mesoderm formation Source: MGI
  13. negative regulation of cell growth Source: Ensembl
  14. negative regulation of chondrocyte proliferation Source: Ensembl
  15. negative regulation of DNA biosynthetic process Source: Ensembl
  16. negative regulation of systemic arterial blood pressure Source: Ensembl
  17. negative regulation of vasoconstriction Source: BHF-UCL
  18. positive regulation of axon extension involved in axon guidance Source: UniProt
  19. positive regulation of BMP signaling pathway Source: Ensembl
  20. positive regulation of bone mineralization Source: Ensembl
  21. positive regulation of endothelial cell migration Source: Ensembl
  22. positive regulation of endothelial cell proliferation Source: Ensembl
  23. positive regulation of osteoblast differentiation Source: Ensembl
  24. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  25. regulation of lung blood pressure Source: BHF-UCL
  26. retina vasculature development in camera-type eye Source: BHF-UCL
  27. transcription from RNA polymerase II promoter Source: Ensembl
  28. vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
  29. venous blood vessel development Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 3474.
ReactomeiREACT_220505. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-2 (EC:2.7.11.30)
Short name:
BMP type-2 receptor
Short name:
BMPR-2
Alternative name(s):
BRK-3
Bone morphogenetic protein receptor type II
Short name:
BMP type II receptor
Short name:
BMPR-II
Gene namesi
Name:Bmpr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1095407. Bmpr2.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basal plasma membrane Source: Ensembl
  3. caveola Source: Ensembl
  4. cell surface Source: MGI
  5. cytoplasm Source: Ensembl
  6. dendrite Source: Ensembl
  7. extracellular space Source: Ensembl
  8. integral component of plasma membrane Source: Ensembl
  9. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 10381012Bone morphogenetic protein receptor type-2PRO_0000024416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 66By similarity
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi94 ↔ 117By similarity
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
Modified residuei379 – 3791PhosphothreonineBy similarity
Modified residuei586 – 5861PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO35607.
PaxDbiO35607.
PRIDEiO35607.

PTM databases

PhosphoSiteiO35607.

Expressioni

Gene expression databases

BgeeiO35607.
ExpressionAtlasiO35607. baseline and differential.
GenevestigatoriO35607.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Prkg1P0C6054EBI-527224,EBI-6991999

Protein-protein interaction databases

BioGridi198373. 4 interactions.
IntActiO35607. 4 interactions.
MINTiMINT-1743993.

Structurei

3D structure databases

ProteinModelPortaliO35607.
SMRiO35607. Positions 33-131, 197-555.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 150124ExtracellularSequence AnalysisAdd
BLAST
Topological domaini172 – 1038867CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini203 – 504302Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi191 – 1944Poly-Ala
Compositional biasi547 – 5504Poly-Ser
Compositional biasi610 – 6189Poly-Thr
Compositional biasi901 – 9088Poly-Asn

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000043088.
HOVERGENiHBG050705.
InParanoidiO35607.
KOiK04671.
OMAiDHYKPAI.
OrthoDBiEOG7JHM5B.
PhylomeDBiO35607.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR015770. BMPR2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PTHR23255:SF63. PTHR23255:SF63. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35607-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSSLHRPFR VPWLLWAVLL VSTTAASQNQ ERLCAFKDPY QQDLGIGESR
60 70 80 90 100
ISHENGTILC SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV
110 120 130 140 150
VTTTPPSIQN GTYRFCCCST DLCNVNFTEN FPPPDTTPLS PPHSFNRDET
160 170 180 190 200
IIIALASVSV LAVLIVALCF GYRMLTGDRK QGLHSMNMME AAAAEPSLDL
210 220 230 240 250
DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF INEKNIYRVP
260 270 280 290 300
LMEHDNIARF IVGDERLTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS
310 320 330 340 350
SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGACVIS
360 370 380 390 400
DFGLSMRLTG NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA
410 420 430 440 450
LKQVDMYALG LIYWEVFMRC TDLFPGESVP DYQMAFQTEV GNHPTFEDMQ
460 470 480 490 500
VLVSREKQRP KFPEAWKENS LAVRSLKETI EDCWDQDAEA RLTAQCAEER
510 520 530 540 550
MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI GPYPDYSSSS
560 570 580 590 600
YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS
610 620 630 640 650
PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETHL HATNVAQSIG
660 670 680 690 700
PTPVCLQLTE EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS
710 720 730 740 750
STSSSLLYPL IKLAVEVTGQ QDFTQAANGQ ACLIPDVPPA QIYPLPKQQN
760 770 780 790 800
LPKRPTSLPL NTKNSTKEPR LKFGNKHKSN LKQVETGVAK MNTINAAEPH
810 820 830 840 850
VVTVTMNGVA GRSHNVNSHA ATTQYANGAV PAGQAANIVA HRSQEMLQNQ
860 870 880 890 900
FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT
910 920 930 940 950
NSNNNNSNPC SEQDILTQGV TSTAADPGPS KPRRAQRPNS LDLSATNILD
960 970 980 990 1000
GSSIQIGEST QDGKSGSGEK IKRRVKTPYS LKRWRPSTWV ISTEPLDCEV
1010 1020 1030
NNNGSDRAVH SKSSTAVYLA EGGTATTTVS KDIGMNCL
Length:1,038
Mass (Da):115,020
Last modified:January 1, 1998 - v1
Checksum:i4106945DC63250E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003942 mRNA. Translation: AAB63042.1.
U78048 mRNA. Translation: AAB87638.1.
CCDSiCCDS35588.1.
PIRiJC5527.
RefSeqiNP_031587.1. NM_007561.4.
UniGeneiMm.391654.
Mm.7106.

Genome annotation databases

EnsembliENSMUST00000087435; ENSMUSP00000084701; ENSMUSG00000067336.
GeneIDi12168.
KEGGimmu:12168.
UCSCiuc007bdz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF003942 mRNA. Translation: AAB63042.1 .
U78048 mRNA. Translation: AAB87638.1 .
CCDSi CCDS35588.1.
PIRi JC5527.
RefSeqi NP_031587.1. NM_007561.4.
UniGenei Mm.391654.
Mm.7106.

3D structure databases

ProteinModelPortali O35607.
SMRi O35607. Positions 33-131, 197-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198373. 4 interactions.
IntActi O35607. 4 interactions.
MINTi MINT-1743993.

PTM databases

PhosphoSitei O35607.

Proteomic databases

MaxQBi O35607.
PaxDbi O35607.
PRIDEi O35607.

Protocols and materials databases

DNASUi 12168.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087435 ; ENSMUSP00000084701 ; ENSMUSG00000067336 .
GeneIDi 12168.
KEGGi mmu:12168.
UCSCi uc007bdz.1. mouse.

Organism-specific databases

CTDi 659.
MGIi MGI:1095407. Bmpr2.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118876.
HOGENOMi HOG000043088.
HOVERGENi HBG050705.
InParanoidi O35607.
KOi K04671.
OMAi DHYKPAI.
OrthoDBi EOG7JHM5B.
PhylomeDBi O35607.
TreeFami TF314724.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 3474.
Reactomei REACT_220505. Signaling by BMP.

Miscellaneous databases

ChiTaRSi BMPR2. mouse.
NextBioi 280539.
PROi O35607.
SOURCEi Search...

Gene expression databases

Bgeei O35607.
ExpressionAtlasi O35607. baseline and differential.
Genevestigatori O35607.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR015770. BMPR2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
PTHR23255:SF63. PTHR23255:SF63. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning and genomic organization of the mouse BMP type II receptor."
    Beppu H., Minowa O., Miyazono K., Kawabata M.
    Biochem. Biophys. Res. Commun. 235:499-504(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of BMP receptor complexes with differential signaling properties and ligand binding profiles."
    Whitaker G.B., Koenig B.B., Ting J., Tiesman J.P., Limberg A.L., Grant R.A., Begley K.B., Rosenbaum J.S.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiBMPR2_MOUSE
AccessioniPrimary (citable) accession number: O35607
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3