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O35602

- RX_MOUSE

UniProt

O35602 - RX_MOUSE

Protein

Retinal homeobox protein Rx

Gene

Rax

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi136 – 19560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. brain development Source: MGI
    2. camera-type eye development Source: MGI
    3. hypothalamus development Source: MGI
    4. limb development Source: MGI
    5. pattern specification process Source: MGI
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinal homeobox protein Rx
    Alternative name(s):
    Retina and anterior neural fold homeobox protein
    Gene namesi
    Name:Rax
    Synonyms:Rx
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:109632. Rax.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Retinal homeobox protein RxPRO_0000049277Add
    BLAST

    Proteomic databases

    PRIDEiO35602.

    PTM databases

    PhosphoSiteiO35602.

    Expressioni

    Tissue specificityi

    Expressed in the photoreceptor and inner nuclear layers.

    Developmental stagei

    Strongly expressed in anterior neural plate at E8.5, followed in optic sulci and ventral forebrain at E9.0, and in eye at E10.5 uniformly expressed in neuroretina at E15.5, and at later stages, expression decreases.

    Gene expression databases

    BgeeiO35602.
    CleanExiMM_RAX.
    GenevestigatoriO35602.

    Interactioni

    Protein-protein interaction databases

    BioGridi202604. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO35602.
    SMRiO35602. Positions 142-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi33 – 408Octapeptide motif
    Motifi319 – 33214OARAdd
    BLAST
    Motifi325 – 3295Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi276 – 2794Poly-Pro

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG261733.
    GeneTreeiENSGT00750000117349.
    HOGENOMiHOG000231518.
    HOVERGENiHBG021349.
    InParanoidiQ6GT92.
    KOiK09332.
    OMAiCGPGFGD.
    OrthoDBiEOG7T1RC6.
    TreeFamiTF315976.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR003654. OAR_dom.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF03826. OAR. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS50803. OAR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35602-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLPGCAPAM ADGSFSLAGH LLRSPGGSTS RLHSIEAILG FTKEDGILDT    50
    FPAERSSRSS KERDPRLGAQ PACPKAPAGG SESSPPAAPG FVPEYEATRP 100
    CYPKEQGEAR PSPGLSVGPA AGDSKLSEEE PPKKKHRRNR TTFTTYQLHE 150
    LERAFEKSHY PDVYSREELA GKVNLPEVRV QVWFQNRRAK WRRQEKLEVS 200
    SMKLQDSPLL SFSRSPPSSA LAPLGTGPGS GSGPPGSALP LEPWLGPPLP 250
    GGGATALQSL PGFGPPGQGL PASYTPPPPF LNSAPLGPGL QQLGPPPAYP 300
    CAPAFGDKFS LEEAYPRNSS IAALRLKAKE HIQAIGKPWQ AL 342
    Length:342
    Mass (Da):36,335
    Last modified:July 27, 2011 - v2
    Checksum:i8315DAF6B038D087
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121D → H in AAB62324. (PubMed:9177348)Curated
    Sequence conflicti213 – 2131S → I in AAB62324. (PubMed:9177348)Curated
    Sequence conflicti248 – 2481P → T in AAB62324. (PubMed:9177348)Curated
    Sequence conflicti314 – 3152AY → RS in AAB62324. (PubMed:9177348)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001906 mRNA. Translation: AAB62324.1.
    U73177 mRNA. Translation: AAC53129.1.
    CH466528 Genomic DNA. Translation: EDL09676.1.
    BC024731 mRNA. Translation: AAH24731.1.
    BC058757 mRNA. Translation: AAH58757.1.
    CCDSiCCDS29311.1.
    RefSeqiNP_038861.2. NM_013833.2.
    UniGeneiMm.431047.

    Genome annotation databases

    EnsembliENSMUST00000025396; ENSMUSP00000025396; ENSMUSG00000024518.
    GeneIDi19434.
    KEGGimmu:19434.
    UCSCiuc008ffl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001906 mRNA. Translation: AAB62324.1 .
    U73177 mRNA. Translation: AAC53129.1 .
    CH466528 Genomic DNA. Translation: EDL09676.1 .
    BC024731 mRNA. Translation: AAH24731.1 .
    BC058757 mRNA. Translation: AAH58757.1 .
    CCDSi CCDS29311.1.
    RefSeqi NP_038861.2. NM_013833.2.
    UniGenei Mm.431047.

    3D structure databases

    ProteinModelPortali O35602.
    SMRi O35602. Positions 142-192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202604. 1 interaction.

    PTM databases

    PhosphoSitei O35602.

    Proteomic databases

    PRIDEi O35602.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025396 ; ENSMUSP00000025396 ; ENSMUSG00000024518 .
    GeneIDi 19434.
    KEGGi mmu:19434.
    UCSCi uc008ffl.1. mouse.

    Organism-specific databases

    CTDi 30062.
    MGIi MGI:109632. Rax.

    Phylogenomic databases

    eggNOGi NOG261733.
    GeneTreei ENSGT00750000117349.
    HOGENOMi HOG000231518.
    HOVERGENi HBG021349.
    InParanoidi Q6GT92.
    KOi K09332.
    OMAi CGPGFGD.
    OrthoDBi EOG7T1RC6.
    TreeFami TF315976.

    Miscellaneous databases

    ChiTaRSi RAX. mouse.
    NextBioi 296571.
    PROi O35602.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35602.
    CleanExi MM_RAX.
    Genevestigatori O35602.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR003654. OAR_dom.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF03826. OAR. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS50803. OAR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Rx homeobox gene is essential for vertebrate eye development."
      Mathers P.H., Grinberg A., Mahon K.A., Jamrich M.
      Nature 387:603-607(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. "Rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina."
      Furukawa T., Kozak C.A., Cepko C.L.
      Proc. Natl. Acad. Sci. U.S.A. 94:3088-3093(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiRX_MOUSE
    AccessioniPrimary (citable) accession number: O35602
    Secondary accession number(s): O08748, Q6GT92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3