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O35602 (RX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinal homeobox protein Rx
Alternative name(s):
Retina and anterior neural fold homeobox protein
Gene names
Name:Rax
Synonyms:Rx
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed in the photoreceptor and inner nuclear layers.

Developmental stage

Strongly expressed in anterior neural plate at E8.5, followed in optic sulci and ventral forebrain at E9.0, and in eye at E10.5 uniformly expressed in neuroretina at E15.5, and at later stages, expression decreases.

Sequence similarities

Belongs to the paired homeobox family. Bicoid subfamily.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Retinal homeobox protein Rx
PRO_0000049277

Regions

DNA binding136 – 19560Homeobox
Motif33 – 408Octapeptide motif
Motif319 – 33214OAR
Motif325 – 3295Nuclear localization signal Potential
Compositional bias276 – 2794Poly-Pro

Experimental info

Sequence conflict121D → H in AAB62324. Ref.1
Sequence conflict2131S → I in AAB62324. Ref.1
Sequence conflict2481P → T in AAB62324. Ref.1
Sequence conflict314 – 3152AY → RS in AAB62324. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35602 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 8315DAF6B038D087

FASTA34236,335
        10         20         30         40         50         60 
MHLPGCAPAM ADGSFSLAGH LLRSPGGSTS RLHSIEAILG FTKEDGILDT FPAERSSRSS 

        70         80         90        100        110        120 
KERDPRLGAQ PACPKAPAGG SESSPPAAPG FVPEYEATRP CYPKEQGEAR PSPGLSVGPA 

       130        140        150        160        170        180 
AGDSKLSEEE PPKKKHRRNR TTFTTYQLHE LERAFEKSHY PDVYSREELA GKVNLPEVRV 

       190        200        210        220        230        240 
QVWFQNRRAK WRRQEKLEVS SMKLQDSPLL SFSRSPPSSA LAPLGTGPGS GSGPPGSALP 

       250        260        270        280        290        300 
LEPWLGPPLP GGGATALQSL PGFGPPGQGL PASYTPPPPF LNSAPLGPGL QQLGPPPAYP 

       310        320        330        340 
CAPAFGDKFS LEEAYPRNSS IAALRLKAKE HIQAIGKPWQ AL 

« Hide

References

« Hide 'large scale' references
[1]"The Rx homeobox gene is essential for vertebrate eye development."
Mathers P.H., Grinberg A., Mahon K.A., Jamrich M.
Nature 387:603-607(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[2]"Rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina."
Furukawa T., Kozak C.A., Cepko C.L.
Proc. Natl. Acad. Sci. U.S.A. 94:3088-3093(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF001906 mRNA. Translation: AAB62324.1.
U73177 mRNA. Translation: AAC53129.1.
CH466528 Genomic DNA. Translation: EDL09676.1.
BC024731 mRNA. Translation: AAH24731.1.
BC058757 mRNA. Translation: AAH58757.1.
RefSeqNP_038861.2. NM_013833.2.
UniGeneMm.431047.

3D structure databases

ProteinModelPortalO35602.
SMRO35602. Positions 142-192.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202604. 1 interaction.

PTM databases

PhosphoSiteO35602.

Proteomic databases

PRIDEO35602.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025396; ENSMUSP00000025396; ENSMUSG00000024518.
GeneID19434.
KEGGmmu:19434.
UCSCuc008ffl.1. mouse.

Organism-specific databases

CTD30062.
MGIMGI:109632. Rax.

Phylogenomic databases

eggNOGNOG261733.
GeneTreeENSGT00750000117349.
HOGENOMHOG000231518.
HOVERGENHBG021349.
InParanoidQ6GT92.
KOK09332.
OMACGPGFGD.
OrthoDBEOG7T1RC6.
TreeFamTF315976.

Gene expression databases

BgeeO35602.
CleanExMM_RAX.
GenevestigatorO35602.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRAX. mouse.
NextBio296571.
PROO35602.
SOURCESearch...

Entry information

Entry nameRX_MOUSE
AccessionPrimary (citable) accession number: O35602
Secondary accession number(s): O08748, Q6GT92
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot