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Protein

Retinal homeobox protein Rx

Gene

Rax

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi136 – 195HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • brain development Source: MGI
  • camera-type eye development Source: MGI
  • hypothalamus development Source: MGI
  • limb development Source: MGI
  • pattern specification process Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal homeobox protein Rx
Alternative name(s):
Retina and anterior neural fold homeobox protein
Gene namesi
Name:Rax
Synonyms:Rx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:109632. Rax.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492771 – 342Retinal homeobox protein RxAdd BLAST342

Proteomic databases

MaxQBiO35602.
PaxDbiO35602.
PRIDEiO35602.

PTM databases

PhosphoSitePlusiO35602.

Expressioni

Tissue specificityi

Expressed in the photoreceptor and inner nuclear layers.

Developmental stagei

Strongly expressed in anterior neural plate at E8.5, followed in optic sulci and ventral forebrain at E9.0, and in eye at E10.5 uniformly expressed in neuroretina at E15.5, and at later stages, expression decreases.

Gene expression databases

BgeeiENSMUSG00000024518.
CleanExiMM_RAX.
GenevisibleiO35602. MM.

Interactioni

Protein-protein interaction databases

BioGridi202604. 1 interactor.
IntActiO35602. 1 interactor.
STRINGi10090.ENSMUSP00000025396.

Structurei

3D structure databases

ProteinModelPortaliO35602.
SMRiO35602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 40Octapeptide motif8
Motifi319 – 332OARPROSITE-ProRule annotationAdd BLAST14
Motifi325 – 329Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 279Poly-Pro4

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiO35602.
KOiK09332.
OMAiYPCGPGF.
OrthoDBiEOG091G0NQL.
TreeFamiTF315976.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR003654. OAR_dom.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.

Sequencei

Sequence statusi: Complete.

O35602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLPGCAPAM ADGSFSLAGH LLRSPGGSTS RLHSIEAILG FTKEDGILDT
60 70 80 90 100
FPAERSSRSS KERDPRLGAQ PACPKAPAGG SESSPPAAPG FVPEYEATRP
110 120 130 140 150
CYPKEQGEAR PSPGLSVGPA AGDSKLSEEE PPKKKHRRNR TTFTTYQLHE
160 170 180 190 200
LERAFEKSHY PDVYSREELA GKVNLPEVRV QVWFQNRRAK WRRQEKLEVS
210 220 230 240 250
SMKLQDSPLL SFSRSPPSSA LAPLGTGPGS GSGPPGSALP LEPWLGPPLP
260 270 280 290 300
GGGATALQSL PGFGPPGQGL PASYTPPPPF LNSAPLGPGL QQLGPPPAYP
310 320 330 340
CAPAFGDKFS LEEAYPRNSS IAALRLKAKE HIQAIGKPWQ AL
Length:342
Mass (Da):36,335
Last modified:July 27, 2011 - v2
Checksum:i8315DAF6B038D087
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12D → H in AAB62324 (PubMed:9177348).Curated1
Sequence conflicti213S → I in AAB62324 (PubMed:9177348).Curated1
Sequence conflicti248P → T in AAB62324 (PubMed:9177348).Curated1
Sequence conflicti314 – 315AY → RS in AAB62324 (PubMed:9177348).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001906 mRNA. Translation: AAB62324.1.
U73177 mRNA. Translation: AAC53129.1.
CH466528 Genomic DNA. Translation: EDL09676.1.
BC024731 mRNA. Translation: AAH24731.1.
BC058757 mRNA. Translation: AAH58757.1.
CCDSiCCDS29311.1.
RefSeqiNP_038861.2. NM_013833.2.
UniGeneiMm.431047.

Genome annotation databases

EnsembliENSMUST00000025396; ENSMUSP00000025396; ENSMUSG00000024518.
GeneIDi19434.
KEGGimmu:19434.
UCSCiuc008ffl.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiRX_MOUSE
AccessioniPrimary (citable) accession number: O35602
Secondary accession number(s): O08748, Q6GT92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: September 27, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families