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Protein

Retinal homeobox protein Rx

Gene

Rax

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi136 – 19560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI

GO - Biological processi

  1. brain development Source: MGI
  2. camera-type eye development Source: MGI
  3. hypothalamus development Source: MGI
  4. limb development Source: MGI
  5. pattern specification process Source: MGI
  6. positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal homeobox protein Rx
Alternative name(s):
Retina and anterior neural fold homeobox protein
Gene namesi
Name:Rax
Synonyms:Rx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:109632. Rax.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Retinal homeobox protein RxPRO_0000049277Add
BLAST

Proteomic databases

PRIDEiO35602.

PTM databases

PhosphoSiteiO35602.

Expressioni

Tissue specificityi

Expressed in the photoreceptor and inner nuclear layers.

Developmental stagei

Strongly expressed in anterior neural plate at E8.5, followed in optic sulci and ventral forebrain at E9.0, and in eye at E10.5 uniformly expressed in neuroretina at E15.5, and at later stages, expression decreases.

Gene expression databases

BgeeiO35602.
CleanExiMM_RAX.
ExpressionAtlasiO35602. differential.
GenevestigatoriO35602.

Interactioni

Protein-protein interaction databases

BioGridi202604. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO35602.
SMRiO35602. Positions 142-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi33 – 408Octapeptide motif
Motifi319 – 33214OARAdd
BLAST
Motifi325 – 3295Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi276 – 2794Poly-Pro

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG261733.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiO35602.
KOiK09332.
OMAiCGPGFGD.
OrthoDBiEOG7T1RC6.
TreeFamiTF315976.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35602-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLPGCAPAM ADGSFSLAGH LLRSPGGSTS RLHSIEAILG FTKEDGILDT
60 70 80 90 100
FPAERSSRSS KERDPRLGAQ PACPKAPAGG SESSPPAAPG FVPEYEATRP
110 120 130 140 150
CYPKEQGEAR PSPGLSVGPA AGDSKLSEEE PPKKKHRRNR TTFTTYQLHE
160 170 180 190 200
LERAFEKSHY PDVYSREELA GKVNLPEVRV QVWFQNRRAK WRRQEKLEVS
210 220 230 240 250
SMKLQDSPLL SFSRSPPSSA LAPLGTGPGS GSGPPGSALP LEPWLGPPLP
260 270 280 290 300
GGGATALQSL PGFGPPGQGL PASYTPPPPF LNSAPLGPGL QQLGPPPAYP
310 320 330 340
CAPAFGDKFS LEEAYPRNSS IAALRLKAKE HIQAIGKPWQ AL
Length:342
Mass (Da):36,335
Last modified:July 27, 2011 - v2
Checksum:i8315DAF6B038D087
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121D → H in AAB62324. (PubMed:9177348)Curated
Sequence conflicti213 – 2131S → I in AAB62324. (PubMed:9177348)Curated
Sequence conflicti248 – 2481P → T in AAB62324. (PubMed:9177348)Curated
Sequence conflicti314 – 3152AY → RS in AAB62324. (PubMed:9177348)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001906 mRNA. Translation: AAB62324.1.
U73177 mRNA. Translation: AAC53129.1.
CH466528 Genomic DNA. Translation: EDL09676.1.
BC024731 mRNA. Translation: AAH24731.1.
BC058757 mRNA. Translation: AAH58757.1.
CCDSiCCDS29311.1.
RefSeqiNP_038861.2. NM_013833.2.
UniGeneiMm.431047.

Genome annotation databases

EnsembliENSMUST00000025396; ENSMUSP00000025396; ENSMUSG00000024518.
GeneIDi19434.
KEGGimmu:19434.
UCSCiuc008ffl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001906 mRNA. Translation: AAB62324.1.
U73177 mRNA. Translation: AAC53129.1.
CH466528 Genomic DNA. Translation: EDL09676.1.
BC024731 mRNA. Translation: AAH24731.1.
BC058757 mRNA. Translation: AAH58757.1.
CCDSiCCDS29311.1.
RefSeqiNP_038861.2. NM_013833.2.
UniGeneiMm.431047.

3D structure databases

ProteinModelPortaliO35602.
SMRiO35602. Positions 142-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202604. 1 interaction.

PTM databases

PhosphoSiteiO35602.

Proteomic databases

PRIDEiO35602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025396; ENSMUSP00000025396; ENSMUSG00000024518.
GeneIDi19434.
KEGGimmu:19434.
UCSCiuc008ffl.1. mouse.

Organism-specific databases

CTDi30062.
MGIiMGI:109632. Rax.

Phylogenomic databases

eggNOGiNOG261733.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000231518.
HOVERGENiHBG021349.
InParanoidiO35602.
KOiK09332.
OMAiCGPGFGD.
OrthoDBiEOG7T1RC6.
TreeFamiTF315976.

Miscellaneous databases

ChiTaRSiRax. mouse.
NextBioi296571.
PROiO35602.
SOURCEiSearch...

Gene expression databases

BgeeiO35602.
CleanExiMM_RAX.
ExpressionAtlasiO35602. differential.
GenevestigatoriO35602.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Rx homeobox gene is essential for vertebrate eye development."
    Mathers P.H., Grinberg A., Mahon K.A., Jamrich M.
    Nature 387:603-607(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "Rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina."
    Furukawa T., Kozak C.A., Cepko C.L.
    Proc. Natl. Acad. Sci. U.S.A. 94:3088-3093(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiRX_MOUSE
AccessioniPrimary (citable) accession number: O35602
Secondary accession number(s): O08748, Q6GT92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.