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O35599

- OPSG_MOUSE

UniProt

O35599 - OPSG_MOUSE

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Protein

Medium-wave-sensitive opsin 1

Gene

Opn1mw

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. photoreceptor activity Source: UniProtKB-KW

GO - Biological processi

  1. phototransduction Source: UniProtKB-KW
  2. protein-chromophore linkage Source: UniProtKB-KW
  3. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

ReactomeiREACT_196615. Retinoid cycle disease events.
REACT_196617. The retinoid cycle in cones (daylight vision).

Names & Taxonomyi

Protein namesi
Recommended name:
Medium-wave-sensitive opsin 1
Alternative name(s):
Green cone photoreceptor pigment
Green-sensitive opsin
Short name:
M opsin
Medium wavelength-sensitive cone opsin
Gene namesi
Name:Opn1mw
Synonyms:Gcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1097692. Opn1mw.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. photoreceptor outer segment Source: MGI
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Medium-wave-sensitive opsin 1PRO_0000197786Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Curated
Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
Modified residuei307 – 3071N6-(retinylidene)lysine

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiO35599.

PTM databases

PhosphoSiteiO35599.

Expressioni

Tissue specificityi

Expressed in cone photoreceptor cells.1 Publication

Gene expression databases

BgeeiO35599.
ExpressionAtlasiO35599. differential.
GenevestigatoriO35599.

Structurei

3D structure databases

ProteinModelPortaliO35599.
SMRiO35599. Positions 16-354.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747ExtracellularSequence AnalysisAdd
BLAST
Topological domaini73 – 8412CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini111 – 12414ExtracellularSequence AnalysisAdd
BLAST
Topological domaini145 – 16319CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini188 – 21326ExtracellularSequence AnalysisAdd
BLAST
Topological domaini242 – 26322CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini288 – 2958ExtracellularSequence Analysis
Topological domaini321 – 35939CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei48 – 7225Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei85 – 11026Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei125 – 14420Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei164 – 18724Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei214 – 24128Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei264 – 28724Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei296 – 32025Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG240324.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000253932.
HOVERGENiHBG107442.
InParanoidiO35599.
KOiK04251.
OrthoDBiEOG72NRQJ.
PhylomeDBiO35599.
TreeFamiTF324998.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR000378. Opsin_red/grn.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00575. OPSINREDGRN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35599-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQRLTGEQT LDHYEDSTHA SIFTYTNSNS TKGPFEGPNY HIAPRWVYHL
60 70 80 90 100
TSTWMILVVV ASVFTNGLVL AATMRFKKLR HPLNWILVNL AVADLAETII
110 120 130 140 150
ASTISVVNQI YGYFVLGHPL CVIEGYIVSL CGITGLWSLA IISWERWLVV
160 170 180 190 200
CKPFGNVRFD AKLATVGIVF SWVWAAIWTA PPIFGWSRYW PYGLKTSCGP
210 220 230 240 250
DVFSGTSYPG VQSYMMVLMV TCCIFPLSII VLCYLQVWLA IRAVAKQQKE
260 270 280 290 300
SESTQKAEKE VTRMVVVMVF AYCLCWGPYT FFACFATAHP GYAFHPLVAS
310 320 330 340 350
LPSYFAKSAT IYNPIIYVFM NRQFRNCILH LFGKKVDDSS ELSSTSKTEV

SSVSSVSPA
Length:359
Mass (Da):40,218
Last modified:January 1, 1998 - v1
Checksum:i1BB5F531A6FAE357
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF011389 mRNA. Translation: AAB64302.1.
AF190672 mRNA. Translation: AAG17991.1.
AF191085
, AF191080, AF191081, AF191082, AF191083, AF191084 Genomic DNA. Translation: AAG17992.1.
BC014826 mRNA. Translation: AAH14826.1.
CCDSiCCDS30220.1.
RefSeqiNP_032132.1. NM_008106.2.
UniGeneiMm.284825.

Genome annotation databases

EnsembliENSMUST00000033771; ENSMUSP00000033771; ENSMUSG00000031394.
GeneIDi14539.
KEGGimmu:14539.
UCSCiuc009tnv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF011389 mRNA. Translation: AAB64302.1 .
AF190672 mRNA. Translation: AAG17991.1 .
AF191085
, AF191080 , AF191081 , AF191082 , AF191083 , AF191084 Genomic DNA. Translation: AAG17992.1 .
BC014826 mRNA. Translation: AAH14826.1 .
CCDSi CCDS30220.1.
RefSeqi NP_032132.1. NM_008106.2.
UniGenei Mm.284825.

3D structure databases

ProteinModelPortali O35599.
SMRi O35599. Positions 16-354.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O35599.

Proteomic databases

PRIDEi O35599.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033771 ; ENSMUSP00000033771 ; ENSMUSG00000031394 .
GeneIDi 14539.
KEGGi mmu:14539.
UCSCi uc009tnv.1. mouse.

Organism-specific databases

CTDi 2652.
MGIi MGI:1097692. Opn1mw.

Phylogenomic databases

eggNOGi NOG240324.
GeneTreei ENSGT00760000118977.
HOGENOMi HOG000253932.
HOVERGENi HBG107442.
InParanoidi O35599.
KOi K04251.
OrthoDBi EOG72NRQJ.
PhylomeDBi O35599.
TreeFami TF324998.

Enzyme and pathway databases

Reactomei REACT_196615. Retinoid cycle disease events.
REACT_196617. The retinoid cycle in cones (daylight vision).

Miscellaneous databases

NextBioi 286212.
PROi O35599.
SOURCEi Search...

Gene expression databases

Bgeei O35599.
ExpressionAtlasi O35599. differential.
Genevestigatori O35599.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR000378. Opsin_red/grn.
IPR027430. Retinal_BS.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00575. OPSINREDGRN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mechanisms of spectral tuning in the mouse green cone pigment."
    Sun H., Macke J.P., Nathans J.
    Proc. Natl. Acad. Sci. U.S.A. 94:8860-8865(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning."
    Applebury M.L., Antoch M.P., Baxter L.C., Chun L.Y., Falk J.D., Farhangfar F., Kage K., Krzystolik M.G., Lyass L.A., Robbins J.T.
    Neuron 27:513-523(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: BALB/c and C57BL/10.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Retina.

Entry informationi

Entry nameiOPSG_MOUSE
AccessioniPrimary (citable) accession number: O35599
Secondary accession number(s): Q548Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3