Medium-wave-sensitive opsin 1 - Mus musculus (Mouse)

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O35599 (OPSG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 100. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Medium-wave-sensitive opsin 1

Alternative name(s):
Green cone photoreceptor pigment
Green-sensitive opsin
Short name=M opsin
Medium wavelength-sensitive cone opsin

Gene names

Name:	Opn1mw
Synonyms:	Gcp

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light. Ref.2
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in cone photoreceptor cells. Ref.2
Post-translational modification	Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Chromophore
Molecular function	G-protein coupled receptor Photoreceptor protein Receptor Retinal protein Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phototransduction Inferred from electronic annotation. Source: UniProtKB-KW protein-chromophore linkage Inferred from electronic annotation. Source: UniProtKB-KW visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW photoreceptor outer segment Inferred from direct assay PubMed 12651948 PubMed 19332056. Source: MGI plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW photoreceptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 359

359

Medium-wave-sensitive opsin 1

PRO_0000197786

Regions

Topological domain

1 – 47

Extracellular Potential

Transmembrane

48 – 72

Helical; Name=1; Potential

Topological domain

73 – 84

Cytoplasmic Potential

Transmembrane

85 – 110

Helical; Name=2; Potential

Topological domain

111 – 124

Extracellular Potential

Transmembrane

125 – 144

Helical; Name=3; Potential

Topological domain

145 – 163

Cytoplasmic Potential

Transmembrane

164 – 187

Helical; Name=4; Potential

Topological domain

188 – 213

Extracellular Potential

Transmembrane

214 – 241

Helical; Name=5; Potential

Topological domain

242 – 263

Cytoplasmic Potential

Transmembrane

264 – 287

Helical; Name=6; Potential

Topological domain

288 – 295

Extracellular Potential

Transmembrane

296 – 320

Helical; Name=7; Potential

Topological domain

321 – 359

Cytoplasmic Potential

Amino acid modifications

Modified residue

307

N6-(retinylidene)lysine

Glycosylation

N-linked (GlcNAc...) Probable

Disulfide bond

121 ↔ 198

Potential

Sequences

Sequence

Length

Mass (Da)

Tools

O35599 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 1BB5F531A6FAE357
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FASTA

359

40,218

        10         20         30         40         50         60 
MAQRLTGEQT LDHYEDSTHA SIFTYTNSNS TKGPFEGPNY HIAPRWVYHL TSTWMILVVV 

        70         80         90        100        110        120 
ASVFTNGLVL AATMRFKKLR HPLNWILVNL AVADLAETII ASTISVVNQI YGYFVLGHPL 

       130        140        150        160        170        180 
CVIEGYIVSL CGITGLWSLA IISWERWLVV CKPFGNVRFD AKLATVGIVF SWVWAAIWTA 

       190        200        210        220        230        240 
PPIFGWSRYW PYGLKTSCGP DVFSGTSYPG VQSYMMVLMV TCCIFPLSII VLCYLQVWLA 

       250        260        270        280        290        300 
IRAVAKQQKE SESTQKAEKE VTRMVVVMVF AYCLCWGPYT FFACFATAHP GYAFHPLVAS 

       310        320        330        340        350 
LPSYFAKSAT IYNPIIYVFM NRQFRNCILH LFGKKVDDSS ELSSTSKTEV SSVSSVSPA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mechanisms of spectral tuning in the mouse green cone pigment." Sun H., Macke J.P., Nathans J. Proc. Natl. Acad. Sci. U.S.A. 94:8860-8865(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning." Applebury M.L., Antoch M.P., Baxter L.C., Chun L.Y., Falk J.D., Farhangfar F., Kage K., Krzystolik M.G., Lyass L.A., Robbins J.T. Neuron 27:513-523(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY. Strain: BALB/c and C57BL/10.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Retina.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF011389 mRNA. Translation: AAB64302.1. AF190672 mRNA. Translation: AAG17991.1. AF191085 AF191084 Genomic DNA. Translation: AAG17992.1. BC014826 mRNA. Translation: AAH14826.1.
IPI	IPI00131882.
RefSeq	NP_032132.1. NM_008106.2.
UniGene	Mm.284825.
3D structure databases
ProteinModelPortal	O35599.
SMR	O35599. Positions 32-329.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O35599.
Proteomic databases
PRIDE	O35599.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000033771; ENSMUSP00000033771; ENSMUSG00000031394.
GeneID	14539.
KEGG	mmu:14539.
Organism-specific databases
CTD	2652.
MGI	MGI:1097692. Opn1mw.
Phylogenomic databases
eggNOG	NOG240324.
GeneTree	ENSGT00700000104057.
HOGENOM	HOG000253932.
HOVERGEN	HBG107442.
KO	K04251.
OrthoDB	EOG40K806.
Gene expression databases
ArrayExpress	O35599.
Bgee	O35599.
Genevestigator	O35599.
GermOnline	ENSMUSG00000031394. Mus musculus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001760. Opsin. IPR000378. Opsin_red/grn. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00238. OPSIN. PR00575. OPSINREDGRN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. PS00238. OPSIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	286212.
SOURCE	Search...

Entry information

Entry name

OPSG_MOUSE

Accession

Primary (citable) accession number: O35599
Secondary accession number(s): Q548Z4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents