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Protein

Medium-wave-sensitive opsin 1

Gene

Opn1mw

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

ReactomeiR-MMU-2187335. The retinoid cycle in cones (daylight vision).
R-MMU-418594. G alpha (i) signalling events.
R-MMU-419771. Opsins.

Names & Taxonomyi

Protein namesi
Recommended name:
Medium-wave-sensitive opsin 1
Alternative name(s):
Green cone photoreceptor pigment
Green-sensitive opsin
Short name:
M opsin
Medium wavelength-sensitive cone opsin
Gene namesi
Name:Opn1mw
Synonyms:Gcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1097692. Opn1mw.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
Transmembranei48 – 72Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini73 – 84CytoplasmicSequence analysisAdd BLAST12
Transmembranei85 – 110Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini111 – 124ExtracellularSequence analysisAdd BLAST14
Transmembranei125 – 144Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini145 – 163CytoplasmicSequence analysisAdd BLAST19
Transmembranei164 – 187Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini188 – 213ExtracellularSequence analysisAdd BLAST26
Transmembranei214 – 241Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini242 – 263CytoplasmicSequence analysisAdd BLAST22
Transmembranei264 – 287Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini288 – 295ExtracellularSequence analysis8
Transmembranei296 – 320Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini321 – 359CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001977861 – 359Medium-wave-sensitive opsin 1Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Curated1
Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
Modified residuei307N6-(retinylidene)lysine1

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO35599.
PRIDEiO35599.

PTM databases

PhosphoSitePlusiO35599.

Expressioni

Tissue specificityi

Expressed in cone photoreceptor cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000031394.
ExpressionAtlasiO35599. baseline and differential.
GenevisibleiO35599. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033771.

Structurei

3D structure databases

ProteinModelPortaliO35599.
SMRiO35599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000253932.
HOVERGENiHBG107442.
InParanoidiO35599.
KOiK04251.
PhylomeDBiO35599.
TreeFamiTF324998.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR000378. Opsin_red/grn.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00575. OPSINREDGRN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRLTGEQT LDHYEDSTHA SIFTYTNSNS TKGPFEGPNY HIAPRWVYHL
60 70 80 90 100
TSTWMILVVV ASVFTNGLVL AATMRFKKLR HPLNWILVNL AVADLAETII
110 120 130 140 150
ASTISVVNQI YGYFVLGHPL CVIEGYIVSL CGITGLWSLA IISWERWLVV
160 170 180 190 200
CKPFGNVRFD AKLATVGIVF SWVWAAIWTA PPIFGWSRYW PYGLKTSCGP
210 220 230 240 250
DVFSGTSYPG VQSYMMVLMV TCCIFPLSII VLCYLQVWLA IRAVAKQQKE
260 270 280 290 300
SESTQKAEKE VTRMVVVMVF AYCLCWGPYT FFACFATAHP GYAFHPLVAS
310 320 330 340 350
LPSYFAKSAT IYNPIIYVFM NRQFRNCILH LFGKKVDDSS ELSSTSKTEV

SSVSSVSPA
Length:359
Mass (Da):40,218
Last modified:January 1, 1998 - v1
Checksum:i1BB5F531A6FAE357
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011389 mRNA. Translation: AAB64302.1.
AF190672 mRNA. Translation: AAG17991.1.
AF191085
, AF191080, AF191081, AF191082, AF191083, AF191084 Genomic DNA. Translation: AAG17992.1.
BC014826 mRNA. Translation: AAH14826.1.
CCDSiCCDS30220.1.
RefSeqiNP_032132.1. NM_008106.2.
UniGeneiMm.284825.

Genome annotation databases

EnsembliENSMUST00000033771; ENSMUSP00000033771; ENSMUSG00000031394.
GeneIDi14539.
KEGGimmu:14539.
UCSCiuc009tnv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011389 mRNA. Translation: AAB64302.1.
AF190672 mRNA. Translation: AAG17991.1.
AF191085
, AF191080, AF191081, AF191082, AF191083, AF191084 Genomic DNA. Translation: AAG17992.1.
BC014826 mRNA. Translation: AAH14826.1.
CCDSiCCDS30220.1.
RefSeqiNP_032132.1. NM_008106.2.
UniGeneiMm.284825.

3D structure databases

ProteinModelPortaliO35599.
SMRiO35599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033771.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO35599.

Proteomic databases

PaxDbiO35599.
PRIDEiO35599.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033771; ENSMUSP00000033771; ENSMUSG00000031394.
GeneIDi14539.
KEGGimmu:14539.
UCSCiuc009tnv.1. mouse.

Organism-specific databases

CTDi2652.
MGIiMGI:1097692. Opn1mw.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000253932.
HOVERGENiHBG107442.
InParanoidiO35599.
KOiK04251.
PhylomeDBiO35599.
TreeFamiTF324998.

Enzyme and pathway databases

ReactomeiR-MMU-2187335. The retinoid cycle in cones (daylight vision).
R-MMU-418594. G alpha (i) signalling events.
R-MMU-419771. Opsins.

Miscellaneous databases

PROiO35599.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031394.
ExpressionAtlasiO35599. baseline and differential.
GenevisibleiO35599. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR000378. Opsin_red/grn.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00575. OPSINREDGRN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPSG_MOUSE
AccessioniPrimary (citable) accession number: O35599
Secondary accession number(s): Q548Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.