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O35599 (OPSG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Medium-wave-sensitive opsin 1
Alternative name(s):
Green cone photoreceptor pigment
Green-sensitive opsin
Short name=M opsin
Medium wavelength-sensitive cone opsin
Gene names
Name:Opn1mw
Synonyms:Gcp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light. Ref.2

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in cone photoreceptor cells. Ref.2

Post-translational modification

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Medium-wave-sensitive opsin 1
PRO_0000197786

Regions

Topological domain1 – 4747Extracellular Potential
Transmembrane48 – 7225Helical; Name=1; Potential
Topological domain73 – 8412Cytoplasmic Potential
Transmembrane85 – 11026Helical; Name=2; Potential
Topological domain111 – 12414Extracellular Potential
Transmembrane125 – 14420Helical; Name=3; Potential
Topological domain145 – 16319Cytoplasmic Potential
Transmembrane164 – 18724Helical; Name=4; Potential
Topological domain188 – 21326Extracellular Potential
Transmembrane214 – 24128Helical; Name=5; Potential
Topological domain242 – 26322Cytoplasmic Potential
Transmembrane264 – 28724Helical; Name=6; Potential
Topological domain288 – 2958Extracellular Potential
Transmembrane296 – 32025Helical; Name=7; Potential
Topological domain321 – 35939Cytoplasmic Potential

Amino acid modifications

Modified residue3071N6-(retinylidene)lysine
Glycosylation291N-linked (GlcNAc...) Probable
Disulfide bond121 ↔ 198 Potential

Sequences

Sequence LengthMass (Da)Tools
O35599 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 1BB5F531A6FAE357

FASTA35940,218
        10         20         30         40         50         60 
MAQRLTGEQT LDHYEDSTHA SIFTYTNSNS TKGPFEGPNY HIAPRWVYHL TSTWMILVVV 

        70         80         90        100        110        120 
ASVFTNGLVL AATMRFKKLR HPLNWILVNL AVADLAETII ASTISVVNQI YGYFVLGHPL 

       130        140        150        160        170        180 
CVIEGYIVSL CGITGLWSLA IISWERWLVV CKPFGNVRFD AKLATVGIVF SWVWAAIWTA 

       190        200        210        220        230        240 
PPIFGWSRYW PYGLKTSCGP DVFSGTSYPG VQSYMMVLMV TCCIFPLSII VLCYLQVWLA 

       250        260        270        280        290        300 
IRAVAKQQKE SESTQKAEKE VTRMVVVMVF AYCLCWGPYT FFACFATAHP GYAFHPLVAS 

       310        320        330        340        350 
LPSYFAKSAT IYNPIIYVFM NRQFRNCILH LFGKKVDDSS ELSSTSKTEV SSVSSVSPA 

« Hide

References

« Hide 'large scale' references
[1]"Mechanisms of spectral tuning in the mouse green cone pigment."
Sun H., Macke J.P., Nathans J.
Proc. Natl. Acad. Sci. U.S.A. 94:8860-8865(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning."
Applebury M.L., Antoch M.P., Baxter L.C., Chun L.Y., Falk J.D., Farhangfar F., Kage K., Krzystolik M.G., Lyass L.A., Robbins J.T.
Neuron 27:513-523(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: BALB/c and C57BL/10.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF011389 mRNA. Translation: AAB64302.1.
AF190672 mRNA. Translation: AAG17991.1.
AF191085 expand/collapse EMBL AC list , AF191080, AF191081, AF191082, AF191083, AF191084 Genomic DNA. Translation: AAG17992.1.
BC014826 mRNA. Translation: AAH14826.1.
CCDSCCDS30220.1.
RefSeqNP_032132.1. NM_008106.2.
UniGeneMm.284825.

3D structure databases

ProteinModelPortalO35599.
SMRO35599. Positions 16-354.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO35599.

Proteomic databases

PRIDEO35599.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033771; ENSMUSP00000033771; ENSMUSG00000031394.
GeneID14539.
KEGGmmu:14539.
UCSCuc009tnv.1. mouse.

Organism-specific databases

CTD2652.
MGIMGI:1097692. Opn1mw.

Phylogenomic databases

eggNOGNOG240324.
GeneTreeENSGT00710000106574.
HOGENOMHOG000253932.
HOVERGENHBG107442.
KOK04251.
OrthoDBEOG72NRQJ.
PhylomeDBO35599.
TreeFamTF324998.

Gene expression databases

BgeeO35599.
GenevestigatorO35599.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR000378. Opsin_red/grn.
IPR027430. Retinal_BS.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00575. OPSINREDGRN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286212.
PROO35599.
SOURCESearch...

Entry information

Entry nameOPSG_MOUSE
AccessionPrimary (citable) accession number: O35599
Secondary accession number(s): Q548Z4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries