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O35599

- OPSG_MOUSE

UniProt

O35599 - OPSG_MOUSE

Protein

Medium-wave-sensitive opsin 1

Gene

Opn1mw

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. photoreceptor activity Source: UniProtKB-KW
    3. protein binding Source: MGI

    GO - Biological processi

    1. phototransduction Source: UniProtKB-KW
    2. protein-chromophore linkage Source: UniProtKB-KW
    3. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    Chromophore

    Enzyme and pathway databases

    ReactomeiREACT_196615. Retinoid cycle disease events.
    REACT_196617. The retinoid cycle in cones (daylight vision).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Medium-wave-sensitive opsin 1
    Alternative name(s):
    Green cone photoreceptor pigment
    Green-sensitive opsin
    Short name:
    M opsin
    Medium wavelength-sensitive cone opsin
    Gene namesi
    Name:Opn1mw
    Synonyms:Gcp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1097692. Opn1mw.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. photoreceptor outer segment Source: MGI
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Medium-wave-sensitive opsin 1PRO_0000197786Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)Curated
    Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
    Modified residuei307 – 3071N6-(retinylidene)lysine

    Post-translational modificationi

    Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiO35599.

    PTM databases

    PhosphoSiteiO35599.

    Expressioni

    Tissue specificityi

    Expressed in cone photoreceptor cells.1 Publication

    Gene expression databases

    BgeeiO35599.
    GenevestigatoriO35599.

    Structurei

    3D structure databases

    ProteinModelPortaliO35599.
    SMRiO35599. Positions 16-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4747ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini73 – 8412CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini111 – 12414ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini145 – 16319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini188 – 21326ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini242 – 26322CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini288 – 2958ExtracellularSequence Analysis
    Topological domaini321 – 35939CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 7225Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei85 – 11026Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei125 – 14420Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei164 – 18724Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei214 – 24128Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei264 – 28724Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei296 – 32025Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG240324.
    GeneTreeiENSGT00710000106574.
    HOGENOMiHOG000253932.
    HOVERGENiHBG107442.
    KOiK04251.
    OrthoDBiEOG72NRQJ.
    PhylomeDBiO35599.
    TreeFamiTF324998.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001760. Opsin.
    IPR000378. Opsin_red/grn.
    IPR027430. Retinal_BS.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00238. OPSIN.
    PR00575. OPSINREDGRN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35599-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQRLTGEQT LDHYEDSTHA SIFTYTNSNS TKGPFEGPNY HIAPRWVYHL    50
    TSTWMILVVV ASVFTNGLVL AATMRFKKLR HPLNWILVNL AVADLAETII 100
    ASTISVVNQI YGYFVLGHPL CVIEGYIVSL CGITGLWSLA IISWERWLVV 150
    CKPFGNVRFD AKLATVGIVF SWVWAAIWTA PPIFGWSRYW PYGLKTSCGP 200
    DVFSGTSYPG VQSYMMVLMV TCCIFPLSII VLCYLQVWLA IRAVAKQQKE 250
    SESTQKAEKE VTRMVVVMVF AYCLCWGPYT FFACFATAHP GYAFHPLVAS 300
    LPSYFAKSAT IYNPIIYVFM NRQFRNCILH LFGKKVDDSS ELSSTSKTEV 350
    SSVSSVSPA 359
    Length:359
    Mass (Da):40,218
    Last modified:January 1, 1998 - v1
    Checksum:i1BB5F531A6FAE357
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF011389 mRNA. Translation: AAB64302.1.
    AF190672 mRNA. Translation: AAG17991.1.
    AF191085
    , AF191080, AF191081, AF191082, AF191083, AF191084 Genomic DNA. Translation: AAG17992.1.
    BC014826 mRNA. Translation: AAH14826.1.
    CCDSiCCDS30220.1.
    RefSeqiNP_032132.1. NM_008106.2.
    UniGeneiMm.284825.

    Genome annotation databases

    EnsembliENSMUST00000033771; ENSMUSP00000033771; ENSMUSG00000031394.
    GeneIDi14539.
    KEGGimmu:14539.
    UCSCiuc009tnv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF011389 mRNA. Translation: AAB64302.1 .
    AF190672 mRNA. Translation: AAG17991.1 .
    AF191085
    , AF191080 , AF191081 , AF191082 , AF191083 , AF191084 Genomic DNA. Translation: AAG17992.1 .
    BC014826 mRNA. Translation: AAH14826.1 .
    CCDSi CCDS30220.1.
    RefSeqi NP_032132.1. NM_008106.2.
    UniGenei Mm.284825.

    3D structure databases

    ProteinModelPortali O35599.
    SMRi O35599. Positions 16-354.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O35599.

    Proteomic databases

    PRIDEi O35599.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033771 ; ENSMUSP00000033771 ; ENSMUSG00000031394 .
    GeneIDi 14539.
    KEGGi mmu:14539.
    UCSCi uc009tnv.1. mouse.

    Organism-specific databases

    CTDi 2652.
    MGIi MGI:1097692. Opn1mw.

    Phylogenomic databases

    eggNOGi NOG240324.
    GeneTreei ENSGT00710000106574.
    HOGENOMi HOG000253932.
    HOVERGENi HBG107442.
    KOi K04251.
    OrthoDBi EOG72NRQJ.
    PhylomeDBi O35599.
    TreeFami TF324998.

    Enzyme and pathway databases

    Reactomei REACT_196615. Retinoid cycle disease events.
    REACT_196617. The retinoid cycle in cones (daylight vision).

    Miscellaneous databases

    NextBioi 286212.
    PROi O35599.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35599.
    Genevestigatori O35599.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001760. Opsin.
    IPR000378. Opsin_red/grn.
    IPR027430. Retinal_BS.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00238. OPSIN.
    PR00575. OPSINREDGRN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mechanisms of spectral tuning in the mouse green cone pigment."
      Sun H., Macke J.P., Nathans J.
      Proc. Natl. Acad. Sci. U.S.A. 94:8860-8865(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning."
      Applebury M.L., Antoch M.P., Baxter L.C., Chun L.Y., Falk J.D., Farhangfar F., Kage K., Krzystolik M.G., Lyass L.A., Robbins J.T.
      Neuron 27:513-523(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: BALB/c and C57BL/10.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Retina.

    Entry informationi

    Entry nameiOPSG_MOUSE
    AccessioniPrimary (citable) accession number: O35599
    Secondary accession number(s): Q548Z4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3