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O35595

- PTC2_MOUSE

UniProt

O35595 - PTC2_MOUSE

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Protein

Protein patched homolog 2

Gene

Ptch2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).

GO - Molecular functioni

  1. hedgehog receptor activity Source: InterPro

GO - Biological processi

  1. epidermis development Source: MGI
  2. hair cycle Source: MGI
  3. skin development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein patched homolog 2
Short name:
PTC2
Gene namesi
Name:Ptch2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1095405. Ptch2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11821182Protein patched homolog 2PRO_0000205971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi812 – 8121N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO35595.

PTM databases

PhosphoSiteiO35595.

Expressioni

Tissue specificityi

Expressed in epithelial cells of the developing hair, tooth and whisker.

Developmental stagei

Detected in 8.5 to 17.5 dpc embryos.

Gene expression databases

BgeeiO35595.
CleanExiMM_PTCH2.
ExpressionAtlasiO35595. baseline and differential.
GenevestigatoriO35595.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030443.

Structurei

3D structure databases

ProteinModelPortaliO35595.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini79 – 394316ExtracellularSequence AnalysisAdd
BLAST
Topological domaini415 – 42814CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini450 – 4578ExtracellularSequence Analysis
Topological domaini479 – 50123CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini523 – 5319ExtracellularSequence Analysis
Topological domaini553 – 686134CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini708 – 963256ExtracellularSequence AnalysisAdd
BLAST
Topological domaini985 – 9917CytoplasmicSequence Analysis
Topological domaini1013 – 10131ExtracellularSequence Analysis
Topological domaini1035 – 106430CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini1086 – 10861ExtracellularSequence Analysis
Topological domaini1108 – 118275CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei58 – 7821HelicalSequence AnalysisAdd
BLAST
Transmembranei395 – 41420HelicalSequence AnalysisAdd
BLAST
Transmembranei429 – 44921HelicalSequence AnalysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence AnalysisAdd
BLAST
Transmembranei502 – 52221HelicalSequence AnalysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence AnalysisAdd
BLAST
Transmembranei687 – 70721HelicalSequence AnalysisAdd
BLAST
Transmembranei964 – 98421HelicalSequence AnalysisAdd
BLAST
Transmembranei992 – 101221HelicalSequence AnalysisAdd
BLAST
Transmembranei1014 – 103421HelicalSequence AnalysisAdd
BLAST
Transmembranei1065 – 108521HelicalSequence AnalysisAdd
BLAST
Transmembranei1087 – 110721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini394 – 552159SSDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the patched family.Curated
Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG313603.
GeneTreeiENSGT00760000119174.
HOGENOMiHOG000231331.
HOVERGENiHBG003801.
InParanoidiO35595.
KOiK11101.
OMAiHCEASSQ.
OrthoDBiEOG7HMS06.
PhylomeDBiO35595.
TreeFamiTF106489.

Family and domain databases

InterProiIPR003392. Patched.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view]
PfamiPF02460. Patched. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00918. 2A060602. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35595-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRPLSLGEL PPSYTPPARS SAPHILAGSL QAPLWLRAYF QGLLFSLGCR
60 70 80 90 100
IQKHCGKVLF LGLVAFGALA LGLRVAVIET DLEQLWVEVG SRVSQELHYT
110 120 130 140 150
KEKLGEEAAY TSQMLIQTAH QEGGNVLTPE ALDLHLQAAL TASKVQVSLY
160 170 180 190 200
GKSWDLNKIC YKSGVPLIEN GMIERMIEKL FPCVILTPLD CFWEGAKLQG
210 220 230 240 250
GSAYLPGRPD IQWTNLDPQQ LLEELGPFAS LEGFRELLDK AQVGQAYVGR
260 270 280 290 300
PCLDPDDPHC PPSAPNRHSR QAPNVAQELS GGCHGFSHKF MHWQEELLLG
310 320 330 340 350
GTARDLQGQL LRAEALQSTF LLMSPRQLYE HFRGDYQTHD IGWSEEQASM
360 370 380 390 400
VLQAWQRRFV QLAQEALPAN ASQQIHAFSS TTLDDILRAF SEVSTTRVVG
410 420 430 440 450
GYLLMLAYAC VTMLRWDCAQ SQGAVGLAGV LLVALAVASG LGLCALLGIT
460 470 480 490 500
FNAATTQVLP FLALGIGVDD IFLLAHAFTK APPDTPLPER MGECLRSTGT
510 520 530 540 550
SVALTSVNNM VAFFMAALVP IPALRAFSLQ AAIVVGCNFA AVMLVFPAIL
560 570 580 590 600
SLDLRRRHRQ RLDVLCCFSS PCSAQVIQML PQELGDRAVP VGIAHLTATV
610 620 630 640 650
QAFTHCEASS QHVVTILPPQ AHLLSPASDP LGSELYSPGG STRDLLSQEE
660 670 680 690 700
GTGPQAACRP LLCAHWTLAH FARYQFAPLL LQTRAKALVL LFFGALLGLS
710 720 730 740 750
LYGATLVQDG LALTDVVPRG TKEHAFLSAQ LRYFSLYEVA LVTQGGFDYA
760 770 780 790 800
HSQRALFDLH QRFSSLKAVL PPPATQAPRT WLHYYRSWLQ GIQAAFDQDW
810 820 830 840 850
ASGRITCHSY RNGSEDGALA YKLLIQTGNA QEPLDFSQLT TRKLVDKEGL
860 870 880 890 900
IPPELFYMGL TVWVSSDPLG LAASQANFYP PPPEWLHDKY DTTGENLRIP
910 920 930 940 950
AAQPLEFAQF PFLLHGLQKT ADFVEAIEGA RAACTEAGQA GVHAYPSGSP
960 970 980 990 1000
FLFWEQYLGL RRCFLLAVCI LLVCTFLVCA LLLLSPWTAG LIVLVLAMMT
1010 1020 1030 1040 1050
VELFGIMGFL GIKLSAIPVV ILVASIGIGV EFTVHVALGF LTSHGSRNLR
1060 1070 1080 1090 1100
AASALEQTFA PVTDGAVSTL LGLLMLAGSN FDFIIRYFFV VLTVLTLLGL
1110 1120 1130 1140 1150
LHGLLLLPVL LSILGPPPQV VQVYKESPQT LNSAAPQRGG LRWDRPPTLP
1160 1170 1180
QSFARVTTSM TVALHPPPLP GAYVHPASEE PT
Length:1,182
Mass (Da):128,586
Last modified:August 1, 1998 - v2
Checksum:i715233D912C352F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133482
, AJ133483, AJ133484, AJ133485 Genomic DNA. Translation: CAC88120.1.
AL671866 Genomic DNA. Translation: CAM26330.1.
AB010833 mRNA. Translation: BAA24691.1.
CCDSiCCDS18526.1.
PIRiT13952.
RefSeqiNP_032984.1. NM_008958.2.
UniGeneiMm.287037.

Genome annotation databases

EnsembliENSMUST00000030443; ENSMUSP00000030443; ENSMUSG00000028681.
GeneIDi19207.
KEGGimmu:19207.
UCSCiuc008uhx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ133482
, AJ133483 , AJ133484 , AJ133485 Genomic DNA. Translation: CAC88120.1 .
AL671866 Genomic DNA. Translation: CAM26330.1 .
AB010833 mRNA. Translation: BAA24691.1 .
CCDSi CCDS18526.1.
PIRi T13952.
RefSeqi NP_032984.1. NM_008958.2.
UniGenei Mm.287037.

3D structure databases

ProteinModelPortali O35595.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000030443.

PTM databases

PhosphoSitei O35595.

Proteomic databases

PRIDEi O35595.

Protocols and materials databases

DNASUi 19207.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030443 ; ENSMUSP00000030443 ; ENSMUSG00000028681 .
GeneIDi 19207.
KEGGi mmu:19207.
UCSCi uc008uhx.1. mouse.

Organism-specific databases

CTDi 8643.
MGIi MGI:1095405. Ptch2.

Phylogenomic databases

eggNOGi NOG313603.
GeneTreei ENSGT00760000119174.
HOGENOMi HOG000231331.
HOVERGENi HBG003801.
InParanoidi O35595.
KOi K11101.
OMAi HCEASSQ.
OrthoDBi EOG7HMS06.
PhylomeDBi O35595.
TreeFami TF106489.

Miscellaneous databases

NextBioi 295942.
PROi O35595.
SOURCEi Search...

Gene expression databases

Bgeei O35595.
CleanExi MM_PTCH2.
ExpressionAtlasi O35595. baseline and differential.
Genevestigatori O35595.

Family and domain databases

InterProi IPR003392. Patched.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view ]
Pfami PF02460. Patched. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00918. 2A060602. 1 hit.
PROSITEi PS50156. SSD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog."
    Motoyama J., Takabatake T., Takeshima K., Hui C.-C.
    Nat. Genet. 18:104-106(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Embryo.
  2. "Genomic structure and refined chromosomal localization of the mouse Ptch2 gene."
    Froehlich L., Zhanquin L., Beier D.R., Lanske B.
    Cytogenet. Genome Res. 97:106-110(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "Hedgehog and patched gene expression in adult ocular tissues."
    Takabatake T., Ogawa M., Takahashi T.C., Mizuno M., Okamoto M., Takeshima K.
    FEBS Lett. 410:485-489(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 196-446.
    Strain: BALB/c.
    Tissue: Neuroretina.

Entry informationi

Entry nameiPTC2_MOUSE
AccessioniPrimary (citable) accession number: O35595
Secondary accession number(s): A2AE82, Q546T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3