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Protein

Protein patched homolog 2

Gene

Ptch2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).

GO - Molecular functioni

GO - Biological processi

  • cell fate determination Source: MGI
  • epidermal cell fate specification Source: MGI
  • epidermis development Source: MGI
  • hair cycle Source: MGI
  • positive regulation of epidermal cell differentiation Source: MGI
  • skin development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein patched homolog 2
Short name:
PTC2
Gene namesi
Name:Ptch2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1095405. Ptch2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57CytoplasmicSequence analysisAdd BLAST57
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 394ExtracellularSequence analysisAdd BLAST316
Transmembranei395 – 414HelicalSequence analysisAdd BLAST20
Topological domaini415 – 428CytoplasmicSequence analysisAdd BLAST14
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 457ExtracellularSequence analysis8
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Topological domaini479 – 501CytoplasmicSequence analysisAdd BLAST23
Transmembranei502 – 522HelicalSequence analysisAdd BLAST21
Topological domaini523 – 531ExtracellularSequence analysis9
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 686CytoplasmicSequence analysisAdd BLAST134
Transmembranei687 – 707HelicalSequence analysisAdd BLAST21
Topological domaini708 – 963ExtracellularSequence analysisAdd BLAST256
Transmembranei964 – 984HelicalSequence analysisAdd BLAST21
Topological domaini985 – 991CytoplasmicSequence analysis7
Transmembranei992 – 1012HelicalSequence analysisAdd BLAST21
Topological domaini1013ExtracellularSequence analysis1
Transmembranei1014 – 1034HelicalSequence analysisAdd BLAST21
Topological domaini1035 – 1064CytoplasmicSequence analysisAdd BLAST30
Transmembranei1065 – 1085HelicalSequence analysisAdd BLAST21
Topological domaini1086ExtracellularSequence analysis1
Transmembranei1087 – 1107HelicalSequence analysisAdd BLAST21
Topological domaini1108 – 1182CytoplasmicSequence analysisAdd BLAST75

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002059711 – 1182Protein patched homolog 2Add BLAST1182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi370N-linked (GlcNAc...)Sequence analysis1
Glycosylationi812N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO35595.
PRIDEiO35595.

PTM databases

iPTMnetiO35595.
PhosphoSitePlusiO35595.

Expressioni

Tissue specificityi

Expressed in epithelial cells of the developing hair, tooth and whisker.

Developmental stagei

Detected in 8.5 to 17.5 dpc embryos.

Gene expression databases

BgeeiENSMUSG00000028681.
CleanExiMM_PTCH2.
ExpressionAtlasiO35595. baseline and differential.
GenevisibleiO35595. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030443.

Structurei

3D structure databases

ProteinModelPortaliO35595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini394 – 552SSDPROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Belongs to the patched family.Curated
Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1935. Eukaryota.
ENOG410XRKU. LUCA.
GeneTreeiENSGT00800000124043.
HOGENOMiHOG000231331.
HOVERGENiHBG003801.
InParanoidiO35595.
KOiK11101.
OMAiGAYIHPA.
OrthoDBiEOG091G0LGQ.
PhylomeDBiO35595.
TreeFamiTF106489.

Family and domain databases

InterProiIPR003392. Ptc/Disp.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view]
PfamiPF02460. Patched. 1 hit.
PF12349. Sterol-sensing. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00918. 2A060602. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRPLSLGEL PPSYTPPARS SAPHILAGSL QAPLWLRAYF QGLLFSLGCR
60 70 80 90 100
IQKHCGKVLF LGLVAFGALA LGLRVAVIET DLEQLWVEVG SRVSQELHYT
110 120 130 140 150
KEKLGEEAAY TSQMLIQTAH QEGGNVLTPE ALDLHLQAAL TASKVQVSLY
160 170 180 190 200
GKSWDLNKIC YKSGVPLIEN GMIERMIEKL FPCVILTPLD CFWEGAKLQG
210 220 230 240 250
GSAYLPGRPD IQWTNLDPQQ LLEELGPFAS LEGFRELLDK AQVGQAYVGR
260 270 280 290 300
PCLDPDDPHC PPSAPNRHSR QAPNVAQELS GGCHGFSHKF MHWQEELLLG
310 320 330 340 350
GTARDLQGQL LRAEALQSTF LLMSPRQLYE HFRGDYQTHD IGWSEEQASM
360 370 380 390 400
VLQAWQRRFV QLAQEALPAN ASQQIHAFSS TTLDDILRAF SEVSTTRVVG
410 420 430 440 450
GYLLMLAYAC VTMLRWDCAQ SQGAVGLAGV LLVALAVASG LGLCALLGIT
460 470 480 490 500
FNAATTQVLP FLALGIGVDD IFLLAHAFTK APPDTPLPER MGECLRSTGT
510 520 530 540 550
SVALTSVNNM VAFFMAALVP IPALRAFSLQ AAIVVGCNFA AVMLVFPAIL
560 570 580 590 600
SLDLRRRHRQ RLDVLCCFSS PCSAQVIQML PQELGDRAVP VGIAHLTATV
610 620 630 640 650
QAFTHCEASS QHVVTILPPQ AHLLSPASDP LGSELYSPGG STRDLLSQEE
660 670 680 690 700
GTGPQAACRP LLCAHWTLAH FARYQFAPLL LQTRAKALVL LFFGALLGLS
710 720 730 740 750
LYGATLVQDG LALTDVVPRG TKEHAFLSAQ LRYFSLYEVA LVTQGGFDYA
760 770 780 790 800
HSQRALFDLH QRFSSLKAVL PPPATQAPRT WLHYYRSWLQ GIQAAFDQDW
810 820 830 840 850
ASGRITCHSY RNGSEDGALA YKLLIQTGNA QEPLDFSQLT TRKLVDKEGL
860 870 880 890 900
IPPELFYMGL TVWVSSDPLG LAASQANFYP PPPEWLHDKY DTTGENLRIP
910 920 930 940 950
AAQPLEFAQF PFLLHGLQKT ADFVEAIEGA RAACTEAGQA GVHAYPSGSP
960 970 980 990 1000
FLFWEQYLGL RRCFLLAVCI LLVCTFLVCA LLLLSPWTAG LIVLVLAMMT
1010 1020 1030 1040 1050
VELFGIMGFL GIKLSAIPVV ILVASIGIGV EFTVHVALGF LTSHGSRNLR
1060 1070 1080 1090 1100
AASALEQTFA PVTDGAVSTL LGLLMLAGSN FDFIIRYFFV VLTVLTLLGL
1110 1120 1130 1140 1150
LHGLLLLPVL LSILGPPPQV VQVYKESPQT LNSAAPQRGG LRWDRPPTLP
1160 1170 1180
QSFARVTTSM TVALHPPPLP GAYVHPASEE PT
Length:1,182
Mass (Da):128,586
Last modified:August 1, 1998 - v2
Checksum:i715233D912C352F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133482
, AJ133483, AJ133484, AJ133485 Genomic DNA. Translation: CAC88120.1.
AL671866 Genomic DNA. Translation: CAM26330.1.
AB010833 mRNA. Translation: BAA24691.1.
CCDSiCCDS18526.1.
PIRiT13952.
RefSeqiNP_032984.1. NM_008958.3.
UniGeneiMm.287037.

Genome annotation databases

EnsembliENSMUST00000030443; ENSMUSP00000030443; ENSMUSG00000028681.
GeneIDi19207.
KEGGimmu:19207.
UCSCiuc008uhx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133482
, AJ133483, AJ133484, AJ133485 Genomic DNA. Translation: CAC88120.1.
AL671866 Genomic DNA. Translation: CAM26330.1.
AB010833 mRNA. Translation: BAA24691.1.
CCDSiCCDS18526.1.
PIRiT13952.
RefSeqiNP_032984.1. NM_008958.3.
UniGeneiMm.287037.

3D structure databases

ProteinModelPortaliO35595.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030443.

PTM databases

iPTMnetiO35595.
PhosphoSitePlusiO35595.

Proteomic databases

PaxDbiO35595.
PRIDEiO35595.

Protocols and materials databases

DNASUi19207.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030443; ENSMUSP00000030443; ENSMUSG00000028681.
GeneIDi19207.
KEGGimmu:19207.
UCSCiuc008uhx.1. mouse.

Organism-specific databases

CTDi8643.
MGIiMGI:1095405. Ptch2.

Phylogenomic databases

eggNOGiKOG1935. Eukaryota.
ENOG410XRKU. LUCA.
GeneTreeiENSGT00800000124043.
HOGENOMiHOG000231331.
HOVERGENiHBG003801.
InParanoidiO35595.
KOiK11101.
OMAiGAYIHPA.
OrthoDBiEOG091G0LGQ.
PhylomeDBiO35595.
TreeFamiTF106489.

Miscellaneous databases

PROiO35595.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028681.
CleanExiMM_PTCH2.
ExpressionAtlasiO35595. baseline and differential.
GenevisibleiO35595. MM.

Family and domain databases

InterProiIPR003392. Ptc/Disp.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view]
PfamiPF02460. Patched. 1 hit.
PF12349. Sterol-sensing. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00918. 2A060602. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTC2_MOUSE
AccessioniPrimary (citable) accession number: O35595
Secondary accession number(s): A2AE82, Q546T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.