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O35595 (PTC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein patched homolog 2

Short name=PTC2
Gene names
Name:Ptch2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1182 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in epithelial cells of the developing hair, tooth and whisker.

Developmental stage

Detected in 8.5 to 17.5 dpc embryos.

Sequence similarities

Belongs to the patched family.

Contains 1 SSD (sterol-sensing) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11821182Protein patched homolog 2
PRO_0000205971

Regions

Topological domain1 – 5757Cytoplasmic Potential
Transmembrane58 – 7821Helical; Potential
Topological domain79 – 394316Extracellular Potential
Transmembrane395 – 41420Helical; Potential
Topological domain415 – 42814Cytoplasmic Potential
Transmembrane429 – 44921Helical; Potential
Topological domain450 – 4578Extracellular Potential
Transmembrane458 – 47821Helical; Potential
Topological domain479 – 50123Cytoplasmic Potential
Transmembrane502 – 52221Helical; Potential
Topological domain523 – 5319Extracellular Potential
Transmembrane532 – 55221Helical; Potential
Topological domain553 – 686134Cytoplasmic Potential
Transmembrane687 – 70721Helical; Potential
Topological domain708 – 963256Extracellular Potential
Transmembrane964 – 98421Helical; Potential
Topological domain985 – 9917Cytoplasmic Potential
Transmembrane992 – 101221Helical; Potential
Topological domain10131Extracellular Potential
Transmembrane1014 – 103421Helical; Potential
Topological domain1035 – 106430Cytoplasmic Potential
Transmembrane1065 – 108521Helical; Potential
Topological domain10861Extracellular Potential
Transmembrane1087 – 110721Helical; Potential
Topological domain1108 – 118275Cytoplasmic Potential
Domain394 – 552159SSD

Amino acid modifications

Glycosylation3701N-linked (GlcNAc...) Potential
Glycosylation8121N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O35595 [UniParc].

Last modified August 1, 1998. Version 2.
Checksum: 715233D912C352F2

FASTA1,182128,586
        10         20         30         40         50         60 
MVRPLSLGEL PPSYTPPARS SAPHILAGSL QAPLWLRAYF QGLLFSLGCR IQKHCGKVLF 

        70         80         90        100        110        120 
LGLVAFGALA LGLRVAVIET DLEQLWVEVG SRVSQELHYT KEKLGEEAAY TSQMLIQTAH 

       130        140        150        160        170        180 
QEGGNVLTPE ALDLHLQAAL TASKVQVSLY GKSWDLNKIC YKSGVPLIEN GMIERMIEKL 

       190        200        210        220        230        240 
FPCVILTPLD CFWEGAKLQG GSAYLPGRPD IQWTNLDPQQ LLEELGPFAS LEGFRELLDK 

       250        260        270        280        290        300 
AQVGQAYVGR PCLDPDDPHC PPSAPNRHSR QAPNVAQELS GGCHGFSHKF MHWQEELLLG 

       310        320        330        340        350        360 
GTARDLQGQL LRAEALQSTF LLMSPRQLYE HFRGDYQTHD IGWSEEQASM VLQAWQRRFV 

       370        380        390        400        410        420 
QLAQEALPAN ASQQIHAFSS TTLDDILRAF SEVSTTRVVG GYLLMLAYAC VTMLRWDCAQ 

       430        440        450        460        470        480 
SQGAVGLAGV LLVALAVASG LGLCALLGIT FNAATTQVLP FLALGIGVDD IFLLAHAFTK 

       490        500        510        520        530        540 
APPDTPLPER MGECLRSTGT SVALTSVNNM VAFFMAALVP IPALRAFSLQ AAIVVGCNFA 

       550        560        570        580        590        600 
AVMLVFPAIL SLDLRRRHRQ RLDVLCCFSS PCSAQVIQML PQELGDRAVP VGIAHLTATV 

       610        620        630        640        650        660 
QAFTHCEASS QHVVTILPPQ AHLLSPASDP LGSELYSPGG STRDLLSQEE GTGPQAACRP 

       670        680        690        700        710        720 
LLCAHWTLAH FARYQFAPLL LQTRAKALVL LFFGALLGLS LYGATLVQDG LALTDVVPRG 

       730        740        750        760        770        780 
TKEHAFLSAQ LRYFSLYEVA LVTQGGFDYA HSQRALFDLH QRFSSLKAVL PPPATQAPRT 

       790        800        810        820        830        840 
WLHYYRSWLQ GIQAAFDQDW ASGRITCHSY RNGSEDGALA YKLLIQTGNA QEPLDFSQLT 

       850        860        870        880        890        900 
TRKLVDKEGL IPPELFYMGL TVWVSSDPLG LAASQANFYP PPPEWLHDKY DTTGENLRIP 

       910        920        930        940        950        960 
AAQPLEFAQF PFLLHGLQKT ADFVEAIEGA RAACTEAGQA GVHAYPSGSP FLFWEQYLGL 

       970        980        990       1000       1010       1020 
RRCFLLAVCI LLVCTFLVCA LLLLSPWTAG LIVLVLAMMT VELFGIMGFL GIKLSAIPVV 

      1030       1040       1050       1060       1070       1080 
ILVASIGIGV EFTVHVALGF LTSHGSRNLR AASALEQTFA PVTDGAVSTL LGLLMLAGSN 

      1090       1100       1110       1120       1130       1140 
FDFIIRYFFV VLTVLTLLGL LHGLLLLPVL LSILGPPPQV VQVYKESPQT LNSAAPQRGG 

      1150       1160       1170       1180 
LRWDRPPTLP QSFARVTTSM TVALHPPPLP GAYVHPASEE PT 

« Hide

References

« Hide 'large scale' references
[1]"Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog."
Motoyama J., Takabatake T., Takeshima K., Hui C.-C.
Nat. Genet. 18:104-106(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Embryo.
[2]"Genomic structure and refined chromosomal localization of the mouse Ptch2 gene."
Froehlich L., Zhanquin L., Beier D.R., Lanske B.
Cytogenet. Genome Res. 97:106-110(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
Tissue: Liver.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"Hedgehog and patched gene expression in adult ocular tissues."
Takabatake T., Ogawa M., Takahashi T.C., Mizuno M., Okamoto M., Takeshima K.
FEBS Lett. 410:485-489(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 196-446.
Strain: BALB/c.
Tissue: Neuroretina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ133482 expand/collapse EMBL AC list , AJ133483, AJ133484, AJ133485 Genomic DNA. Translation: CAC88120.1.
AL671866 Genomic DNA. Translation: CAM26330.1.
AB010833 mRNA. Translation: BAA24691.1.
CCDSCCDS18526.1.
PIRT13952.
RefSeqNP_032984.1. NM_008958.2.
UniGeneMm.287037.

3D structure databases

ProteinModelPortalO35595.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000030443.

PTM databases

PhosphoSiteO35595.

Proteomic databases

PRIDEO35595.

Protocols and materials databases

DNASU19207.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030443; ENSMUSP00000030443; ENSMUSG00000028681.
GeneID19207.
KEGGmmu:19207.
UCSCuc008uhx.1. mouse.

Organism-specific databases

CTD8643.
MGIMGI:1095405. Ptch2.

Phylogenomic databases

eggNOGNOG313603.
GeneTreeENSGT00680000099777.
HOGENOMHOG000231331.
HOVERGENHBG003801.
InParanoidA2AE82.
KOK11101.
OMAHCEASSQ.
OrthoDBEOG7HMS06.
PhylomeDBO35595.
TreeFamTF106489.

Gene expression databases

ArrayExpressO35595.
BgeeO35595.
CleanExMM_PTCH2.
GenevestigatorO35595.

Family and domain databases

InterProIPR003392. Patched.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view]
PfamPF02460. Patched. 1 hit.
[Graphical view]
TIGRFAMsTIGR00918. 2A060602. 1 hit.
PROSITEPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295942.
PROO35595.
SOURCESearch...

Entry information

Entry namePTC2_MOUSE
AccessionPrimary (citable) accession number: O35595
Secondary accession number(s): A2AE82, Q546T0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot