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O35595

- PTC2_MOUSE

UniProt

O35595 - PTC2_MOUSE

Protein

Protein patched homolog 2

Gene

Ptch2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).

    GO - Molecular functioni

    1. hedgehog receptor activity Source: InterPro

    GO - Biological processi

    1. epidermis development Source: MGI
    2. hair cycle Source: MGI
    3. skin development Source: MGI

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein patched homolog 2
    Short name:
    PTC2
    Gene namesi
    Name:Ptch2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1095405. Ptch2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11821182Protein patched homolog 2PRO_0000205971Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi812 – 8121N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiO35595.

    PTM databases

    PhosphoSiteiO35595.

    Expressioni

    Tissue specificityi

    Expressed in epithelial cells of the developing hair, tooth and whisker.

    Developmental stagei

    Detected in 8.5 to 17.5 dpc embryos.

    Gene expression databases

    ArrayExpressiO35595.
    BgeeiO35595.
    CleanExiMM_PTCH2.
    GenevestigatoriO35595.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000030443.

    Structurei

    3D structure databases

    ProteinModelPortaliO35595.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5757CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini79 – 394316ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini415 – 42814CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini450 – 4578ExtracellularSequence Analysis
    Topological domaini479 – 50123CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini523 – 5319ExtracellularSequence Analysis
    Topological domaini553 – 686134CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini708 – 963256ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini985 – 9917CytoplasmicSequence Analysis
    Topological domaini1013 – 10131ExtracellularSequence Analysis
    Topological domaini1035 – 106430CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1086 – 10861ExtracellularSequence Analysis
    Topological domaini1108 – 118275CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei58 – 7821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei395 – 41420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei429 – 44921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei458 – 47821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei502 – 52221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei532 – 55221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei687 – 70721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei964 – 98421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei992 – 101221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1014 – 103421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1065 – 108521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1087 – 110721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini394 – 552159SSDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the patched family.Curated
    Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG313603.
    GeneTreeiENSGT00680000099777.
    HOGENOMiHOG000231331.
    HOVERGENiHBG003801.
    InParanoidiA2AE82.
    KOiK11101.
    OMAiHCEASSQ.
    OrthoDBiEOG7HMS06.
    PhylomeDBiO35595.
    TreeFamiTF106489.

    Family and domain databases

    InterProiIPR003392. Patched.
    IPR000731. SSD.
    IPR004766. TM_rcpt_patched.
    [Graphical view]
    PfamiPF02460. Patched. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00918. 2A060602. 1 hit.
    PROSITEiPS50156. SSD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35595-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRPLSLGEL PPSYTPPARS SAPHILAGSL QAPLWLRAYF QGLLFSLGCR     50
    IQKHCGKVLF LGLVAFGALA LGLRVAVIET DLEQLWVEVG SRVSQELHYT 100
    KEKLGEEAAY TSQMLIQTAH QEGGNVLTPE ALDLHLQAAL TASKVQVSLY 150
    GKSWDLNKIC YKSGVPLIEN GMIERMIEKL FPCVILTPLD CFWEGAKLQG 200
    GSAYLPGRPD IQWTNLDPQQ LLEELGPFAS LEGFRELLDK AQVGQAYVGR 250
    PCLDPDDPHC PPSAPNRHSR QAPNVAQELS GGCHGFSHKF MHWQEELLLG 300
    GTARDLQGQL LRAEALQSTF LLMSPRQLYE HFRGDYQTHD IGWSEEQASM 350
    VLQAWQRRFV QLAQEALPAN ASQQIHAFSS TTLDDILRAF SEVSTTRVVG 400
    GYLLMLAYAC VTMLRWDCAQ SQGAVGLAGV LLVALAVASG LGLCALLGIT 450
    FNAATTQVLP FLALGIGVDD IFLLAHAFTK APPDTPLPER MGECLRSTGT 500
    SVALTSVNNM VAFFMAALVP IPALRAFSLQ AAIVVGCNFA AVMLVFPAIL 550
    SLDLRRRHRQ RLDVLCCFSS PCSAQVIQML PQELGDRAVP VGIAHLTATV 600
    QAFTHCEASS QHVVTILPPQ AHLLSPASDP LGSELYSPGG STRDLLSQEE 650
    GTGPQAACRP LLCAHWTLAH FARYQFAPLL LQTRAKALVL LFFGALLGLS 700
    LYGATLVQDG LALTDVVPRG TKEHAFLSAQ LRYFSLYEVA LVTQGGFDYA 750
    HSQRALFDLH QRFSSLKAVL PPPATQAPRT WLHYYRSWLQ GIQAAFDQDW 800
    ASGRITCHSY RNGSEDGALA YKLLIQTGNA QEPLDFSQLT TRKLVDKEGL 850
    IPPELFYMGL TVWVSSDPLG LAASQANFYP PPPEWLHDKY DTTGENLRIP 900
    AAQPLEFAQF PFLLHGLQKT ADFVEAIEGA RAACTEAGQA GVHAYPSGSP 950
    FLFWEQYLGL RRCFLLAVCI LLVCTFLVCA LLLLSPWTAG LIVLVLAMMT 1000
    VELFGIMGFL GIKLSAIPVV ILVASIGIGV EFTVHVALGF LTSHGSRNLR 1050
    AASALEQTFA PVTDGAVSTL LGLLMLAGSN FDFIIRYFFV VLTVLTLLGL 1100
    LHGLLLLPVL LSILGPPPQV VQVYKESPQT LNSAAPQRGG LRWDRPPTLP 1150
    QSFARVTTSM TVALHPPPLP GAYVHPASEE PT 1182
    Length:1,182
    Mass (Da):128,586
    Last modified:August 1, 1998 - v2
    Checksum:i715233D912C352F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133482
    , AJ133483, AJ133484, AJ133485 Genomic DNA. Translation: CAC88120.1.
    AL671866 Genomic DNA. Translation: CAM26330.1.
    AB010833 mRNA. Translation: BAA24691.1.
    CCDSiCCDS18526.1.
    PIRiT13952.
    RefSeqiNP_032984.1. NM_008958.2.
    UniGeneiMm.287037.

    Genome annotation databases

    EnsembliENSMUST00000030443; ENSMUSP00000030443; ENSMUSG00000028681.
    GeneIDi19207.
    KEGGimmu:19207.
    UCSCiuc008uhx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ133482
    , AJ133483 , AJ133484 , AJ133485 Genomic DNA. Translation: CAC88120.1 .
    AL671866 Genomic DNA. Translation: CAM26330.1 .
    AB010833 mRNA. Translation: BAA24691.1 .
    CCDSi CCDS18526.1.
    PIRi T13952.
    RefSeqi NP_032984.1. NM_008958.2.
    UniGenei Mm.287037.

    3D structure databases

    ProteinModelPortali O35595.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000030443.

    PTM databases

    PhosphoSitei O35595.

    Proteomic databases

    PRIDEi O35595.

    Protocols and materials databases

    DNASUi 19207.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030443 ; ENSMUSP00000030443 ; ENSMUSG00000028681 .
    GeneIDi 19207.
    KEGGi mmu:19207.
    UCSCi uc008uhx.1. mouse.

    Organism-specific databases

    CTDi 8643.
    MGIi MGI:1095405. Ptch2.

    Phylogenomic databases

    eggNOGi NOG313603.
    GeneTreei ENSGT00680000099777.
    HOGENOMi HOG000231331.
    HOVERGENi HBG003801.
    InParanoidi A2AE82.
    KOi K11101.
    OMAi HCEASSQ.
    OrthoDBi EOG7HMS06.
    PhylomeDBi O35595.
    TreeFami TF106489.

    Miscellaneous databases

    NextBioi 295942.
    PROi O35595.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35595.
    Bgeei O35595.
    CleanExi MM_PTCH2.
    Genevestigatori O35595.

    Family and domain databases

    InterProi IPR003392. Patched.
    IPR000731. SSD.
    IPR004766. TM_rcpt_patched.
    [Graphical view ]
    Pfami PF02460. Patched. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00918. 2A060602. 1 hit.
    PROSITEi PS50156. SSD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog."
      Motoyama J., Takabatake T., Takeshima K., Hui C.-C.
      Nat. Genet. 18:104-106(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Embryo.
    2. "Genomic structure and refined chromosomal localization of the mouse Ptch2 gene."
      Froehlich L., Zhanquin L., Beier D.R., Lanske B.
      Cytogenet. Genome Res. 97:106-110(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
      Tissue: Liver.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "Hedgehog and patched gene expression in adult ocular tissues."
      Takabatake T., Ogawa M., Takahashi T.C., Mizuno M., Okamoto M., Takeshima K.
      FEBS Lett. 410:485-489(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 196-446.
      Strain: BALB/c.
      Tissue: Neuroretina.

    Entry informationi

    Entry nameiPTC2_MOUSE
    AccessioniPrimary (citable) accession number: O35595
    Secondary accession number(s): A2AE82, Q546T0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3