Protein patched homolog 2 - Mus musculus (Mouse)

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O35595 (PTC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 92. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein patched homolog 2
Short name=PTC2

Gene names

Name:

Ptch2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1182 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in epithelial cells of the developing hair, tooth and whisker.
Developmental stage	Detected in 8.5 to 17.5 dpc embryos.
Sequence similarities	Belongs to the patched family. Contains 1 SSD (sterol-sensing) domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	hair cycle Inferred from mutant phenotype PubMed 16914743. Source: MGI skin development Inferred from mutant phenotype PubMed 16914743. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	hedgehog receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1182

1182

Protein patched homolog 2

PRO_0000205971

Regions

Topological domain

1 – 57

Cytoplasmic Potential

Transmembrane

58 – 78

Helical; Potential

Topological domain

79 – 394

316

Extracellular Potential

Transmembrane

395 – 414

Helical; Potential

Topological domain

415 – 428

Cytoplasmic Potential

Transmembrane

429 – 449

Helical; Potential

Topological domain

450 – 457

Extracellular Potential

Transmembrane

458 – 478

Helical; Potential

Topological domain

479 – 501

Cytoplasmic Potential

Transmembrane

502 – 522

Helical; Potential

Topological domain

523 – 531

Extracellular Potential

Transmembrane

532 – 552

Helical; Potential

Topological domain

553 – 686

134

Cytoplasmic Potential

Transmembrane

687 – 707

Helical; Potential

Topological domain

708 – 963

256

Extracellular Potential

Transmembrane

964 – 984

Helical; Potential

Topological domain

985 – 991

Cytoplasmic Potential

Transmembrane

992 – 1012

Helical; Potential

Topological domain

1013

Extracellular Potential

Transmembrane

1014 – 1034

Helical; Potential

Topological domain

1035 – 1064

Cytoplasmic Potential

Transmembrane

1065 – 1085

Helical; Potential

Topological domain

1086

Extracellular Potential

Transmembrane

1087 – 1107

Helical; Potential

Topological domain

1108 – 1182

Cytoplasmic Potential

Domain

394 – 552

159

SSD

Amino acid modifications

Glycosylation

370

N-linked (GlcNAc...) Potential

Glycosylation

812

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

O35595 [UniParc].

Last modified August 1, 1998. Version 2.
Checksum: 715233D912C352F2
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FASTA

1,182

128,586

        10         20         30         40         50         60 
MVRPLSLGEL PPSYTPPARS SAPHILAGSL QAPLWLRAYF QGLLFSLGCR IQKHCGKVLF 

        70         80         90        100        110        120 
LGLVAFGALA LGLRVAVIET DLEQLWVEVG SRVSQELHYT KEKLGEEAAY TSQMLIQTAH 

       130        140        150        160        170        180 
QEGGNVLTPE ALDLHLQAAL TASKVQVSLY GKSWDLNKIC YKSGVPLIEN GMIERMIEKL 

       190        200        210        220        230        240 
FPCVILTPLD CFWEGAKLQG GSAYLPGRPD IQWTNLDPQQ LLEELGPFAS LEGFRELLDK 

       250        260        270        280        290        300 
AQVGQAYVGR PCLDPDDPHC PPSAPNRHSR QAPNVAQELS GGCHGFSHKF MHWQEELLLG 

       310        320        330        340        350        360 
GTARDLQGQL LRAEALQSTF LLMSPRQLYE HFRGDYQTHD IGWSEEQASM VLQAWQRRFV 

       370        380        390        400        410        420 
QLAQEALPAN ASQQIHAFSS TTLDDILRAF SEVSTTRVVG GYLLMLAYAC VTMLRWDCAQ 

       430        440        450        460        470        480 
SQGAVGLAGV LLVALAVASG LGLCALLGIT FNAATTQVLP FLALGIGVDD IFLLAHAFTK 

       490        500        510        520        530        540 
APPDTPLPER MGECLRSTGT SVALTSVNNM VAFFMAALVP IPALRAFSLQ AAIVVGCNFA 

       550        560        570        580        590        600 
AVMLVFPAIL SLDLRRRHRQ RLDVLCCFSS PCSAQVIQML PQELGDRAVP VGIAHLTATV 

       610        620        630        640        650        660 
QAFTHCEASS QHVVTILPPQ AHLLSPASDP LGSELYSPGG STRDLLSQEE GTGPQAACRP 

       670        680        690        700        710        720 
LLCAHWTLAH FARYQFAPLL LQTRAKALVL LFFGALLGLS LYGATLVQDG LALTDVVPRG 

       730        740        750        760        770        780 
TKEHAFLSAQ LRYFSLYEVA LVTQGGFDYA HSQRALFDLH QRFSSLKAVL PPPATQAPRT 

       790        800        810        820        830        840 
WLHYYRSWLQ GIQAAFDQDW ASGRITCHSY RNGSEDGALA YKLLIQTGNA QEPLDFSQLT 

       850        860        870        880        890        900 
TRKLVDKEGL IPPELFYMGL TVWVSSDPLG LAASQANFYP PPPEWLHDKY DTTGENLRIP 

       910        920        930        940        950        960 
AAQPLEFAQF PFLLHGLQKT ADFVEAIEGA RAACTEAGQA GVHAYPSGSP FLFWEQYLGL 

       970        980        990       1000       1010       1020 
RRCFLLAVCI LLVCTFLVCA LLLLSPWTAG LIVLVLAMMT VELFGIMGFL GIKLSAIPVV 

      1030       1040       1050       1060       1070       1080 
ILVASIGIGV EFTVHVALGF LTSHGSRNLR AASALEQTFA PVTDGAVSTL LGLLMLAGSN 

      1090       1100       1110       1120       1130       1140 
FDFIIRYFFV VLTVLTLLGL LHGLLLLPVL LSILGPPPQV VQVYKESPQT LNSAAPQRGG 

      1150       1160       1170       1180 
LRWDRPPTLP QSFARVTTSM TVALHPPPLP GAYVHPASEE PT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog." Motoyama J., Takabatake T., Takeshima K., Hui C.-C. Nat. Genet. 18:104-106(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Embryo.
[2]	"Genomic structure and refined chromosomal localization of the mouse Ptch2 gene." Froehlich L., Zhanquin L., Beier D.R., Lanske B. Cytogenet. Genome Res. 97:106-110(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ. Tissue: Liver.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"Hedgehog and patched gene expression in adult ocular tissues." Takabatake T., Ogawa M., Takahashi T.C., Mizuno M., Okamoto M., Takeshima K. FEBS Lett. 410:485-489(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 196-446. Strain: BALB/c. Tissue: Neuroretina.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ133482 , AJ133483, AJ133484, AJ133485 Genomic DNA. Translation: CAC88120.1. AL671866 Genomic DNA. Translation: CAM26330.1. AB010833 mRNA. Translation: BAA24691.1.
IPI	IPI00131879.
PIR	T13952.
RefSeq	NP_032984.1. NM_008958.2.
UniGene	Mm.287037.
3D structure databases
ProteinModelPortal	O35595.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000030443.
PTM databases
PhosphoSite	O35595.
Proteomic databases
PRIDE	O35595.
Protocols and materials databases
DNASU	19207.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030443; ENSMUSP00000030443; ENSMUSG00000028681.
GeneID	19207.
KEGG	mmu:19207.
UCSC	uc008uhx.1. mouse.
Organism-specific databases
CTD	8643.
MGI	MGI:1095405. Ptch2.
Phylogenomic databases
eggNOG	NOG313603.
GeneTree	ENSGT00680000099777.
HOGENOM	HOG000231331.
HOVERGEN	HBG003801.
InParanoid	A2AE82.
KO	K11101.
OMA	CPPSAPN.
OrthoDB	EOG49CQ6V.
Gene expression databases
ArrayExpress	O35595.
Bgee	O35595.
CleanEx	MM_PTCH2.
Genevestigator	O35595.
GermOnline	ENSMUSG00000028681. Mus musculus.
Family and domain databases
InterPro	IPR003392. Patched. IPR000731. SSD. IPR004766. TM_rcpt_patched. [Graphical view]
Pfam	PF02460. Patched. 1 hit. [Graphical view]
TIGRFAMs	TIGR00918. 2A060602. 1 hit.
PROSITE	PS50156. SSD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	295942.
SOURCE	Search...

Entry information

Entry name

PTC2_MOUSE

Accession

Primary (citable) accession number: O35595
Secondary accession number(s): A2AE82, Q546T0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents