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Protein

NGFI-A-binding protein 1

Gene

NAB1

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.By similarity

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
NGFI-A-binding protein 1
Alternative name(s):
EGR-1-binding protein 1
Transcriptional repressor TA16
Gene namesi
Name:NAB1
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
Proteomesi
  • UP000189706 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000770391 – 485NGFI-A-binding protein 1Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki126Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki143Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei171PhosphoserineBy similarity1
Modified residuei182PhosphoserineBy similarity1
Cross-linki211Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei327PhosphoserineBy similarity1
Cross-linki332Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki332Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki354Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki368Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei405PhosphoserineBy similarity1
Cross-linki452Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki463Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki475Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Expressioni

Inductioni

By glucocorticoids.

Interactioni

Subunit structurei

Homomultimers may associate with EGR1 bound to DNA.By similarity

Structurei

3D structure databases

ProteinModelPortaliO35589.
SMRiO35589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 82NCD1Add BLAST79
Regioni220 – 309NCD2Add BLAST90
Regioni306 – 337Necessary for nuclear localizationBy similarityAdd BLAST32

Domaini

The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.

Sequence similaritiesi

Belongs to the NAB family.Curated

Phylogenomic databases

HOVERGENiHBG003127.
OrthoDBiEOG091G0NQE.

Family and domain databases

InterProiView protein in InterPro
IPR006986. Nab1_C.
IPR006989. NAB_co-repressor_dom.
IPR006988. Nab_N.
PfamiView protein in Pfam
PF04902. Nab1. 1 hit.
PF04904. NCD1. 1 hit.
PF04905. NCD2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD342192. Nab_N. 1 hit.

Sequencei

Sequence statusi: Complete.

O35589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATALPRTLG ELQLYRILQK ANLLSYFGAF IQQGGDDVQQ LCEAGEEEFL
60 70 80 90 100
EIMALVGMAS KPLHVRRLQK ALRDWVTNPG LFNQPLTSLP VSSIPIYKLP
110 120 130 140 150
KGSPTWLGIS CNSYERNSSA REPHLKIPKC AATTCVQSLG QGKSEVGSLA
160 170 180 190 200
VQSVSESRLW QGHHATESEH SLSPADVGSP ASPKESSEAL DAAAALSVAE
210 220 230 240 250
CVERMASTLP KSDLNEVKEL LKNNKKLAKM IGHIFEMSDE DPHKEEEIRK
260 270 280 290 300
YSAIYGRFDS KRKDGKHLTL HELTVNEAAA QLCVKDNALL TRRDELFALA
310 320 330 340 350
RQVSREVTYK YTYRTTRLKC GERDELSPKR IKVEDGFPDF QEPVQTLFQQ
360 370 380 390 400
ARAKSEELAA LSSQQTEKGM AKQMELLCAQ ASYERLQQER RLTAGLYRQS
410 420 430 440 450
SGEHSPDGLP SDGSDGQGER PLNLRMPNVQ NRQPHHFVAD GELSRLYSSE
460 470 480
AKSHSSENLG ILKDYPHSAF TLEKKVIKTE PEDSR
Length:485
Mass (Da):54,062
Last modified:January 1, 1998 - v1
Checksum:iAD8EFC04D1460F62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88975 mRNA. Translation: AAC53313.1.
RefSeqiNP_001268536.1. NM_001281607.1.

Genome annotation databases

GeneIDi101827193.

Similar proteinsi

Entry informationi

Entry nameiNAB1_MESAU
AccessioniPrimary (citable) accession number: O35589
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families