Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NGFI-A-binding protein 1

Gene

NAB1

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
NGFI-A-binding protein 1
Alternative name(s):
EGR-1-binding protein 1
Transcriptional repressor TA16
Gene namesi
Name:NAB1
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485NGFI-A-binding protein 1PRO_0000077039Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki129 – 129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei171 – 1711PhosphoserineBy similarity
Modified residuei182 – 1821PhosphoserineBy similarity
Modified residuei327 – 3271PhosphoserineBy similarity
Cross-linki332 – 332Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki354 – 354Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei405 – 4051PhosphoserineBy similarity
Cross-linki478 – 478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Expressioni

Inductioni

By glucocorticoids.

Interactioni

Subunit structurei

Homomultimers may associate with EGR1 bound to DNA.By similarity

Structurei

3D structure databases

ProteinModelPortaliO35589.
SMRiO35589. Positions 181-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4 – 8279NCD1Add
BLAST
Regioni220 – 30990NCD2Add
BLAST
Regioni306 – 33732Necessary for nuclear localizationBy similarityAdd
BLAST

Domaini

The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.

Sequence similaritiesi

Belongs to the NAB family.Curated

Phylogenomic databases

HOVERGENiHBG003127.

Family and domain databases

InterProiIPR006986. Nab1_C.
IPR006989. NAB_co-repressor_dom.
IPR006988. Nab_N.
[Graphical view]
PfamiPF04902. Nab1. 1 hit.
PF04904. NCD1. 1 hit.
PF04905. NCD2. 1 hit.
[Graphical view]
ProDomiPD342192. Nab_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

O35589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATALPRTLG ELQLYRILQK ANLLSYFGAF IQQGGDDVQQ LCEAGEEEFL
60 70 80 90 100
EIMALVGMAS KPLHVRRLQK ALRDWVTNPG LFNQPLTSLP VSSIPIYKLP
110 120 130 140 150
KGSPTWLGIS CNSYERNSSA REPHLKIPKC AATTCVQSLG QGKSEVGSLA
160 170 180 190 200
VQSVSESRLW QGHHATESEH SLSPADVGSP ASPKESSEAL DAAAALSVAE
210 220 230 240 250
CVERMASTLP KSDLNEVKEL LKNNKKLAKM IGHIFEMSDE DPHKEEEIRK
260 270 280 290 300
YSAIYGRFDS KRKDGKHLTL HELTVNEAAA QLCVKDNALL TRRDELFALA
310 320 330 340 350
RQVSREVTYK YTYRTTRLKC GERDELSPKR IKVEDGFPDF QEPVQTLFQQ
360 370 380 390 400
ARAKSEELAA LSSQQTEKGM AKQMELLCAQ ASYERLQQER RLTAGLYRQS
410 420 430 440 450
SGEHSPDGLP SDGSDGQGER PLNLRMPNVQ NRQPHHFVAD GELSRLYSSE
460 470 480
AKSHSSENLG ILKDYPHSAF TLEKKVIKTE PEDSR
Length:485
Mass (Da):54,062
Last modified:January 1, 1998 - v1
Checksum:iAD8EFC04D1460F62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88975 mRNA. Translation: AAC53313.1.
RefSeqiNP_001268536.1. NM_001281607.1.

Genome annotation databases

GeneIDi101827193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88975 mRNA. Translation: AAC53313.1.
RefSeqiNP_001268536.1. NM_001281607.1.

3D structure databases

ProteinModelPortaliO35589.
SMRiO35589. Positions 181-316.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101827193.

Organism-specific databases

CTDi4664.

Phylogenomic databases

HOVERGENiHBG003127.

Family and domain databases

InterProiIPR006986. Nab1_C.
IPR006989. NAB_co-repressor_dom.
IPR006988. Nab_N.
[Graphical view]
PfamiPF04902. Nab1. 1 hit.
PF04904. NCD1. 1 hit.
PF04905. NCD2. 1 hit.
[Graphical view]
ProDomiPD342192. Nab_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of TA16, a transcriptional repressor that may mediate glucocorticoid-induced growth arrest of leiomyosarcoma cells."
    Fan W., Ma J.-X., Cheng L., Norris J.S.
    Mol. Endocrinol. 11:1342-1352(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Leiomyosarcoma.

Entry informationi

Entry nameiNAB1_MESAU
AccessioniPrimary (citable) accession number: O35589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.