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O35568

- FBLN3_RAT

UniProt

O35568 - FBLN3_RAT

Protein

EGF-containing fibulin-like extracellular matrix protein 1

Gene

Efemp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.1 Publication

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. epidermal growth factor-activated receptor activity Source: UniProtKB
    3. epidermal growth factor receptor binding Source: UniProtKB
    4. protein binding Source: RGD

    GO - Biological processi

    1. epidermal growth factor receptor signaling pathway Source: UniProtKB
    2. negative regulation of chondrocyte differentiation Source: UniProtKB
    3. peptidyl-tyrosine phosphorylation Source: UniProtKB
    4. regulation of transcription, DNA-templated Source: UniProtKB

    Keywords - Molecular functioni

    Growth factor

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EGF-containing fibulin-like extracellular matrix protein 1
    Alternative name(s):
    Fibulin-3
    Short name:
    FIBL-3
    T16 protein
    Gene namesi
    Name:Efemp1
    Synonyms:Fbln3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1308528. Efemp1.

    Subcellular locationi

    Secretedextracellular space 1 Publication. Secretedextracellular spaceextracellular matrix 1 Publication
    Note: Localizes to the lamina propria underneath the olfactory epithelium.

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 493476EGF-containing fibulin-like extracellular matrix protein 1PRO_0000007573Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi177 ↔ 190PROSITE-ProRule annotation
    Disulfide bondi184 ↔ 199PROSITE-ProRule annotation
    Disulfide bondi201 ↔ 212PROSITE-ProRule annotation
    Disulfide bondi218 ↔ 228PROSITE-ProRule annotation
    Disulfide bondi224 ↔ 237PROSITE-ProRule annotation
    Disulfide bondi239 ↔ 252PROSITE-ProRule annotation
    Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi258 ↔ 268PROSITE-ProRule annotation
    Disulfide bondi264 ↔ 277PROSITE-ProRule annotation
    Disulfide bondi279 ↔ 292PROSITE-ProRule annotation
    Disulfide bondi298 ↔ 309PROSITE-ProRule annotation
    Disulfide bondi305 ↔ 318PROSITE-ProRule annotation
    Disulfide bondi320 ↔ 332PROSITE-ProRule annotation
    Disulfide bondi338 ↔ 350PROSITE-ProRule annotation
    Disulfide bondi344 ↔ 359PROSITE-ProRule annotation
    Disulfide bondi365 ↔ 377PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO35568.
    PRIDEiO35568.

    PTM databases

    PhosphoSiteiO35568.

    Expressioni

    Tissue specificityi

    Expressed by olfactory ensheathing cells (at protein level). Detected in lung, intestine and kidney.1 Publication

    Gene expression databases

    GenevestigatoriO35568.

    Interactioni

    Subunit structurei

    Interacts with ECM1. Interacts with TIMP3.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000062660.

    Structurei

    3D structure databases

    ProteinModelPortaliO35568.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 7146EGF-like 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini173 – 21341EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini214 – 25340EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini254 – 29340EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini294 – 33340EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini334 – 37845EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni259 – 493235Mediates interaction with TIMP3By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the fibulin family.Curated
    Contains 6 EGF-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG250502.
    HOGENOMiHOG000234337.
    HOVERGENiHBG051560.
    InParanoidiO35568.
    PhylomeDBiO35568.

    Family and domain databases

    InterProiIPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view]
    PfamiPF12662. cEGF. 3 hits.
    PF07645. EGF_CA. 2 hits.
    [Graphical view]
    SMARTiSM00179. EGF_CA. 4 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35568-1 [UniParc]FASTAAdd to Basket

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    MLQTVFLTML TLALVKSQVT EETITYTQCT DGYEWDPVRQ QCKDIDECDI    50
    VPDACKGGMK CVNHYGGYLC LPKTAQIIVN NEQPQQETPA AEASSGAATG 100
    TIAARSMATS GVIPGGGFIA SATAVAGPEV QTGRNNFVIR RNPADPQRIP 150
    SNPSHRIQCA AGYEQSEHNV CQDIDECTSG THNCRLDQVC INLRGSFTCH 200
    CLPGYQKRGE QCVDIDECSV PPYCHQGCVN TPGSFYCQCN PGFQLAANNY 250
    TCVDINECDA SNQCAQQCYN ILGSFICQCN QGYELSSDRL NCEDIDECRT 300
    SSYLCQYQCV NEPGKFSCMC PQGYQVVRSR TCQDINECET TNECREDEMC 350
    WNYHGGFRCY PQNPCQDPYV LTSENRCVCP VSNTMCRDVP QSIVYKYMNI 400
    RSDRSVPSDI FQIQATTIYA NTINTFRIKS GNENGEFYLR QTSPVSAMLV 450
    LVKSLTGPRE HIVGLEMLTV SSIGTFRTSS VLRLTIIVGP FSF 493
    Length:493
    Mass (Da):54,596
    Last modified:January 1, 1998 - v1
    Checksum:i22DAFD70BACF1CA5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89730 mRNA. Translation: BAA22265.1.
    PIRiJC5621.
    UniGeneiRn.163265.

    Genome annotation databases

    UCSCiRGD:1308528. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89730 mRNA. Translation: BAA22265.1 .
    PIRi JC5621.
    UniGenei Rn.163265.

    3D structure databases

    ProteinModelPortali O35568.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000062660.

    PTM databases

    PhosphoSitei O35568.

    Proteomic databases

    PaxDbi O35568.
    PRIDEi O35568.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:1308528. rat.

    Organism-specific databases

    RGDi 1308528. Efemp1.

    Phylogenomic databases

    eggNOGi NOG250502.
    HOGENOMi HOG000234337.
    HOVERGENi HBG051560.
    InParanoidi O35568.
    PhylomeDBi O35568.

    Miscellaneous databases

    PROi O35568.

    Gene expression databases

    Genevestigatori O35568.

    Family and domain databases

    InterProi IPR026823. cEGF.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    [Graphical view ]
    Pfami PF12662. cEGF. 3 hits.
    PF07645. EGF_CA. 2 hits.
    [Graphical view ]
    SMARTi SM00179. EGF_CA. 4 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 4 hits.
    PS01186. EGF_2. 4 hits.
    PS50026. EGF_3. 4 hits.
    PS01187. EGF_CA. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interaction of DA41, a DAN-binding protein, with the epidermal growth factor-like protein, S(1-5)."
      Ozaki T., Kondo K., Nakamura Y., Ichimiya S., Nakagawara A., Sakiyama S.
      Biochem. Biophys. Res. Commun. 237:245-250(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Lung.
    2. "The glycoprotein fibulin-3 regulates morphology and motility of olfactory ensheathing cells in vitro."
      Vukovic J., Ruitenberg M.J., Roet K., Franssen E., Arulpragasam A., Sasaki T., Verhaagen J., Harvey A.R., Busfield S.J., Plant G.W.
      Glia 57:424-443(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiFBLN3_RAT
    AccessioniPrimary (citable) accession number: O35568
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3