O35567Q6IN16PUR9_RATBifunctional purine biosynthesis protein ATICAICAR transformylase/inosine monophosphate cyclohydrolaseATICPhosphoribosylaminoimidazolecarboxamide formyltransferase2.1.2.35-aminoimidazole-4-carboxamide ribonucleotide formyltransferaseAICAR formyltransferaseAICAR transformylaseInosine 5'-monophosphate cyclohydrolaseIMP cyclohydrolase3.5.4.10IMP synthaseInosinicaseAticPurhRattus norvegicusRatEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattusMolecular cloning and expression of a rat cDNA encoding 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.NUCLEOTIDE SEQUENCE [MRNA]TISSUE SPECIFICITYThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]PROTEIN SEQUENCE OF 178-194; 531-545 AND 570-588IDENTIFICATION BY MASS SPECTROMETRYThe last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.FUNCTIONSUBUNITINTERACTION WITH INSRBifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP (By similarity). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide10-formyldihydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + 7,8-dihydrofolateH2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamideAMP and XMP inhibit AICAR formyltransferase activity.Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.Homodimer (By similarity). Associates with internalized INSR complexes on Golgi/endosomal membranes (PubMed:25687571). Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis (PubMed:25687571).O35567PRO_0000016698false3CytoplasmCytosolExpressed in liver.The IMP cyclohydrolase activity resides in the N-terminal region.The de novo purine synthesis pathway includes 10 sequential steps, beginning with phosphoribosyl pyrophosphate and ending with inositol monophosphate (IMP), the first purin compound of the pathway.Belongs to the PurH family.AcetylationCytoplasmDirect protein sequencingHydrolaseMultifunctional enzymePurine biosynthesisReference proteomeTransferaseIMPIMPIMPIMPIMP5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideligand shared between dimeric partners5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideligand shared between dimeric partners5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideligand shared between dimeric partners5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideligand shared between dimeric partners5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideligand shared between dimeric partners5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideligand shared between dimeric partners(6R)-10-formyltetrahydrofolate5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideligand shared between dimeric partners(6R)-10-formyltetrahydrofolate(6R)-10-formyltetrahydrofolate5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideligand shared between dimeric partnersLHMASSQLALFSVSDKTGLVEFARNLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLIRVVVCNLYPFVKTVASPDVTVEAAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYGAVAAEMQGSGNKDTSLETRRHLALKAFTHTAQYDEAISDYFRRQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINLCDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDLYPTLTPLAIAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGSYCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEVSNAIDQYVTGTIGEGEDLVKWKALFEEVPELLTEAEKKEWVDKLSGVSVSSDAFFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH
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