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Protein

CD151 antigen

Gene

Cd151

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.By similarity

GO - Molecular functioni

  1. integrin binding Source: MGI

GO - Biological processi

  1. cell migration Source: MGI
  2. T cell proliferation Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_199046. Assembly of collagen fibrils and other multimeric structures.
REACT_262098. Type I hemidesmosome assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
CD151 antigen
Alternative name(s):
GP27
Membrane glycoprotein SFA-1
Platelet-endothelial tetraspan antigen 3
Short name:
PETA-3
CD_antigen: CD151
Gene namesi
Name:Cd151
Synonyms:Peta3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1096360. Cd151.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei19 – 3921HelicalSequence AnalysisAdd
BLAST
Topological domaini40 – 5718ExtracellularSequence AnalysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence AnalysisAdd
BLAST
Topological domaini79 – 9113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence AnalysisAdd
BLAST
Topological domaini113 – 221109ExtracellularSequence AnalysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence AnalysisAdd
BLAST
Topological domaini243 – 25311CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. focal adhesion Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253CD151 antigenPRO_0000219232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi11 – 111S-palmitoyl cysteineBy similarity
Lipidationi15 – 151S-palmitoyl cysteineBy similarity
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
Lipidationi242 – 2421S-palmitoyl cysteineBy similarity
Lipidationi243 – 2431S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiO35566.
PaxDbiO35566.
PRIDEiO35566.

PTM databases

PhosphoSiteiO35566.

Expressioni

Gene expression databases

BgeeiO35566.
CleanExiMM_CD151.
GenevestigatoriO35566.

Interactioni

Protein-protein interaction databases

BioGridi198574. 1 interaction.
IntActiO35566. 2 interactions.
MINTiMINT-4090123.

Structurei

3D structure databases

ProteinModelPortaliO35566.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG281510.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230651.
HOVERGENiHBG107306.
InParanoidiO35566.
KOiK06537.
OMAiCATFKEQ.
OrthoDBiEOG7PGDRZ.
PhylomeDBiO35566.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEFNEKKAT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS
60 70 80 90 100
LLASSTYLAT AYILVVAGVV VMVTGVLGCC ATFKERRNLL RLYFILLLII
110 120 130 140 150
FLLEIIAGIL AYVYYQQLNT ELKENLKDTM VKRYHQSGHE GVSSAVDKLQ
160 170 180 190 200
QEFHCCGSNN SQDWQDSEWI RSGEADSRVV PDSCCKTMVA GCGKRDHASN
210 220 230 240 250
IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF TCCLYRSLKL

EHY
Length:253
Mass (Da):28,246
Last modified:May 30, 2000 - v2
Checksum:iAEBEEBCE2D765F1B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371G → S in BAA22447 (PubMed:9294006).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89290 mRNA. Translation: BAA22447.1.
AF033620 Genomic DNA. Translation: AAC25952.1.
U89772 mRNA. Translation: AAC25976.1.
CCDSiCCDS22017.1.
RefSeqiNP_001104519.1. NM_001111049.1.
NP_001104520.1. NM_001111050.1.
NP_033972.2. NM_009842.3.
UniGeneiMm.30246.
Mm.483720.

Genome annotation databases

EnsembliENSMUST00000058746; ENSMUSP00000061636; ENSMUSG00000025510.
ENSMUST00000106000; ENSMUSP00000101622; ENSMUSG00000025510.
ENSMUST00000177840; ENSMUSP00000136331; ENSMUSG00000025510.
GeneIDi12476.
KEGGimmu:12476.
UCSCiuc009kll.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89290 mRNA. Translation: BAA22447.1.
AF033620 Genomic DNA. Translation: AAC25952.1.
U89772 mRNA. Translation: AAC25976.1.
CCDSiCCDS22017.1.
RefSeqiNP_001104519.1. NM_001111049.1.
NP_001104520.1. NM_001111050.1.
NP_033972.2. NM_009842.3.
UniGeneiMm.30246.
Mm.483720.

3D structure databases

ProteinModelPortaliO35566.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198574. 1 interaction.
IntActiO35566. 2 interactions.
MINTiMINT-4090123.

PTM databases

PhosphoSiteiO35566.

Proteomic databases

MaxQBiO35566.
PaxDbiO35566.
PRIDEiO35566.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058746; ENSMUSP00000061636; ENSMUSG00000025510.
ENSMUST00000106000; ENSMUSP00000101622; ENSMUSG00000025510.
ENSMUST00000177840; ENSMUSP00000136331; ENSMUSG00000025510.
GeneIDi12476.
KEGGimmu:12476.
UCSCiuc009kll.2. mouse.

Organism-specific databases

CTDi977.
MGIiMGI:1096360. Cd151.

Phylogenomic databases

eggNOGiNOG281510.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230651.
HOVERGENiHBG107306.
InParanoidiO35566.
KOiK06537.
OMAiCATFKEQ.
OrthoDBiEOG7PGDRZ.
PhylomeDBiO35566.
TreeFamiTF352892.

Enzyme and pathway databases

ReactomeiREACT_199046. Assembly of collagen fibrils and other multimeric structures.
REACT_262098. Type I hemidesmosome assembly.

Miscellaneous databases

NextBioi281358.
PROiO35566.
SOURCEiSearch...

Gene expression databases

BgeeiO35566.
CleanExiMM_CD151.
GenevestigatoriO35566.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily."
    Hasegawa H., Watanabe H., Nomura T., Utsunomiya Y., Yanagisawa K., Fujita S.
    Biochim. Biophys. Acta 1353:125-130(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms."
    Fitter S., Seldin M.F., Ashman L.K.
    Biochim. Biophys. Acta 1398:75-85(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv.

Entry informationi

Entry nameiCD151_MOUSE
AccessioniPrimary (citable) accession number: O35566
Secondary accession number(s): O89118
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: February 4, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.