O35566 (CD151_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CD151 antigen

Alternative name(s):
GP27
Membrane glycoprotein SFA-1
Platelet-endothelial tetraspan antigen 3
Short name=PETA-3
CD_antigen=CD151

Gene names

Name:	Cd151
Synonyms:	Peta3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Essential for the proper assembly of the glomerular and tubular basement membranes in kidney By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell proliferation Inferred from mutant phenotype PubMed 15199151. Source: MGI cell migration Inferred from mutant phenotype PubMed 15199151. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	CD151 antigen		PRO_0000219232
Regions
	Topological domain	1 – 18	18	Cytoplasmic Potential
	Transmembrane	19 – 39	21	Helical; Potential
	Topological domain	40 – 57	18	Extracellular Potential
	Transmembrane	58 – 78	21	Helical; Potential
	Topological domain	79 – 91	13	Cytoplasmic Potential
	Transmembrane	92 – 112	21	Helical; Potential
	Topological domain	113 – 221	109	Extracellular Potential
	Transmembrane	222 – 242	21	Helical; Potential
	Topological domain	243 – 253	11	Cytoplasmic Potential
Amino acid modifications
	Lipidation	11	1	S-palmitoyl cysteine By similarity
	Lipidation	15	1	S-palmitoyl cysteine By similarity
	Lipidation	242	1	S-palmitoyl cysteine By similarity
	Lipidation	243	1	S-palmitoyl cysteine By similarity
	Glycosylation	159	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	237	1	G → S in BAA22447. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O35566 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: AEBEEBCE2D765F1B	FASTA	253	28,246
	10 20 30 40 50 60 MGEFNEKKAT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS LLASSTYLAT 70 80 90 100 110 120 AYILVVAGVV VMVTGVLGCC ATFKERRNLL RLYFILLLII FLLEIIAGIL AYVYYQQLNT 130 140 150 160 170 180 ELKENLKDTM VKRYHQSGHE GVSSAVDKLQ QEFHCCGSNN SQDWQDSEWI RSGEADSRVV 190 200 210 220 230 240 PDSCCKTMVA GCGKRDHASN IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF 250 TCCLYRSLKL EHY

References

[1]	"Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily." Hasegawa H., Watanabe H., Nomura T., Utsunomiya Y., Yanagisawa K., Fujita S. Biochim. Biophys. Acta 1353:125-130(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms." Fitter S., Seldin M.F., Ashman L.K. Biochim. Biophys. Acta 1398:75-85(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: 129/Sv.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D89290 mRNA. Translation: BAA22447.1. AF033620 Genomic DNA. Translation: AAC25952.1. U89772 mRNA. Translation: AAC25976.1.
IPI	IPI00266426.
RefSeq	NP_001104519.1. NM_001111049.1. NP_001104520.1. NM_001111050.1. NP_033972.2. NM_009842.3.
UniGene	Mm.30246. Mm.483720.
3D structure databases
ProteinModelPortal	O35566.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4090123.
PTM databases
PhosphoSite	O35566.
Proteomic databases
PaxDb	O35566.
PRIDE	O35566.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000058746; ENSMUSP00000061636; ENSMUSG00000025510. ENSMUST00000106000; ENSMUSP00000101622; ENSMUSG00000025510. ENSMUST00000177840; ENSMUSP00000136331; ENSMUSG00000025510.
GeneID	12476.
KEGG	mmu:12476.
UCSC	uc009kll.2. mouse.
Organism-specific databases
CTD	977.
MGI	MGI:1096360. Cd151.
Phylogenomic databases
eggNOG	NOG281510.
GeneTree	ENSGT00680000099759.
HOGENOM	HOG000230651.
HOVERGEN	HBG107306.
InParanoid	O35566.
KO	K06537.
OMA	CKTVVAG.
OrthoDB	EOG46144V.
Gene expression databases
Bgee	O35566.
CleanEx	MM_CD151.
Genevestigator	O35566.
GermOnline	ENSMUSG00000025510. Mus musculus.
Family and domain databases
InterPro	IPR000301. Tetraspanin. IPR018499. Tetraspanin/Peripherin. IPR018503. Tetraspanin_CS. IPR008952. Tetraspanin_EC2. [Graphical view]
Pfam	PF00335. Tetraspannin. 1 hit. [Graphical view]
PIRSF	PIRSF002419. Tetraspanin. 1 hit.
PRINTS	PR00259. TMFOUR.
SUPFAM	SSF48652. Tetraspanin. 1 hit.
PROSITE	PS00421. TM4_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	281358.
SOURCE	Search...

Entry information

Entry name

CD151_MOUSE

Accession

Primary (citable) accession number: O35566
Secondary accession number(s): O89118

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 30, 2000
Last modified:	May 29, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program