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O35566

- CD151_MOUSE

UniProt

O35566 - CD151_MOUSE

Protein

CD151 antigen

Gene

Cd151

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.By similarity

    GO - Biological processi

    1. cell migration Source: MGI
    2. T cell proliferation Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD151 antigen
    Alternative name(s):
    GP27
    Membrane glycoprotein SFA-1
    Platelet-endothelial tetraspan antigen 3
    Short name:
    PETA-3
    CD_antigen: CD151
    Gene namesi
    Name:Cd151
    Synonyms:Peta3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1096360. Cd151.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 253253CD151 antigenPRO_0000219232Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi11 – 111S-palmitoyl cysteineBy similarity
    Lipidationi15 – 151S-palmitoyl cysteineBy similarity
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
    Lipidationi242 – 2421S-palmitoyl cysteineBy similarity
    Lipidationi243 – 2431S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiO35566.
    PaxDbiO35566.
    PRIDEiO35566.

    PTM databases

    PhosphoSiteiO35566.

    Expressioni

    Gene expression databases

    BgeeiO35566.
    CleanExiMM_CD151.
    GenevestigatoriO35566.

    Interactioni

    Protein-protein interaction databases

    BioGridi198574. 1 interaction.
    IntActiO35566. 2 interactions.
    MINTiMINT-4090123.

    Structurei

    3D structure databases

    ProteinModelPortaliO35566.
    SMRiO35566. Positions 112-219.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini40 – 5718ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini79 – 9113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini113 – 221109ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini243 – 25311CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG281510.
    GeneTreeiENSGT00740000115083.
    HOGENOMiHOG000230651.
    HOVERGENiHBG107306.
    InParanoidiO35566.
    KOiK06537.
    OMAiRVYFILL.
    OrthoDBiEOG7PGDRZ.
    PhylomeDBiO35566.
    TreeFamiTF352892.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35566-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEFNEKKAT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS    50
    LLASSTYLAT AYILVVAGVV VMVTGVLGCC ATFKERRNLL RLYFILLLII 100
    FLLEIIAGIL AYVYYQQLNT ELKENLKDTM VKRYHQSGHE GVSSAVDKLQ 150
    QEFHCCGSNN SQDWQDSEWI RSGEADSRVV PDSCCKTMVA GCGKRDHASN 200
    IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF TCCLYRSLKL 250
    EHY 253
    Length:253
    Mass (Da):28,246
    Last modified:May 30, 2000 - v2
    Checksum:iAEBEEBCE2D765F1B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti237 – 2371G → S in BAA22447. (PubMed:9294006)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89290 mRNA. Translation: BAA22447.1.
    AF033620 Genomic DNA. Translation: AAC25952.1.
    U89772 mRNA. Translation: AAC25976.1.
    CCDSiCCDS22017.1.
    RefSeqiNP_001104519.1. NM_001111049.1.
    NP_001104520.1. NM_001111050.1.
    NP_033972.2. NM_009842.3.
    UniGeneiMm.30246.
    Mm.483720.

    Genome annotation databases

    EnsembliENSMUST00000058746; ENSMUSP00000061636; ENSMUSG00000025510.
    ENSMUST00000106000; ENSMUSP00000101622; ENSMUSG00000025510.
    ENSMUST00000177840; ENSMUSP00000136331; ENSMUSG00000025510.
    GeneIDi12476.
    KEGGimmu:12476.
    UCSCiuc009kll.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89290 mRNA. Translation: BAA22447.1 .
    AF033620 Genomic DNA. Translation: AAC25952.1 .
    U89772 mRNA. Translation: AAC25976.1 .
    CCDSi CCDS22017.1.
    RefSeqi NP_001104519.1. NM_001111049.1.
    NP_001104520.1. NM_001111050.1.
    NP_033972.2. NM_009842.3.
    UniGenei Mm.30246.
    Mm.483720.

    3D structure databases

    ProteinModelPortali O35566.
    SMRi O35566. Positions 112-219.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198574. 1 interaction.
    IntActi O35566. 2 interactions.
    MINTi MINT-4090123.

    PTM databases

    PhosphoSitei O35566.

    Proteomic databases

    MaxQBi O35566.
    PaxDbi O35566.
    PRIDEi O35566.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000058746 ; ENSMUSP00000061636 ; ENSMUSG00000025510 .
    ENSMUST00000106000 ; ENSMUSP00000101622 ; ENSMUSG00000025510 .
    ENSMUST00000177840 ; ENSMUSP00000136331 ; ENSMUSG00000025510 .
    GeneIDi 12476.
    KEGGi mmu:12476.
    UCSCi uc009kll.2. mouse.

    Organism-specific databases

    CTDi 977.
    MGIi MGI:1096360. Cd151.

    Phylogenomic databases

    eggNOGi NOG281510.
    GeneTreei ENSGT00740000115083.
    HOGENOMi HOG000230651.
    HOVERGENi HBG107306.
    InParanoidi O35566.
    KOi K06537.
    OMAi RVYFILL.
    OrthoDBi EOG7PGDRZ.
    PhylomeDBi O35566.
    TreeFami TF352892.

    Miscellaneous databases

    NextBioi 281358.
    PROi O35566.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35566.
    CleanExi MM_CD151.
    Genevestigatori O35566.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily."
      Hasegawa H., Watanabe H., Nomura T., Utsunomiya Y., Yanagisawa K., Fujita S.
      Biochim. Biophys. Acta 1353:125-130(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms."
      Fitter S., Seldin M.F., Ashman L.K.
      Biochim. Biophys. Acta 1398:75-85(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129/Sv.

    Entry informationi

    Entry nameiCD151_MOUSE
    AccessioniPrimary (citable) accession number: O35566
    Secondary accession number(s): O89118
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3