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O35566 (CD151_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD151 antigen
Alternative name(s):
GP27
Membrane glycoprotein SFA-1
Platelet-endothelial tetraspan antigen 3
Short name=PETA-3
CD_antigen=CD151
Gene names
Name:Cd151
Synonyms:Peta3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 253253CD151 antigen
PRO_0000219232

Regions

Topological domain1 – 1818Cytoplasmic Potential
Transmembrane19 – 3921Helical; Potential
Topological domain40 – 5718Extracellular Potential
Transmembrane58 – 7821Helical; Potential
Topological domain79 – 9113Cytoplasmic Potential
Transmembrane92 – 11221Helical; Potential
Topological domain113 – 221109Extracellular Potential
Transmembrane222 – 24221Helical; Potential
Topological domain243 – 25311Cytoplasmic Potential

Amino acid modifications

Lipidation111S-palmitoyl cysteine By similarity
Lipidation151S-palmitoyl cysteine By similarity
Lipidation2421S-palmitoyl cysteine By similarity
Lipidation2431S-palmitoyl cysteine By similarity
Glycosylation1591N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2371G → S in BAA22447. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35566 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: AEBEEBCE2D765F1B

FASTA25328,246
        10         20         30         40         50         60 
MGEFNEKKAT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS LLASSTYLAT 

        70         80         90        100        110        120 
AYILVVAGVV VMVTGVLGCC ATFKERRNLL RLYFILLLII FLLEIIAGIL AYVYYQQLNT 

       130        140        150        160        170        180 
ELKENLKDTM VKRYHQSGHE GVSSAVDKLQ QEFHCCGSNN SQDWQDSEWI RSGEADSRVV 

       190        200        210        220        230        240 
PDSCCKTMVA GCGKRDHASN IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF 

       250 
TCCLYRSLKL EHY 

« Hide

References

[1]"Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily."
Hasegawa H., Watanabe H., Nomura T., Utsunomiya Y., Yanagisawa K., Fujita S.
Biochim. Biophys. Acta 1353:125-130(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms."
Fitter S., Seldin M.F., Ashman L.K.
Biochim. Biophys. Acta 1398:75-85(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: 129/Sv.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D89290 mRNA. Translation: BAA22447.1.
AF033620 Genomic DNA. Translation: AAC25952.1.
U89772 mRNA. Translation: AAC25976.1.
CCDSCCDS22017.1.
RefSeqNP_001104519.1. NM_001111049.1.
NP_001104520.1. NM_001111050.1.
NP_033972.2. NM_009842.3.
UniGeneMm.30246.
Mm.483720.

3D structure databases

ProteinModelPortalO35566.
SMRO35566. Positions 112-219.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198574. 1 interaction.
IntActO35566. 2 interactions.
MINTMINT-4090123.

PTM databases

PhosphoSiteO35566.

Proteomic databases

MaxQBO35566.
PaxDbO35566.
PRIDEO35566.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000058746; ENSMUSP00000061636; ENSMUSG00000025510.
ENSMUST00000106000; ENSMUSP00000101622; ENSMUSG00000025510.
ENSMUST00000177840; ENSMUSP00000136331; ENSMUSG00000025510.
GeneID12476.
KEGGmmu:12476.
UCSCuc009kll.2. mouse.

Organism-specific databases

CTD977.
MGIMGI:1096360. Cd151.

Phylogenomic databases

eggNOGNOG281510.
GeneTreeENSGT00740000115083.
HOGENOMHOG000230651.
HOVERGENHBG107306.
InParanoidO35566.
KOK06537.
OMARVYFILL.
OrthoDBEOG7PGDRZ.
PhylomeDBO35566.
TreeFamTF352892.

Gene expression databases

BgeeO35566.
CleanExMM_CD151.
GenevestigatorO35566.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281358.
PROO35566.
SOURCESearch...

Entry information

Entry nameCD151_MOUSE
AccessionPrimary (citable) accession number: O35566
Secondary accession number(s): O89118
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot