O35565 (FGF10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 10
Short name=FGF-10

Alternative name(s):
Keratinocyte growth factor 2

Gene names

Name:

Fgf10

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
Subunit structure	Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 By similarity.
Subcellular location	Secreted Potential.
Tissue specificity	Expressed abundantly in embryos and the lung, and at much lower levels in brain and heart.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara Harderian gland development Inferred from mutant phenotype PubMed 10964474. Source: MGI Type II pneumocyte differentiation Inferred from direct assay PubMed 15531758. Source: MGI actin cytoskeleton reorganization Inferred from electronic annotation. Source: Compara activation of MAPK activity Inferred from electronic annotation. Source: Compara angiogenesis Inferred from electronic annotation. Source: Compara blood vessel morphogenesis Inferred from mutant phenotype PubMed 17560563. Source: MGI blood vessel remodeling Inferred from genetic interaction PubMed 17000704. Source: MGI branch elongation involved in salivary gland morphogenesis Inferred from mutant phenotype PubMed 15972105. Source: MGI bronchiole morphogenesis Inferred from mutant phenotype PubMed 15800000. Source: MGI bud outgrowth involved in lung branching Inferred from electronic annotation. Source: Compara determination of left/right symmetry Inferred from mutant phenotype PubMed 15329346. Source: MGI embryonic camera-type eye development Inferred from mutant phenotype PubMed 15958512. Source: MGI embryonic digestive tract morphogenesis Inferred from mutant phenotype PubMed 15017552PubMed 16618415. Source: MGI embryonic genitalia morphogenesis Inferred from mutant phenotype PubMed 12004962. Source: MGI embryonic pattern specification Inferred from mutant phenotype PubMed 16618415PubMed 17522155. Source: MGI epithelial cell migration Inferred from mutant phenotype PubMed 15958512. Source: MGI epithelial cell proliferation involved in salivary gland morphogenesis Inferred from mutant phenotype PubMed 15972105. Source: MGI epithelial tube branching involved in lung morphogenesis Inferred from direct assay PubMed 16169547PubMed 16375885PubMed 9428423. Source: MGI female genitalia morphogenesis Inferred from mutant phenotype PubMed 12004962. Source: MGI fibroblast growth factor receptor signaling pathway involved in mammary gland specification Inferred from direct assay PubMed 16720875. Source: MGI hair follicle morphogenesis Inferred from mutant phenotype PubMed 11062007. Source: MGI induction of positive chemotaxis Inferred from direct assay PubMed 16308329. Source: MGI keratinocyte proliferation Inferred from mutant phenotype PubMed 10984614. Source: MGI lacrimal gland development Inferred from mutant phenotype PubMed 10821755PubMed 10964474PubMed 15654336. Source: MGI limb bud formation Inferred from mutant phenotype PubMed 9784490. Source: MGI lung alveolus development Inferred from mutant phenotype PubMed 17560563. Source: MGI lung proximal/distal axis specification Inferred from direct assay PubMed 15531758. Source: MGI lung saccule development Inferred from electronic annotation. Source: Compara male genitalia morphogenesis Inferred from mutant phenotype PubMed 12004962. Source: MGI mammary gland bud formation Inferred from mutant phenotype PubMed 11782400. Source: MGI mesenchymal cell differentiation involved in lung development Inferred from genetic interaction PubMed 16989802. Source: MGI mesenchymal-epithelial cell signaling involved in lung development Inferred from direct assay PubMed 15531758. Source: MGI mesonephros development Inferred from electronic annotation. Source: Compara metanephros morphogenesis Inferred from mutant phenotype PubMed 11062007. Source: MGI muscle cell fate commitment Inferred from mutant phenotype PubMed 15800000. Source: MGI negative regulation of apoptotic process Inferred from mutant phenotype PubMed 16956603. Source: MGI negative regulation of cell cycle arrest Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from direct assay PubMed 16141225. Source: MGI odontogenesis of dentin-containing tooth Inferred from mutant phenotype PubMed 11062007PubMed 11880361. Source: MGI organ growth Inferred from mutant phenotype PubMed 16618415. Source: MGI organ induction Inferred from genetic interaction PubMed 12810586. Source: MGI otic vesicle formation Inferred from genetic interaction PubMed 14623822. Source: MGI pancreas development Inferred from mutant phenotype PubMed 15329346. Source: MGI pituitary gland development Inferred from mutant phenotype PubMed 11062007. Source: MGI positive regulation of ATPase activity Inferred from electronic annotation. Source: Compara positive regulation of DNA repair Inferred from electronic annotation. Source: Compara positive regulation of DNA replication Inferred from electronic annotation. Source: Compara positive regulation of ERK1 and ERK2 cascade Inferred from mutant phenotype PubMed 15130516. Source: MGI positive regulation of Notch signaling pathway Inferred from genetic interaction PubMed 16324690. Source: MGI positive regulation of Ras protein signal transduction Inferred from electronic annotation. Source: Compara positive regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 16720875. Source: MGI positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell migration Inferred from direct assay PubMed 15531758. Source: MGI positive regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 16956603. Source: MGI positive regulation of fibroblast proliferation Inferred from mutant phenotype PubMed 15130516. Source: MGI positive regulation of hair follicle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of keratinocyte migration Inferred from electronic annotation. Source: Compara positive regulation of keratinocyte proliferation Inferred from electronic annotation. Source: Compara positive regulation of lymphocyte proliferation Inferred from electronic annotation. Source: Compara positive regulation of mitotic cell cycle Inferred from mutant phenotype PubMed 16956603. Source: MGI positive regulation of peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 11287183. Source: MGI positive regulation of urothelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of vascular endothelial growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 17560563. Source: MGI positive regulation of white fat cell proliferation Inferred from mutant phenotype PubMed 15130516. Source: MGI protein localization to cell surface Inferred from electronic annotation. Source: Compara radial glial cell differentiation Inferred from mutant phenotype PubMed 19607792. Source: UniProtKB regulation of activin receptor signaling pathway Inferred from mutant phenotype PubMed 15958512. Source: MGI regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Inferred from direct assay PubMed 18559345. Source: MGI regulation of prostatic bud formation Inferred from genetic interaction PubMed 12941620. Source: MGI regulation of saliva secretion Inferred from electronic annotation. Source: Compara regulation of smoothened signaling pathway Inferred from mutant phenotype PubMed 15958512PubMed 16618415. Source: MGI response to estradiol stimulus Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara secretion by lung epithelial cell involved in lung growth Inferred from electronic annotation. Source: Compara semicircular canal fusion Inferred from mutant phenotype PubMed 15765517. Source: MGI smooth muscle cell differentiation Inferred from mutant phenotype PubMed 17560563. Source: MGI somatic stem cell maintenance Inferred from mutant phenotype PubMed 11880361. Source: MGI spleen development Inferred from mutant phenotype PubMed 15329346. Source: MGI submandibular salivary gland formation Inferred from mutant phenotype PubMed 11062007. Source: MGI tear secretion Inferred from electronic annotation. Source: Compara thymus development Inferred from electronic annotation. Source: Compara thyroid gland development Inferred from mutant phenotype PubMed 11062007. Source: MGI tissue regeneration Inferred from electronic annotation. Source: Compara urothelial cell proliferation Inferred from electronic annotation. Source: Compara white fat cell differentiation Inferred from mutant phenotype PubMed 11959839PubMed 15130516. Source: MGI
Cellular_component	extracellular matrix Inferred from electronic annotation. Source: Compara extracellular space Inferred from direct assay PubMed 12837279PubMed 15199404PubMed 9393979PubMed 9428423. Source: MGI nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	chemoattractant activity Inferred from direct assay PubMed 15531758PubMed 16169547PubMed 16308329. Source: MGI heparin binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 36	36	Potential
	Chain	37 – 209	173	Fibroblast growth factor 10		PRO_0000008982
Regions
	Compositional bias	52 – 63	12	Poly-Ser
Amino acid modifications
	Glycosylation	50	1	N-linked (GlcNAc...) Potential
	Glycosylation	197	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O35565 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 7FD22227BF4943CC	FASTA	209	23,597
	10 20 30 40 50 60 MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SFPVTCQALG QDMVSQEATN CSSSSSSFSS 70 80 90 100 110 120 PSSAGRHVRS YNHLQGDVRW RRLFSFTKYF LTIEKNGKVS GTKNEDCPYS VLEITSVEIG 130 140 150 160 170 180 VVAVKAINSN YYLAMNKKGK LYGSKEFNND CKLKERIEEN GYNTYASFNW QHNGRQMYVA 190 200 LNGKGAPRRG QKTRRKNTSA HFLPMTIQT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of mouse FGF10 and up-regulation of its gene expression during wound healing." Tagashira S., Harada H., Katsumata T., Itoh N., Nakatsuka M. Gene 197:399-404(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Duan D.R., Florence C. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Hippocampus and Stomach.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Olfactory epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D89080 mRNA. Translation: BAA22836.1. U94517 mRNA. Translation: AAD00761.1. AK034742 mRNA. Translation: BAC28816.1. AK045267 mRNA. Translation: BAC32287.1. AK085244 mRNA. Translation: BAC39398.1. AK141633 mRNA. Translation: BAE24777.1. BC048229 mRNA. Translation: AAH48229.1.
IPI	IPI00131722.
RefSeq	NP_032028.1. NM_008002.4.
UniGene	Mm.317323.
3D structure databases
ProteinModelPortal	O35565.
SMR	O35565. Positions 70-208.
ModBase	Search...
PTM databases
PhosphoSite	O35565.
Proteomic databases
PRIDE	O35565.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000022246; ENSMUSP00000022246; ENSMUSG00000021732.
GeneID	14165.
KEGG	mmu:14165.
UCSC	uc007ryv.2. mouse.
Organism-specific databases
CTD	2255.
MGI	MGI:1099809. Fgf10.
Phylogenomic databases
eggNOG	NOG327524.
GeneTree	ENSGT00700000104371.
HOGENOM	HOG000236341.
HOVERGEN	HBG007580.
InParanoid	O35565.
KO	K04358.
OMA	GSKEFNT.
OrthoDB	EOG4DZ1WH.
Gene expression databases
ArrayExpress	O35565.
Bgee	O35565.
CleanEx	MM_FGF10.
Genevestigator	O35565.
GermOnline	ENSMUSG00000021732. Mus musculus.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. PTHR11486. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	285306.
SOURCE	Search...

Entry information

Entry name

FGF10_MOUSE

Accession

Primary (citable) accession number: O35565
Secondary accession number(s): Q543V5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program