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Protein

Fibroblast growth factor 10

Gene

Fgf10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton reorganization Source: MGI
  • activation of MAPK activity Source: MGI
  • angiogenesis Source: Ensembl
  • blood vessel morphogenesis Source: MGI
  • blood vessel remodeling Source: MGI
  • branch elongation involved in salivary gland morphogenesis Source: MGI
  • branching involved in salivary gland morphogenesis Source: MGI
  • branching morphogenesis of an epithelial tube Source: MGI
  • bronchiole morphogenesis Source: MGI
  • bud elongation involved in lung branching Source: MGI
  • bud outgrowth involved in lung branching Source: MGI
  • cell-cell signaling Source: MGI
  • chemotaxis Source: MGI
  • determination of left/right symmetry Source: MGI
  • digestive tract development Source: MGI
  • embryonic camera-type eye development Source: MGI
  • embryonic digestive tract development Source: MGI
  • embryonic digestive tract morphogenesis Source: MGI
  • embryonic genitalia morphogenesis Source: MGI
  • embryonic pattern specification Source: MGI
  • epidermis development Source: MGI
  • epidermis morphogenesis Source: MGI
  • epithelial cell differentiation Source: MGI
  • epithelial cell migration Source: MGI
  • epithelial cell proliferation Source: MGI
  • epithelial cell proliferation involved in salivary gland morphogenesis Source: MGI
  • epithelial tube branching involved in lung morphogenesis Source: MGI
  • ERK1 and ERK2 cascade Source: MGI
  • establishment of mitotic spindle orientation Source: MGI
  • female genitalia morphogenesis Source: MGI
  • fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: MGI
  • hair follicle morphogenesis Source: MGI
  • Harderian gland development Source: MGI
  • induction of positive chemotaxis Source: MGI
  • inner ear morphogenesis Source: MGI
  • keratinocyte proliferation Source: MGI
  • lacrimal gland development Source: MGI
  • limb bud formation Source: MGI
  • limb development Source: MGI
  • limb morphogenesis Source: MGI
  • lung alveolus development Source: MGI
  • lung development Source: MGI
  • lung epithelium development Source: MGI
  • lung morphogenesis Source: MGI
  • lung proximal/distal axis specification Source: MGI
  • lung saccule development Source: MGI
  • male genitalia morphogenesis Source: MGI
  • mammary gland bud formation Source: MGI
  • mammary gland specification Source: MGI
  • mesenchymal cell differentiation involved in lung development Source: MGI
  • mesenchymal-epithelial cell signaling involved in lung development Source: MGI
  • mesonephros development Source: Ensembl
  • metanephros morphogenesis Source: MGI
  • muscle cell fate commitment Source: MGI
  • negative regulation of cell cycle arrest Source: MGI
  • negative regulation of cell differentiation Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • organ formation Source: MGI
  • organ growth Source: MGI
  • organ induction Source: MGI
  • organ morphogenesis Source: MGI
  • otic vesicle formation Source: MGI
  • pancreas development Source: MGI
  • pituitary gland development Source: MGI
  • positive chemotaxis Source: MGI
  • positive regulation of ATPase activity Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: MGI
  • positive regulation of DNA repair Source: MGI
  • positive regulation of DNA replication Source: MGI
  • positive regulation of epithelial cell migration Source: MGI
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: MGI
  • positive regulation of fibroblast proliferation Source: MGI
  • positive regulation of hair follicle cell proliferation Source: MGI
  • positive regulation of keratinocyte migration Source: MGI
  • positive regulation of keratinocyte proliferation Source: MGI
  • positive regulation of lymphocyte proliferation Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of mitotic cell cycle Source: MGI
  • positive regulation of Notch signaling pathway Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of Ras protein signal transduction Source: MGI
  • positive regulation of transcription, DNA-templated Source: CACAO
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of urothelial cell proliferation Source: MGI
  • positive regulation of vascular endothelial growth factor receptor signaling pathway Source: MGI
  • positive regulation of white fat cell proliferation Source: MGI
  • positive regulation of Wnt signaling pathway Source: MGI
  • prostatic bud formation Source: MGI
  • protein localization to cell surface Source: MGI
  • radial glial cell differentiation Source: UniProtKB
  • regulation of activin receptor signaling pathway Source: MGI
  • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: MGI
  • regulation of epithelial cell proliferation Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of saliva secretion Source: MGI
  • regulation of smoothened signaling pathway Source: MGI
  • respiratory system development Source: MGI
  • response to estradiol Source: Ensembl
  • response to lipopolysaccharide Source: Ensembl
  • salivary gland development Source: MGI
  • salivary gland morphogenesis Source: MGI
  • secretion by lung epithelial cell involved in lung growth Source: MGI
  • semicircular canal fusion Source: MGI
  • semicircular canal morphogenesis Source: MGI
  • smooth muscle cell differentiation Source: MGI
  • somatic stem cell maintenance Source: MGI
  • spleen development Source: MGI
  • submandibular salivary gland formation Source: MGI
  • tear secretion Source: MGI
  • thymus development Source: MGI
  • thyroid gland development Source: MGI
  • tissue regeneration Source: Ensembl
  • Type II pneumocyte differentiation Source: MGI
  • urothelial cell proliferation Source: MGI
  • white fat cell differentiation Source: MGI
  • wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_289551. FGFR1b ligand binding and activation.
REACT_296789. Regulation of gene expression in early pancreatic precursor cells.
REACT_297015. FGFR2b ligand binding and activation.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_357393. Negative regulation of FGFR2 signaling.
REACT_357671. FRS-mediated FGFR1 signaling.
REACT_358096. Phospholipase C-mediated cascade: FGFR1.
REACT_359069. Phospholipase C-mediated cascade, FGFR2.
REACT_359435. Negative regulation of FGFR1 signaling.
REACT_359700. FRS-mediated FGFR2 signaling.
REACT_359709. PI-3K cascade:FGFR2.
REACT_361588. SHC-mediated cascade:FGFR2.
REACT_361629. PI-3K cascade:FGFR1.
REACT_361860. SHC-mediated cascade:FGFR1.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 10
Short name:
FGF-10
Alternative name(s):
Keratinocyte growth factor 2
Gene namesi
Name:Fgf10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1099809. Fgf10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636Sequence AnalysisAdd
BLAST
Chaini37 – 209173Fibroblast growth factor 10PRO_0000008982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO35565.

PTM databases

PhosphoSiteiO35565.

Expressioni

Tissue specificityi

Expressed abundantly in embryos and the lung, and at much lower levels in brain and heart.

Gene expression databases

BgeeiO35565.
CleanExiMM_FGF10.
ExpressionAtlasiO35565. baseline and differential.
GenevestigatoriO35565.

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199639. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO35565.
SMRiO35565. Positions 70-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi52 – 6312Poly-SerAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG327524.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiO35565.
KOiK04358.
OMAiSSIPVTC.
OrthoDBiEOG7992S1.
PhylomeDBiO35565.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35565-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SFPVTCQALG QDMVSQEATN
60 70 80 90 100
CSSSSSSFSS PSSAGRHVRS YNHLQGDVRW RRLFSFTKYF LTIEKNGKVS
110 120 130 140 150
GTKNEDCPYS VLEITSVEIG VVAVKAINSN YYLAMNKKGK LYGSKEFNND
160 170 180 190 200
CKLKERIEEN GYNTYASFNW QHNGRQMYVA LNGKGAPRRG QKTRRKNTSA

HFLPMTIQT
Length:209
Mass (Da):23,597
Last modified:January 1, 1998 - v1
Checksum:i7FD22227BF4943CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89080 mRNA. Translation: BAA22836.1.
U94517 mRNA. Translation: AAD00761.1.
AK034742 mRNA. Translation: BAC28816.1.
AK045267 mRNA. Translation: BAC32287.1.
AK085244 mRNA. Translation: BAC39398.1.
AK141633 mRNA. Translation: BAE24777.1.
BC048229 mRNA. Translation: AAH48229.1.
CCDSiCCDS26795.1.
RefSeqiNP_032028.1. NM_008002.4.
UniGeneiMm.317323.

Genome annotation databases

EnsembliENSMUST00000022246; ENSMUSP00000022246; ENSMUSG00000021732.
GeneIDi14165.
KEGGimmu:14165.
UCSCiuc007ryv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89080 mRNA. Translation: BAA22836.1.
U94517 mRNA. Translation: AAD00761.1.
AK034742 mRNA. Translation: BAC28816.1.
AK045267 mRNA. Translation: BAC32287.1.
AK085244 mRNA. Translation: BAC39398.1.
AK141633 mRNA. Translation: BAE24777.1.
BC048229 mRNA. Translation: AAH48229.1.
CCDSiCCDS26795.1.
RefSeqiNP_032028.1. NM_008002.4.
UniGeneiMm.317323.

3D structure databases

ProteinModelPortaliO35565.
SMRiO35565. Positions 70-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199639. 1 interaction.

PTM databases

PhosphoSiteiO35565.

Proteomic databases

PRIDEiO35565.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022246; ENSMUSP00000022246; ENSMUSG00000021732.
GeneIDi14165.
KEGGimmu:14165.
UCSCiuc007ryv.2. mouse.

Organism-specific databases

CTDi2255.
MGIiMGI:1099809. Fgf10.

Phylogenomic databases

eggNOGiNOG327524.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiO35565.
KOiK04358.
OMAiSSIPVTC.
OrthoDBiEOG7992S1.
PhylomeDBiO35565.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiREACT_289551. FGFR1b ligand binding and activation.
REACT_296789. Regulation of gene expression in early pancreatic precursor cells.
REACT_297015. FGFR2b ligand binding and activation.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_357393. Negative regulation of FGFR2 signaling.
REACT_357671. FRS-mediated FGFR1 signaling.
REACT_358096. Phospholipase C-mediated cascade: FGFR1.
REACT_359069. Phospholipase C-mediated cascade, FGFR2.
REACT_359435. Negative regulation of FGFR1 signaling.
REACT_359700. FRS-mediated FGFR2 signaling.
REACT_359709. PI-3K cascade:FGFR2.
REACT_361588. SHC-mediated cascade:FGFR2.
REACT_361629. PI-3K cascade:FGFR1.
REACT_361860. SHC-mediated cascade:FGFR1.

Miscellaneous databases

NextBioi285306.
PROiO35565.
SOURCEiSearch...

Gene expression databases

BgeeiO35565.
CleanExiMM_FGF10.
ExpressionAtlasiO35565. baseline and differential.
GenevestigatoriO35565.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse FGF10 and up-regulation of its gene expression during wound healing."
    Tagashira S., Harada H., Katsumata T., Itoh N., Nakatsuka M.
    Gene 197:399-404(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Duan D.R., Florence C.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus and Stomach.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiFGF10_MOUSE
AccessioniPrimary (citable) accession number: O35565
Secondary accession number(s): Q543V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: May 27, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.