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O35565 (FGF10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 10

Short name=FGF-10
Alternative name(s):
Keratinocyte growth factor 2
Gene names
Name:Fgf10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

Subunit structure

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 By similarity.

Subcellular location

Secreted Potential.

Tissue specificity

Expressed abundantly in embryos and the lung, and at much lower levels in brain and heart.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

Harderian gland development

Inferred from mutant phenotype PubMed 10964474. Source: MGI

Type II pneumocyte differentiation

Inferred from direct assay PubMed 15531758. Source: MGI

actin cytoskeleton reorganization

Inferred from electronic annotation. Source: Ensembl

activation of MAPK activity

Inferred from electronic annotation. Source: Ensembl

angiogenesis

Inferred from electronic annotation. Source: Ensembl

blood vessel morphogenesis

Inferred from mutant phenotype PubMed 17560563. Source: MGI

blood vessel remodeling

Inferred from genetic interaction PubMed 17000704. Source: MGI

branch elongation involved in salivary gland morphogenesis

Inferred from mutant phenotype PubMed 15972105. Source: MGI

branching involved in salivary gland morphogenesis

Inferred from direct assay PubMed 18559345. Source: MGI

bronchiole morphogenesis

Inferred from mutant phenotype PubMed 15800000. Source: MGI

bud elongation involved in lung branching

Inferred from genetic interaction PubMed 21764747. Source: MGI

bud outgrowth involved in lung branching

Inferred from electronic annotation. Source: Ensembl

cell-cell signaling

Inferred from direct assay PubMed 9428423. Source: MGI

chemotaxis

Inferred from direct assay PubMed 16169547. Source: MGI

determination of left/right symmetry

Inferred from mutant phenotype PubMed 15329346. Source: MGI

digestive tract development

Inferred from mutant phenotype PubMed 15234214. Source: MGI

embryonic camera-type eye development

Inferred from mutant phenotype PubMed 15958512. Source: MGI

embryonic digestive tract development

Inferred from mutant phenotype PubMed 16308329. Source: MGI

embryonic digestive tract morphogenesis

Inferred from mutant phenotype PubMed 15017552PubMed 16618415. Source: MGI

embryonic genitalia morphogenesis

Inferred from mutant phenotype PubMed 12004962. Source: MGI

embryonic pattern specification

Inferred from mutant phenotype PubMed 16618415PubMed 17522155. Source: MGI

epidermis development

Inferred from mutant phenotype PubMed 10984614. Source: MGI

epidermis morphogenesis

Inferred from mutant phenotype PubMed 14530295. Source: MGI

epithelial cell differentiation

Inferred from mutant phenotype PubMed 16618415. Source: MGI

epithelial cell migration

Inferred from mutant phenotype PubMed 15958512. Source: MGI

epithelial cell proliferation

Inferred from mutant phenotype PubMed 15958512. Source: MGI

epithelial cell proliferation involved in salivary gland morphogenesis

Inferred from mutant phenotype PubMed 15972105. Source: MGI

epithelial tube branching involved in lung morphogenesis

Inferred from direct assay PubMed 16169547PubMed 16375885PubMed 9428423. Source: MGI

establishment of mitotic spindle orientation

Inferred from genetic interaction PubMed 21764747. Source: MGI

female genitalia morphogenesis

Inferred from mutant phenotype PubMed 12004962. Source: MGI

fibroblast growth factor receptor signaling pathway involved in mammary gland specification

Inferred from direct assay PubMed 16720875. Source: MGI

hair follicle morphogenesis

Inferred from mutant phenotype PubMed 11062007. Source: MGI

induction of positive chemotaxis

Inferred from direct assay PubMed 16308329. Source: MGI

inner ear morphogenesis

Inferred from mutant phenotype PubMed 11062007. Source: MGI

keratinocyte proliferation

Inferred from mutant phenotype PubMed 10984614. Source: MGI

lacrimal gland development

Inferred from mutant phenotype PubMed 10821755PubMed 10964474PubMed 15654336. Source: MGI

limb bud formation

Inferred from mutant phenotype PubMed 9784490. Source: MGI

limb development

Inferred from mutant phenotype PubMed 10804187. Source: MGI

limb morphogenesis

Inferred from mutant phenotype PubMed 9916808. Source: MGI

lung alveolus development

Inferred from mutant phenotype PubMed 17560563. Source: MGI

lung development

Inferred from direct assay PubMed 16375885PubMed 9428423. Source: MGI

lung morphogenesis

Inferred from mutant phenotype PubMed 15800000. Source: MGI

lung proximal/distal axis specification

Inferred from direct assay PubMed 15531758. Source: MGI

lung saccule development

Inferred from electronic annotation. Source: Ensembl

male genitalia morphogenesis

Inferred from mutant phenotype PubMed 12004962. Source: MGI

mammary gland bud formation

Inferred from mutant phenotype PubMed 11782400. Source: MGI

mammary gland specification

Inferred from genetic interaction PubMed 16720875. Source: MGI

mesenchymal cell differentiation involved in lung development

Inferred from genetic interaction PubMed 16989802. Source: MGI

mesenchymal-epithelial cell signaling involved in lung development

Inferred from direct assay PubMed 15531758. Source: MGI

mesonephros development

Inferred from electronic annotation. Source: Ensembl

metanephros morphogenesis

Inferred from mutant phenotype PubMed 11062007. Source: MGI

muscle cell fate commitment

Inferred from mutant phenotype PubMed 15800000. Source: MGI

negative regulation of cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell differentiation

Inferred from direct assay PubMed 14604677. Source: MGI

negative regulation of cell proliferation

Inferred from direct assay PubMed 16141225. Source: MGI

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from mutant phenotype PubMed 16956603. Source: MGI

odontogenesis of dentin-containing tooth

Inferred from mutant phenotype PubMed 11062007PubMed 11880361. Source: MGI

organ formation

Inferred from mutant phenotype PubMed 11062007. Source: MGI

organ growth

Inferred from mutant phenotype PubMed 16618415. Source: MGI

organ induction

Inferred from genetic interaction PubMed 12810586. Source: MGI

organ morphogenesis

Inferred from direct assay PubMed 14651921. Source: MGI

otic vesicle formation

Inferred from genetic interaction PubMed 14623822. Source: MGI

pancreas development

Inferred from mutant phenotype PubMed 15329346. Source: MGI

pituitary gland development

Inferred from mutant phenotype PubMed 11062007. Source: MGI

positive chemotaxis

Inferred from direct assay PubMed 15531758. Source: MGI

positive regulation of ATPase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of DNA repair

Inferred from electronic annotation. Source: Ensembl

positive regulation of DNA replication

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from mutant phenotype PubMed 15130516. Source: MGI

positive regulation of Notch signaling pathway

Inferred from genetic interaction PubMed 16324690. Source: MGI

positive regulation of Ras protein signal transduction

Inferred from electronic annotation. Source: Ensembl

positive regulation of Wnt signaling pathway

Inferred from mutant phenotype PubMed 17560563. Source: MGI

positive regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 16720875. Source: MGI

positive regulation of cell proliferation

Inferred from direct assay PubMed 14697353PubMed 15199404PubMed 9428423. Source: MGI

positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell migration

Inferred from direct assay PubMed 15531758. Source: MGI

positive regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 16956603. Source: MGI

positive regulation of fibroblast proliferation

Inferred from mutant phenotype PubMed 15130516. Source: MGI

positive regulation of hair follicle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of keratinocyte migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of keratinocyte proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of lymphocyte proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of mitotic cell cycle

Inferred from mutant phenotype PubMed 16956603. Source: MGI

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 11287183. Source: MGI

positive regulation of urothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of vascular endothelial growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 17560563. Source: MGI

positive regulation of white fat cell proliferation

Inferred from mutant phenotype PubMed 15130516. Source: MGI

prostatic bud formation

Inferred from genetic interaction PubMed 12941620. Source: MGI

protein localization to cell surface

Inferred from electronic annotation. Source: Ensembl

radial glial cell differentiation

Inferred from mutant phenotype PubMed 19607792. Source: UniProtKB

regulation of activin receptor signaling pathway

Inferred from mutant phenotype PubMed 15958512. Source: MGI

regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

Inferred from direct assay PubMed 18559345. Source: MGI

regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 15972105. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 15958512. Source: MGI

regulation of saliva secretion

Inferred from electronic annotation. Source: Ensembl

regulation of smoothened signaling pathway

Inferred from mutant phenotype PubMed 15958512PubMed 16618415. Source: MGI

respiratory system development

Inferred from direct assay PubMed 11287183. Source: MGI

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

salivary gland morphogenesis

Inferred from mutant phenotype PubMed 15654336. Source: MGI

secretion by lung epithelial cell involved in lung growth

Inferred from electronic annotation. Source: Ensembl

semicircular canal fusion

Inferred from mutant phenotype PubMed 15765517. Source: MGI

semicircular canal morphogenesis

Inferred from genetic interaction PubMed 17601531. Source: MGI

smooth muscle cell differentiation

Inferred from mutant phenotype PubMed 17560563. Source: MGI

somatic stem cell maintenance

Inferred from mutant phenotype PubMed 11880361. Source: MGI

spleen development

Inferred from mutant phenotype PubMed 15329346. Source: MGI

submandibular salivary gland formation

Inferred from mutant phenotype PubMed 11062007. Source: MGI

tear secretion

Inferred from electronic annotation. Source: Ensembl

thymus development

Inferred from electronic annotation. Source: Ensembl

thyroid gland development

Inferred from mutant phenotype PubMed 11062007. Source: MGI

tissue regeneration

Inferred from electronic annotation. Source: Ensembl

urothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

white fat cell differentiation

Inferred from mutant phenotype PubMed 11959839PubMed 15130516. Source: MGI

   Cellular_componentextracellular matrix

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from direct assay PubMed 12837279PubMed 15199404PubMed 9393979PubMed 9428423. Source: MGI

nucleus

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionchemoattractant activity

Inferred from direct assay PubMed 15531758PubMed 16169547PubMed 16308329. Source: MGI

heparin binding

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 15806171. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3636 Potential
Chain37 – 209173Fibroblast growth factor 10
PRO_0000008982

Regions

Compositional bias52 – 6312Poly-Ser

Amino acid modifications

Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation1971N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O35565 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 7FD22227BF4943CC

FASTA20923,597
        10         20         30         40         50         60 
MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SFPVTCQALG QDMVSQEATN CSSSSSSFSS 

        70         80         90        100        110        120 
PSSAGRHVRS YNHLQGDVRW RRLFSFTKYF LTIEKNGKVS GTKNEDCPYS VLEITSVEIG 

       130        140        150        160        170        180 
VVAVKAINSN YYLAMNKKGK LYGSKEFNND CKLKERIEEN GYNTYASFNW QHNGRQMYVA 

       190        200 
LNGKGAPRRG QKTRRKNTSA HFLPMTIQT 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of mouse FGF10 and up-regulation of its gene expression during wound healing."
Tagashira S., Harada H., Katsumata T., Itoh N., Nakatsuka M.
Gene 197:399-404(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Duan D.R., Florence C.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Hippocampus and Stomach.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D89080 mRNA. Translation: BAA22836.1.
U94517 mRNA. Translation: AAD00761.1.
AK034742 mRNA. Translation: BAC28816.1.
AK045267 mRNA. Translation: BAC32287.1.
AK085244 mRNA. Translation: BAC39398.1.
AK141633 mRNA. Translation: BAE24777.1.
BC048229 mRNA. Translation: AAH48229.1.
CCDSCCDS26795.1.
RefSeqNP_032028.1. NM_008002.4.
UniGeneMm.317323.

3D structure databases

ProteinModelPortalO35565.
SMRO35565. Positions 70-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199639. 1 interaction.

PTM databases

PhosphoSiteO35565.

Proteomic databases

PRIDEO35565.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022246; ENSMUSP00000022246; ENSMUSG00000021732.
GeneID14165.
KEGGmmu:14165.
UCSCuc007ryv.2. mouse.

Organism-specific databases

CTD2255.
MGIMGI:1099809. Fgf10.

Phylogenomic databases

eggNOGNOG327524.
GeneTreeENSGT00730000110261.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidO35565.
KOK04358.
OMASSIPVTC.
OrthoDBEOG7992S1.
PhylomeDBO35565.
TreeFamTF317805.

Gene expression databases

ArrayExpressO35565.
BgeeO35565.
CleanExMM_FGF10.
GenevestigatorO35565.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285306.
PROO35565.
SOURCESearch...

Entry information

Entry nameFGF10_MOUSE
AccessionPrimary (citable) accession number: O35565
Secondary accession number(s): Q543V5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot