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Protein

Fibroblast growth factor 10

Gene

Fgf10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

GO - Molecular functioni

  1. chemoattractant activity Source: MGI
  2. fibroblast growth factor receptor binding Source: MGI
  3. growth factor activity Source: MGI
  4. heparin binding Source: MGI
  5. type 2 fibroblast growth factor receptor binding Source: MGI

GO - Biological processi

  1. actin cytoskeleton reorganization Source: MGI
  2. activation of MAPK activity Source: MGI
  3. angiogenesis Source: Ensembl
  4. blood vessel morphogenesis Source: MGI
  5. blood vessel remodeling Source: MGI
  6. branch elongation involved in salivary gland morphogenesis Source: MGI
  7. branching involved in salivary gland morphogenesis Source: MGI
  8. branching morphogenesis of an epithelial tube Source: MGI
  9. bronchiole morphogenesis Source: MGI
  10. bud elongation involved in lung branching Source: MGI
  11. bud outgrowth involved in lung branching Source: MGI
  12. cell-cell signaling Source: MGI
  13. chemotaxis Source: MGI
  14. determination of left/right symmetry Source: MGI
  15. digestive tract development Source: MGI
  16. embryonic camera-type eye development Source: MGI
  17. embryonic digestive tract development Source: MGI
  18. embryonic digestive tract morphogenesis Source: MGI
  19. embryonic genitalia morphogenesis Source: MGI
  20. embryonic pattern specification Source: MGI
  21. epidermis development Source: MGI
  22. epidermis morphogenesis Source: MGI
  23. epithelial cell differentiation Source: MGI
  24. epithelial cell migration Source: MGI
  25. epithelial cell proliferation Source: MGI
  26. epithelial cell proliferation involved in salivary gland morphogenesis Source: MGI
  27. epithelial tube branching involved in lung morphogenesis Source: MGI
  28. ERK1 and ERK2 cascade Source: MGI
  29. establishment of mitotic spindle orientation Source: MGI
  30. female genitalia morphogenesis Source: MGI
  31. fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: MGI
  32. hair follicle morphogenesis Source: MGI
  33. Harderian gland development Source: MGI
  34. induction of positive chemotaxis Source: MGI
  35. inner ear morphogenesis Source: MGI
  36. keratinocyte proliferation Source: MGI
  37. lacrimal gland development Source: MGI
  38. limb bud formation Source: MGI
  39. limb development Source: MGI
  40. limb morphogenesis Source: MGI
  41. lung alveolus development Source: MGI
  42. lung development Source: MGI
  43. lung epithelium development Source: MGI
  44. lung morphogenesis Source: MGI
  45. lung proximal/distal axis specification Source: MGI
  46. lung saccule development Source: MGI
  47. male genitalia morphogenesis Source: MGI
  48. mammary gland bud formation Source: MGI
  49. mammary gland specification Source: MGI
  50. mesenchymal cell differentiation involved in lung development Source: MGI
  51. mesenchymal-epithelial cell signaling involved in lung development Source: MGI
  52. mesonephros development Source: Ensembl
  53. metanephros morphogenesis Source: MGI
  54. muscle cell fate commitment Source: MGI
  55. negative regulation of cell cycle arrest Source: MGI
  56. negative regulation of cell differentiation Source: MGI
  57. negative regulation of cell proliferation Source: MGI
  58. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  59. odontogenesis of dentin-containing tooth Source: MGI
  60. organ formation Source: MGI
  61. organ growth Source: MGI
  62. organ induction Source: MGI
  63. organ morphogenesis Source: MGI
  64. otic vesicle formation Source: MGI
  65. pancreas development Source: MGI
  66. pituitary gland development Source: MGI
  67. positive chemotaxis Source: MGI
  68. positive regulation of ATPase activity Source: MGI
  69. positive regulation of canonical Wnt signaling pathway Source: MGI
  70. positive regulation of cell proliferation Source: MGI
  71. positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: MGI
  72. positive regulation of DNA repair Source: MGI
  73. positive regulation of DNA replication Source: MGI
  74. positive regulation of epithelial cell migration Source: MGI
  75. positive regulation of epithelial cell proliferation Source: MGI
  76. positive regulation of ERK1 and ERK2 cascade Source: MGI
  77. positive regulation of fibroblast proliferation Source: MGI
  78. positive regulation of hair follicle cell proliferation Source: MGI
  79. positive regulation of keratinocyte migration Source: MGI
  80. positive regulation of keratinocyte proliferation Source: MGI
  81. positive regulation of lymphocyte proliferation Source: MGI
  82. positive regulation of MAPK cascade Source: MGI
  83. positive regulation of mitotic cell cycle Source: MGI
  84. positive regulation of Notch signaling pathway Source: MGI
  85. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  86. positive regulation of Ras protein signal transduction Source: MGI
  87. positive regulation of transcription, DNA-templated Source: MGI
  88. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  89. positive regulation of urothelial cell proliferation Source: MGI
  90. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: MGI
  91. positive regulation of white fat cell proliferation Source: MGI
  92. positive regulation of Wnt signaling pathway Source: MGI
  93. prostatic bud formation Source: MGI
  94. protein localization to cell surface Source: MGI
  95. radial glial cell differentiation Source: UniProtKB
  96. regulation of activin receptor signaling pathway Source: MGI
  97. regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: MGI
  98. regulation of epithelial cell proliferation Source: MGI
  99. regulation of gene expression Source: MGI
  100. regulation of saliva secretion Source: MGI
  101. regulation of smoothened signaling pathway Source: MGI
  102. respiratory system development Source: MGI
  103. response to estradiol Source: Ensembl
  104. response to lipopolysaccharide Source: Ensembl
  105. salivary gland development Source: MGI
  106. salivary gland morphogenesis Source: MGI
  107. secretion by lung epithelial cell involved in lung growth Source: MGI
  108. semicircular canal fusion Source: MGI
  109. semicircular canal morphogenesis Source: MGI
  110. smooth muscle cell differentiation Source: MGI
  111. somatic stem cell maintenance Source: MGI
  112. spleen development Source: MGI
  113. submandibular salivary gland formation Source: MGI
  114. tear secretion Source: MGI
  115. thymus development Source: MGI
  116. thyroid gland development Source: MGI
  117. tissue regeneration Source: Ensembl
  118. Type II pneumocyte differentiation Source: MGI
  119. urothelial cell proliferation Source: MGI
  120. white fat cell differentiation Source: MGI
  121. wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_289551. FGFR1b ligand binding and activation.
REACT_296789. Regulation of gene expression in early pancreatic precursor cells.
REACT_297015. FGFR2b ligand binding and activation.
REACT_321421. SHC-mediated cascade.
REACT_323826. Phospholipase C-mediated cascade.
REACT_326306. Signaling by FGFR mutants.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.
REACT_332023. Negative regulation of FGFR signaling.
REACT_332809. FRS2-mediated cascade.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_334662. PI-3K cascade.
REACT_349060. Activated point mutants of FGFR2.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 10
Short name:
FGF-10
Alternative name(s):
Keratinocyte growth factor 2
Gene namesi
Name:Fgf10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1099809. Fgf10.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. cell surface Source: MGI
  2. extracellular matrix Source: Ensembl
  3. extracellular space Source: MGI
  4. nucleus Source: MGI
  5. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636Sequence AnalysisAdd
BLAST
Chaini37 – 209173Fibroblast growth factor 10PRO_0000008982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO35565.

PTM databases

PhosphoSiteiO35565.

Expressioni

Tissue specificityi

Expressed abundantly in embryos and the lung, and at much lower levels in brain and heart.

Gene expression databases

BgeeiO35565.
CleanExiMM_FGF10.
ExpressionAtlasiO35565. baseline and differential.
GenevestigatoriO35565.

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199639. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO35565.
SMRiO35565. Positions 70-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi52 – 6312Poly-SerAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG327524.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiO35565.
KOiK04358.
OMAiSSIPVTC.
OrthoDBiEOG7992S1.
PhylomeDBiO35565.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35565-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SFPVTCQALG QDMVSQEATN
60 70 80 90 100
CSSSSSSFSS PSSAGRHVRS YNHLQGDVRW RRLFSFTKYF LTIEKNGKVS
110 120 130 140 150
GTKNEDCPYS VLEITSVEIG VVAVKAINSN YYLAMNKKGK LYGSKEFNND
160 170 180 190 200
CKLKERIEEN GYNTYASFNW QHNGRQMYVA LNGKGAPRRG QKTRRKNTSA

HFLPMTIQT
Length:209
Mass (Da):23,597
Last modified:December 31, 1997 - v1
Checksum:i7FD22227BF4943CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89080 mRNA. Translation: BAA22836.1.
U94517 mRNA. Translation: AAD00761.1.
AK034742 mRNA. Translation: BAC28816.1.
AK045267 mRNA. Translation: BAC32287.1.
AK085244 mRNA. Translation: BAC39398.1.
AK141633 mRNA. Translation: BAE24777.1.
BC048229 mRNA. Translation: AAH48229.1.
CCDSiCCDS26795.1.
RefSeqiNP_032028.1. NM_008002.4.
UniGeneiMm.317323.

Genome annotation databases

EnsembliENSMUST00000022246; ENSMUSP00000022246; ENSMUSG00000021732.
GeneIDi14165.
KEGGimmu:14165.
UCSCiuc007ryv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89080 mRNA. Translation: BAA22836.1.
U94517 mRNA. Translation: AAD00761.1.
AK034742 mRNA. Translation: BAC28816.1.
AK045267 mRNA. Translation: BAC32287.1.
AK085244 mRNA. Translation: BAC39398.1.
AK141633 mRNA. Translation: BAE24777.1.
BC048229 mRNA. Translation: AAH48229.1.
CCDSiCCDS26795.1.
RefSeqiNP_032028.1. NM_008002.4.
UniGeneiMm.317323.

3D structure databases

ProteinModelPortaliO35565.
SMRiO35565. Positions 70-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199639. 1 interaction.

PTM databases

PhosphoSiteiO35565.

Proteomic databases

PRIDEiO35565.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022246; ENSMUSP00000022246; ENSMUSG00000021732.
GeneIDi14165.
KEGGimmu:14165.
UCSCiuc007ryv.2. mouse.

Organism-specific databases

CTDi2255.
MGIiMGI:1099809. Fgf10.

Phylogenomic databases

eggNOGiNOG327524.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiO35565.
KOiK04358.
OMAiSSIPVTC.
OrthoDBiEOG7992S1.
PhylomeDBiO35565.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiREACT_289551. FGFR1b ligand binding and activation.
REACT_296789. Regulation of gene expression in early pancreatic precursor cells.
REACT_297015. FGFR2b ligand binding and activation.
REACT_321421. SHC-mediated cascade.
REACT_323826. Phospholipase C-mediated cascade.
REACT_326306. Signaling by FGFR mutants.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.
REACT_332023. Negative regulation of FGFR signaling.
REACT_332809. FRS2-mediated cascade.
REACT_332866. PI3K Cascade.
REACT_333474. PIP3 activates AKT signaling.
REACT_334662. PI-3K cascade.
REACT_349060. Activated point mutants of FGFR2.

Miscellaneous databases

NextBioi285306.
PROiO35565.
SOURCEiSearch...

Gene expression databases

BgeeiO35565.
CleanExiMM_FGF10.
ExpressionAtlasiO35565. baseline and differential.
GenevestigatoriO35565.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028252. FGF10.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF21. PTHR11486:SF21. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse FGF10 and up-regulation of its gene expression during wound healing."
    Tagashira S., Harada H., Katsumata T., Itoh N., Nakatsuka M.
    Gene 197:399-404(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Duan D.R., Florence C.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus and Stomach.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiFGF10_MOUSE
AccessioniPrimary (citable) accession number: O35565
Secondary accession number(s): Q543V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1999
Last sequence update: December 31, 1997
Last modified: March 31, 2015
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.