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O35565

- FGF10_MOUSE

UniProt

O35565 - FGF10_MOUSE

Protein

Fibroblast growth factor 10

Gene

Fgf10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.

    GO - Molecular functioni

    1. chemoattractant activity Source: MGI
    2. heparin binding Source: Ensembl
    3. protein binding Source: MGI

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: Ensembl
    2. activation of MAPK activity Source: Ensembl
    3. angiogenesis Source: Ensembl
    4. blood vessel morphogenesis Source: MGI
    5. blood vessel remodeling Source: MGI
    6. branch elongation involved in salivary gland morphogenesis Source: MGI
    7. branching involved in salivary gland morphogenesis Source: MGI
    8. bronchiole morphogenesis Source: MGI
    9. bud elongation involved in lung branching Source: MGI
    10. bud outgrowth involved in lung branching Source: Ensembl
    11. cell-cell signaling Source: MGI
    12. chemotaxis Source: MGI
    13. determination of left/right symmetry Source: MGI
    14. digestive tract development Source: MGI
    15. embryonic camera-type eye development Source: MGI
    16. embryonic digestive tract development Source: MGI
    17. embryonic digestive tract morphogenesis Source: MGI
    18. embryonic genitalia morphogenesis Source: MGI
    19. embryonic pattern specification Source: MGI
    20. epidermis development Source: MGI
    21. epidermis morphogenesis Source: MGI
    22. epithelial cell differentiation Source: MGI
    23. epithelial cell migration Source: MGI
    24. epithelial cell proliferation Source: MGI
    25. epithelial cell proliferation involved in salivary gland morphogenesis Source: MGI
    26. epithelial tube branching involved in lung morphogenesis Source: MGI
    27. ERK1 and ERK2 cascade Source: Ensembl
    28. establishment of mitotic spindle orientation Source: MGI
    29. female genitalia morphogenesis Source: MGI
    30. fibroblast growth factor receptor signaling pathway involved in mammary gland specification Source: MGI
    31. hair follicle morphogenesis Source: MGI
    32. Harderian gland development Source: MGI
    33. induction of positive chemotaxis Source: MGI
    34. inner ear morphogenesis Source: MGI
    35. keratinocyte proliferation Source: MGI
    36. lacrimal gland development Source: MGI
    37. limb bud formation Source: MGI
    38. limb development Source: MGI
    39. limb morphogenesis Source: MGI
    40. lung alveolus development Source: MGI
    41. lung development Source: MGI
    42. lung morphogenesis Source: MGI
    43. lung proximal/distal axis specification Source: MGI
    44. lung saccule development Source: Ensembl
    45. male genitalia morphogenesis Source: MGI
    46. mammary gland bud formation Source: MGI
    47. mammary gland specification Source: MGI
    48. mesenchymal cell differentiation involved in lung development Source: MGI
    49. mesenchymal-epithelial cell signaling involved in lung development Source: MGI
    50. mesonephros development Source: Ensembl
    51. metanephros morphogenesis Source: MGI
    52. muscle cell fate commitment Source: MGI
    53. negative regulation of cell cycle arrest Source: Ensembl
    54. negative regulation of cell differentiation Source: MGI
    55. negative regulation of cell proliferation Source: MGI
    56. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    57. odontogenesis of dentin-containing tooth Source: MGI
    58. organ formation Source: MGI
    59. organ growth Source: MGI
    60. organ induction Source: MGI
    61. organ morphogenesis Source: MGI
    62. otic vesicle formation Source: MGI
    63. pancreas development Source: MGI
    64. pituitary gland development Source: MGI
    65. positive chemotaxis Source: MGI
    66. positive regulation of ATPase activity Source: Ensembl
    67. positive regulation of canonical Wnt signaling pathway Source: MGI
    68. positive regulation of cell proliferation Source: MGI
    69. positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: Ensembl
    70. positive regulation of DNA repair Source: Ensembl
    71. positive regulation of DNA replication Source: Ensembl
    72. positive regulation of epithelial cell migration Source: MGI
    73. positive regulation of epithelial cell proliferation Source: MGI
    74. positive regulation of ERK1 and ERK2 cascade Source: MGI
    75. positive regulation of fibroblast proliferation Source: MGI
    76. positive regulation of hair follicle cell proliferation Source: Ensembl
    77. positive regulation of keratinocyte migration Source: Ensembl
    78. positive regulation of keratinocyte proliferation Source: Ensembl
    79. positive regulation of lymphocyte proliferation Source: Ensembl
    80. positive regulation of mitotic cell cycle Source: MGI
    81. positive regulation of Notch signaling pathway Source: MGI
    82. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    83. positive regulation of Ras protein signal transduction Source: Ensembl
    84. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    85. positive regulation of urothelial cell proliferation Source: Ensembl
    86. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: MGI
    87. positive regulation of white fat cell proliferation Source: MGI
    88. positive regulation of Wnt signaling pathway Source: MGI
    89. prostatic bud formation Source: MGI
    90. protein localization to cell surface Source: Ensembl
    91. radial glial cell differentiation Source: UniProtKB
    92. regulation of activin receptor signaling pathway Source: MGI
    93. regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: MGI
    94. regulation of epithelial cell proliferation Source: MGI
    95. regulation of gene expression Source: MGI
    96. regulation of saliva secretion Source: Ensembl
    97. regulation of smoothened signaling pathway Source: MGI
    98. respiratory system development Source: MGI
    99. response to estradiol Source: Ensembl
    100. response to lipopolysaccharide Source: Ensembl
    101. salivary gland morphogenesis Source: MGI
    102. secretion by lung epithelial cell involved in lung growth Source: Ensembl
    103. semicircular canal fusion Source: MGI
    104. semicircular canal morphogenesis Source: MGI
    105. smooth muscle cell differentiation Source: MGI
    106. somatic stem cell maintenance Source: MGI
    107. spleen development Source: MGI
    108. submandibular salivary gland formation Source: MGI
    109. tear secretion Source: Ensembl
    110. thymus development Source: Ensembl
    111. thyroid gland development Source: MGI
    112. tissue regeneration Source: Ensembl
    113. Type II pneumocyte differentiation Source: MGI
    114. urothelial cell proliferation Source: Ensembl
    115. white fat cell differentiation Source: MGI

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_196455. Signaling by FGFR mutants.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_208465. Regulation of gene expression in early pancreatic precursor cells.
    REACT_220836. FGFR1b ligand binding and activation.
    REACT_223937. FGFR2b ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 10
    Short name:
    FGF-10
    Alternative name(s):
    Keratinocyte growth factor 2
    Gene namesi
    Name:Fgf10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1099809. Fgf10.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular space Source: MGI
    3. nucleus Source: Ensembl
    4. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3636Sequence AnalysisAdd
    BLAST
    Chaini37 – 209173Fibroblast growth factor 10PRO_0000008982Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiO35565.

    PTM databases

    PhosphoSiteiO35565.

    Expressioni

    Tissue specificityi

    Expressed abundantly in embryos and the lung, and at much lower levels in brain and heart.

    Gene expression databases

    ArrayExpressiO35565.
    BgeeiO35565.
    CleanExiMM_FGF10.
    GenevestigatoriO35565.

    Interactioni

    Subunit structurei

    Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi199639. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO35565.
    SMRiO35565. Positions 70-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi52 – 6312Poly-SerAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG327524.
    GeneTreeiENSGT00730000110261.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiO35565.
    KOiK04358.
    OMAiSSIPVTC.
    OrthoDBiEOG7992S1.
    PhylomeDBiO35565.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028252. FGF10.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF21. PTHR11486:SF21. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35565-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SFPVTCQALG QDMVSQEATN    50
    CSSSSSSFSS PSSAGRHVRS YNHLQGDVRW RRLFSFTKYF LTIEKNGKVS 100
    GTKNEDCPYS VLEITSVEIG VVAVKAINSN YYLAMNKKGK LYGSKEFNND 150
    CKLKERIEEN GYNTYASFNW QHNGRQMYVA LNGKGAPRRG QKTRRKNTSA 200
    HFLPMTIQT 209
    Length:209
    Mass (Da):23,597
    Last modified:January 1, 1998 - v1
    Checksum:i7FD22227BF4943CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89080 mRNA. Translation: BAA22836.1.
    U94517 mRNA. Translation: AAD00761.1.
    AK034742 mRNA. Translation: BAC28816.1.
    AK045267 mRNA. Translation: BAC32287.1.
    AK085244 mRNA. Translation: BAC39398.1.
    AK141633 mRNA. Translation: BAE24777.1.
    BC048229 mRNA. Translation: AAH48229.1.
    CCDSiCCDS26795.1.
    RefSeqiNP_032028.1. NM_008002.4.
    UniGeneiMm.317323.

    Genome annotation databases

    EnsembliENSMUST00000022246; ENSMUSP00000022246; ENSMUSG00000021732.
    GeneIDi14165.
    KEGGimmu:14165.
    UCSCiuc007ryv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89080 mRNA. Translation: BAA22836.1 .
    U94517 mRNA. Translation: AAD00761.1 .
    AK034742 mRNA. Translation: BAC28816.1 .
    AK045267 mRNA. Translation: BAC32287.1 .
    AK085244 mRNA. Translation: BAC39398.1 .
    AK141633 mRNA. Translation: BAE24777.1 .
    BC048229 mRNA. Translation: AAH48229.1 .
    CCDSi CCDS26795.1.
    RefSeqi NP_032028.1. NM_008002.4.
    UniGenei Mm.317323.

    3D structure databases

    ProteinModelPortali O35565.
    SMRi O35565. Positions 70-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199639. 1 interaction.

    PTM databases

    PhosphoSitei O35565.

    Proteomic databases

    PRIDEi O35565.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022246 ; ENSMUSP00000022246 ; ENSMUSG00000021732 .
    GeneIDi 14165.
    KEGGi mmu:14165.
    UCSCi uc007ryv.2. mouse.

    Organism-specific databases

    CTDi 2255.
    MGIi MGI:1099809. Fgf10.

    Phylogenomic databases

    eggNOGi NOG327524.
    GeneTreei ENSGT00730000110261.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi O35565.
    KOi K04358.
    OMAi SSIPVTC.
    OrthoDBi EOG7992S1.
    PhylomeDBi O35565.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_196455. Signaling by FGFR mutants.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_208465. Regulation of gene expression in early pancreatic precursor cells.
    REACT_220836. FGFR1b ligand binding and activation.
    REACT_223937. FGFR2b ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    NextBioi 285306.
    PROi O35565.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35565.
    Bgeei O35565.
    CleanExi MM_FGF10.
    Genevestigatori O35565.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028252. FGF10.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF21. PTHR11486:SF21. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of mouse FGF10 and up-regulation of its gene expression during wound healing."
      Tagashira S., Harada H., Katsumata T., Itoh N., Nakatsuka M.
      Gene 197:399-404(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Duan D.R., Florence C.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus and Stomach.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiFGF10_MOUSE
    AccessioniPrimary (citable) accession number: O35565
    Secondary accession number(s): Q543V5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3