Reviewed, UniProtKB/Swiss-Prot O35565 (FGF10_MOUSE)

Names and origin

Protein names

Recommended name:
    Fibroblast growth factor 10
      Short name=FGF-10
Alternative name(s):
    Keratinocyte growth factor 2

Gene names

Name:

Fgf10

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Could be a growth factor active in the process of wound healing. Acts as a mitogen in the lung. May act in a manner similar to FGF-7.
Subunit structure	Interacts with FGFBP1 By similarity.
Subcellular location	Secreted Potential.
Tissue specificity	Expressed abundantly in embryos and the lung, and at much lower levels in brain and heart.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	alveolus development Inferred from mutant phenotype. Source: MGI blood vessel remodeling Inferred from genetic interaction. Source: MGI branching morphogenesis of a tube Inferred from direct assay. Source: MGI chemotaxis Inferred from direct assay. Source: MGI determination of left/right symmetry Inferred from mutant phenotype. Source: MGI embryonic gut development Inferred from mutant phenotype. Source: MGI embryonic limb morphogenesis Non-traceable author statement. Source: UniProtKB embryonic pattern specification Inferred from mutant phenotype. Source: MGI epidermis development Inferred from mutant phenotype. Source: MGI fibroblast growth factor receptor signaling pathway Non-traceable author statement. Source: UniProtKB induction of an organ Inferred from genetic interaction. Source: MGI induction of positive chemotaxis Inferred from direct assay. Source: MGI inner ear morphogenesis Inferred from genetic interaction. Source: MGI keratinocyte proliferation Inferred from mutant phenotype. Source: MGI lacrimal gland development Inferred from mutant phenotype. Source: MGI negative regulation of cell differentiation Inferred from direct assay. Source: MGI negative regulation of cell proliferation Inferred from direct assay. Source: MGI pancreas development Inferred from mutant phenotype. Source: MGI positive regulation of Wnt receptor signaling pathway Inferred from mutant phenotype. Source: MGI positive regulation of receptor-mediated endocytosis Non-traceable author statement. Source: UniProtKB positive regulation of urothelial cell proliferation Inferred from direct assay. Source: UniProtKB positive regulation of vascular endothelial growth factor receptor signaling pathway Inferred from mutant phenotype. Source: MGI protein import into nucleus, translocation Non-traceable author statement. Source: UniProtKB regulation of transcription Non-traceable author statement. Source: UniProtKB response to stress Non-traceable author statement. Source: UniProtKB smooth muscle cell differentiation Inferred from mutant phenotype. Source: MGI spleen development Inferred from mutant phenotype. Source: MGI
Cellular component	cell surface Non-traceable author statement. Source: UniProtKB extracellular space Inferred from direct assay. Source: MGI nucleus Inferred from direct assay. Source: UniProtKB
Molecular function	chemoattractant activity Inferred from direct assay. Source: MGI fibroblast growth factor receptor binding Inferred from direct assay. Source: UniProtKB growth factor activity Inferred from direct assay. Source: UniProtKB heparin binding Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 36	36	Potential
	Chain	37 – 209	173	Fibroblast growth factor 10		PRO_0000008982
Regions
	Compositional bias	52 – 63	12	Poly-Ser
Amino acid modifications
	Glycosylation	50	1	N-linked (GlcNAc...) Potential
	Glycosylation	197	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O35565-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 7FD22227BF4943CC	FASTA	209	23,597
	10 20 30 40 50 60 MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SFPVTCQALG QDMVSQEATN CSSSSSSFSS 70 80 90 100 110 120 PSSAGRHVRS YNHLQGDVRW RRLFSFTKYF LTIEKNGKVS GTKNEDCPYS VLEITSVEIG 130 140 150 160 170 180 VVAVKAINSN YYLAMNKKGK LYGSKEFNND CKLKERIEEN GYNTYASFNW QHNGRQMYVA 190 200 LNGKGAPRRG QKTRRKNTSA HFLPMTIQT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of mouse FGF10 and up-regulation of its gene expression during wound healing." Tagashira S., Harada H., Katsumata T., Itoh N., Nakatsuka M. Gene 197:399-404(1997) [PubMed: 9332392] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Duan D.R., Florence C. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Hippocampus and Stomach.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Olfactory epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D89080 mRNA. Translation: BAA22836.1. U94517 mRNA. Translation: AAD00761.1. AK034742 mRNA. Translation: BAC28816.1. AK045267 mRNA. Translation: BAC32287.1. AK085244 mRNA. Translation: BAC39398.1. AK141633 mRNA. Translation: BAE24777.1. BC048229 mRNA. Translation: AAH48229.1.
IPI	IPI00131722.
RefSeq	NP_032028.1.
UniGene	Mm.317323
3D structure databases
HSSP	HSSP built from PDB template 1NUN based on UniProtKB O15520.
ModBase	Search...
PTM databases
PhosphoSite	O35565.
Genome annotation databases
Ensembl	ENSMUSG00000021732. Mus musculus. [Contig view]
GeneID	14165.
KEGG	mmu:14165.
Organism-specific databases
MGI	MGI:1099809. Fgf10.
Phylogenomic databases
HOGENOM	O35565.
HOVERGEN	O35565.
OMA	O35565. XKEFNND.
Gene expression databases
ArrayExpress	O35565.
Bgee	O35565.
CleanEx	MM_FGF10.
GermOnline	ENSMUSG00000021732. Mus musculus.
Family and domain databases
InterPro	IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
ProDom	PD000831. IL1_HBGF. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00442. FGF. 1 hit. [Graphical view]
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	285306.
SOURCE	Search...

Entry information

Entry name

FGF10_MOUSE

Accession

Primary (citable) accession number: O35565
Secondary accession number(s): Q543V5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)