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Unreviewed, UniProtKB/TrEMBL O35558 (O35558_MOUSE)

Last modified January 19, 2010. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    ERK2 EMBL BAA22620.1
Gene names
Name: Mapk1 MGI 1346858
Synonyms: Erk2 EMBL BAA22620.1
OrganismMus musculus (Mouse) EMBL BAA22620.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. Spearmint SPM003527

Sequence similarities

Belongs to the protein kinase superfamily.

Contains 1 protein kinase domain.

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Ontologies

Keywords
   LigandATP-binding Spearmint SPM003527 RuleBase RU000304V2
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase RuleBase RU000305V3 Spearmint SPM003527
Transferase
Gene Ontology (GO)
   Biological processB cell receptor signaling pathway

Inferred from direct assay. Source: MGI

T cell receptor signaling pathway

Inferred from direct assay. Source: MGI

cytosine metabolic process

Inferred from direct assay. Source: MGI

labyrinthine layer blood vessel development

Inferred from mutant phenotype. Source: MGI

lipopolysaccharide-mediated signaling pathway

Inferred from direct assay. Source: MGI

negative regulation of cell differentiation

Inferred from genetic interaction. Source: MGI

nuclear translocation of MAPK

Inferred from electronic annotation. Source: Compara

organ morphogenesis

Inferred from direct assay. Source: MGI

positive regulation of cell migration

Inferred from electronic annotation. Source: Compara

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Compara

positive regulation of transcription

Inferred from electronic annotation. Source: Compara

positive regulation of translation

Inferred from electronic annotation. Source: Compara

protein amino acid phosphorylation

Inferred from direct assay. Source: MGI

response to DNA damage stimulus

Inferred from direct assay. Source: MGI

response to estrogen stimulus

Inferred from electronic annotation. Source: Compara

response to exogenous dsRNA

Inferred from direct assay. Source: MGI

response to lipopolysaccharide

Inferred from direct assay. Source: MGI

sensory perception of pain

Inferred from electronic annotation. Source: Compara

   Cellular componentaxon part

Inferred from electronic annotation. Source: Compara

cytoskeleton

Inferred from electronic annotation. Source: Compara

cytosol

Inferred from electronic annotation. Source: Compara

dendrite cytoplasm

Inferred from electronic annotation. Source: Compara

insoluble fraction

Inferred from electronic annotation. Source: Compara

nucleoplasm

Inferred from electronic annotation. Source: Compara

perikaryon

Inferred from electronic annotation. Source: Compara

protein complex

Inferred from electronic annotation. Source: Compara

soluble fraction

Inferred from electronic annotation. Source: Compara

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase 2 activity

Inferred from direct assay. Source: MGI

mitogen-activated protein kinase kinase kinase binding

Inferred from electronic annotation. Source: Compara

phosphotyrosine binding

Inferred from mutant phenotype. Source: MGI

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
O35558-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 7088216F35A8A260

FASTA29133,601
        10         20         30         40         50         60 
MAAAAAAGPE MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA YDNLNKVRVA IKKISPFEHQ 

        70         80         90        100        110        120 
TYCQRTLREI KILLRFRHEN IIGINDIIRA PTIEQMKDVY IVQDLMETDL YKLLKTQHLS 

       130        140        150        160        170        180 
NDHICYFLYQ ILRGLKYIHS ANVLHRDLKP SNLLLNTTCD LKICDFGLAR VADPDHDHTG 

       190        200        210        220        230        240 
FLTEYVATRW YRAPEIMLNS KGYTKSIDIW SVGCILAEML SNRPIFPGKH YLDQLNHILG 

       250        260        270        280        290 
ILGSPSQEDL ELYNKFKART ILLSLPHKNK VPWNRLSQML TPKLWIYWIK C

« Hide

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References

[1]"The mouse extracellular signal-regulated kinase 2 gene. Gene structure and characterization of the promoter."
Sugiura N., Suga T., Ozeki Y., Mamiya G., Takishima K.
J. Biol. Chem. 272:21575-21581(1997) [PubMed: 9261178] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D87271 Genomic DNA. Translation: BAA22620.1.
IPIIPI00474243.
UniGeneMm.196581

3D structure databases

HSSPHSSP built from PDB template 1PME based on UniProtKB P28482.
SMRO35558. Positions 6-276.
ModBaseSearch...

Protein-protein interaction databases

STRINGO35558.

Proteomic databases

PRIDEO35558.

Genome annotation databases

EnsemblENSMUST00000023462; ENSMUSP00000023462; ENSMUSG00000063358; Mus musculus. [Genome view]
ENSMUST00000069107; ENSMUSP00000065983; ENSMUSG00000063358; Mus musculus. [Genome view]
ENSMUST00000115731; ENSMUSP00000111396; ENSMUSG00000063358; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:1346858. Mapk1.

Phylogenomic databases

eggNOGroNOG04134.
HOVERGENO35558.
InParanoidO35558.
PhylomeDBO35558.

Gene expression databases

ArrayExpressO35558.
BgeeO35558.
GenevestigatorO35558.

Family and domain databases

InterProIPR008349. Erk_1_2_MAPK.
IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
IPR002290. Ser/Thr_prot_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01770. ERK1ERK2MAPK.
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameO35558_MOUSE
AccessionPrimary (citable) accession number: O35558
Entry history
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: January 19, 2010
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information