##gff-version 3 O35552 UniProtKB Chain 1 555 . . . ID=PRO_0000179969;Note=6-phosphofructo-2-kinase/fructose-2%2C6-bisphosphatase 3 O35552 UniProtKB Region 1 245 . . . Note=6-phosphofructo-2-kinase O35552 UniProtKB Region 246 555 . . . Note=Fructose-2%2C6-bisphosphatase O35552 UniProtKB Region 475 504 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O35552 UniProtKB Active site 125 125 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O35552 UniProtKB Active site 155 155 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O35552 UniProtKB Active site 254 254 . . . Note=Tele-phosphohistidine intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Active site 323 323 . . . Note=Proton donor/acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 42 50 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 75 75 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 99 99 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 127 127 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 133 133 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 164 169 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 169 169 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 190 190 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 194 194 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 253 253 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 260 260 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 266 266 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 334 334 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 345 348 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953 O35552 UniProtKB Binding site 348 348 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 352 352 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 363 363 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 389 393 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953 O35552 UniProtKB Binding site 389 389 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Binding site 393 393 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953 O35552 UniProtKB Binding site 425 425 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Site 253 253 . . . Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Site 260 260 . . . Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Site 388 388 . . . Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Modified residue 490 490 . . . Note=Phosphoserine%3B by AMPK and PKA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Modified residue 492 492 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Modified residue 496 496 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 O35552 UniProtKB Alternative sequence 448 476 . . . ID=VSP_004681;Note=In isoform 4%2C isoform 5%2C isoform 6 and isoform 8. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 O35552 UniProtKB Alternative sequence 535 555 . . . ID=VSP_004683;Note=In isoform 3 and isoform 6. PLLGKACLRTVCHIFSKFSPY->NMRSPRSGAESSQKH;Ontology_term=ECO:0000305;evidence=ECO:0000305 O35552 UniProtKB Alternative sequence 543 555 . . . ID=VSP_004682;Note=In isoform 2 and isoform 5. RTVCHIFSKFSPY->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 O35552 UniProtKB Alternative sequence 543 555 . . . ID=VSP_004684;Note=In isoform 7 and isoform 8. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 O35552 UniProtKB Sequence conflict 185 185 . . . Note=D->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 O35552 UniProtKB Sequence conflict 367 367 . . . Note=V->L;Ontology_term=ECO:0000305;evidence=ECO:0000305