Skip Header

Contribute Send feedback
Read comments (?) or add your own

O35550 (RABE1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rab GTPase-binding effector protein 1
Alternative name(s):
Rabaptin-5
Rabaptin-5alpha
Gene names
Name:Rabep1
Synonyms:Rabpt5, Rabpt5a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length862 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A By similarity.

Subunit structure

Heterodimer with RABGEF1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2 By similarity. Interacts with ECM29 By similarity.

Subcellular location

Cytoplasm By similarity. Early endosome By similarity. Recycling endosome By similarity. Cytoplasmic vesicle By similarity.

Post-translational modification

Proteolytic cleavage by caspases in apoptotic cells causes loss of endosome fusion activity By similarity.

Sequence similarities

Belongs to the rabaptin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 862862Rab GTPase-binding effector protein 1
PRO_0000187558

Regions

Coiled coil11 – 328318 Potential
Coiled coil534 – 816283 Potential

Amino acid modifications

Modified residue2821N6-acetyllysine By similarity
Modified residue4071Phosphoserine By similarity
Modified residue4101Phosphoserine By similarity

Experimental info

Sequence conflict791W → S in AAB47746. Ref.2
Sequence conflict841E → D in AAB47746. Ref.2
Sequence conflict4581G → E in AAB47746. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O35550 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9C93CD967EF3202D

FASTA86299,428
        10         20         30         40         50         60 
MAQPGPAPQP DVSLQQRVAE LEKINAEFLR AQQQLEQEFN QKRAKFKELY LAKEEDLKRQ 

        70         80         90        100        110        120 
NAVLQAAQDD LGHLRTQLWE AQAEMENIKA IATVSENTKQ EAIDEVKRQW REEVASLQAV 

       130        140        150        160        170        180 
MKETVRDYEH QFHLRLEQER AQWAQYRESA DREIADLRRR LSEGQEEENL ENEMKKAQED 

       190        200        210        220        230        240 
AEKLRSVVMP MEKEIAALKD KLTEAEDKIK ELEASKVKEL NHYLEAEKSC RTDLEMYVAV 

       250        260        270        280        290        300 
LNTQKSVLQE DAEKLRKELH EVCHLLEQER QQHNQLKHTW QKANDQFLES QRLLMRDMQR 

       310        320        330        340        350        360 
MEIVLTSEQL RQVEELKKKD QEEDEQQRIN KGKDNKKIDT EEEVKIPVVC ALTQEESSTP 

       370        380        390        400        410        420 
LSNEEEHLDS THGSVHSLDA DLLLPSGDPF SKSDNDMFKE GLRRAQSTDS LGTSSSLQSK 

       430        440        450        460        470        480 
ALGYNYKAKS AGNLDESDFG PLVGADSVSE NFDTVSLGSL QMPSGFMLTK DQERAIKAMT 

       490        500        510        520        530        540 
PEQEETASLL SSVTQGMESA YVSPSGYRLV SETEWNLLQK EVHNAGNKLG RRCDMCSNYE 

       550        560        570        580        590        600 
KQLQGIQIQE AETRDQVKKL QLMLRQANDQ LEKTMKEKQE LEDFLRQSAE DSSHQISALV 

       610        620        630        640        650        660 
LRAQASEVLL EELQQSFSQA KRDVQEQMAV LMQSREQVSE ELVRLQKDND SLQGKHSLHV 

       670        680        690        700        710        720 
SLQLAEDFIL PDTVQVLREL VLKYRENIVH VRTAADHMEE KLKAEILFLK EQIQAEQCLK 

       730        740        750        760        770        780 
ENLEETLQLE IENCKEEIAS ISSLKAELER IKVEKGQLES TLREKSQQLE SLQEIKVNLE 

       790        800        810        820        830        840 
EQLKKETAAK ATVEQLMFEE KNKAQRLQTE LDVSEQVQRD FVKLSQTLQV QLERIRQADS 

       850        860 
LERIRAILND TKLTDINQLP ET

« Hide

References

[1]Fujimoto H., Uyeda A., Nishimune H., Taguchi T.
Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]Wang Y., Suedhof T.C.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]Lubec G., Diao W.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 60-75; 301-311 AND 587-602, MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D85844 mRNA. Translation: BAA21782.1.
U70777 mRNA. Translation: AAB47746.1.
IPIIPI00210534.
RefSeqNP_061997.1. NM_019124.1.
UniGeneRn.5876.

3D structure databases

ProteinModelPortalO35550.
SMRO35550. Positions 553-640, 802-854.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000060198.

PTM databases

PhosphoSiteO35550.

Proteomic databases

PaxDbO35550.
PRIDEO35550.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID54190.
KEGGrno:54190.
UCSCRGD:708568. rat.

Organism-specific databases

CTD9135.
RGD708568. Rabep1.

Phylogenomic databases

eggNOGNOG237924.
HOGENOMHOG000234329.
HOVERGENHBG055335.
InParanoidO35550.
KOK12480.

Gene expression databases

ArrayExpressO35550.
GenevestigatorO35550.
GermOnlineENSRNOG00000005015. Rattus norvegicus.

Family and domain databases

InterProIPR003914. Rabaptin.
IPR018514. Rabaptin_coiled-coil.
IPR015390. Rabaptin_Rab5-bd_dom.
[Graphical view]
PfamPF09311. Rab5-bind. 1 hit.
PF03528. Rabaptin. 2 hits.
[Graphical view]
PRINTSPR01432. RABAPTIN.
ProtoNetSearch...

Other

NextBio610630.

Entry information

Entry nameRABE1_RAT
AccessionPrimary (citable) accession number: O35550
Secondary accession number(s): P70609
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 1, 1998
Last modified: May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents