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Reviewed, UniProtKB/Swiss-Prot O35547 (ACSL4_RAT)

Last modified January 19, 2010. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Long-chain-fatty-acid--CoA ligase 4
    EC=6.2.1.3
Alternative name(s):
    Long-chain acyl-CoA synthetase 4
      Short name=LACS 4
Gene names
Name: Acsl4
Synonyms: Acs4, Facl4
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length670 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.

Catalytic activity

ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 670670Long-chain-fatty-acid--CoA ligase 4
PRO_0000193111

Amino acid modifications

Modified residue481N6-acetyllysine By similarity

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Sequences

Sequence LengthMass (Da)Tools
O35547-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: B7D290973B650CB6

FASTA67074,327
        10         20         30         40         50         60 
MAKRIKAKPT SDKPGSPYRS VTHFDSLAVI DIPGADTLDK LFDHAVAKFG KKDSLGTREI 

        70         80         90        100        110        120 
LSEENEMQPN GKVFKKLILG NYKWINYLEV NCRVNNFGSG LTALGLKPKN TIAIFCETRA 

       130        140        150        160        170        180 
EWMIAAQTCF KYNFPLVTLY ATLGKEAVVH GLNESEASYL ITSVELLESK LKAALLDINC 

       190        200        210        220        230        240 
VKHIIYVDNK TINRAEYPEG LEIHSMQSVE ELGSKPENSS IPPSRPTPSD MAIVMYTSGS 

       250        260        270        280        290        300 
TGRPKGVMMH HSNLIAGMTG QCERIPGLGP KDTYIGYLPL AHVLELTAEI SCFTYGCRIG 

       310        320        330        340        350        360 
YSSPLTLSDQ SSKIKKGSKG DCTVLKPTLM AAVPEIMDRI YKNVMSKVQE MNYIQKTLFK 

       370        380        390        400        410        420 
IGYDYKLEQI KKGYDAPLCN LILFKKVKAL LGGNVRMMLS GGAPLSPQTH RFMNVCFCCP 

       430        440        450        460        470        480 
IGQGYGLTES CGAGTVTEVT DYTTGRVGAP LICCEIKLKD WQEGGYTVHD KPNPRGEIVI 

       490        500        510        520        530        540 
GGQNISMGYF KNEEKTAEDY SVDENGQRWF CTGDIGEFHP DGCLQIIDRK KDLVKLQAGE 

       550        560        570        580        590        600 
YVSLGKVEAA LKNCPLIDNI CAFAKSDQSY VISFVVPNQK KLTLLAQQKG VEGSWVDICN 

       610        620        630        640        650        660 
NPAMEAEILK EIREAANAMK LERFEIPIKV RLSPEPWTPE TGLVTDAFKL KRKELKNHYL 

       670 
KDIERMYGGK

« Hide

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References

[1]"A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis."
Kang M., Fujino T., Sasano H., Minekura H., Yabuki N., Nagura H., Iijima H., Yamamoto T.T.
Proc. Natl. Acad. Sci. U.S.A. 94:2880-2884(1997) [PubMed: 9096315] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D85189 mRNA. Translation: BAA22195.1.
IPIIPI00210503.
RefSeqNP_446075.1.
UniGeneRn.87821

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGO35547.

Proteomic databases

PRIDEO35547.

Genome annotation databases

EnsemblENSRNOT00000026057; ENSRNOP00000026057; ENSRNOG00000019180; Rattus norvegicus. [Genome view]
GeneID113976.
KEGGrno:113976.
NMPDRfig|10116.3.peg.31115.
UCSCNM_053623. rat.

Organism-specific databases

CTD113976.
RGD69401. Acsl4.

Phylogenomic databases

eggNOGroNOG09303.
HOVERGENO35547.
InParanoidO35547.
PhylomeDBO35547.

Enzyme and pathway databases

BRENDA6.2.1.3. 248.

Gene expression databases

ArrayExpressO35547.
GenevestigatorO35547.
GermOnlineENSRNOG00000019180. Rattus norvegicus.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio618117.

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Entry information

Entry nameACSL4_RAT
AccessionPrimary (citable) accession number: O35547
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: January 19, 2010
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents