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O35547

- ACSL4_RAT

UniProt

O35547 - ACSL4_RAT

Protein

Long-chain-fatty-acid--CoA ligase 4

Gene

Acsl4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. arachidonate-CoA ligase activity Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. long-chain fatty acid-CoA ligase activity Source: RGD
    4. very long-chain fatty acid-CoA ligase activity Source: Ensembl

    GO - Biological processi

    1. dendritic spine development Source: RGD
    2. embryonic process involved in female pregnancy Source: Ensembl
    3. fatty acid metabolic process Source: RGD
    4. fatty acid transport Source: RGD
    5. lipid biosynthetic process Source: Ensembl
    6. negative regulation of prostaglandin secretion Source: Ensembl
    7. positive regulation of cell growth Source: Ensembl
    8. response to interleukin-15 Source: RGD
    9. response to nutrient Source: RGD
    10. triglyceride metabolic process Source: RGD

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi6.2.1.3. 5301.
    SABIO-RKO35547.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase 4 (EC:6.2.1.3)
    Alternative name(s):
    Long-chain acyl-CoA synthetase 4
    Short name:
    LACS 4
    Gene namesi
    Name:Acsl4
    Synonyms:Acs4, Facl4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi69401. Acsl4.

    Subcellular locationi

    GO - Cellular componenti

    1. lipid particle Source: Ensembl
    2. mitochondrial membrane Source: RGD
    3. neuronal cell body Source: RGD
    4. peroxisome Source: RGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 670670Long-chain-fatty-acid--CoA ligase 4PRO_0000193111Add
    BLAST

    Proteomic databases

    PaxDbiO35547.
    PRIDEiO35547.

    Expressioni

    Gene expression databases

    GenevestigatoriO35547.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4567100.
    STRINGi10116.ENSRNOP00000026057.

    Structurei

    3D structure databases

    ProteinModelPortaliO35547.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1022.
    GeneTreeiENSGT00690000102168.
    HOGENOMiHOG000159459.
    HOVERGENiHBG106947.
    InParanoidiO35547.
    KOiK01897.
    OMAiNAMKLER.
    OrthoDBiEOG7P2XRD.
    PhylomeDBiO35547.
    TreeFamiTF314012.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35547-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKRIKAKPT SDKPGSPYRS VTHFDSLAVI DIPGADTLDK LFDHAVAKFG    50
    KKDSLGTREI LSEENEMQPN GKVFKKLILG NYKWINYLEV NCRVNNFGSG 100
    LTALGLKPKN TIAIFCETRA EWMIAAQTCF KYNFPLVTLY ATLGKEAVVH 150
    GLNESEASYL ITSVELLESK LKAALLDINC VKHIIYVDNK TINRAEYPEG 200
    LEIHSMQSVE ELGSKPENSS IPPSRPTPSD MAIVMYTSGS TGRPKGVMMH 250
    HSNLIAGMTG QCERIPGLGP KDTYIGYLPL AHVLELTAEI SCFTYGCRIG 300
    YSSPLTLSDQ SSKIKKGSKG DCTVLKPTLM AAVPEIMDRI YKNVMSKVQE 350
    MNYIQKTLFK IGYDYKLEQI KKGYDAPLCN LILFKKVKAL LGGNVRMMLS 400
    GGAPLSPQTH RFMNVCFCCP IGQGYGLTES CGAGTVTEVT DYTTGRVGAP 450
    LICCEIKLKD WQEGGYTVHD KPNPRGEIVI GGQNISMGYF KNEEKTAEDY 500
    SVDENGQRWF CTGDIGEFHP DGCLQIIDRK KDLVKLQAGE YVSLGKVEAA 550
    LKNCPLIDNI CAFAKSDQSY VISFVVPNQK KLTLLAQQKG VEGSWVDICN 600
    NPAMEAEILK EIREAANAMK LERFEIPIKV RLSPEPWTPE TGLVTDAFKL 650
    KRKELKNHYL KDIERMYGGK 670
    Length:670
    Mass (Da):74,327
    Last modified:January 1, 1998 - v1
    Checksum:iB7D290973B650CB6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D85189 mRNA. Translation: BAA22195.1.
    RefSeqiNP_446075.1. NM_053623.1.
    XP_006257377.1. XM_006257315.1.
    XP_006257378.1. XM_006257316.1.
    XP_006257379.1. XM_006257317.1.
    UniGeneiRn.87821.

    Genome annotation databases

    EnsembliENSRNOT00000026057; ENSRNOP00000026057; ENSRNOG00000019180.
    GeneIDi113976.
    KEGGirno:113976.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D85189 mRNA. Translation: BAA22195.1 .
    RefSeqi NP_446075.1. NM_053623.1.
    XP_006257377.1. XM_006257315.1.
    XP_006257378.1. XM_006257316.1.
    XP_006257379.1. XM_006257317.1.
    UniGenei Rn.87821.

    3D structure databases

    ProteinModelPortali O35547.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4567100.
    STRINGi 10116.ENSRNOP00000026057.

    Proteomic databases

    PaxDbi O35547.
    PRIDEi O35547.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026057 ; ENSRNOP00000026057 ; ENSRNOG00000019180 .
    GeneIDi 113976.
    KEGGi rno:113976.

    Organism-specific databases

    CTDi 2182.
    RGDi 69401. Acsl4.

    Phylogenomic databases

    eggNOGi COG1022.
    GeneTreei ENSGT00690000102168.
    HOGENOMi HOG000159459.
    HOVERGENi HBG106947.
    InParanoidi O35547.
    KOi K01897.
    OMAi NAMKLER.
    OrthoDBi EOG7P2XRD.
    PhylomeDBi O35547.
    TreeFami TF314012.

    Enzyme and pathway databases

    BRENDAi 6.2.1.3. 5301.
    SABIO-RK O35547.

    Miscellaneous databases

    NextBioi 618117.

    Gene expression databases

    Genevestigatori O35547.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis."
      Kang M., Fujino T., Sasano H., Minekura H., Yabuki N., Nagura H., Iijima H., Yamamoto T.T.
      Proc. Natl. Acad. Sci. U.S.A. 94:2880-2884(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Liver.

    Entry informationi

    Entry nameiACSL4_RAT
    AccessioniPrimary (citable) accession number: O35547
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3