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O35547

- ACSL4_RAT

UniProt

O35547 - ACSL4_RAT

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Protein

Long-chain-fatty-acid--CoA ligase 4

Gene
Acsl4, Acs4, Facl4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. arachidonate-CoA ligase activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. long-chain fatty acid-CoA ligase activity Source: RGD
  4. very long-chain fatty acid-CoA ligase activity Source: Ensembl

GO - Biological processi

  1. dendritic spine development Source: RGD
  2. embryonic process involved in female pregnancy Source: Ensembl
  3. fatty acid metabolic process Source: RGD
  4. fatty acid transport Source: RGD
  5. lipid biosynthetic process Source: Ensembl
  6. negative regulation of prostaglandin secretion Source: Ensembl
  7. positive regulation of cell growth Source: Ensembl
  8. response to interleukin-15 Source: RGD
  9. response to nutrient Source: RGD
  10. triglyceride metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.2.1.3. 5301.
SABIO-RKO35547.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase 4 (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase 4
Short name:
LACS 4
Gene namesi
Name:Acsl4
Synonyms:Acs4, Facl4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi69401. Acsl4.

Subcellular locationi

GO - Cellular componenti

  1. lipid particle Source: Ensembl
  2. mitochondrial membrane Source: RGD
  3. neuronal cell body Source: RGD
  4. peroxisome Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Long-chain-fatty-acid--CoA ligase 4PRO_0000193111Add
BLAST

Proteomic databases

PaxDbiO35547.
PRIDEiO35547.

Expressioni

Gene expression databases

GenevestigatoriO35547.

Interactioni

Protein-protein interaction databases

MINTiMINT-4567100.
STRINGi10116.ENSRNOP00000026057.

Structurei

3D structure databases

ProteinModelPortaliO35547.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
GeneTreeiENSGT00690000102168.
HOGENOMiHOG000159459.
HOVERGENiHBG106947.
InParanoidiO35547.
KOiK01897.
OMAiNAMKLER.
OrthoDBiEOG7P2XRD.
PhylomeDBiO35547.
TreeFamiTF314012.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35547-1 [UniParc]FASTAAdd to Basket

« Hide

MAKRIKAKPT SDKPGSPYRS VTHFDSLAVI DIPGADTLDK LFDHAVAKFG    50
KKDSLGTREI LSEENEMQPN GKVFKKLILG NYKWINYLEV NCRVNNFGSG 100
LTALGLKPKN TIAIFCETRA EWMIAAQTCF KYNFPLVTLY ATLGKEAVVH 150
GLNESEASYL ITSVELLESK LKAALLDINC VKHIIYVDNK TINRAEYPEG 200
LEIHSMQSVE ELGSKPENSS IPPSRPTPSD MAIVMYTSGS TGRPKGVMMH 250
HSNLIAGMTG QCERIPGLGP KDTYIGYLPL AHVLELTAEI SCFTYGCRIG 300
YSSPLTLSDQ SSKIKKGSKG DCTVLKPTLM AAVPEIMDRI YKNVMSKVQE 350
MNYIQKTLFK IGYDYKLEQI KKGYDAPLCN LILFKKVKAL LGGNVRMMLS 400
GGAPLSPQTH RFMNVCFCCP IGQGYGLTES CGAGTVTEVT DYTTGRVGAP 450
LICCEIKLKD WQEGGYTVHD KPNPRGEIVI GGQNISMGYF KNEEKTAEDY 500
SVDENGQRWF CTGDIGEFHP DGCLQIIDRK KDLVKLQAGE YVSLGKVEAA 550
LKNCPLIDNI CAFAKSDQSY VISFVVPNQK KLTLLAQQKG VEGSWVDICN 600
NPAMEAEILK EIREAANAMK LERFEIPIKV RLSPEPWTPE TGLVTDAFKL 650
KRKELKNHYL KDIERMYGGK 670
Length:670
Mass (Da):74,327
Last modified:January 1, 1998 - v1
Checksum:iB7D290973B650CB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D85189 mRNA. Translation: BAA22195.1.
RefSeqiNP_446075.1. NM_053623.1.
XP_006257377.1. XM_006257315.1.
XP_006257378.1. XM_006257316.1.
XP_006257379.1. XM_006257317.1.
UniGeneiRn.87821.

Genome annotation databases

EnsembliENSRNOT00000026057; ENSRNOP00000026057; ENSRNOG00000019180.
GeneIDi113976.
KEGGirno:113976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D85189 mRNA. Translation: BAA22195.1 .
RefSeqi NP_446075.1. NM_053623.1.
XP_006257377.1. XM_006257315.1.
XP_006257378.1. XM_006257316.1.
XP_006257379.1. XM_006257317.1.
UniGenei Rn.87821.

3D structure databases

ProteinModelPortali O35547.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4567100.
STRINGi 10116.ENSRNOP00000026057.

Proteomic databases

PaxDbi O35547.
PRIDEi O35547.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026057 ; ENSRNOP00000026057 ; ENSRNOG00000019180 .
GeneIDi 113976.
KEGGi rno:113976.

Organism-specific databases

CTDi 2182.
RGDi 69401. Acsl4.

Phylogenomic databases

eggNOGi COG1022.
GeneTreei ENSGT00690000102168.
HOGENOMi HOG000159459.
HOVERGENi HBG106947.
InParanoidi O35547.
KOi K01897.
OMAi NAMKLER.
OrthoDBi EOG7P2XRD.
PhylomeDBi O35547.
TreeFami TF314012.

Enzyme and pathway databases

BRENDAi 6.2.1.3. 5301.
SABIO-RK O35547.

Miscellaneous databases

NextBioi 618117.

Gene expression databases

Genevestigatori O35547.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis."
    Kang M., Fujino T., Sasano H., Minekura H., Yabuki N., Nagura H., Iijima H., Yamamoto T.T.
    Proc. Natl. Acad. Sci. U.S.A. 94:2880-2884(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Liver.

Entry informationi

Entry nameiACSL4_RAT
AccessioniPrimary (citable) accession number: O35547
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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