Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Excitatory amino acid transporter 4

Gene

Slc1a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium (By similarity).By similarity

GO - Molecular functioni

  • L-glutamate transmembrane transporter activity Source: MGI
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • L-glutamate transport Source: MGI
  • regulation of membrane potential Source: MGI
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-210500. Glutamate Neurotransmitter Release Cycle.
R-MMU-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.

Names & Taxonomyi

Protein namesi
Recommended name:
Excitatory amino acid transporter 4
Alternative name(s):
High-affinity neuronal glutamate transporter
Sodium-dependent glutamate/aspartate transporter
Solute carrier family 1 member 6
Gene namesi
Name:Slc1a6
Synonyms:Eaat4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1096331. Slc1a6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 261ExtracellularSequence analysisAdd BLAST111
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • Golgi apparatus Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002020711 – 561Excitatory amino acid transporter 4Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Glycosylationi213N-linked (GlcNAc...)Sequence analysis1
Glycosylationi229N-linked (GlcNAc...)Sequence analysis1
Glycosylationi236N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO35544.
PaxDbiO35544.
PRIDEiO35544.

PTM databases

iPTMnetiO35544.
PhosphoSitePlusiO35544.
SwissPalmiO35544.

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

BgeeiENSMUSG00000005357.
ExpressionAtlasiO35544. baseline and differential.
GenevisibleiO35544. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005490.

Structurei

3D structure databases

ProteinModelPortaliO35544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiO35544.
KOiK05617.
OMAiIAVYIGC.
OrthoDBiEOG091G0UCE.
PhylomeDBiO35544.
TreeFamiTF315206.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35544-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHGNSLFL RESGAGGGCL QGLQDSLQQR ALRTRLRLQT MTREHVRRFL
60 70 80 90 100
RRNAFILLTV SAVIIGVSLA FALRPYQLSY RQIKYFSFPG ELLMRMLQML
110 120 130 140 150
VLPLIVSSLV TGMASLDNKA TGRMGMRAAV YYMVTTVIAV FIGILMVTII
160 170 180 190 200
HPGKGSKEGL HREGRIETVP TADAFMDLVR NMFPPNLVEA CFKQFKTQYS
210 220 230 240 250
TRVVTRTIVR TDNGSELGAS MSPTSSVENE TSILENVTRA LGTLQEVISF
260 270 280 290 300
EETVPVPGSA NGINALGLVV FSVAFGLVIG GMKHKGRVLR DFFDSLNEAI
310 320 330 340 350
MRLVGIIIWY APVGILFLIA GKILEMEDMA VLGGQLGMYT LTVIVGLFLH
360 370 380 390 400
AGGVLPLIYF LVTHRNPFPF IGGMLQALIT AMGTSSSSAT LPITFRCLEE
410 420 430 440 450
GLGVDRRITR FVLPVGATVN MDGTALYEAL AAIFIAQVNN YELNLGQITT
460 470 480 490 500
ISITATAASV GAAGIPQAGL VTMVIVLTSV GLPTEDITLI IAVDWFLDRL
510 520 530 540 550
RTMTNVLGDS IGAAVIEHLS QRELELQEAE LTLPSLGKPY KSLMAQEKGA
560
SRGRGGNESV M
Length:561
Mass (Da):60,784
Last modified:January 1, 1998 - v1
Checksum:iCCFE3FD499D4CBBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83262 mRNA. Translation: BAA23640.1.
CCDSiCCDS23970.1.
RefSeqiNP_033226.1. NM_009200.3.
UniGeneiMm.6257.

Genome annotation databases

EnsembliENSMUST00000005490; ENSMUSP00000005490; ENSMUSG00000005357.
GeneIDi20513.
KEGGimmu:20513.
UCSCiuc007fyg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83262 mRNA. Translation: BAA23640.1.
CCDSiCCDS23970.1.
RefSeqiNP_033226.1. NM_009200.3.
UniGeneiMm.6257.

3D structure databases

ProteinModelPortaliO35544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005490.

PTM databases

iPTMnetiO35544.
PhosphoSitePlusiO35544.
SwissPalmiO35544.

Proteomic databases

MaxQBiO35544.
PaxDbiO35544.
PRIDEiO35544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005490; ENSMUSP00000005490; ENSMUSG00000005357.
GeneIDi20513.
KEGGimmu:20513.
UCSCiuc007fyg.2. mouse.

Organism-specific databases

CTDi6511.
MGIiMGI:1096331. Slc1a6.

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiO35544.
KOiK05617.
OMAiIAVYIGC.
OrthoDBiEOG091G0UCE.
PhylomeDBiO35544.
TreeFamiTF315206.

Enzyme and pathway databases

ReactomeiR-MMU-210500. Glutamate Neurotransmitter Release Cycle.
R-MMU-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.

Miscellaneous databases

PROiO35544.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005357.
ExpressionAtlasiO35544. baseline and differential.
GenevisibleiO35544. MM.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEAA4_MOUSE
AccessioniPrimary (citable) accession number: O35544
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.