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O35544

- EAA4_MOUSE

UniProt

O35544 - EAA4_MOUSE

Protein

Excitatory amino acid transporter 4

Gene

Slc1a6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium By similarity.By similarity

    GO - Molecular functioni

    1. L-glutamate transmembrane transporter activity Source: MGI
    2. sodium:dicarboxylate symporter activity Source: InterPro

    GO - Biological processi

    1. L-glutamate transport Source: MGI
    2. regulation of membrane potential Source: MGI

    Keywords - Biological processi

    Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Excitatory amino acid transporter 4
    Alternative name(s):
    High-affinity neuronal glutamate transporter
    Sodium-dependent glutamate/aspartate transporter
    Solute carrier family 1 member 6
    Gene namesi
    Name:Slc1a6
    Synonyms:Eaat4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1096331. Slc1a6.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 561561Excitatory amino acid transporter 4PRO_0000202071Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO35544.
    PRIDEiO35544.

    PTM databases

    PhosphoSiteiO35544.

    Expressioni

    Tissue specificityi

    Brain specific.

    Gene expression databases

    BgeeiO35544.
    GenevestigatoriO35544.

    Structurei

    3D structure databases

    ProteinModelPortaliO35544.
    SMRiO35544. Positions 62-186, 256-516.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5252CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini151 – 261111ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei130 – 15021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei367 – 38721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei415 – 43521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei457 – 47721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei478 – 49821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1301.
    GeneTreeiENSGT00730000110358.
    HOGENOMiHOG000208776.
    HOVERGENiHBG000080.
    InParanoidiO35544.
    KOiK05617.
    OMAiCPPRPDQ.
    OrthoDBiEOG7RV9G2.
    PhylomeDBiO35544.
    TreeFamiTF315206.

    Family and domain databases

    Gene3Di1.10.3860.10. 2 hits.
    InterProiIPR001991. Na-dicarboxylate_symporter.
    IPR018107. Na-dicarboxylate_symporter_CS.
    [Graphical view]
    PANTHERiPTHR11958. PTHR11958. 1 hit.
    PfamiPF00375. SDF. 1 hit.
    [Graphical view]
    PRINTSiPR00173. EDTRNSPORT.
    SUPFAMiSSF118215. SSF118215. 2 hits.
    PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
    PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35544-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSHGNSLFL RESGAGGGCL QGLQDSLQQR ALRTRLRLQT MTREHVRRFL    50
    RRNAFILLTV SAVIIGVSLA FALRPYQLSY RQIKYFSFPG ELLMRMLQML 100
    VLPLIVSSLV TGMASLDNKA TGRMGMRAAV YYMVTTVIAV FIGILMVTII 150
    HPGKGSKEGL HREGRIETVP TADAFMDLVR NMFPPNLVEA CFKQFKTQYS 200
    TRVVTRTIVR TDNGSELGAS MSPTSSVENE TSILENVTRA LGTLQEVISF 250
    EETVPVPGSA NGINALGLVV FSVAFGLVIG GMKHKGRVLR DFFDSLNEAI 300
    MRLVGIIIWY APVGILFLIA GKILEMEDMA VLGGQLGMYT LTVIVGLFLH 350
    AGGVLPLIYF LVTHRNPFPF IGGMLQALIT AMGTSSSSAT LPITFRCLEE 400
    GLGVDRRITR FVLPVGATVN MDGTALYEAL AAIFIAQVNN YELNLGQITT 450
    ISITATAASV GAAGIPQAGL VTMVIVLTSV GLPTEDITLI IAVDWFLDRL 500
    RTMTNVLGDS IGAAVIEHLS QRELELQEAE LTLPSLGKPY KSLMAQEKGA 550
    SRGRGGNESV M 561
    Length:561
    Mass (Da):60,784
    Last modified:January 1, 1998 - v1
    Checksum:iCCFE3FD499D4CBBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83262 mRNA. Translation: BAA23640.1.
    CCDSiCCDS23970.1.
    RefSeqiNP_033226.1. NM_009200.3.
    UniGeneiMm.6257.

    Genome annotation databases

    EnsembliENSMUST00000005490; ENSMUSP00000005490; ENSMUSG00000005357.
    GeneIDi20513.
    KEGGimmu:20513.
    UCSCiuc007fyg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83262 mRNA. Translation: BAA23640.1 .
    CCDSi CCDS23970.1.
    RefSeqi NP_033226.1. NM_009200.3.
    UniGenei Mm.6257.

    3D structure databases

    ProteinModelPortali O35544.
    SMRi O35544. Positions 62-186, 256-516.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O35544.

    Proteomic databases

    PaxDbi O35544.
    PRIDEi O35544.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005490 ; ENSMUSP00000005490 ; ENSMUSG00000005357 .
    GeneIDi 20513.
    KEGGi mmu:20513.
    UCSCi uc007fyg.2. mouse.

    Organism-specific databases

    CTDi 6511.
    MGIi MGI:1096331. Slc1a6.

    Phylogenomic databases

    eggNOGi COG1301.
    GeneTreei ENSGT00730000110358.
    HOGENOMi HOG000208776.
    HOVERGENi HBG000080.
    InParanoidi O35544.
    KOi K05617.
    OMAi CPPRPDQ.
    OrthoDBi EOG7RV9G2.
    PhylomeDBi O35544.
    TreeFami TF315206.

    Miscellaneous databases

    NextBioi 298715.
    PROi O35544.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35544.
    Genevestigatori O35544.

    Family and domain databases

    Gene3Di 1.10.3860.10. 2 hits.
    InterProi IPR001991. Na-dicarboxylate_symporter.
    IPR018107. Na-dicarboxylate_symporter_CS.
    [Graphical view ]
    PANTHERi PTHR11958. PTHR11958. 1 hit.
    Pfami PF00375. SDF. 1 hit.
    [Graphical view ]
    PRINTSi PR00173. EDTRNSPORT.
    SUPFAMi SSF118215. SSF118215. 2 hits.
    PROSITEi PS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
    PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and functional expression of the cloned mouse neuronal high-affinity glutamate transporter."
      Maeno-Hikichi Y., Tanaka K., Shibata T., Watanabe M., Inoue Y., Mukainaka Y., Wada K.
      Brain Res. Mol. Brain Res. 48:176-180(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Cerebellum.

    Entry informationi

    Entry nameiEAA4_MOUSE
    AccessioniPrimary (citable) accession number: O35544
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3