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O35536 (TFPI2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tissue factor pathway inhibitor 2
Short name=TFPI-2
Gene names
Name:Tfpi2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin By similarity.

Subcellular location

Secreted.

Tissue specificity

Highly expressed in placenta. Also expressed in liver and kidney.

Domain

This inhibitor contains three inhibitory domains.

Sequence similarities

Contains 3 BPTI/Kunitz inhibitor domains.

Ontologies

Keywords
   Biological processBlood coagulation
   Cellular componentSecreted
   DomainRepeat
Signal
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processblood coagulation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 230208Tissue factor pathway inhibitor 2
PRO_0000016877

Regions

Domain36 – 8651BPTI/Kunitz inhibitor 1
Domain96 – 14651BPTI/Kunitz inhibitor 2
Domain156 – 20651BPTI/Kunitz inhibitor 3

Sites

Site46 – 472Reactive bond By similarity
Site106 – 1072Reactive bond By similarity
Site166 – 1672Reactive bond By similarity

Amino acid modifications

Glycosylation1681N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 86 By similarity
Disulfide bond45 ↔ 69 By similarity
Disulfide bond61 ↔ 82 By similarity
Disulfide bond96 ↔ 146 By similarity
Disulfide bond105 ↔ 129 By similarity
Disulfide bond121 ↔ 142 By similarity
Disulfide bond156 ↔ 206 By similarity
Disulfide bond165 ↔ 189 By similarity
Disulfide bond181 ↔ 202 By similarity

Sequences

Sequence LengthMass (Da)Tools
O35536 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 57EADB2E36521C7B

FASTA23026,137
        10         20         30         40         50         60 
MDPAMPLQLW NLPLLLVGSV LGLTSVSAQG NNLEICLLPL DAGPCQALIP KFYYDRDQQK 

        70         80         90        100        110        120 
CRRFNYGGCL GNANNFHSRD LCQQTCGSIE KVPPVCRSEL KTYPCDKPNI RFFFNLNTMT 

       130        140        150        160        170        180 
CEPLRPGLCS RTINVFSEEA TCKGLCEPRK HIPSFCSSPK DEGLCSANVT RFYFNSRNKT 

       190        200        210        220        230 
CETFTYTGCG GNENNFYYLD ACHRACVKGW KKPKRWKIGD FLPRFWKHLS

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6."
Miyagi Y., Yasumitsu H., Mizushima H., Koshikawa N., Matsuda Y., Itoh H., Hori T., Aoki I., Misugi K., Miyazaki K.
DNA Cell Biol. 15:947-954(1996) [PubMed: 8945635] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ICR.
Tissue: Placenta.
[2]"Nucleotide sequence of the gene encoding murine tissue factor pathway inhibitor-2."
Kazama Y., Kamei S., Kuijper J.L., Foster D.C., Kisiel W.
Thromb. Haemost. 83:141-147(2000) [PubMed: 10669168] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D50586 mRNA. Translation: BAA22585.1.
AF180353 Genomic DNA. Translation: AAF40412.1.
BC021639 mRNA. Translation: AAH21639.1.
IPIIPI00131643.
RefSeqNP_033390.1. NM_009364.3.
UniGeneMm.25612.

3D structure databases

ProteinModelPortalO35536.
SMRO35536. Positions 30-209.
ModBaseSearch...

Protein-protein interaction databases

STRINGO35536.

Protein family/group databases

MEROPSI02.013.

Proteomic databases

PRIDEO35536.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031674; ENSMUSP00000031674; ENSMUSG00000029664.
GeneID21789.
KEGGmmu:21789.

Organism-specific databases

CTD7980.
MGIMGI:108543. Tfpi2.

Phylogenomic databases

eggNOGroNOG13418.
HOGENOMHBG715101.
HOVERGENHBG056804.
InParanoidO35536.
OMAYDRYTQS.
OrthoDBEOG49W2GF.
PhylomeDBO35536.

Gene expression databases

ArrayExpressO35536.
BgeeO35536.
CleanExMM_TFPI2.
GenevestigatorO35536.
GermOnlineENSMUSG00000029664. Mus musculus.

Family and domain databases

InterProIPR002223. Prot_inh_Kunz-m.
IPR008296. Prot_inhib_I2_TFPI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
Gene3DG3DSA:4.10.410.10. Prot_inh_Kunz-m. 3 hits.
PfamPF00014. Kunitz_BPTI. 3 hits.
[Graphical view]
PIRSFPIRSF001620. TFPI. 1 hit.
PRINTSPR00759. BASICPTASE.
SMARTSM00131. KU. 3 hits.
[Graphical view]
SUPFAMSSF57362. Prot_inh_Kunz-m. 3 hits.
PROSITEPS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio301148.
SOURCESearch...

Entry information

Entry nameTFPI2_MOUSE
AccessionPrimary (citable) accession number: O35536
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 1, 1998
Last modified: November 16, 2011
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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