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Protein

Tissue factor pathway inhibitor 2

Gene

Tfpi2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei46 – 47Reactive bondBy similarity2
Sitei106 – 107Reactive bondBy similarity2
Sitei166 – 167Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Protein family/group databases

MEROPSiI02.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue factor pathway inhibitor 2
Short name:
TFPI-2
Gene namesi
Name:Tfpi2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:108543. Tfpi2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001687723 – 230Tissue factor pathway inhibitor 2Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 86PROSITE-ProRule annotation
Disulfide bondi45 ↔ 69PROSITE-ProRule annotation
Disulfide bondi61 ↔ 82PROSITE-ProRule annotation
Disulfide bondi96 ↔ 146PROSITE-ProRule annotation
Disulfide bondi105 ↔ 129PROSITE-ProRule annotation
Disulfide bondi121 ↔ 142PROSITE-ProRule annotation
Disulfide bondi156 ↔ 206PROSITE-ProRule annotation
Disulfide bondi165 ↔ 189PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi181 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35536.
PRIDEiO35536.

PTM databases

PhosphoSitePlusiO35536.

Expressioni

Tissue specificityi

Highly expressed in placenta. Also expressed in liver and kidney.

Gene expression databases

BgeeiENSMUSG00000029664.
CleanExiMM_TFPI2.
ExpressionAtlasiO35536. baseline and differential.
GenevisibleiO35536. MM.

Interactioni

Subunit structurei

Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031674.

Structurei

3D structure databases

ProteinModelPortaliO35536.
SMRiO35536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 86BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini96 – 146BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51
Domaini156 – 206BPTI/Kunitz inhibitor 3PROSITE-ProRule annotationAdd BLAST51

Domaini

This inhibitor contains three inhibitory domains.

Sequence similaritiesi

Contains 3 BPTI/Kunitz inhibitor domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000231818.
HOVERGENiHBG056804.
InParanoidiO35536.
OMAiDRYTQSC.
OrthoDBiEOG091G14M8.
PhylomeDBiO35536.
TreeFamiTF315349.

Family and domain databases

Gene3Di4.10.410.10. 3 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 3 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 3 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 3 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPAMPLQLW NLPLLLVGSV LGLTSVSAQG NNLEICLLPL DAGPCQALIP
60 70 80 90 100
KFYYDRDQQK CRRFNYGGCL GNANNFHSRD LCQQTCGSIE KVPPVCRSEL
110 120 130 140 150
KTYPCDKPNI RFFFNLNTMT CEPLRPGLCS RTINVFSEEA TCKGLCEPRK
160 170 180 190 200
HIPSFCSSPK DEGLCSANVT RFYFNSRNKT CETFTYTGCG GNENNFYYLD
210 220 230
ACHRACVKGW KKPKRWKIGD FLPRFWKHLS
Length:230
Mass (Da):26,137
Last modified:January 1, 1998 - v1
Checksum:i57EADB2E36521C7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50586 mRNA. Translation: BAA22585.1.
AF180353 Genomic DNA. Translation: AAF40412.1.
BC021639 mRNA. Translation: AAH21639.1.
CCDSiCCDS19892.1.
RefSeqiNP_033390.1. NM_009364.4.
XP_011239357.1. XM_011241055.2.
UniGeneiMm.25612.

Genome annotation databases

EnsembliENSMUST00000031674; ENSMUSP00000031674; ENSMUSG00000029664.
GeneIDi21789.
KEGGimmu:21789.
UCSCiuc009avh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50586 mRNA. Translation: BAA22585.1.
AF180353 Genomic DNA. Translation: AAF40412.1.
BC021639 mRNA. Translation: AAH21639.1.
CCDSiCCDS19892.1.
RefSeqiNP_033390.1. NM_009364.4.
XP_011239357.1. XM_011241055.2.
UniGeneiMm.25612.

3D structure databases

ProteinModelPortaliO35536.
SMRiO35536.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031674.

Protein family/group databases

MEROPSiI02.013.

PTM databases

PhosphoSitePlusiO35536.

Proteomic databases

PaxDbiO35536.
PRIDEiO35536.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031674; ENSMUSP00000031674; ENSMUSG00000029664.
GeneIDi21789.
KEGGimmu:21789.
UCSCiuc009avh.1. mouse.

Organism-specific databases

CTDi7980.
MGIiMGI:108543. Tfpi2.

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000231818.
HOVERGENiHBG056804.
InParanoidiO35536.
OMAiDRYTQSC.
OrthoDBiEOG091G14M8.
PhylomeDBiO35536.
TreeFamiTF315349.

Miscellaneous databases

PROiO35536.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029664.
CleanExiMM_TFPI2.
ExpressionAtlasiO35536. baseline and differential.
GenevisibleiO35536. MM.

Family and domain databases

Gene3Di4.10.410.10. 3 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 3 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 3 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 3 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTFPI2_MOUSE
AccessioniPrimary (citable) accession number: O35536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.