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Protein

Tissue factor pathway inhibitor 2

Gene

Tfpi2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei46 – 47Reactive bondBy similarity2
Sitei106 – 107Reactive bondBy similarity2
Sitei166 – 167Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Hemostasis

Protein family/group databases

MEROPSiI02.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue factor pathway inhibitor 2
Short name:
TFPI-2
Gene namesi
Name:Tfpi2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:108543. Tfpi2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001687723 – 230Tissue factor pathway inhibitor 2Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 86PROSITE-ProRule annotation
Disulfide bondi45 ↔ 69PROSITE-ProRule annotation
Disulfide bondi61 ↔ 82PROSITE-ProRule annotation
Disulfide bondi96 ↔ 146PROSITE-ProRule annotation
Disulfide bondi105 ↔ 129PROSITE-ProRule annotation
Disulfide bondi121 ↔ 142PROSITE-ProRule annotation
Disulfide bondi156 ↔ 206PROSITE-ProRule annotation
Disulfide bondi165 ↔ 189PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi181 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35536.
PRIDEiO35536.

PTM databases

PhosphoSitePlusiO35536.

Expressioni

Tissue specificityi

Highly expressed in placenta. Also expressed in liver and kidney.

Gene expression databases

BgeeiENSMUSG00000029664.
CleanExiMM_TFPI2.
ExpressionAtlasiO35536. baseline and differential.
GenevisibleiO35536. MM.

Interactioni

Subunit structurei

Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031674.

Structurei

3D structure databases

ProteinModelPortaliO35536.
SMRiO35536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 86BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini96 – 146BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51
Domaini156 – 206BPTI/Kunitz inhibitor 3PROSITE-ProRule annotationAdd BLAST51

Domaini

This inhibitor contains three inhibitory domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00740000114929.
HOGENOMiHOG000231818.
HOVERGENiHBG056804.
InParanoidiO35536.
OMAiDRYTQSC.
OrthoDBiEOG091G14M8.
PhylomeDBiO35536.
TreeFamiTF315349.

Family and domain databases

CDDicd00109. KU. 2 hits.
Gene3Di4.10.410.10. 3 hits.
InterProiView protein in InterPro
IPR002223. Kunitz_BPTI.
IPR036880. Kunitz_BPTI_sf.
IPR020901. Prtase_inh_Kunz-CS.
IPR008296. TFPI-like.
PfamiView protein in Pfam
PF00014. Kunitz_BPTI. 3 hits.
PIRSFiPIRSF001620. TFPI. 1 hit.
PRINTSiPR00759. BASICPTASE.
SMARTiView protein in SMART
SM00131. KU. 3 hits.
SUPFAMiSSF57362. SSF57362. 3 hits.
PROSITEiView protein in PROSITE
PS00280. BPTI_KUNITZ_1. 2 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPAMPLQLW NLPLLLVGSV LGLTSVSAQG NNLEICLLPL DAGPCQALIP
60 70 80 90 100
KFYYDRDQQK CRRFNYGGCL GNANNFHSRD LCQQTCGSIE KVPPVCRSEL
110 120 130 140 150
KTYPCDKPNI RFFFNLNTMT CEPLRPGLCS RTINVFSEEA TCKGLCEPRK
160 170 180 190 200
HIPSFCSSPK DEGLCSANVT RFYFNSRNKT CETFTYTGCG GNENNFYYLD
210 220 230
ACHRACVKGW KKPKRWKIGD FLPRFWKHLS
Length:230
Mass (Da):26,137
Last modified:January 1, 1998 - v1
Checksum:i57EADB2E36521C7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50586 mRNA. Translation: BAA22585.1.
AF180353 Genomic DNA. Translation: AAF40412.1.
BC021639 mRNA. Translation: AAH21639.1.
CCDSiCCDS19892.1.
RefSeqiNP_033390.1. NM_009364.4.
XP_011239357.1. XM_011241055.2.
UniGeneiMm.25612.

Genome annotation databases

EnsembliENSMUST00000031674; ENSMUSP00000031674; ENSMUSG00000029664.
GeneIDi21789.
KEGGimmu:21789.
UCSCiuc009avh.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiTFPI2_MOUSE
AccessioniPrimary (citable) accession number: O35536
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot