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Protein
Submitted name:

CD86 molecule

Gene

Cd86

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • receptor binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • B cell activation Source: RGD
  • cellular response to cytokine stimulus Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to metal ion Source: RGD
  • defense response to virus Source: RGD
  • myeloid dendritic cell differentiation Source: RGD
  • negative regulation of T cell anergy Source: RGD
  • positive regulation of activated T cell proliferation Source: RGD
  • positive regulation of T cell proliferation Source: RGD
  • response to drug Source: RGD
  • response to interferon-gamma Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to yeast Source: RGD
  • T cell proliferation involved in immune response Source: RGD
  • toll-like receptor 3 signaling pathway Source: RGD
  • toll-like receptor signaling pathway Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-1257604 PIP3 activates AKT signaling
R-RNO-389356 CD28 co-stimulation
R-RNO-389357 CD28 dependent PI3K/Akt signaling
R-RNO-389359 CD28 dependent Vav1 pathway
R-RNO-389513 CTLA4 inhibitory signaling
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Submitted name:
CD86 moleculeImported
Submitted name:
Cd86 antigen, isoform CRA_cImported
Submitted name:
Membrane glycoproteinImported
Gene namesi
Name:Cd86Imported
ORF Names:rCG_52586Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi628714 Cd86

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei249 – 268HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000038835

Interactioni

GO - Molecular functioni

  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003129

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 127Ig-likeInterPro annotationAdd BLAST90

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IYP1 Eukaryota
ENOG410ZD66 LUCA
GeneTreeiENSGT00720000108819
HOGENOMiHOG000276893
HOVERGENiHBG004093
KOiK05413
OMAiELVVFWQ
OrthoDBiEOG091G0QVY
TreeFamiTF331083

Family and domain databases

CDDicd16087 IgV_CD86, 1 hit
Gene3Di2.60.40.102 hits
InterProiView protein in InterPro
IPR037677 CD86_IgV
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
SMARTiView protein in SMART
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

O35531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVVKTCVTC TMYLGILFSV LAYLLSDAVP VKRQAYFNST AYLPCPFTKA
60 70 80 90 100
QNISPSELVV FWQDRKKSVL YEHYLGAEKL DNVNAKYLGR TSFDRDNQAL
110 120 130 140 150
RLHNVQIKDT GLYDCFIQQK TPTGSIILQQ WETELSVIAN FSEPEIEEAQ
160 170 180 190 200
NETRNTGINL TCSSKQGYPK PTKMYFLITN STNEYGDNMQ ISQDNVTKLF
210 220 230 240 250
SVSISLSLPF PDGVYNMTIV CILETESMNI SSKPHNMVFS QPQFDRKTWI
260 270 280 290 300
QIAGPSSLLC CLFLLVVYKA VKKCLKMQNQ PGRPSRKTCE SKQDSGVDES
310
INLEEVEPQL HQQ
Length:313
Mass (Da):35,574
Last modified:January 1, 1998 - v1
Checksum:i3106246B8901B5D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07034349 Genomic DNA No translation available.
D50558 mRNA Translation: BAA23470.1
CH473967 Genomic DNA Translation: EDM11277.1
RefSeqiNP_064466.1, NM_020081.1
UniGeneiRn.229570

Genome annotation databases

EnsembliENSRNOT00000003129; ENSRNOP00000003129; ENSRNOG00000038835
GeneIDi56822
KEGGirno:56822

Similar proteinsi

Entry informationi

Entry nameiO35531_RAT
AccessioniPrimary (citable) accession number: O35531
Secondary accession number(s): F1LNG0
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: February 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported