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O35526

- STX1A_MOUSE

UniProt

O35526 - STX1A_MOUSE

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Protein
Syntaxin-1A
Gene
Stx1a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca2+-regulation of exocytosis acrosomal reaction in sperm.1 Publication

GO - Molecular functioni

  1. SNARE binding Source: MGI
  2. calcium channel inhibitor activity Source: MGI
  3. glycoprotein binding Source: MGI
  4. protein binding Source: UniProtKB

GO - Biological processi

  1. calcium ion-dependent exocytosis Source: MGI
  2. intracellular protein transport Source: InterPro
  3. positive regulation of exocytosis Source: Ensembl
  4. positive regulation of neurotransmitter secretion Source: Ensembl
  5. response to gravity Source: Ensembl
  6. synaptic vesicle docking involved in exocytosis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiREACT_205038. Acetylcholine Neurotransmitter Release Cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-1A
Alternative name(s):
Neuron-specific antigen HPC-1
Gene namesi
Name:Stx1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:109355. Stx1a.

Subcellular locationi

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Single-pass type IV membrane protein. Cell junctionsynapsesynaptosome 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 265265Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei266 – 28621Helical; Anchor for type IV membrane protein; Reviewed prediction
Add
BLAST
Topological domaini287 – 2882Extracellular Reviewed prediction

GO - Cellular componenti

  1. SNARE complex Source: UniProtKB
  2. actomyosin Source: Ensembl
  3. cell junction Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. membrane Source: MGI
  6. neuron projection Source: MGI
  7. plasma membrane Source: MGI
  8. secretory granule Source: Ensembl
  9. synaptic vesicle Source: UniProtKB
  10. synaptic vesicle membrane Source: MGI
  11. synaptobrevin 2-SNAP-25-syntaxin-1a complex Source: MGI
  12. synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex Source: MGI
  13. synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Syntaxin-1A
PRO_0000210187Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphoserine1 Publication
Modified residuei188 – 1881Phosphoserine; by DAPK1 By similarity

Post-translational modificationi

Phosphorylated by CK2. Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1 By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO35526.
PaxDbiO35526.
PRIDEiO35526.

PTM databases

PhosphoSiteiO35526.

Expressioni

Gene expression databases

ArrayExpressiO35526.
BgeeiO35526.
CleanExiMM_STX1A.
GenevestigatoriO35526.

Interactioni

Subunit structurei

Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Interacts with VAPA and SYBU. Binds STXBP6. Found in a complex with VAMP8 and SNAP23. Found in a ternary complex with STX1A and SNAP25 By similarity. Interacts with SLC6A4 By similarity. Binds SYTL4. Interacts with OTOF and LGI3. Interacts with SYT6 and SYT8; the interaction is Ca2+-dependent. Interacts with STXBP1 and DAPK1 By similarity.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Syt2P460972EBI-400878,EBI-457969

Protein-protein interaction databases

BioGridi203561. 15 interactions.
IntActiO35526. 17 interactions.
MINTiMINT-2411610.

Structurei

3D structure databases

ProteinModelPortaliO35526.
SMRiO35526. Positions 27-286.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini192 – 25463t-SNARE coiled-coil homology
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili68 – 10942 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5074.
HOGENOMiHOG000286023.
HOVERGENiHBG000497.
InParanoidiO35526.
KOiK04560.
OMAiHEETKAV.
OrthoDBiEOG7X9G7R.
PhylomeDBiO35526.
TreeFamiTF313763.

Family and domain databases

InterProiIPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF84. PTHR19957:SF84. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35526-1 [UniParc]FASTAAdd to Basket

« Hide

MKDRTQELRT AKDSDDDDDV TVTVDRDRFM DEFFEQVEEI RGFIDKIAEN    50
VEEVKRKHSA ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI 100
EQEEGLNRSS ADLRIRKTQH STLSRKFVEV MSEYNATQSD YRERCKGRIQ 150
RQLEITGRTT TSEELEDMLE SGNPAIFASG IIMDSSISKQ ALSEIETRHS 200
EIIKLETSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA VDYVERAVSD 250
TKKAVKYQSK ARRKKIMIII CCVILGIIIA STIGGIFG 288
Length:288
Mass (Da):33,054
Last modified:December 19, 2001 - v3
Checksum:i8F8255F2EEF886CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45208 mRNA. Translation: BAA28865.2.
CCDSiCCDS19731.1.
RefSeqiNP_058081.2. NM_016801.3.
UniGeneiMm.6225.

Genome annotation databases

EnsembliENSMUST00000005509; ENSMUSP00000005509; ENSMUSG00000007207.
GeneIDi20907.
KEGGimmu:20907.
UCSCiuc008zxk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45208 mRNA. Translation: BAA28865.2 .
CCDSi CCDS19731.1.
RefSeqi NP_058081.2. NM_016801.3.
UniGenei Mm.6225.

3D structure databases

ProteinModelPortali O35526.
SMRi O35526. Positions 27-286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203561. 15 interactions.
IntActi O35526. 17 interactions.
MINTi MINT-2411610.

PTM databases

PhosphoSitei O35526.

Proteomic databases

MaxQBi O35526.
PaxDbi O35526.
PRIDEi O35526.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000005509 ; ENSMUSP00000005509 ; ENSMUSG00000007207 .
GeneIDi 20907.
KEGGi mmu:20907.
UCSCi uc008zxk.1. mouse.

Organism-specific databases

CTDi 6804.
MGIi MGI:109355. Stx1a.

Phylogenomic databases

eggNOGi COG5074.
HOGENOMi HOG000286023.
HOVERGENi HBG000497.
InParanoidi O35526.
KOi K04560.
OMAi HEETKAV.
OrthoDBi EOG7X9G7R.
PhylomeDBi O35526.
TreeFami TF313763.

Enzyme and pathway databases

Reactomei REACT_205038. Acetylcholine Neurotransmitter Release Cycle.

Miscellaneous databases

NextBioi 299781.
PROi O35526.
SOURCEi Search...

Gene expression databases

ArrayExpressi O35526.
Bgeei O35526.
CleanExi MM_STX1A.
Genevestigatori O35526.

Family and domain databases

InterProi IPR028669. STX1A/1B.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view ]
PANTHERi PTHR19957:SF84. PTHR19957:SF84. 1 hit.
Pfami PF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view ]
SMARTi SM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view ]
SUPFAMi SSF47661. SSF47661. 1 hit.
PROSITEi PS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Fujiwara T., Genda M., Nagai A., Okazaki M., Watanabe T., Nagamatsu S., Akagawa K.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 29-41; 47-56; 58-84; 95-108; 126-142; 152-158 AND 233-246, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a."
    Torii S., Zhao S., Yi Z., Takeuchi T., Izumi T.
    Mol. Cell. Biol. 22:5518-5526(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SYTL4.
  4. "Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction."
    Hutt D.M., Baltz J.M., Ngsee J.K.
    J. Biol. Chem. 280:20197-20203(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SYT6 AND SYT8.
  5. "Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse."
    Roux I., Safieddine S., Nouvian R., Grati M., Simmler M.-C., Bahloul A., Perfettini I., Le Gall M., Rostaing P., Hamard G., Triller A., Avan P., Moser T., Petit C.
    Cell 127:277-289(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OTOF.
    Strain: BALB/c.
    Tissue: Cochlea.
  6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  7. "Leucine-rich glioma inactivated 3 associates with syntaxin 1."
    Park W.-J., Lee S.E., Kwon N.S., Baek K.J., Kim D.-S., Yun H.-Y.
    Neurosci. Lett. 444:240-244(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH LGI3.

Entry informationi

Entry nameiSTX1A_MOUSE
AccessioniPrimary (citable) accession number: O35526
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 19, 2001
Last modified: September 3, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi