O35524 (PSB9_MUSSI) Reviewed, UniProtKB/Swiss-Prot
Last modified June 11, 2014. Version 80. History...
Names and origin
|Protein names||Recommended name:|
Proteasome subunit beta type-9
Low molecular mass protein 2
Macropain chain 7
Multicatalytic endopeptidase complex chain 7
Proteasome chain 7
Proteasome subunit beta-1i
Really interesting new gene 12 protein
|Organism||Mus spicilegus (Steppe mouse)|
|Taxonomic identifier||10103 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus|
|Sequence length||219 AA.|
|Sequence processing||The displayed sequence is further processed into a mature form.|
|Protein existence||Evidence at protein level|
General annotation (Comments)
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
Cleavage of peptide bonds with very broad specificity.
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent houskeeping subunit PSMB6. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.
Up-regulated by interferon gamma (at protein level).
Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity By similarity.
Encoded in the MHC class II region.
Belongs to the peptidase T1B family.
|Gene Ontology (GO)|
|Biological_process||immune system process|
Inferred from electronic annotation. Source: UniProtKB-KWproteolysis involved in cellular protein catabolic process
Inferred from electronic annotation. Source: InterPro
Inferred from electronic annotation. Source: UniProtKB-SubCellnucleus
Inferred from electronic annotation. Source: UniProtKB-SubCellproteasome core complex
Inferred from electronic annotation. Source: InterProspermatoproteasome complex
Inferred from sequence or structural similarity. Source: UniProtKB
|Molecular_function||threonine-type endopeptidase activity|
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Propeptide||1 – 20||20||Removed in mature form By similarity||PRO_0000026629|
|Chain||21 – 219||199||Proteasome subunit beta type-9||PRO_0000026630|
|Active site||21||1||Nucleophile By similarity|
|Site||20 – 21||2||Cleavage; by autocatalysis By similarity|
Amino acid modifications
|Modified residue||53||1||N6-acetyllysine By similarity|
|Modified residue||109||1||N6-acetyllysine By similarity|
|D44463 mRNA. Translation: BAA22584.1.|
3D structure databases
|SMR||O35524. Positions 21-216. |
Protein family/group databases
Protocols and materials databases
|MGI||MGI:1346526. Psmb9. |
Family and domain databases
|Gene3D||126.96.36.199. 1 hit. |
|InterPro||IPR029055. Ntn_hydrolases_N. |
|Pfam||PF00227. Proteasome. 1 hit. |
|PRINTS||PR00141. PROTEASOME. |
|SUPFAM||SSF56235. SSF56235. 1 hit. |
|PROSITE||PS00854. PROTEASOME_BETA_1. 1 hit. |
PS51476. PROTEASOME_BETA_2. 1 hit.
|Accession||Primary (citable) accession number: O35524|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|