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O35509

- RB11B_RAT

UniProt

O35509 - RB11B_RAT

Protein

Ras-related protein Rab-11B

Gene

Rab11b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 269GTPBy similarity
    Nucleotide bindingi66 – 705GTPBy similarity
    Nucleotide bindingi124 – 1274GTPBy similarity
    Nucleotide bindingi154 – 1563GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTPase activity Source: UniProtKB
    3. GTP binding Source: UniProtKB

    GO - Biological processi

    1. cellular component movement Source: RGD
    2. cellular response to acidic pH Source: UniProtKB
    3. constitutive secretory pathway Source: UniProtKB
    4. insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
    5. melanosome transport Source: UniProtKB
    6. receptor recycling Source: UniProtKB
    7. regulated secretory pathway Source: UniProtKB
    8. regulation of anion transport Source: UniProtKB
    9. regulation of endocytic recycling Source: UniProtKB
    10. regulation of protein localization to cell surface Source: UniProtKB
    11. retrograde transport, endosome to plasma membrane Source: UniProtKB
    12. small GTPase mediated signal transduction Source: InterPro
    13. transferrin transport Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-11B
    Gene namesi
    Name:Rab11b
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi68369. Rab11b.

    Subcellular locationi

    Recycling endosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Recruited to phagosomes containing S.aureus.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytoplasmic membrane-bounded vesicle Source: MGI
    3. mitochondrion Source: Ensembl
    4. phagocytic vesicle Source: UniProtKB
    5. phagocytic vesicle membrane Source: UniProtKB-SubCell
    6. recycling endosome Source: UniProtKB
    7. recycling endosome membrane Source: UniProtKB-SubCell
    8. synaptic vesicle Source: UniProtKB
    9. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 215214Ras-related protein Rab-11BPRO_0000121160Add
    BLAST
    Propeptidei216 – 2183Removed in mature formSequence AnalysisPRO_0000370817

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycineBy similarity
    Modified residuei4 – 41CitrullineBy similarity
    Lipidationi214 – 2141S-geranylgeranyl cysteineBy similarity
    Modified residuei215 – 2151Cysteine methyl esterSequence Analysis
    Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity

    Post-translational modificationi

    Citrullinated by PADI4.By similarity

    Keywords - PTMi

    Acetylation, Citrullination, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiO35509.
    PRIDEiO35509.

    PTM databases

    PhosphoSiteiO35509.

    Expressioni

    Gene expression databases

    GenevestigatoriO35509.

    Interactioni

    Subunit structurei

    Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. May interact with TBC1D14. Interacts with KCNMA1. Interacts with ATP6V1E1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi249465. 1 interaction.
    IntActiO35509. 1 interaction.
    MINTiMINT-4542683.
    STRINGi10116.ENSRNOP00000010197.

    Structurei

    3D structure databases

    ProteinModelPortaliO35509.
    SMRiO35509. Positions 8-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 489Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00710000106372.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiO35509.
    KOiK07905.
    OMAiIQVDAKT.
    OrthoDBiEOG7SFHZ2.
    PhylomeDBiO35509.
    TreeFamiTF300099.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35509-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT    50
    RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE 100
    NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNNLSF 150
    IETSALDSTN VEEAFKNILT EIYRIVSQKQ IADRAAHDES PGNNVVDISV 200
    PPTTDGQKPN KLQCCQNL 218
    Length:218
    Mass (Da):24,489
    Last modified:January 23, 2007 - v4
    Checksum:i8DF146BA39EBD9FF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti120 – 1201M → L in BAA22522. 1 PublicationCurated
    Sequence conflicti135 – 1373PTD → CPLT in BAA22522. 1 PublicationCurated
    Sequence conflicti145 – 1473KNN → RH in BAA22522. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D01046 mRNA. Translation: BAA22522.1.
    AF286534 mRNA. Translation: AAG00542.1.
    BC062041 mRNA. Translation: AAH62041.1.
    RefSeqiNP_116006.1. NM_032617.2.
    UniGeneiRn.124832.

    Genome annotation databases

    EnsembliENSRNOT00000010197; ENSRNOP00000010197; ENSRNOG00000007648.
    GeneIDi79434.
    KEGGirno:79434.
    UCSCiRGD:68369. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D01046 mRNA. Translation: BAA22522.1 .
    AF286534 mRNA. Translation: AAG00542.1 .
    BC062041 mRNA. Translation: AAH62041.1 .
    RefSeqi NP_116006.1. NM_032617.2.
    UniGenei Rn.124832.

    3D structure databases

    ProteinModelPortali O35509.
    SMRi O35509. Positions 8-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249465. 1 interaction.
    IntActi O35509. 1 interaction.
    MINTi MINT-4542683.
    STRINGi 10116.ENSRNOP00000010197.

    PTM databases

    PhosphoSitei O35509.

    Proteomic databases

    PaxDbi O35509.
    PRIDEi O35509.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010197 ; ENSRNOP00000010197 ; ENSRNOG00000007648 .
    GeneIDi 79434.
    KEGGi rno:79434.
    UCSCi RGD:68369. rat.

    Organism-specific databases

    CTDi 9230.
    RGDi 68369. Rab11b.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00710000106372.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi O35509.
    KOi K07905.
    OMAi IQVDAKT.
    OrthoDBi EOG7SFHZ2.
    PhylomeDBi O35509.
    TreeFami TF300099.

    Miscellaneous databases

    NextBioi 614803.
    PROi O35509.

    Gene expression databases

    Genevestigatori O35509.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel YPT1/SEC4 related gene from rat brain."
      Sakurada K., Aisaka K., Ito S., Takeyama Y., Hori Y., Takai Y.
      Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. Zhao H., Gao L., Vaananen K.H.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Bone.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    4. "Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis."
      Khvotchev M.V., Ren M., Takamori S., Jahn R., Suedhof T.C.
      J. Neurosci. 23:10531-10539(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN EXOCYTOSIS, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiRB11B_RAT
    AccessioniPrimary (citable) accession number: O35509
    Secondary accession number(s): Q9ET14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 120 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3