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O35509 (RB11B_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ras-related protein Rab-11B
Gene names
Name:Rab11b
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis By similarity.

Subunit structure

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4 By similarity. May interact with TBC1D14 By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Cytoplasmic vesicle › phagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Recruited to phagosomes containing S.aureus or Mycobacterium By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 215214Ras-related protein Rab-11B
PRO_0000121160
Propeptide216 – 2183Removed in mature form Potential
PRO_0000370817

Regions

Nucleotide binding18 – 269GTP By similarity
Nucleotide binding66 – 705GTP By similarity
Nucleotide binding124 – 1274GTP By similarity
Nucleotide binding154 – 1563GTP By similarity
Motif40 – 489Effector region By similarity

Amino acid modifications

Modified residue21N-acetylglycine By similarity
Modified residue2151Cysteine methyl ester Potential
Lipidation2141S-geranylgeranyl cysteine By similarity
Lipidation2151S-geranylgeranyl cysteine By similarity

Experimental info

Sequence conflict1201M → L in BAA22522. Ref.1
Sequence conflict135 – 1373PTD → CPLT in BAA22522. Ref.1
Sequence conflict145 – 1473KNN → RH in BAA22522. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35509 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 8DF146BA39EBD9FF

FASTA21824,489
        10         20         30         40         50         60 
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT RSIQVDGKTI 

        70         80         90        100        110        120 
KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE NVERWLKELR DHADSNIVIM 

       130        140        150        160        170        180 
LVGNKSDLRH LRAVPTDEAR AFAEKNNLSF IETSALDSTN VEEAFKNILT EIYRIVSQKQ 

       190        200        210 
IADRAAHDES PGNNVVDISV PPTTDGQKPN KLQCCQNL

« Hide

References

« Hide 'large scale' references
[1]"A novel YPT1/SEC4 related gene from rat brain."
Sakurada K., Aisaka K., Ito S., Takeyama Y., Hori Y., Takai Y.
Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]Zhao H., Gao L., Vaananen K.H.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Bone.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D01046 mRNA. Translation: BAA22522.1.
AF286534 mRNA. Translation: AAG00542.1.
BC062041 mRNA. Translation: AAH62041.1.
IPIIPI00210381.
RefSeqNP_116006.1. NM_032617.2.
UniGeneRn.124832.

3D structure databases

ProteinModelPortalO35509.
ModBaseSearch...

Protein-protein interaction databases

IntActO35509. 1 interaction.
STRING10116.ENSRNOP00000010197.

PTM databases

PhosphoSiteO35509.

Proteomic databases

PaxDbO35509.
PRIDEO35509.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000010197; ENSRNOP00000010197; ENSRNOG00000007648.
GeneID79434.
KEGGrno:79434.
UCSCRGD:68369. rat.

Organism-specific databases

CTD9230.
RGD68369. Rab11b.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00690000101664.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidO35509.
KOK07905.
OMAERSAHDE.
OrthoDBEOG4RR6J7.

Gene expression databases

GenevestigatorO35509.
GermOnlineENSRNOG00000007648. Rattus norvegicus.

Family and domain databases

InterProIPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio614803.

Entry information

Entry nameRB11B_RAT
AccessionPrimary (citable) accession number: O35509
Secondary accession number(s): Q9ET14
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 110 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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