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O35509

- RB11B_RAT

UniProt

O35509 - RB11B_RAT

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Protein

Ras-related protein Rab-11B

Gene

Rab11b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269GTPBy similarity
Nucleotide bindingi66 – 705GTPBy similarity
Nucleotide bindingi124 – 1274GTPBy similarity
Nucleotide bindingi154 – 1563GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTPase activity Source: UniProtKB
  3. GTP binding Source: UniProtKB

GO - Biological processi

  1. cellular component movement Source: RGD
  2. cellular response to acidic pH Source: UniProtKB
  3. constitutive secretory pathway Source: UniProtKB
  4. GTP catabolic process Source: GOC
  5. insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
  6. melanosome transport Source: UniProtKB
  7. receptor recycling Source: UniProtKB
  8. regulated secretory pathway Source: UniProtKB
  9. regulation of anion transport Source: UniProtKB
  10. regulation of endocytic recycling Source: UniProtKB
  11. regulation of protein localization to cell surface Source: UniProtKB
  12. retrograde transport, endosome to plasma membrane Source: UniProtKB
  13. small GTPase mediated signal transduction Source: InterPro
  14. transferrin transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-11B
Gene namesi
Name:Rab11b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi68369. Rab11b.

Subcellular locationi

Recycling endosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane 1 Publication; Lipid-anchor 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Recruited to phagosomes containing S.aureus.By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasmic membrane-bounded vesicle Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. mitochondrion Source: Ensembl
  5. phagocytic vesicle Source: UniProtKB
  6. recycling endosome Source: UniProtKB
  7. recycling endosome membrane Source: Ensembl
  8. synaptic vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 215214Ras-related protein Rab-11BPRO_0000121160Add
BLAST
Propeptidei216 – 2183Removed in mature formSequence AnalysisPRO_0000370817

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycineBy similarity
Modified residuei4 – 41CitrullineBy similarity
Lipidationi214 – 2141S-geranylgeranyl cysteineBy similarity
Modified residuei215 – 2151Cysteine methyl esterSequence Analysis
Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiO35509.
PRIDEiO35509.

PTM databases

PhosphoSiteiO35509.

Expressioni

Gene expression databases

GenevestigatoriO35509.

Interactioni

Subunit structurei

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. May interact with TBC1D14. Interacts with KCNMA1. Interacts with ATP6V1E1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249465. 1 interaction.
IntActiO35509. 1 interaction.
MINTiMINT-4542683.
STRINGi10116.ENSRNOP00000010197.

Structurei

3D structure databases

ProteinModelPortaliO35509.
SMRiO35509. Positions 8-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 489Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiO35509.
KOiK07905.
OMAiIQVDAKT.
OrthoDBiEOG7SFHZ2.
PhylomeDBiO35509.
TreeFamiTF300099.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35509-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT
60 70 80 90 100
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE
110 120 130 140 150
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNNLSF
160 170 180 190 200
IETSALDSTN VEEAFKNILT EIYRIVSQKQ IADRAAHDES PGNNVVDISV
210
PPTTDGQKPN KLQCCQNL
Length:218
Mass (Da):24,489
Last modified:January 23, 2007 - v4
Checksum:i8DF146BA39EBD9FF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201M → L in BAA22522. 1 PublicationCurated
Sequence conflicti135 – 1373PTD → CPLT in BAA22522. 1 PublicationCurated
Sequence conflicti145 – 1473KNN → RH in BAA22522. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01046 mRNA. Translation: BAA22522.1.
AF286534 mRNA. Translation: AAG00542.1.
BC062041 mRNA. Translation: AAH62041.1.
RefSeqiNP_116006.1. NM_032617.2.
UniGeneiRn.124832.

Genome annotation databases

EnsembliENSRNOT00000010197; ENSRNOP00000010197; ENSRNOG00000007648.
GeneIDi79434.
KEGGirno:79434.
UCSCiRGD:68369. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01046 mRNA. Translation: BAA22522.1 .
AF286534 mRNA. Translation: AAG00542.1 .
BC062041 mRNA. Translation: AAH62041.1 .
RefSeqi NP_116006.1. NM_032617.2.
UniGenei Rn.124832.

3D structure databases

ProteinModelPortali O35509.
SMRi O35509. Positions 8-179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249465. 1 interaction.
IntActi O35509. 1 interaction.
MINTi MINT-4542683.
STRINGi 10116.ENSRNOP00000010197.

PTM databases

PhosphoSitei O35509.

Proteomic databases

PaxDbi O35509.
PRIDEi O35509.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010197 ; ENSRNOP00000010197 ; ENSRNOG00000007648 .
GeneIDi 79434.
KEGGi rno:79434.
UCSCi RGD:68369. rat.

Organism-specific databases

CTDi 9230.
RGDi 68369. Rab11b.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000118841.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi O35509.
KOi K07905.
OMAi IQVDAKT.
OrthoDBi EOG7SFHZ2.
PhylomeDBi O35509.
TreeFami TF300099.

Miscellaneous databases

NextBioi 614803.
PROi O35509.

Gene expression databases

Genevestigatori O35509.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel YPT1/SEC4 related gene from rat brain."
    Sakurada K., Aisaka K., Ito S., Takeyama Y., Hori Y., Takai Y.
    Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. Zhao H., Gao L., Vaananen K.H.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Bone.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  4. "Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis."
    Khvotchev M.V., Ren M., Takamori S., Jahn R., Suedhof T.C.
    J. Neurosci. 23:10531-10539(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN EXOCYTOSIS, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRB11B_RAT
AccessioniPrimary (citable) accession number: O35509
Secondary accession number(s): Q9ET14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 122 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3