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Protein

Ras-related protein Rab-11B

Gene

Rab11b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26GTPBy similarity9
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4
Nucleotide bindingi154 – 156GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-8854214 TBC/RABGAPs
R-RNO-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-11B
Gene namesi
Name:Rab11b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi68369 Rab11b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001211602 – 215Ras-related protein Rab-11BAdd BLAST214
PropeptideiPRO_0000370817216 – 218Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei4CitrullineBy similarity1
Lipidationi214S-geranylgeranyl cysteineBy similarity1
Modified residuei215Cysteine methyl esterSequence analysis1
Lipidationi215S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiO35509
PRIDEiO35509

PTM databases

iPTMnetiO35509
PhosphoSitePlusiO35509

Expressioni

Gene expression databases

BgeeiENSRNOG00000007648
ExpressionAtlasiO35509 baseline and differential
GenevisibleiO35509 RN

Interactioni

Subunit structurei

Interacts with KCNMA1 (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. May interact with TBC1D14. Interacts with ATP6V1E1. Interacts with PI4KB (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249465, 1 interactor
IntActiO35509, 2 interactors
STRINGi10116.ENSRNOP00000010197

Structurei

3D structure databases

ProteinModelPortaliO35509
SMRiO35509
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0087 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiO35509
KOiK07905
OMAiKHSTYES
OrthoDBiEOG091G0O1R
PhylomeDBiO35509
TreeFamiTF300099

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35509-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT
60 70 80 90 100
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE
110 120 130 140 150
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNNLSF
160 170 180 190 200
IETSALDSTN VEEAFKNILT EIYRIVSQKQ IADRAAHDES PGNNVVDISV
210
PPTTDGQKPN KLQCCQNL
Length:218
Mass (Da):24,489
Last modified:January 23, 2007 - v4
Checksum:i8DF146BA39EBD9FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120M → L in BAA22522 (Ref. 1) Curated1
Sequence conflicti135 – 137PTD → CPLT in BAA22522 (Ref. 1) Curated3
Sequence conflicti145 – 147KNN → RH in BAA22522 (Ref. 1) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01046 mRNA Translation: BAA22522.1
AF286534 mRNA Translation: AAG00542.1
BC062041 mRNA Translation: AAH62041.1
RefSeqiNP_116006.1, NM_032617.2
UniGeneiRn.124832

Genome annotation databases

EnsembliENSRNOT00000010197; ENSRNOP00000010197; ENSRNOG00000007648
GeneIDi79434
KEGGirno:79434
UCSCiRGD:68369 rat

Similar proteinsi

Entry informationi

Entry nameiRB11B_RAT
AccessioniPrimary (citable) accession number: O35509
Secondary accession number(s): Q9ET14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 152 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health