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O35509

- RB11B_RAT

UniProt

O35509 - RB11B_RAT

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Protein
Ras-related protein Rab-11B
Gene
Rab11b
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269GTP By similarity
Nucleotide bindingi66 – 705GTP By similarity
Nucleotide bindingi124 – 1274GTP By similarity
Nucleotide bindingi154 – 1563GTP By similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB
  3. GTPase activity Source: UniProtKB

GO - Biological processi

  1. cellular component movement Source: RGD
  2. cellular response to acidity Source: UniProtKB
  3. constitutive secretory pathway Source: UniProtKB
  4. insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
  5. melanosome transport Source: UniProtKB
  6. receptor recycling Source: UniProtKB
  7. regulated secretory pathway Source: UniProtKB
  8. regulation of anion transport Source: UniProtKB
  9. regulation of endocytic recycling Source: UniProtKB
  10. regulation of protein localization to cell surface Source: UniProtKB
  11. retrograde transport, endosome to plasma membrane Source: UniProtKB
  12. small GTPase mediated signal transduction Source: InterPro
  13. transferrin transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-11B
Gene namesi
Name:Rab11b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi68369. Rab11b.

Subcellular locationi

Recycling endosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Lipid-anchor; Cytoplasmic side Inferred. Cytoplasmic vesiclephagosome membrane; Lipid-anchor; Cytoplasmic side By similarity
Note: Recruited to phagosomes containing S.aureus By similarity.1 Publication

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytoplasmic membrane-bounded vesicle Source: MGI
  3. mitochondrion Source: Ensembl
  4. phagocytic vesicle Source: UniProtKB
  5. phagocytic vesicle membrane Source: UniProtKB-SubCell
  6. recycling endosome Source: UniProtKB
  7. recycling endosome membrane Source: UniProtKB-SubCell
  8. synaptic vesicle Source: UniProtKB
  9. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 215214Ras-related protein Rab-11B
PRO_0000121160Add
BLAST
Propeptidei216 – 2183Removed in mature form Reviewed prediction
PRO_0000370817

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine By similarity
Modified residuei4 – 41Citrulline By similarity
Lipidationi214 – 2141S-geranylgeranyl cysteine By similarity
Modified residuei215 – 2151Cysteine methyl ester Reviewed prediction
Lipidationi215 – 2151S-geranylgeranyl cysteine By similarity

Post-translational modificationi

Citrullinated by PADI4 By similarity.

Keywords - PTMi

Acetylation, Citrullination, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiO35509.
PRIDEiO35509.

PTM databases

PhosphoSiteiO35509.

Expressioni

Gene expression databases

GenevestigatoriO35509.

Interactioni

Subunit structurei

Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. May interact with TBC1D14. Interacts with KCNMA1. Interacts with ATP6V1E1 By similarity.

Protein-protein interaction databases

BioGridi249465. 1 interaction.
IntActiO35509. 1 interaction.
MINTiMINT-4542683.
STRINGi10116.ENSRNOP00000010197.

Structurei

3D structure databases

ProteinModelPortaliO35509.
SMRiO35509. Positions 8-188.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 489Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00710000106372.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiO35509.
KOiK07905.
OMAiIQVDAKT.
OrthoDBiEOG7SFHZ2.
PhylomeDBiO35509.
TreeFamiTF300099.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35509-1 [UniParc]FASTAAdd to Basket

« Hide

MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT    50
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE 100
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNNLSF 150
IETSALDSTN VEEAFKNILT EIYRIVSQKQ IADRAAHDES PGNNVVDISV 200
PPTTDGQKPN KLQCCQNL 218
Length:218
Mass (Da):24,489
Last modified:January 23, 2007 - v4
Checksum:i8DF146BA39EBD9FF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201M → L in BAA22522. 1 Publication
Sequence conflicti135 – 1373PTD → CPLT in BAA22522. 1 Publication
Sequence conflicti145 – 1473KNN → RH in BAA22522. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D01046 mRNA. Translation: BAA22522.1.
AF286534 mRNA. Translation: AAG00542.1.
BC062041 mRNA. Translation: AAH62041.1.
RefSeqiNP_116006.1. NM_032617.2.
UniGeneiRn.124832.

Genome annotation databases

EnsembliENSRNOT00000010197; ENSRNOP00000010197; ENSRNOG00000007648.
GeneIDi79434.
KEGGirno:79434.
UCSCiRGD:68369. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D01046 mRNA. Translation: BAA22522.1 .
AF286534 mRNA. Translation: AAG00542.1 .
BC062041 mRNA. Translation: AAH62041.1 .
RefSeqi NP_116006.1. NM_032617.2.
UniGenei Rn.124832.

3D structure databases

ProteinModelPortali O35509.
SMRi O35509. Positions 8-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249465. 1 interaction.
IntActi O35509. 1 interaction.
MINTi MINT-4542683.
STRINGi 10116.ENSRNOP00000010197.

PTM databases

PhosphoSitei O35509.

Proteomic databases

PaxDbi O35509.
PRIDEi O35509.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010197 ; ENSRNOP00000010197 ; ENSRNOG00000007648 .
GeneIDi 79434.
KEGGi rno:79434.
UCSCi RGD:68369. rat.

Organism-specific databases

CTDi 9230.
RGDi 68369. Rab11b.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00710000106372.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi O35509.
KOi K07905.
OMAi IQVDAKT.
OrthoDBi EOG7SFHZ2.
PhylomeDBi O35509.
TreeFami TF300099.

Miscellaneous databases

NextBioi 614803.
PROi O35509.

Gene expression databases

Genevestigatori O35509.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel YPT1/SEC4 related gene from rat brain."
    Sakurada K., Aisaka K., Ito S., Takeyama Y., Hori Y., Takai Y.
    Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. Zhao H., Gao L., Vaananen K.H.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Bone.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  4. "Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis."
    Khvotchev M.V., Ren M., Takamori S., Jahn R., Suedhof T.C.
    J. Neurosci. 23:10531-10539(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN EXOCYTOSIS, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRB11B_RAT
AccessioniPrimary (citable) accession number: O35509
Secondary accession number(s): Q9ET14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 119 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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