Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-crystallin S

Gene

Crygs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

  • structural constituent of eye lens Source: MGI

GO - Biological processi

  • lens development in camera-type eye Source: MGI
  • morphogenesis of an epithelium Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-crystallin S
Alternative name(s):
Gamma-S-crystallin
Gamma-crystallin S
Gene namesi
Name:Crygs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1298216. Crygs.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000575662 – 178Beta-crystallin SAdd BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO35486.
PRIDEiO35486.

PTM databases

PhosphoSitePlusiO35486.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033501.
CleanExiMM_CRYGS.
ExpressionAtlasiO35486. baseline and differential.
GenevisibleiO35486. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043588.

Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 16Combined sources10
Beta strandi18 – 25Combined sources8
Turni31 – 33Combined sources3
Beta strandi38 – 52Combined sources15
Turni53 – 55Combined sources3
Beta strandi56 – 62Combined sources7
Beta strandi64 – 69Combined sources6
Helixi70 – 73Combined sources4
Beta strandi76 – 78Combined sources3
Beta strandi82 – 86Combined sources5
Beta strandi96 – 101Combined sources6
Turni102 – 104Combined sources3
Beta strandi105 – 113Combined sources9
Helixi118 – 122Combined sources5
Beta strandi129 – 132Combined sources4
Beta strandi137 – 142Combined sources6
Turni143 – 145Combined sources3
Beta strandi146 – 152Combined sources7
Beta strandi154 – 157Combined sources4
Helixi160 – 163Combined sources4
Beta strandi166 – 168Combined sources3
Beta strandi172 – 175Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZWMNMR-A2-178[»]
1ZWONMR-A2-178[»]
2A5MNMR-A2-178[»]
ProteinModelPortaliO35486.
SMRiO35486.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35486.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 44Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini45 – 87Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini94 – 134Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini135 – 177Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 5N-terminal arm4
Regioni88 – 93Connecting peptide6

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEJ7. Eukaryota.
ENOG4111EVU. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiO35486.
OMAiSIMEEWH.
OrthoDBiEOG091G0L2P.
PhylomeDBiO35486.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35486-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKTGGKISF YEDRNFQGRR YDCDCDCADF RSYLSRCNSI RVEGGTWAVY
60 70 80 90 100
ERPNFSGHMY ILPQGEYPEY QRWMGLNDRL GSCRAVHLSS GGQAKIQVFE
110 120 130 140 150
KGDFNGQMYE TTEDCPSIME QFHLREIHSC KVVEGTWIFY ELPNYRGRQY
160 170
LLDKKEYRKP VDWGAASPAI QSFRRIVE
Length:178
Mass (Da):20,850
Last modified:January 23, 2007 - v3
Checksum:i40AD1B4835A87C4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032995 mRNA. Translation: AAC53579.1.
AF055703, AF055702 Genomic DNA. Translation: AAC40120.1.
BC056452 mRNA. Translation: AAH56452.1.
CCDSiCCDS28069.1.
RefSeqiNP_034097.1. NM_009967.2.
UniGeneiMm.6253.

Genome annotation databases

EnsembliENSMUST00000040592; ENSMUSP00000043588; ENSMUSG00000033501.
GeneIDi12970.
KEGGimmu:12970.
UCSCiuc007ysj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032995 mRNA. Translation: AAC53579.1.
AF055703, AF055702 Genomic DNA. Translation: AAC40120.1.
BC056452 mRNA. Translation: AAH56452.1.
CCDSiCCDS28069.1.
RefSeqiNP_034097.1. NM_009967.2.
UniGeneiMm.6253.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZWMNMR-A2-178[»]
1ZWONMR-A2-178[»]
2A5MNMR-A2-178[»]
ProteinModelPortaliO35486.
SMRiO35486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043588.

PTM databases

PhosphoSitePlusiO35486.

Proteomic databases

PaxDbiO35486.
PRIDEiO35486.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040592; ENSMUSP00000043588; ENSMUSG00000033501.
GeneIDi12970.
KEGGimmu:12970.
UCSCiuc007ysj.2. mouse.

Organism-specific databases

CTDi1427.
MGIiMGI:1298216. Crygs.

Phylogenomic databases

eggNOGiENOG410IEJ7. Eukaryota.
ENOG4111EVU. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiO35486.
OMAiSIMEEWH.
OrthoDBiEOG091G0L2P.
PhylomeDBiO35486.

Miscellaneous databases

EvolutionaryTraceiO35486.
PROiO35486.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033501.
CleanExiMM_CRYGS.
ExpressionAtlasiO35486. baseline and differential.
GenevisibleiO35486. MM.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRBS_MOUSE
AccessioniPrimary (citable) accession number: O35486
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.