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Protein

Vascular endothelial growth factor B

Gene

Vegfb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Heparin-binding, Mitogen

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation
R-RNO-194313 VEGF ligand-receptor interactions
R-RNO-195399 VEGF binds to VEGFR leading to receptor dimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor B
Short name:
VEGF-B
Alternative name(s):
VEGF-related factor
Short name:
VRF
Gene namesi
Name:Vegfb
Synonyms:Vrf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi619799 Vegfb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000004517422 – 207Vascular endothelial growth factor BAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72InterchainBy similarity
Disulfide bondi78 ↔ 122By similarity
Disulfide bondi81InterchainBy similarity
Disulfide bondi82 ↔ 124By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO35485

PTM databases

iPTMnetiO35485
PhosphoSitePlusiO35485

Expressioni

Gene expression databases

BgeeiENSRNOG00000021156

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Can also form heterodimer with VEGF (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049757

Structurei

3D structure databases

ProteinModelPortaliO35485
SMRiO35485
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II0A Eukaryota
ENOG410ZN1X LUCA
GeneTreeiENSGT00730000110791
HOVERGENiHBG000105
InParanoidiO35485
KOiK16858
OMAiTMELMGT
OrthoDBiEOG091G0G6M
PhylomeDBiO35485
TreeFamiTF319554

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform VEGF-B186 (identifier: O35485-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPLLRRLLL VALLQLACTQ APVSQFDGPS HQKKVVSWID VYARATCQPR
60 70 80 90 100
EVVVPLSMEL MGNVVKQLVP SCVTVQRCGG CCPDDGLECV PIGQHQVRMQ
110 120 130 140 150
ILMIQYPSSQ LGEMSLEEHS QCECRPKRKE SAVKPDRVAI PHHRPQPRSV
160 170 180 190 200
LSWDSAPGAS SPADIIHPTP APGPSAHAAP SAVSALIPGP AVAAADAAAS

SIAKGGA
Length:207
Mass (Da):21,869
Last modified:December 20, 2005 - v3
Checksum:i1A7F7DC4F8D0C9E2
GO
Isoform VEGF-B167 (identifier: O35485-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-207: RVAIPHHRPQ...AASSIAKGGA → SPRTLCPRCT...NPDTCRSSET

Show »
Length:186
Mass (Da):21,102
Checksum:iCC76A0CDC97E9427
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32 – 33QK → KR in AAB95447 (Ref. 3) Curated2
Sequence conflicti60L → F in AAB95447 (Ref. 3) Curated1
Sequence conflicti68L → F in AAB95447 (Ref. 3) Curated1
Sequence conflicti129K → R in AAB86884 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016662137 – 207RVAIP…AKGGA → SPRTLCPRCTQRRQRPDPRT CRCRCRRRRFLHCQGRGLEL NPDTCRSSET in isoform VEGF-B167. 2 PublicationsAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03002421 Genomic DNA No translation available.
BC076395 mRNA Translation: AAH76395.1
AF022952 mRNA Translation: AAB95447.1
AF032925 mRNA Translation: AAB86884.1
RefSeqiNP_446001.1, NM_053549.1 [O35485-2]
XP_006230972.1, XM_006230910.3 [O35485-1]
XP_006230973.1, XM_006230911.3 [O35485-1]
UniGeneiRn.198550

Genome annotation databases

EnsembliENSRNOT00000050891; ENSRNOP00000049757; ENSRNOG00000021156 [O35485-2]
GeneIDi89811
KEGGirno:89811
UCSCiRGD:619799 rat [O35485-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVEGFB_RAT
AccessioniPrimary (citable) accession number: O35485
Secondary accession number(s): O54881, Q6DGF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: December 20, 2005
Last modified: May 23, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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