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Protein

Antizyme inhibitor 1

Gene

Azin1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:16916800, PubMed:18062773, PubMed:18508777). Inhibits antizyme-dependent ODC degradation by binding to antizymes (PubMed:18062773). Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1.5 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Polyamine biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-350562. Regulation of ornithine decarboxylase (ODC).

Names & Taxonomyi

Protein namesi
Recommended name:
Antizyme inhibitor 1
Short name:
AZI
Alternative name(s):
Ornithine decarboxylase antizyme inhibitor
Gene namesi
Name:Azin1
Synonyms:Oazi, Oazin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1859169. Azin1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499931 – 448Antizyme inhibitor 1Add BLAST448

Post-translational modificationi

Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei69Not modifiedCombined sources1 Publication1

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiO35484.
PRIDEiO35484.

PTM databases

iPTMnetiO35484.
PhosphoSitePlusiO35484.

Expressioni

Tissue specificityi

Expressed during testis development.2 Publications

Gene expression databases

BgeeiENSMUSG00000037458.
CleanExiMM_AZIN1.
ExpressionAtlasiO35484. baseline and differential.
GenevisibleiO35484. MM.

Interactioni

Subunit structurei

Monomer. Interacts with OAZ1 and OAZ3; the interactions stabilize the complex by inhibiting AZIN2 ubiquitination and degradation.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065544.

Structurei

Secondary structure

1448
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 15Combined sources6
Helixi21 – 34Combined sources14
Beta strandi40 – 44Combined sources5
Helixi45 – 58Combined sources14
Beta strandi62 – 67Combined sources6
Helixi68 – 70Combined sources3
Helixi74 – 83Combined sources10
Beta strandi86 – 91Combined sources6
Helixi92 – 100Combined sources9
Helixi105 – 107Combined sources3
Beta strandi108 – 110Combined sources3
Helixi117 – 126Combined sources10
Beta strandi130 – 133Combined sources4
Helixi136 – 145Combined sources10
Beta strandi150 – 155Combined sources6
Helixi174 – 187Combined sources14
Beta strandi190 – 195Combined sources6
Helixi207 – 224Combined sources18
Beta strandi231 – 233Combined sources3
Helixi242 – 259Combined sources18
Beta strandi267 – 270Combined sources4
Helixi274 – 277Combined sources4
Turni278 – 280Combined sources3
Beta strandi281 – 292Combined sources12
Beta strandi312 – 317Combined sources6
Turni320 – 324Combined sources5
Helixi325 – 328Combined sources4
Beta strandi348 – 354Combined sources7
Beta strandi363 – 371Combined sources9
Beta strandi378 – 383Combined sources6
Helixi394 – 396Combined sources3
Beta strandi402 – 408Combined sources7
Helixi409 – 417Combined sources9
Helixi420 – 422Combined sources3
Helixi424 – 426Combined sources3
Beta strandi429 – 433Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BTNX-ray2.05A/B1-448[»]
ProteinModelPortaliO35484.
SMRiO35484.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35484.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiO35484.
OMAiNDKFSSG.
OrthoDBiEOG091G0AJV.
PhylomeDBiO35484.
TreeFamiTF300760.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR031178. Azin1.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF7. PTHR11482:SF7. 1 hit.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35484-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGFIDDANY SVGLLDEGTN LGNVIDNYVY EHTLTGKNAF FVGDLGKIVK
60 70 80 90 100
KHSQWQTVVA QIKPFYTVKC NSTPAVLEIL AALGTGFACS SKNEMALVQE
110 120 130 140 150
LGVSPENIIF TSPCKQVSQI KYAAKVGVNI MTCDNEIELK KIARNHPNAK
160 170 180 190 200
VLLHIATEDN IGGEDGNMKF GTTLKNCRHL LECAKELDVQ IIGVKFHVSS
210 220 230 240 250
ACKEYQVYVH ALSDARCVFD MAGEFGFTMN MLDIGGGFTG TEIQLEEVNH
260 270 280 290 300
VISPLLDIYF PEGSGIQIIS EPGSYYVSSA FTLAVNIIAK KVVENDKFSS
310 320 330 340 350
GVEKNGSDEP AFVYYMNDGV YGSFASKLSE DLNTIPEVHK KYKEDEPLFT
360 370 380 390 400
SSLWGPSCDE LDQIVESCLL PELNVGDWLI FDNMGADSFH EPSAFNDFQR
410 420 430 440
PAIYFMMSFS DWYEMQDAGI TSDAMMKNFF FAPSCIQLSQ EDSFSTEA
Length:448
Mass (Da):49,549
Last modified:January 1, 1998 - v1
Checksum:i117F3C2C24DDCA0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36G → E in AAH19412 (PubMed:15489334).Curated1
Sequence conflicti367S → G in BAC40151 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032128 mRNA. Translation: AAB87464.1.
AK049680 mRNA. Translation: BAC33870.1.
AK088112 mRNA. Translation: BAC40151.1.
AK088671 mRNA. Translation: BAC40494.1.
BC019412 mRNA. Translation: AAH19412.1.
BC043722 mRNA. Translation: AAH43722.1.
CCDSiCCDS37065.1.
RefSeqiNP_001095928.1. NM_001102458.1.
NP_001288617.1. NM_001301688.1.
NP_061215.1. NM_018745.5.
UniGeneiMm.250214.

Genome annotation databases

EnsembliENSMUST00000065308; ENSMUSP00000065544; ENSMUSG00000037458.
ENSMUST00000110329; ENSMUSP00000105958; ENSMUSG00000037458.
GeneIDi54375.
KEGGimmu:54375.
UCSCiuc007vns.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032128 mRNA. Translation: AAB87464.1.
AK049680 mRNA. Translation: BAC33870.1.
AK088112 mRNA. Translation: BAC40151.1.
AK088671 mRNA. Translation: BAC40494.1.
BC019412 mRNA. Translation: AAH19412.1.
BC043722 mRNA. Translation: AAH43722.1.
CCDSiCCDS37065.1.
RefSeqiNP_001095928.1. NM_001102458.1.
NP_001288617.1. NM_001301688.1.
NP_061215.1. NM_018745.5.
UniGeneiMm.250214.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BTNX-ray2.05A/B1-448[»]
ProteinModelPortaliO35484.
SMRiO35484.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065544.

PTM databases

iPTMnetiO35484.
PhosphoSitePlusiO35484.

Proteomic databases

PaxDbiO35484.
PRIDEiO35484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065308; ENSMUSP00000065544; ENSMUSG00000037458.
ENSMUST00000110329; ENSMUSP00000105958; ENSMUSG00000037458.
GeneIDi54375.
KEGGimmu:54375.
UCSCiuc007vns.1. mouse.

Organism-specific databases

CTDi51582.
MGIiMGI:1859169. Azin1.

Phylogenomic databases

eggNOGiKOG0622. Eukaryota.
COG0019. LUCA.
GeneTreeiENSGT00390000011560.
HOGENOMiHOG000274133.
HOVERGENiHBG005456.
InParanoidiO35484.
OMAiNDKFSSG.
OrthoDBiEOG091G0AJV.
PhylomeDBiO35484.
TreeFamiTF300760.

Enzyme and pathway databases

ReactomeiR-MMU-350562. Regulation of ornithine decarboxylase (ODC).

Miscellaneous databases

ChiTaRSiAzin1. mouse.
EvolutionaryTraceiO35484.
PROiO35484.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037458.
CleanExiMM_AZIN1.
ExpressionAtlasiO35484. baseline and differential.
GenevisibleiO35484. MM.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR031178. Azin1.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR002433. Orn_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PANTHERiPTHR11482:SF7. PTHR11482:SF7. 1 hit.
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSiPR01179. ODADCRBXLASE.
PR01182. ORNDCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
PROSITEiPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAZIN1_MOUSE
AccessioniPrimary (citable) accession number: O35484
Secondary accession number(s): Q542G5, Q8C2R8, Q8K1E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.