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Protein

Medium-wave-sensitive opsin 1

Gene

Opn1mw

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.

Absorptioni

Abs(max)=509 nm

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological processSensory transduction, Vision
LigandChromophore

Enzyme and pathway databases

ReactomeiR-RNO-2187335 The retinoid cycle in cones (daylight vision)
R-RNO-418594 G alpha (i) signalling events
R-RNO-419771 Opsins

Names & Taxonomyi

Protein namesi
Recommended name:
Medium-wave-sensitive opsin 1
Alternative name(s):
Green cone photoreceptor pigment
Green-sensitive opsin
Medium wavelength-sensitive cone opsin
Gene namesi
Name:Opn1mw
Synonyms:Gcp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi620978 Opn1mw

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
Transmembranei48 – 72Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini73 – 84CytoplasmicSequence analysisAdd BLAST12
Transmembranei85 – 110Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini111 – 124ExtracellularSequence analysisAdd BLAST14
Transmembranei125 – 144Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini145 – 163CytoplasmicSequence analysisAdd BLAST19
Transmembranei164 – 187Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini188 – 213ExtracellularSequence analysisAdd BLAST26
Transmembranei214 – 241Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini242 – 263CytoplasmicSequence analysisAdd BLAST22
Transmembranei264 – 287Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini288 – 295ExtracellularSequence analysis8
Transmembranei296 – 320Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini321 – 359CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001977891 – 359Medium-wave-sensitive opsin 1Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
Modified residuei307N6-(retinylidene)lysine1

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO35476

PTM databases

PhosphoSitePlusiO35476

Expressioni

Tissue specificityi

Expressed in cone photoreceptor cells.

Gene expression databases

GenevisibleiO35476 RN

Interactioni

Subunit structurei

Monomer. Homodimer. Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053164

Structurei

3D structure databases

ProteinModelPortaliO35476
SMRiO35476
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118977
HOVERGENiHBG107442
InParanoidiO35476
KOiK04251
OMAiHLTSAWM
OrthoDBiEOG091G0BDA

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR000378 Opsin_red/grn
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
PR00575 OPSINREDGRN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequencei

Sequence statusi: Complete.

O35476-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQQLTGEQT LDHYEDSTQA SIFTYTNSNS TRGPFEGPNY HIAPRWVYHL
60 70 80 90 100
TSTWMILVVI ASVFTNGLVL AATMRFKKLR HPLNWILVNL AVADLAETII
110 120 130 140 150
ASTISVVNQI YGYFVLGHPL CVIEGYIVSL CGITGLWSLA IISWERWLVV
160 170 180 190 200
CKPFGNVRFD AKLATVGIVF SWVWAAVWTA PPIFGWSRYW PYGLKTSCGP
210 220 230 240 250
DVFSGTSYPG VQSYMMVLMV TCCIFPLSII VLCYLQVWLA IRAVAKQQKE
260 270 280 290 300
SESTQKAEKE VTRMVVVMVF AYCLCWGPYT FFACFATAHP GYAFHPLVAS
310 320 330 340 350
LPSYFAKSAT IYNPIIYVFM NRQFRNCILQ LFGKKVDDSS ELSSTSKTEV

SSVSSVSPA
Length:359
Mass (Da):40,200
Last modified:November 1, 1998 - v2
Checksum:i08D9294EE6BE8A05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054246
, AF054241, AF054242, AF054243, AF054244, AF054245 Genomic DNA Translation: AAC64920.1
AF031528 mRNA Translation: AAB86946.1
RefSeqiNP_446000.1, NM_053548.1
UniGeneiRn.81056

Genome annotation databases

EnsembliENSRNOT00000083147; ENSRNOP00000072867; ENSRNOG00000051529
GeneIDi89810
KEGGirno:89810

Similar proteinsi

Entry informationi

Entry nameiOPSG_RAT
AccessioniPrimary (citable) accession number: O35476
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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