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Protein

Medium-wave-sensitive opsin 1

Gene

Opn1mw

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light.

Absorptioni

Abs(max)=509 nm

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

ReactomeiR-RNO-2187335. The retinoid cycle in cones (daylight vision).
R-RNO-419771. Opsins.

Names & Taxonomyi

Protein namesi
Recommended name:
Medium-wave-sensitive opsin 1
Alternative name(s):
Green cone photoreceptor pigment
Green-sensitive opsin
Medium wavelength-sensitive cone opsin
Gene namesi
Name:Opn1mw
Synonyms:Gcp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi620978. Opn1mw.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747ExtracellularSequence analysisAdd
BLAST
Transmembranei48 – 7225Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini73 – 8412CytoplasmicSequence analysisAdd
BLAST
Transmembranei85 – 11026Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini111 – 12414ExtracellularSequence analysisAdd
BLAST
Transmembranei125 – 14420Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini145 – 16319CytoplasmicSequence analysisAdd
BLAST
Transmembranei164 – 18724Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini188 – 21326ExtracellularSequence analysisAdd
BLAST
Transmembranei214 – 24128Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini242 – 26322CytoplasmicSequence analysisAdd
BLAST
Transmembranei264 – 28724Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini288 – 2958ExtracellularSequence analysis
Transmembranei296 – 32025Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini321 – 35939CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Medium-wave-sensitive opsin 1PRO_0000197789Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
Modified residuei307 – 3071N6-(retinylidene)lysine

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO35476.

PTM databases

PhosphoSiteiO35476.

Expressioni

Tissue specificityi

Expressed in cone photoreceptor cells.

Gene expression databases

GenevisibleiO35476. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053164.

Structurei

3D structure databases

ProteinModelPortaliO35476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOVERGENiHBG107442.
InParanoidiO35476.
KOiK04251.
OMAiTSAWMIF.
OrthoDBiEOG091G0BDA.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR000378. Opsin_red/grn.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00575. OPSINREDGRN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35476-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQQLTGEQT LDHYEDSTQA SIFTYTNSNS TRGPFEGPNY HIAPRWVYHL
60 70 80 90 100
TSTWMILVVI ASVFTNGLVL AATMRFKKLR HPLNWILVNL AVADLAETII
110 120 130 140 150
ASTISVVNQI YGYFVLGHPL CVIEGYIVSL CGITGLWSLA IISWERWLVV
160 170 180 190 200
CKPFGNVRFD AKLATVGIVF SWVWAAVWTA PPIFGWSRYW PYGLKTSCGP
210 220 230 240 250
DVFSGTSYPG VQSYMMVLMV TCCIFPLSII VLCYLQVWLA IRAVAKQQKE
260 270 280 290 300
SESTQKAEKE VTRMVVVMVF AYCLCWGPYT FFACFATAHP GYAFHPLVAS
310 320 330 340 350
LPSYFAKSAT IYNPIIYVFM NRQFRNCILQ LFGKKVDDSS ELSSTSKTEV

SSVSSVSPA
Length:359
Mass (Da):40,200
Last modified:November 1, 1998 - v2
Checksum:i08D9294EE6BE8A05
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054246
, AF054241, AF054242, AF054243, AF054244, AF054245 Genomic DNA. Translation: AAC64920.1.
AF031528 mRNA. Translation: AAB86946.1.
RefSeqiNP_446000.1. NM_053548.1.
UniGeneiRn.81056.

Genome annotation databases

EnsembliENSRNOT00000083147; ENSRNOP00000072867; ENSRNOG00000051529.
GeneIDi89810.
KEGGirno:89810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054246
, AF054241, AF054242, AF054243, AF054244, AF054245 Genomic DNA. Translation: AAC64920.1.
AF031528 mRNA. Translation: AAB86946.1.
RefSeqiNP_446000.1. NM_053548.1.
UniGeneiRn.81056.

3D structure databases

ProteinModelPortaliO35476.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053164.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO35476.

Proteomic databases

PaxDbiO35476.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000083147; ENSRNOP00000072867; ENSRNOG00000051529.
GeneIDi89810.
KEGGirno:89810.

Organism-specific databases

CTDi2652.
RGDi620978. Opn1mw.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOVERGENiHBG107442.
InParanoidiO35476.
KOiK04251.
OMAiTSAWMIF.
OrthoDBiEOG091G0BDA.

Enzyme and pathway databases

ReactomeiR-RNO-2187335. The retinoid cycle in cones (daylight vision).
R-RNO-419771. Opsins.

Miscellaneous databases

PROiO35476.

Gene expression databases

GenevisibleiO35476. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001760. Opsin.
IPR000378. Opsin_red/grn.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00575. OPSINREDGRN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPSG_RAT
AccessioniPrimary (citable) accession number: O35476
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.