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Protein

Nuclear nucleic acid-binding protein C1D

Gene

C1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).By similarity2 Publications

GO - Molecular functioni

  • DNA binding Source: MGI
  • ligand-dependent nuclear receptor binding Source: MGI
  • RNA binding Source: MGI
  • transcription corepressor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Apoptosis, rRNA processing, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear nucleic acid-binding protein C1D
Short name:
mC1D
Alternative name(s):
Small unique nuclear receptor corepressor
Short name:
Sun-CoR
Short name:
SunCoR
Gene namesi
Name:C1d
Synonyms:Suncor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1927354. C1d.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm By similarity
  • Nucleusnucleolus By similarity

  • Note: EXOSC10 is required for nucleolar localization. Colocalizes with TSNAX in the nucleus.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleolus Source: MGI
  • nucleus Source: MGI
  • transcriptional repressor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003163011 – 141Nuclear nucleic acid-binding protein C1DAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki119Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylated by PRKDC.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO35473.
PaxDbiO35473.
PeptideAtlasiO35473.
PRIDEiO35473.

PTM databases

PhosphoSitePlusiO35473.

Expressioni

Tissue specificityi

Kidney, heart, brain, spleen, lung, testis, liver and small intestine.1 Publication

Inductioni

Up-regulated during adipocyte and myogenic differentiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000000581.
CleanExiMM_C1D.
ExpressionAtlasiO35473. baseline and differential.
GenevisibleiO35473. MM.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with EXOSC10; the interaction probably mediates the association with the nuclear form of the RNA exosome. The homodimeric form interacts with TSNAX following gamma-radiation. Interacts with RAC3 (By similarity). Interacts with NR1D1, THRA, THRB, NCOR1 and NCOR2.By similarity2 Publications

GO - Molecular functioni

  • ligand-dependent nuclear receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000594.

Structurei

3D structure databases

ProteinModelPortaliO35473.
SMRiO35473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 100Required for transcriptional repressionAdd BLAST100
Regioni50 – 100Interaction with NR1D11 PublicationAdd BLAST51
Regioni100 – 141Interaction with NCOR1 and NCOR21 PublicationAdd BLAST42

Sequence similaritiesi

Belongs to the C1D family.Curated

Phylogenomic databases

eggNOGiKOG4835. Eukaryota.
ENOG4111ZX6. LUCA.
GeneTreeiENSGT00390000015405.
HOGENOMiHOG000007644.
HOVERGENiHBG097935.
InParanoidiO35473.
KOiK12592.
OMAiIRTYMNK.
OrthoDBiEOG091G0YK9.
PhylomeDBiO35473.
TreeFamiTF314651.

Family and domain databases

InterProiIPR011082. Exosome-assoc_fac/DNA_repair.
IPR007146. Sas10/Utp3/C1D.
[Graphical view]
PANTHERiPTHR15341. PTHR15341. 1 hit.
PfamiPF04000. Sas10_Utp3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEEMNEDY PVEIHESLTA LESSLGAVDD MLKTMMAVSR NELLQKLDPL
60 70 80 90 100
EQAKVDLVSA YTLNSMFWVY LATQGVNPKE HPVKQELERI RVYMNRVKEI
110 120 130 140
TDKKKAAKLD RGAASRFVKN ALWEPKAKST PKVANKGKSK H
Length:141
Mass (Da):15,945
Last modified:January 1, 1998 - v1
Checksum:iC9AF68033A0FD04E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120N → K in CAA64844 (PubMed:9469821).Curated1
Sequence conflicti127A → R in CAA64844 (PubMed:9469821).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031426 Genomic DNA. Translation: AAC53520.1.
X95591 mRNA. Translation: CAA64844.1.
AK028702 mRNA. Translation: BAC26075.1.
AK035169 mRNA. Translation: BAC28967.1.
AL603925 Genomic DNA. Translation: CAI24257.1.
AL603925 Genomic DNA. Translation: CAI24258.1.
BC005436 mRNA. Translation: AAH05436.1.
CCDSiCCDS24451.1.
RefSeqiNP_001317578.1. NM_001330649.1.
NP_065583.2. NM_020558.4.
UniGeneiMm.287982.

Genome annotation databases

EnsembliENSMUST00000000594; ENSMUSP00000000594; ENSMUSG00000000581.
GeneIDi57316.
KEGGimmu:57316.
UCSCiuc007ice.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031426 Genomic DNA. Translation: AAC53520.1.
X95591 mRNA. Translation: CAA64844.1.
AK028702 mRNA. Translation: BAC26075.1.
AK035169 mRNA. Translation: BAC28967.1.
AL603925 Genomic DNA. Translation: CAI24257.1.
AL603925 Genomic DNA. Translation: CAI24258.1.
BC005436 mRNA. Translation: AAH05436.1.
CCDSiCCDS24451.1.
RefSeqiNP_001317578.1. NM_001330649.1.
NP_065583.2. NM_020558.4.
UniGeneiMm.287982.

3D structure databases

ProteinModelPortaliO35473.
SMRiO35473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000594.

PTM databases

PhosphoSitePlusiO35473.

Proteomic databases

MaxQBiO35473.
PaxDbiO35473.
PeptideAtlasiO35473.
PRIDEiO35473.

Protocols and materials databases

DNASUi57316.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000594; ENSMUSP00000000594; ENSMUSG00000000581.
GeneIDi57316.
KEGGimmu:57316.
UCSCiuc007ice.1. mouse.

Organism-specific databases

CTDi10438.
MGIiMGI:1927354. C1d.

Phylogenomic databases

eggNOGiKOG4835. Eukaryota.
ENOG4111ZX6. LUCA.
GeneTreeiENSGT00390000015405.
HOGENOMiHOG000007644.
HOVERGENiHBG097935.
InParanoidiO35473.
KOiK12592.
OMAiIRTYMNK.
OrthoDBiEOG091G0YK9.
PhylomeDBiO35473.
TreeFamiTF314651.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiO35473.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000581.
CleanExiMM_C1D.
ExpressionAtlasiO35473. baseline and differential.
GenevisibleiO35473. MM.

Family and domain databases

InterProiIPR011082. Exosome-assoc_fac/DNA_repair.
IPR007146. Sas10/Utp3/C1D.
[Graphical view]
PANTHERiPTHR15341. PTHR15341. 1 hit.
PfamiPF04000. Sas10_Utp3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1D_MOUSE
AccessioniPrimary (citable) accession number: O35473
Secondary accession number(s): Q5SWJ6, Q61368
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.