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O35468

- WNT9B_MOUSE

UniProt

O35468 - WNT9B_MOUSE

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Protein
Protein Wnt-9b
Gene
Wnt9b, Wnt14b, Wnt15
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

GO - Molecular functioni

  1. frizzled binding Source: RefGenome
  2. receptor binding Source: MGI

GO - Biological processi

  1. Wnt signaling pathway Source: MGI
  2. Wnt signaling pathway, planar cell polarity pathway Source: MGI
  3. branching involved in ureteric bud morphogenesis Source: MGI
  4. branching morphogenesis of an epithelial tube Source: MGI
  5. canonical Wnt signaling pathway Source: MGI
  6. cell fate commitment Source: RefGenome
  7. cell-cell signaling Source: MGI
  8. cellular response to starvation Source: MGI
  9. collecting duct development Source: MGI
  10. embryonic cranial skeleton morphogenesis Source: MGI
  11. establishment of planar polarity involved in nephron morphogenesis Source: MGI
  12. in utero embryonic development Source: MGI
  13. kidney development Source: MGI
  14. kidney morphogenesis Source: MGI
  15. kidney rudiment formation Source: MGI
  16. male genitalia development Source: MGI
  17. mesenchymal stem cell maintenance involved in nephron morphogenesis Source: MGI
  18. mesonephric duct formation Source: MGI
  19. mesonephric tubule development Source: MGI
  20. metanephric tubule development Source: MGI
  21. metanephric tubule formation Source: MGI
  22. nephron tubule morphogenesis Source: MGI
  23. neuron differentiation Source: RefGenome
  24. organ morphogenesis Source: MGI
  25. palate development Source: MGI
  26. positive regulation of catalytic activity Source: MGI
  27. regulation of asymmetric cell division Source: MGI
  28. regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: MGI
  29. regulation of protein phosphorylation Source: MGI
  30. regulation of tube size Source: MGI
  31. signal transduction Source: MGI
  32. uterus morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-9b
Alternative name(s):
Protein Wnt-14b
Protein Wnt-15
Gene namesi
Name:Wnt9b
Synonyms:Wnt14b, Wnt15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1197020. Wnt9b.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RefGenome
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 359336Protein Wnt-9b
PRO_0000041459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi91 ↔ 102 By similarity
Glycosylationi101 – 1011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi137 ↔ 145 By similarity
Disulfide bondi147 ↔ 164 By similarity
Disulfide bondi212 ↔ 226 By similarity
Disulfide bondi214 ↔ 221 By similarity
Lipidationi218 – 2181O-palmitoyl serine; by PORCN By similarity
Disulfide bondi307 ↔ 318 By similarity
Disulfide bondi333 ↔ 348 By similarity
Disulfide bondi335 ↔ 345 By similarity
Disulfide bondi340 ↔ 341 By similarity

Post-translational modificationi

Palmitoylation at Ser-218 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO35468.
PRIDEiO35468.

PTM databases

PhosphoSiteiO35468.

Expressioni

Gene expression databases

BgeeiO35468.
CleanExiMM_WNT9B.
GenevestigatoriO35468.

Interactioni

Subunit structurei

Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6 By similarity.

Protein-protein interaction databases

DIPiDIP-59409N.
IntActiO35468. 1 interaction.
MINTiMINT-8389631.

Structurei

3D structure databases

ProteinModelPortaliO35468.
SMRiO35468. Positions 71-358.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG291879.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiO35468.
KOiK01064.
OMAiEEEVYTC.
OrthoDBiEOG7G7KP9.
PhylomeDBiO35468.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026535. WNT9B.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF84. PTHR12027:SF84. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35468-1 [UniParc]FASTAAdd to Basket

« Hide

MRPAPALALA ALCLLVLPAA AAAAAYFGLT GREVLTPFPG LGTAAAPAQA    50
GAHLKQCDLL KLSRRQKQLC RREPGLAETL RDAAHLGLLE CQFQFRQERW 100
NCSLEGRTGL LQRGFKETAF LYAVSAAALT HALARACSAG RMERCTCDDS 150
PGLESRQAWQ WGVCGDNLKY STKFLSNFLG PKRGSKDLRA RADAHNTHVG 200
IKAVKSGLRT TCKCHGVSGS CAVRTCWKQL SPFRETGQVL KLRYDTAVKV 250
SSATNEALGR LELWAPAKPG GPAKGLAPRP GDLVYMEDSP SFCRPSKYSP 300
GTAGRVCSRD SSCSSLCCGR GYDTQSRMVV FSCHCQVQWC CYVECQQCAQ 350
QELVYTCKR 359
Length:359
Mass (Da):38,982
Last modified:April 30, 2003 - v2
Checksum:iC98D7B5F566B70F5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti310 – 3101D → G in AAC39950. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB073819 mRNA. Translation: BAB83866.1.
AF469004 mRNA. Translation: AAL82385.1.
AF031169 Genomic DNA. Translation: AAC39950.1.
CCDSiCCDS25522.1.
RefSeqiNP_035849.3. NM_011719.4.
UniGeneiMm.215161.

Genome annotation databases

EnsembliENSMUST00000018630; ENSMUSP00000018630; ENSMUSG00000018486.
GeneIDi22412.
KEGGimmu:22412.
UCSCiuc007lvr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB073819 mRNA. Translation: BAB83866.1 .
AF469004 mRNA. Translation: AAL82385.1 .
AF031169 Genomic DNA. Translation: AAC39950.1 .
CCDSi CCDS25522.1.
RefSeqi NP_035849.3. NM_011719.4.
UniGenei Mm.215161.

3D structure databases

ProteinModelPortali O35468.
SMRi O35468. Positions 71-358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59409N.
IntActi O35468. 1 interaction.
MINTi MINT-8389631.

PTM databases

PhosphoSitei O35468.

Proteomic databases

PaxDbi O35468.
PRIDEi O35468.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000018630 ; ENSMUSP00000018630 ; ENSMUSG00000018486 .
GeneIDi 22412.
KEGGi mmu:22412.
UCSCi uc007lvr.1. mouse.

Organism-specific databases

CTDi 7484.
MGIi MGI:1197020. Wnt9b.

Phylogenomic databases

eggNOGi NOG291879.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi O35468.
KOi K01064.
OMAi EEEVYTC.
OrthoDBi EOG7G7KP9.
PhylomeDBi O35468.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_213918. WNT ligand biogenesis and trafficking.

Miscellaneous databases

NextBioi 302817.
PROi O35468.
SOURCEi Search...

Gene expression databases

Bgeei O35468.
CleanExi MM_WNT9B.
Genevestigatori O35468.

Family and domain databases

InterProi IPR005817. Wnt.
IPR026535. WNT9B.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF84. PTHR12027:SF84. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of mouse Wnt14b, clustered with mouse Wnt3 in mouse chromosome 11."
    Kirikoshi H., Katoh M.
    Int. J. Mol. Med. 9:135-139(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Mouse Wnt9b transforming activity, tissue-specific expression, and evolution."
    Qian J., Jiang Z., Li M., Heaphy P., Liu Y.H., Shackleford G.M.
    Genomics 81:34-46(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
    Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
    Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-310.

Entry informationi

Entry nameiWNT9B_MOUSE
AccessioniPrimary (citable) accession number: O35468
Secondary accession number(s): Q8VI90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 30, 2003
Last modified: September 3, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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