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O35468

- WNT9B_MOUSE

UniProt

O35468 - WNT9B_MOUSE

Protein

Protein Wnt-9b

Gene

Wnt9b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (30 Apr 2003)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. receptor binding Source: MGI

    GO - Biological processi

    1. branching involved in ureteric bud morphogenesis Source: MGI
    2. branching morphogenesis of an epithelial tube Source: MGI
    3. canonical Wnt signaling pathway Source: MGI
    4. cell-cell signaling Source: MGI
    5. cell fate commitment Source: RefGenome
    6. cellular response to starvation Source: MGI
    7. collecting duct development Source: MGI
    8. embryonic cranial skeleton morphogenesis Source: MGI
    9. establishment of planar polarity involved in nephron morphogenesis Source: MGI
    10. in utero embryonic development Source: MGI
    11. kidney development Source: MGI
    12. kidney morphogenesis Source: MGI
    13. kidney rudiment formation Source: MGI
    14. male genitalia development Source: MGI
    15. mesenchymal stem cell maintenance involved in nephron morphogenesis Source: MGI
    16. mesonephric duct formation Source: MGI
    17. mesonephric tubule development Source: MGI
    18. metanephric tubule development Source: MGI
    19. metanephric tubule formation Source: MGI
    20. nephron tubule morphogenesis Source: MGI
    21. neuron differentiation Source: RefGenome
    22. organ morphogenesis Source: MGI
    23. palate development Source: MGI
    24. positive regulation of catalytic activity Source: MGI
    25. regulation of asymmetric cell division Source: MGI
    26. regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: MGI
    27. regulation of protein phosphorylation Source: MGI
    28. regulation of tube size Source: MGI
    29. signal transduction Source: MGI
    30. uterus morphogenesis Source: MGI
    31. Wnt signaling pathway Source: MGI
    32. Wnt signaling pathway, planar cell polarity pathway Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-9b
    Alternative name(s):
    Protein Wnt-14b
    Protein Wnt-15
    Gene namesi
    Name:Wnt9b
    Synonyms:Wnt14b, Wnt15
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1197020. Wnt9b.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RefGenome
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 359336Protein Wnt-9bPRO_0000041459Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi91 ↔ 102By similarity
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi137 ↔ 145By similarity
    Disulfide bondi147 ↔ 164By similarity
    Disulfide bondi212 ↔ 226By similarity
    Disulfide bondi214 ↔ 221By similarity
    Lipidationi218 – 2181O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi307 ↔ 318By similarity
    Disulfide bondi333 ↔ 348By similarity
    Disulfide bondi335 ↔ 345By similarity
    Disulfide bondi340 ↔ 341By similarity

    Post-translational modificationi

    Palmitoylation at Ser-218 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiO35468.
    PRIDEiO35468.

    PTM databases

    PhosphoSiteiO35468.

    Expressioni

    Gene expression databases

    BgeeiO35468.
    CleanExiMM_WNT9B.
    GenevestigatoriO35468.

    Interactioni

    Subunit structurei

    Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6 By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-59409N.
    IntActiO35468. 1 interaction.
    MINTiMINT-8389631.

    Structurei

    3D structure databases

    ProteinModelPortaliO35468.
    SMRiO35468. Positions 71-358.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG291879.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiO35468.
    KOiK01064.
    OMAiEEEVYTC.
    OrthoDBiEOG7G7KP9.
    PhylomeDBiO35468.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026535. WNT9B.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF84. PTHR12027:SF84. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35468-1 [UniParc]FASTAAdd to Basket

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    MRPAPALALA ALCLLVLPAA AAAAAYFGLT GREVLTPFPG LGTAAAPAQA    50
    GAHLKQCDLL KLSRRQKQLC RREPGLAETL RDAAHLGLLE CQFQFRQERW 100
    NCSLEGRTGL LQRGFKETAF LYAVSAAALT HALARACSAG RMERCTCDDS 150
    PGLESRQAWQ WGVCGDNLKY STKFLSNFLG PKRGSKDLRA RADAHNTHVG 200
    IKAVKSGLRT TCKCHGVSGS CAVRTCWKQL SPFRETGQVL KLRYDTAVKV 250
    SSATNEALGR LELWAPAKPG GPAKGLAPRP GDLVYMEDSP SFCRPSKYSP 300
    GTAGRVCSRD SSCSSLCCGR GYDTQSRMVV FSCHCQVQWC CYVECQQCAQ 350
    QELVYTCKR 359
    Length:359
    Mass (Da):38,982
    Last modified:April 30, 2003 - v2
    Checksum:iC98D7B5F566B70F5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti310 – 3101D → G in AAC39950. (PubMed:9441749)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073819 mRNA. Translation: BAB83866.1.
    AF469004 mRNA. Translation: AAL82385.1.
    AF031169 Genomic DNA. Translation: AAC39950.1.
    CCDSiCCDS25522.1.
    RefSeqiNP_035849.3. NM_011719.4.
    UniGeneiMm.215161.

    Genome annotation databases

    EnsembliENSMUST00000018630; ENSMUSP00000018630; ENSMUSG00000018486.
    GeneIDi22412.
    KEGGimmu:22412.
    UCSCiuc007lvr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB073819 mRNA. Translation: BAB83866.1 .
    AF469004 mRNA. Translation: AAL82385.1 .
    AF031169 Genomic DNA. Translation: AAC39950.1 .
    CCDSi CCDS25522.1.
    RefSeqi NP_035849.3. NM_011719.4.
    UniGenei Mm.215161.

    3D structure databases

    ProteinModelPortali O35468.
    SMRi O35468. Positions 71-358.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59409N.
    IntActi O35468. 1 interaction.
    MINTi MINT-8389631.

    PTM databases

    PhosphoSitei O35468.

    Proteomic databases

    PaxDbi O35468.
    PRIDEi O35468.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018630 ; ENSMUSP00000018630 ; ENSMUSG00000018486 .
    GeneIDi 22412.
    KEGGi mmu:22412.
    UCSCi uc007lvr.1. mouse.

    Organism-specific databases

    CTDi 7484.
    MGIi MGI:1197020. Wnt9b.

    Phylogenomic databases

    eggNOGi NOG291879.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi O35468.
    KOi K01064.
    OMAi EEEVYTC.
    OrthoDBi EOG7G7KP9.
    PhylomeDBi O35468.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_213918. WNT ligand biogenesis and trafficking.

    Miscellaneous databases

    NextBioi 302817.
    PROi O35468.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35468.
    CleanExi MM_WNT9B.
    Genevestigatori O35468.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026535. WNT9B.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF84. PTHR12027:SF84. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of mouse Wnt14b, clustered with mouse Wnt3 in mouse chromosome 11."
      Kirikoshi H., Katoh M.
      Int. J. Mol. Med. 9:135-139(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Mouse Wnt9b transforming activity, tissue-specific expression, and evolution."
      Qian J., Jiang Z., Li M., Heaphy P., Liu Y.H., Shackleford G.M.
      Genomics 81:34-46(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
      Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
      Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-310.

    Entry informationi

    Entry nameiWNT9B_MOUSE
    AccessioniPrimary (citable) accession number: O35468
    Secondary accession number(s): Q8VI90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: April 30, 2003
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3