Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O35468 (WNT9B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-9b
Alternative name(s):
Protein Wnt-14b
Protein Wnt-15
Gene names
Name:Wnt9b
Synonyms:Wnt14b, Wnt15
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

Subunit structure

Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6 By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Post-translational modification

Palmitoylation at Ser-218 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-91. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from mutant phenotype PubMed 16054034. Source: MGI

Wnt signaling pathway, planar cell polarity pathway

Inferred from mutant phenotype PubMed 19543268. Source: MGI

branching involved in ureteric bud morphogenesis

Inferred from mutant phenotype PubMed 16054034. Source: MGI

branching morphogenesis of an epithelial tube

Inferred from mutant phenotype PubMed 16054034. Source: MGI

canonical Wnt signaling pathway

Inferred from genetic interaction PubMed 21350016. Source: MGI

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell-cell signaling

Traceable author statement PubMed 9889131. Source: MGI

cellular response to starvation

Inferred from expression pattern PubMed 23260145. Source: MGI

collecting duct development

Inferred from mutant phenotype PubMed 16054034. Source: MGI

embryonic cranial skeleton morphogenesis

Inferred from mutant phenotype PubMed 16054034PubMed 16998816. Source: MGI

establishment of planar polarity involved in nephron morphogenesis

Inferred from mutant phenotype PubMed 19543268. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 16054034. Source: MGI

kidney development

Inferred from mutant phenotype PubMed 19543268. Source: MGI

kidney morphogenesis

Inferred from mutant phenotype PubMed 16054034. Source: MGI

kidney rudiment formation

Inferred from mutant phenotype PubMed 16054034. Source: MGI

male genitalia development

Inferred from mutant phenotype PubMed 16054034. Source: MGI

mesenchymal stem cell maintenance involved in nephron morphogenesis

Inferred from mutant phenotype PubMed 21350016. Source: MGI

mesonephric duct formation

Inferred from mutant phenotype PubMed 16054034. Source: MGI

mesonephric tubule development

Inferred from mutant phenotype PubMed 16054034. Source: MGI

metanephric tubule development

Inferred from mutant phenotype PubMed 16054034. Source: MGI

metanephric tubule formation

Inferred from mutant phenotype PubMed 21350016. Source: MGI

nephron tubule morphogenesis

Inferred from mutant phenotype PubMed 19543268. Source: MGI

neuron differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

organ morphogenesis

Traceable author statement PubMed 9889131. Source: MGI

palate development

Inferred from mutant phenotype PubMed 16054034. Source: MGI

positive regulation of catalytic activity

Inferred from mutant phenotype PubMed 19543268. Source: MGI

regulation of asymmetric cell division

Inferred from mutant phenotype PubMed 19543268. Source: MGI

regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from direct assay PubMed 16054034. Source: MGI

regulation of protein phosphorylation

Inferred from mutant phenotype PubMed 19543268. Source: MGI

regulation of tube size

Inferred from mutant phenotype PubMed 19543268. Source: MGI

signal transduction

Traceable author statement PubMed 9889131. Source: MGI

uterus morphogenesis

Inferred from mutant phenotype PubMed 16054034. Source: MGI

   Cellular_componentextracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

receptor binding

Traceable author statement PubMed 9889131. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 359336Protein Wnt-9b
PRO_0000041459

Amino acid modifications

Lipidation911S-palmitoyl cysteine By similarity
Lipidation2181O-palmitoyl serine; by PORCN By similarity
Glycosylation1011N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3101D → G in AAC39950. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O35468 [UniParc].

Last modified April 30, 2003. Version 2.
Checksum: C98D7B5F566B70F5

FASTA35938,982
        10         20         30         40         50         60 
MRPAPALALA ALCLLVLPAA AAAAAYFGLT GREVLTPFPG LGTAAAPAQA GAHLKQCDLL 

        70         80         90        100        110        120 
KLSRRQKQLC RREPGLAETL RDAAHLGLLE CQFQFRQERW NCSLEGRTGL LQRGFKETAF 

       130        140        150        160        170        180 
LYAVSAAALT HALARACSAG RMERCTCDDS PGLESRQAWQ WGVCGDNLKY STKFLSNFLG 

       190        200        210        220        230        240 
PKRGSKDLRA RADAHNTHVG IKAVKSGLRT TCKCHGVSGS CAVRTCWKQL SPFRETGQVL 

       250        260        270        280        290        300 
KLRYDTAVKV SSATNEALGR LELWAPAKPG GPAKGLAPRP GDLVYMEDSP SFCRPSKYSP 

       310        320        330        340        350 
GTAGRVCSRD SSCSSLCCGR GYDTQSRMVV FSCHCQVQWC CYVECQQCAQ QELVYTCKR 

« Hide

References

[1]"Molecular cloning and characterization of mouse Wnt14b, clustered with mouse Wnt3 in mouse chromosome 11."
Kirikoshi H., Katoh M.
Int. J. Mol. Med. 9:135-139(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Mouse Wnt9b transforming activity, tissue-specific expression, and evolution."
Qian J., Jiang Z., Li M., Heaphy P., Liu Y.H., Shackleford G.M.
Genomics 81:34-46(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[3]"Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21."
Bergstein I., Eisenberg L.M., Bhalerao J., Jenkins N.A., Copeland N.G., Osborne M.P., Bowcock A.M., Brown A.M.C.
Genomics 46:450-458(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-310.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB073819 mRNA. Translation: BAB83866.1.
AF469004 mRNA. Translation: AAL82385.1.
AF031169 Genomic DNA. Translation: AAC39950.1.
CCDSCCDS25522.1.
RefSeqNP_035849.3. NM_011719.4.
UniGeneMm.215161.

3D structure databases

ProteinModelPortalO35468.
SMRO35468. Positions 71-358.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59409N.
IntActO35468. 1 interaction.
MINTMINT-8389631.

PTM databases

PhosphoSiteO35468.

Proteomic databases

PaxDbO35468.
PRIDEO35468.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000018630; ENSMUSP00000018630; ENSMUSG00000018486.
GeneID22412.
KEGGmmu:22412.
UCSCuc007lvr.1. mouse.

Organism-specific databases

CTD7484.
MGIMGI:1197020. Wnt9b.

Phylogenomic databases

eggNOGNOG291879.
HOGENOMHOG000039529.
HOVERGENHBG001595.
InParanoidO35468.
KOK01064.
OMAEEEVYTC.
OrthoDBEOG7G7KP9.
PhylomeDBO35468.
TreeFamTF105310.

Gene expression databases

BgeeO35468.
CleanExMM_WNT9B.
GenevestigatorO35468.

Family and domain databases

InterProIPR005817. Wnt.
IPR026535. WNT9B.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF84. PTHR12027:SF84. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302817.
PROO35468.
SOURCESearch...

Entry information

Entry nameWNT9B_MOUSE
AccessionPrimary (citable) accession number: O35468
Secondary accession number(s): Q8VI90
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 30, 2003
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot