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Protein

Angiopoietin-1

Gene

Angpt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • animal organ regeneration Source: RGD
  • cell differentiation Source: UniProtKB-KW
  • glomerulus vasculature development Source: UniProtKB
  • negative regulation of apoptotic process Source: RGD
  • ovarian follicle development Source: RGD
  • protein homooligomerization Source: RGD
  • response to estrogen Source: RGD
  • response to hypoxia Source: RGD
  • response to vitamin B3 Source: RGD
  • Tie signaling pathway Source: InterPro

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-1
Short name:
ANG-1
Gene namesi
Name:Angpt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628896 Angpt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000911220 – 497Angiopoietin-1Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi285 ↔ 314PROSITE-ProRule annotation
Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi438 ↔ 451PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35460
PRIDEiO35460

PTM databases

iPTMnetiO35460
PhosphoSitePlusiO35460

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007979

Structurei

3D structure databases

ProteinModelPortaliO35460
SMRiO35460
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini276 – 496Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili81 – 119Sequence analysisAdd BLAST39
Coiled coili153 – 261Sequence analysisAdd BLAST109

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
HOGENOMiHOG000037128
HOVERGENiHBG001644
InParanoidiO35460
KOiK05465
PhylomeDBiO35460

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR028843 Ang-1
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PANTHERiPTHR19143:SF156 PTHR19143:SF156, 1 hit
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVFLSFAFF AAILTHIGCS NQRRSPENGG RRYNRIQHGQ CAYTFILPEH
60 70 80 90 100
DGNCRESATE QYNTNALQRD APHVETDFSS QKLQHLEHVM ENYTQWLQKL
110 120 130 140 150
ENYIVENMKS EMAQIQQNAV QNHTATMLEI GTSLLSQTAE QTRKLTDVET
160 170 180 190 200
QVLNQTSRLE IQLLENSLST YELEKQLLQQ TNEILKIQEK NSLLEHKILE
210 220 230 240 250
MEGKHKEELD TLKEEKENLQ GLVTRQTFII QELEKQLSRA TSNNSVLQKQ
260 270 280 290 300
QLELMDTVHN LVSLCTKEVL LKGGKREEEK PFRDCADVYQ AGFNKSGIYT
310 320 330 340 350
IYFNNMPEPK KVFCNMDVNE GGWTVIQHRE DGSLDFQRGW KEYKMGFGNP
360 370 380 390 400
SGEYWLGNEF IFAITSQRQY MLRIELMDWE GNRAYSQYDR FHIGNQKQNY
410 420 430 440 450
RLYLKGHTGT AGKQSSLILH GADFSTKDAD NDNCMCKCAL MLTGGWWFDA
460 470 480 490
CGPSNLNGMF YTAGQNHGKL NGIKWHYFKG PSYSLRSTTM MIRPLDF
Length:497
Mass (Da):57,461
Last modified:November 8, 2002 - v2
Checksum:i08E66AEBEFD868AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98Q → E in AAC78246 (PubMed:9776732).Curated1
Sequence conflicti172E → K in AAC78246 (PubMed:9776732).Curated1
Sequence conflicti189E → K in AAC78246 (PubMed:9776732).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080023 mRNA Translation: BAC10290.1
AF030376 mRNA Translation: AAC78246.1
RefSeqiNP_445998.1, NM_053546.1
UniGeneiRn.161953

Genome annotation databases

GeneIDi89807
KEGGirno:89807
UCSCiRGD:628896 rat

Similar proteinsi

Entry informationi

Entry nameiANGP1_RAT
AccessioniPrimary (citable) accession number: O35460
Secondary accession number(s): Q8K4Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 8, 2002
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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