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Protein

C-C chemokine receptor-like 2

Gene

Ccrl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity).By similarity3 Publications

GO - Molecular functioni

  • C-C chemokine receptor activity Source: MGI
  • CCR chemokine receptor binding Source: MGI
  • chemokine receptor binding Source: UniProtKB

GO - Biological processi

  • chemotaxis Source: InterPro
  • inflammatory response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor-like 2
Alternative name(s):
Chemokine receptor CCR11
G-protein coupled beta chemokine receptor
Lipopolysaccharide-inducible C-C chemokine receptor
Short name:
L-CCR
Gene namesi
Name:Ccrl2
Synonyms:Ccr11, Lccr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1920904. Ccrl2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 42ExtracellularSequence analysisAdd BLAST42
Transmembranei43 – 63Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini64 – 73CytoplasmicSequence analysis10
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 109ExtracellularSequence analysisAdd BLAST15
Transmembranei110 – 130Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini131 – 141CytoplasmicSequence analysisAdd BLAST11
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 202ExtracellularSequence analysisAdd BLAST40
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 243CytoplasmicSequence analysisAdd BLAST20
Transmembranei244 – 264Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini265 – 285ExtracellularSequence analysisAdd BLAST21
Transmembranei286 – 307Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini308 – 360CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Deficient-mice have normal numbers of mast cells in all tissues analyzed. Wild-type and deficient mice develop marked local inflammation when sensitized with a high dose of DNP-specific IgE, however deficient mice have significantly reduced IgE-dependent passive cutaneous anaphylaxis (PCA) reactions when lower sensitizing dose is used. Deficient-mice show normal recruitment of circulating DC into the lung, but a defective trafficking of antigen-loaded lung DC to mediastinal lymph nodes. This defect was associated to a reduction in lymph node cellularity and reduced priming of T-helper cell 2 response.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002368001 – 360C-C chemokine receptor-like 2Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi108 ↔ 185PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35457.
PRIDEiO35457.

PTM databases

PhosphoSitePlusiO35457.

Expressioni

Tissue specificityi

Expressed in macrophages, astrocytes, in glial cells. Constitutively expressed by mast cells. Detected in bronchial epithelium in OVA-induced airway inflammation. Up-regulated during dendritic cell (DC) maturation.5 Publications

Inductioni

By bacterial lipopolysaccharide in astrocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000043953.
CleanExiMM_CCRL2.
ExpressionAtlasiO35457. baseline and differential.
GenevisibleiO35457. MM.

Interactioni

GO - Molecular functioni

  • CCR chemokine receptor binding Source: MGI
  • chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107519.

Structurei

3D structure databases

ProteinModelPortaliO35457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Lacks the conserved DRYLAIV motif in the second intracellular loop that is required for signaling of functional chemokine receptors.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKE4. Eukaryota.
ENOG411157E. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO35457.
KOiK08373.
OMAiDETFWKH.
OrthoDBiEOG091G0FG5.
PhylomeDBiO35457.
TreeFamiTF330966.

Family and domain databases

InterProiIPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNYTVAPDD EYDVLILDDY LDNSGPDQVP APEFLSPQQV LQFCCAVFAV
60 70 80 90 100
GLLDNVLAVF ILVKYKGLKN LGNIYFLNLA LSNLCFLLPL PFWAHTAAHG
110 120 130 140 150
ESPGNGTCKV LVGLHSSGLY SEVFSNILLL VQGYRVFSQG RLASIFTTVS
160 170 180 190 200
CGIVACILAW AMATALSLPE SVFYEPRMER QKHKCAFGKP HFLPIEAPLW
210 220 230 240 250
KYVLTSKMII LVLAFPLLVF IICCRQLRRR QSFRERQYDL HKPALVITGV
260 270 280 290 300
FLLMWAPYNT VLFLSAFQEH LSLQDEKSSY HLDASVQVTQ LVATTHCCVN
310 320 330 340 350
PLLYLLLDRK AFMRYLRSLF PRCNDIPYQS SGGYQQAPPR EGHGRPIELY
360
SNLHQRQDII
Length:360
Mass (Da):40,745
Last modified:May 30, 2006 - v2
Checksum:iE0DBF990A8595E3B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37P → S in BAE26775 (PubMed:16141072).Curated1
Sequence conflicti39Q → R in CAC79612 (PubMed:12555200).Curated1
Sequence conflicti157I → V in AAB86479 (Ref. 3) Curated1
Sequence conflicti215F → L in CAC79612 (PubMed:12555200).Curated1
Sequence conflicti292V → A in CAC79612 (PubMed:12555200).Curated1
Sequence conflicti334Y → S in AAB86479 (Ref. 3) Curated1
Sequence conflicti341E → K in AAB86479 (Ref. 3) Curated1
Sequence conflicti359I → K in CAJ18456 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009384 mRNA. Translation: BAA25879.1.
AJ318863 mRNA. Translation: CAC79612.1.
AF316576 mRNA. Translation: AAG30950.1.
AF030185 mRNA. Translation: AAB86479.1.
AK007808 mRNA. Translation: BAB25273.1.
AK145946 mRNA. Translation: BAE26775.1.
AK151856 mRNA. Translation: BAE30745.1.
CT010248 mRNA. Translation: CAJ18456.1.
BC038631 mRNA. Translation: AAH38631.1.
CCDSiCCDS23582.1.
RefSeqiNP_001289305.1. NM_001302376.1.
NP_001289306.1. NM_001302377.1.
NP_059494.2. NM_017466.5.
UniGeneiMm.7336.

Genome annotation databases

EnsembliENSMUST00000111888; ENSMUSP00000107519; ENSMUSG00000043953.
ENSMUST00000199839; ENSMUSP00000143116; ENSMUSG00000043953.
GeneIDi54199.
KEGGimmu:54199.
UCSCiuc009rvk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009384 mRNA. Translation: BAA25879.1.
AJ318863 mRNA. Translation: CAC79612.1.
AF316576 mRNA. Translation: AAG30950.1.
AF030185 mRNA. Translation: AAB86479.1.
AK007808 mRNA. Translation: BAB25273.1.
AK145946 mRNA. Translation: BAE26775.1.
AK151856 mRNA. Translation: BAE30745.1.
CT010248 mRNA. Translation: CAJ18456.1.
BC038631 mRNA. Translation: AAH38631.1.
CCDSiCCDS23582.1.
RefSeqiNP_001289305.1. NM_001302376.1.
NP_001289306.1. NM_001302377.1.
NP_059494.2. NM_017466.5.
UniGeneiMm.7336.

3D structure databases

ProteinModelPortaliO35457.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107519.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO35457.

Proteomic databases

PaxDbiO35457.
PRIDEiO35457.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111888; ENSMUSP00000107519; ENSMUSG00000043953.
ENSMUST00000199839; ENSMUSP00000143116; ENSMUSG00000043953.
GeneIDi54199.
KEGGimmu:54199.
UCSCiuc009rvk.2. mouse.

Organism-specific databases

CTDi9034.
MGIiMGI:1920904. Ccrl2.

Phylogenomic databases

eggNOGiENOG410IKE4. Eukaryota.
ENOG411157E. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiO35457.
KOiK08373.
OMAiDETFWKH.
OrthoDBiEOG091G0FG5.
PhylomeDBiO35457.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.

Miscellaneous databases

ChiTaRSiCcrl2. mouse.
PROiO35457.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043953.
CleanExiMM_CCRL2.
ExpressionAtlasiO35457. baseline and differential.
GenevisibleiO35457. MM.

Family and domain databases

InterProiIPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCRL2_MOUSE
AccessioniPrimary (citable) accession number: O35457
Secondary accession number(s): O70171
, Q3UKM6, Q4FK04, Q91YD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

It was initially reported that CCRL2 responds functionally to CCL2, CCL5, CCL7, and CCL8 via intracellular calcium mobilization and transwell chemotaxis although no evidence for a direct ligand-receptor interaction was provided in this report (PubMed:14999816). These results are now controversial and other studies failed to confirm CCRL2 recognition and transwell chemotaxis of these chemokines or a series of other CC- and CXC-chemokines using CCRL2-transfected cells (PubMed:18794339).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.