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Protein
Submitted name:

Protein Tnxb

Gene

Tnxb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • collagen binding Source: MGI
  • heparin binding Source: MGI

GO - Biological processi

  • cell-matrix adhesion Source: MGI
  • collagen fibril organization Source: MGI
  • collagen metabolic process Source: MGI
  • elastic fiber assembly Source: MGI
  • extracellular fibril organization Source: MGI
  • extracellular matrix organization Source: MGI
  • fatty acid metabolic process Source: MGI
  • lipid metabolic process Source: MGI
  • regulation of JUN kinase activity Source: MGI
  • single organismal cell-cell adhesion Source: MGI
  • triglyceride metabolic process Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein TnxbImported
Submitted name:
Tenascin XImported
Gene namesi
Name:TnxbImported
Synonyms:TNXImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1932137. Tnxb.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: MGI
  • intracellular Source: MGI
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500877857622 – 4006Sequence analysisAdd BLAST3985

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000033327.

Interactioni

GO - Molecular functioni

  • collagen binding Source: MGI

Protein-protein interaction databases

MINTiMINT-4104733.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini201 – 232EGF-likeInterPro annotationAdd BLAST32
Domaini325 – 356EGF-likeInterPro annotationAdd BLAST32
Domaini387 – 418EGF-likeInterPro annotationAdd BLAST32
Domaini480 – 511EGF-likeInterPro annotationAdd BLAST32
Domaini542 – 573EGF-likeInterPro annotationAdd BLAST32
Domaini604 – 635EGF-likeInterPro annotationAdd BLAST32
Domaini702 – 733EGF-likeInterPro annotationAdd BLAST32
Domaini738 – 828Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini829 – 918Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini949 – 1042Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1051 – 1141Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini1145 – 1238Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1244 – 1332Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1350 – 1443Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1463 – 1552Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1555 – 1650Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1660 – 1753Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1755 – 1846Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini1853 – 1945Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini1960 – 2050Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini2069 – 2158Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini2168 – 2257Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini2282 – 2370Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini2386 – 2479Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini2504 – 2597Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini2606 – 2700Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini2719 – 2812Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini2821 – 2916Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini2934 – 3026Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini3030 – 3121Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini3123 – 3216Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini3217 – 3306Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini3315 – 3409Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini3419 – 3516Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini3520 – 3609Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini3610 – 3696Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini3697 – 3787Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini3783 – 3998Fibrinogen C-terminalInterPro annotationAdd BLAST216

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00830000128240.
HOGENOMiHOG000114625.
HOVERGENiHBG006855.
OMAiPEGHFDH.
OrthoDBiEOG091G03M1.
TreeFamiTF329915.

Family and domain databases

CDDicd00063. FN3. 29 hits.
cd00087. FReD. 1 hit.
Gene3Di2.60.40.10. 29 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR033081. TNX.
[Graphical view]
PANTHERiPTHR19143:SF244. PTHR19143:SF244. 3 hits.
PfamiPF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 29 hits.
[Graphical view]
SMARTiSM00181. EGF. 18 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 29 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 27 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 19 hits.
PS01186. EGF_2. 19 hits.
PS50026. EGF_3. 7 hits.
PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 30 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35452-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQCTPSIL TILVLLGLAR AGPFSPRSNV TLPAPRPPPK PGGPSSQLYE
60 70 80 90 100
HTVEGGEKQV VFTHRINLPP SAGCGCPPGS EPPVPASEVQ ALRVRLEILE
110 120 130 140 150
ELVKGLKEHC TGGCCPTAAQ AGTGQTDVRS LCSLHGVFDL SRCACSCEPG
160 170 180 190 200
WGGPTCSDPT DTKTPTSSPP SKSCPEDCND QGRCVRGRCV CFPGYSGPSC
210 220 230 240 250
SWPSCPGDCQ GRGRCVKGVC VCRAGFSGPD CSQRSCPRNC NQRGRCEEGR
260 270 280 290 300
CVCDPGYSGE DCGVRSCPRG CSQRGRCENG LCVCNPGYSG EDCGVRNCPR
310 320 330 340 350
GCSQRGRCED GRCVCDPGYS GEDCSMRTCP WDCGDGGRCV DGRCVCWPGY
360 370 380 390 400
SGEDCSTRTC PRDCRGRGRC EDGECICDAG YSGDDCGVRS CPGDCNQRGH
410 420 430 440 450
CEDGRCVCWP GYTGADCSTR ACPRDCRGRG RCEDGVCVCH AGYSGEDCGV
460 470 480 490 500
RSCPGDCRGR GNCESGRCVC WPGYTGRDCG TRACPGDCRG RGRCVDGRCV
510 520 530 540 550
CNPGFTGEDC GSRRCPGDCR GHGHCENGVC VCAVGYSGDD CSTRSCPSDC
560 570 580 590 600
RGRGQCLNGL CECDEGYSGE DCGIRRCPRD CSQHGVCQDG LCMCHAGYAG
610 620 630 640 650
EDCSIRTCPA DCRRRGRCED GRCVCNPGYT GPACATRTCP ADCRGRGRCV
660 670 680 690 700
QGVCMCYVGY SGEDCGQEEP PASACPGGCG PRELCRAGQC VCVEGFRGPD
710 720 730 740 750
CAIQTCPGDC RSRGECIQGR CVCQEGYAGD DCGEEIPAIQ NMRMHLLEET
760 770 780 790 800
TVRTEWTRAP GPVDAYEIQF IPMTEGVSPP FTARVPSSAS AYDQRGLAPG
810 820 830 840 850
QDYQVTVRAL RGTSWGPPAS KTITTMIDGP QDLRVVAVTP TTLDLSWLRP
860 870 880 890 900
QAEVDRFVVS YVSAGNQRVR LEVPPEADRT QLTDLMPGVE YVVTVTAERG
910 920 930 940 950
HAVSYPASIR ANTGSLPSGL LEATDEPPPS GPSTTQGAQA PILILEHHPL
960 970 980 990 1000
GELKVLGRDK AGRLSVAWTA QPDSFAHFQL RMQVAEGPWA HEELLPGDVQ
1010 1020 1030 1040 1050
QALVPPPPPG APYKLFLHGI TPGGKISVPI TYQGIMDRAQ EQPGKPSVQP
1060 1070 1080 1090 1100
RLGELTVTGL TSDSLLLHWT VPEGEFDSFL IQYKDKDGPQ AISVEGPQRS
1110 1120 1130 1140 1150
TPISGLEPGR KYKFILYGLI GKKRHGPLMA EAKILIQSDP DPGSPPRLGE
1160 1170 1180 1190 1200
LWVTDPTPHS LHLSWTVLGG QFDSFVVQYR DKEGQPRVVP VEGPDRSVVI
1210 1220 1230 1240 1250
SPLDPNRKYR FTLFGIANKK RYGPLTADGT TAAETKEESS EPPRLGELTV
1260 1270 1280 1290 1300
TGVTPDSLRL SWTVARGPFD SFVILYKDAQ GQPQSVPIEG DENEVTVPGL
1310 1320 1330 1340 1350
ESNRKYKMNL YGLRGRQRVG PVSVVAKTAP PDVVDQPLSP PEPSTEAPEP
1360 1370 1380 1390 1400
PEKPLLRELI VTDTTPNSLS LSWTVSEGQF DQFVIQYKNG DGQPKVVRVP
1410 1420 1430 1440 1450
GHEDQVTISG LEPDHKYKMN LYGIHSGQRV GPVSVVGVTA AEEEPPSPTE
1460 1470 1480 1490 1500
PSTEAPEPTE EPLLGELTVT GSSPDSLSLS WTVPQGDFDS FTVQYKSSDG
1510 1520 1530 1540 1550
RPQVMRVGGQ EREVIVRDLD PGHKYKMNLY GLHEGHRVGP VSTVGTTDKQ
1560 1570 1580 1590 1600
PEEKPPLEPR LEELTVTGVT PNSVSLSWIV PEGQFDSFVV QYQDRDGQPR
1610 1620 1630 1640 1650
EVPLTAEQRE VTVLDLDPAR IYKMNFYGLH GRRRVGPLSV SAMTAPAPAT
1660 1670 1680 1690 1700
EASKLLPEPR LGELTVTDVT PDSVGLLWTV PEGEFDSFTV QYKDRDGQPH
1710 1720 1730 1740 1750
VVSVAADLRE VTIPGLEPSR KYKFLLFGVQ DGKRRSQVSV EAKTATHDDT
1760 1770 1780 1790 1800
SPGAPPRLGE LWVTDPTTDS LRLSWTVPEG HFDSFVVQFK DKSGPRVVPV
1810 1820 1830 1840 1850
KGQERTATIT ALDAGRKYRF LLYGLLGRKR FGPLTAEGIT EPTNAADHTK
1860 1870 1880 1890 1900
SRLGEELRVT GVTQNSVDLS WTVSEGQFDS FVVQYKDRDG QSQVVPVDGS
1910 1920 1930 1940 1950
HREVRVSGLD PGRRYKLLLY GLRDSKRVGP LSVIAVTDPR ETTEAWTEVP
1960 1970 1980 1990 2000
TTSTPAAVPR LGELRVEEAT PHSLHLSWVV TEGEFNSFEV QYTDRDGQLR
2010 2020 2030 2040 2050
VASTEGDQTD ITLTGLESNH RYLITLYGFH DGQPVGSAQI EALTVPWEEE
2060 2070 2080 2090 2100
EEEEESTEPP TMTPEPRPQL GELTVTDATP DSLSLSWTVP EGQFDQFVIQ
2110 2120 2130 2140 2150
YKNGDGQPKV VRVPGHEDQV TISGLEPDHK YKLNLYGIHS GQRFGPVSTV
2160 2170 2180 2190 2200
GVTDPKEEPT DASSLKPRLE ELTVTDATPD SLSLSWTVPE GQFDQFVIQY
2210 2220 2230 2240 2250
KNGDGQPKVV RVPGHEDQVT ISGLEPDHKY KMNLYGIYSG QRVGPVSAVG
2260 2270 2280 2290 2300
VTAAEEEPPS PTEPRTEAPE PTEAPEPTEE PRLGELTVTG SSPDSLSLSW
2310 2320 2330 2340 2350
TIPKGDFDSF TVQYKDSDGR PQVIRVRGQE REVIVRDLDP GRKYKMNLYG
2360 2370 2380 2390 2400
LHEGRRVGPV STIGVTAPEE EALTTQAVPT TTPEPPPKKP HLGELTVTDA
2410 2420 2430 2440 2450
TPDSLSLSWT VPEEQFDQFV IQYKNGDGQP KVVRVPGHED QVTISGLEPD
2460 2470 2480 2490 2500
HKYKMNLYGI YSGQRVGPVS VVGVTAAEEE PPSPEPSTEA PEPTEAPEPT
2510 2520 2530 2540 2550
EEPLLGELTV TGSSPDSLIL SWTIPKGDFD SFTVQYKDSD GRPQVMRVGG
2560 2570 2580 2590 2600
QEREVIVRDL DPGRKYKMNL YGLHEGRRVG PVSTVGVTEE EATTTQAEPI
2610 2620 2630 2640 2650
VTTEPPPKKP HLGVLTVTDA TPDSLSLSWT VPEAHFDQFV IQYKNGDGQP
2660 2670 2680 2690 2700
KVVRVPGHED QVTISGLEPD HKYKMNLYGI YSGQRVGPVS AVGVTAAEEE
2710 2720 2730 2740 2750
PPSPTEPSTE APESTEEPLL GELTVTGSSP DSLSLSWTVP QGEFDSFTVQ
2760 2770 2780 2790 2800
YKDSDGRPQV MRVGGQEREV IVRDLDPGRK YKMNLYGLHE GRRVGPVSTV
2810 2820 2830 2840 2850
GMTEKEALTT QVVPTTTPEP PPKKPHLGEL TVTDATSDSL SLSWTVPEGQ
2860 2870 2880 2890 2900
FEQFVIQYKN GDGQPKVVRV PGHEDQVTIS GLEPDHKYKM NLYGIHSGQR
2910 2920 2930 2940 2950
FGPVSTVGVT TAVEEPPSPT EPSIEAPEPT EEPLLGELTV TGSSPDSLSL
2960 2970 2980 2990 3000
SWTVPQGDFD SFTVQYKDSD GRPQVMRVGG QEREVIVRDL DPGRKYKMNL
3010 3020 3030 3040 3050
YGLHEGRRVG PVSTVGVTAS LTTEPPIEPR LGELAAVEVT SSTVHLSWTV
3060 3070 3080 3090 3100
AQGPFDSFLV QYKDTQGQPQ MVPVSGDLGE VTVSGLEPAR KYKFLLFGLK
3110 3120 3130 3140 3150
DGKRHGPVST EAKTVSDAKL LPRLGELTVT DTTQNSVGLS WTVPEGEFDS
3160 3170 3180 3190 3200
FLVQYKNRGG QVQVVPAAAD QREVTISSLE PNRKYRFLLF GLIGLKRLGP
3210 3220 3230 3240 3250
VSVEGTTAPV EKTPQPRLGE LSVTEETSDS MHLSWSVAQG PFDSFLVQYK
3260 3270 3280 3290 3300
DRDGQLQTVS LAADQREVTI EGLQPGRKYK FLLYGLTGGK RLGPISALGV
3310 3320 3330 3340 3350
TASEVDISAP DHTEPPHAPG LGTLAVTEAT PDSLRLSWAV ARGPFDSFVV
3360 3370 3380 3390 3400
QYQDTENETQ ALLVDGDQDK VLISGLEPKT SYKFFLYGLR EGTRHGPVSV
3410 3420 3430 3440 3450
EGTTDPVPAG QGPGDPGPRL SQLSVSDVTT SSLRLNWEAP LGAFDSFLLR
3460 3470 3480 3490 3500
FGVPLLSTLE QNPRTLQQRE LMVPGVRRSA MLRDLRPGTL YSLTLYGLRG
3510 3520 3530 3540 3550
PHKADSIQGT ARTLSPVLES PRDLQFSDIG ETSAKVKWVP PTSRVDSFKI
3560 3570 3580 3590 3600
SYQLADGGEP QSVQVDGRTQ TQILQGLIPD TRYEVTVVSV RGFEESEPLT
3610 3620 3630 3640 3650
GFLTTVPDGP TQLRALNLTD GSALLHWKPP HKPVDKYDVE VESPGAPPLQ
3660 3670 3680 3690 3700
ASAPGSAVDY PLTDLALDTN YTATVRGLRG PNFTSPASIT FTTGLKPPQD
3710 3720 3730 3740 3750
LEAKEVTPRT ALLTWTEPEV PPTGYLLSFD TPGGQIQEIL LPAGTTSHRL
3760 3770 3780 3790 3800
LRLFPSTFYS AQLRAIWGES LTPPVLTSFT TGGLRIPFPR DCGEELKNGP
3810 3820 3830 3840 3850
SASKTTTIFL NGNRERPLDV FCDMETDGGG WLVFQRRMDG QTDFWRDWEE
3860 3870 3880 3890 3900
YAHGFGNISG EFWLGNEALH SLTQAGDYSL RVDLRAGKEA VFAQYDFFRV
3910 3920 3930 3940 3950
DSAKENYRLH LEGYHGTAGD SMSYHSGSVF SARDRDPNNL LISCAVSYRG
3960 3970 3980 3990 4000
AWWYRNCHYA NLNGLYGSTV DHQGVSWYHW KGFEFSVPFT EMKLRPRNFQ

VPTRGT
Length:4,006
Mass (Da):435,479
Last modified:January 1, 1998 - v1
Checksum:i553FBE873498A4FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573030 Genomic DNA. No translation available.
AF030001 Genomic DNA. Translation: AAB82015.1.
PIRiT09070.
UniGeneiMm.290527.

Genome annotation databases

EnsembliENSMUST00000087399; ENSMUSP00000084661; ENSMUSG00000033327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT573030 Genomic DNA. No translation available.
AF030001 Genomic DNA. Translation: AAB82015.1.
PIRiT09070.
UniGeneiMm.290527.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4104733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087399; ENSMUSP00000084661; ENSMUSG00000033327.

Organism-specific databases

MGIiMGI:1932137. Tnxb.

Phylogenomic databases

GeneTreeiENSGT00830000128240.
HOGENOMiHOG000114625.
HOVERGENiHBG006855.
OMAiPEGHFDH.
OrthoDBiEOG091G03M1.
TreeFamiTF329915.

Miscellaneous databases

ChiTaRSiTnxb. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033327.

Family and domain databases

CDDicd00063. FN3. 29 hits.
cd00087. FReD. 1 hit.
Gene3Di2.60.40.10. 29 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR033081. TNX.
[Graphical view]
PANTHERiPTHR19143:SF244. PTHR19143:SF244. 3 hits.
PfamiPF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 29 hits.
[Graphical view]
SMARTiSM00181. EGF. 18 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 29 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 27 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 19 hits.
PS01186. EGF_2. 19 hits.
PS50026. EGF_3. 7 hits.
PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 30 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO35452_MOUSE
AccessioniPrimary (citable) accession number: O35452
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.