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Protein

Cyclic AMP-dependent transcription factor ATF-6 beta

Gene

Atf6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN9CCAC[GA]-3') when NF-Y is bound to ERSE (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei407Important for cleavage by PS2By similarity1
Sitei410Important for cleavage by PS2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-6 beta
Short name:
cAMP-dependent transcription factor ATF-6 beta
Alternative name(s):
Activating transcription factor 6 beta
Short name:
ATF6-beta
cAMP response element-binding protein-related protein
Short name:
Creb-rp
cAMP-responsive element-binding protein-like 1
Cleaved into the following chain:
Gene namesi
Name:Atf6b
Synonyms:Crebl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:105121 Atf6b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 393CytoplasmicSequence analysisAdd BLAST392
Transmembranei394 – 414Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini415 – 699LumenalSequence analysisAdd BLAST285

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000765912 – 699Cyclic AMP-dependent transcription factor ATF-6 betaAdd BLAST698
ChainiPRO_00002962022 – ?Processed cyclic AMP-dependent transcription factor ATF-6 beta

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi502N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi607N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi624N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi673N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

During unfolded protein response, a fragment of approximately 60 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 protease (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei437 – 438Cleavage; by PS1By similarity2

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

MaxQBiO35451
PaxDbiO35451
PeptideAtlasiO35451
PRIDEiO35451

PTM databases

iPTMnetiO35451
PhosphoSitePlusiO35451

Interactioni

Subunit structurei

Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC) (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Hspa5P200292EBI-8361741,EBI-772325

Protein-protein interaction databases

DIPiDIP-61156N
IntActiO35451, 3 interactors
MINTiO35451
STRINGi10090.ENSMUSP00000015605

Structurei

3D structure databases

ProteinModelPortaliO35451
SMRiO35451
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini322 – 385bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni324 – 344Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni347 – 354Leucine-zipperPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi93 – 102Poly-Ser10

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4343 Eukaryota
ENOG410ZAAP LUCA
HOGENOMiHOG000253938
HOVERGENiHBG050608
InParanoidiO35451
PhylomeDBiO35451
TreeFamiTF316079

Family and domain databases

InterProiView protein in InterPro
IPR029809 ATF6B
IPR004827 bZIP
PANTHERiPTHR22952:SF168 PTHR22952:SF168, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELMLLSEI ADPTRFFTDN LLSPEDWDST LYSGLDEVAE EQAQLFRCVE
60 70 80 90 100
QDVPFDSSSL DVGMDVSPPE PPWDPLPIFP DLQVKSEPSS PCSSSSLSSE
110 120 130 140 150
SSHLSTEPPS QVPGVGEVLH VKMESLAPPL CLLGDDPASP FETVQITVGS
160 170 180 190 200
ASDDLSDIQT KLEPASPSSS VHSEASLLSA DSPSQPFIGE EVLEVKTESP
210 220 230 240 250
SPPGCLLWDV PASSLGAVQI SMGPSPDSSS GKAPATRKPP LQPKPVVLTT
260 270 280 290 300
VPVPPRAGPT SAAVLLQPLV QQPAVSPVVL IQGAIRVQPE GPAPAAPRPE
310 320 330 340 350
RKSIVPAPMP GNSCPPEVDA KLLKRQQRMI KNRESACQSR RKKKEYLQGL
360 370 380 390 400
EARLQAVLAD NQQLRRENAA LRRRLEALLA ENSGLKLGSG NRKVVCIMVF
410 420 430 440 450
LLFIAFNFGP VSISEPPPAP MSPRMSREEP RPQRHLLGFS EPGPAHGMEP
460 470 480 490 500
LREAAQSPGE QQPSSAGRPS FRNLTAFPGG AKELLLRDLD QLFLSSDCRH
510 520 530 540 550
FNRTESLRLA DELSGWVQRH QRGRRKIPHR AQERQKSQLR KKSPPVKPVP
560 570 580 590 600
TQPPGPPERD PVGQLQLYRH PGRSQPEFLD AIDRREDTFY VVSFRRDHLL
610 620 630 640 650
LPAISHNKTS RPKMSLVMPA MAPNETVSGR GPPGDYEEMM QIECEVMDTR
660 670 680 690
VIHIKTSTVP PSLRKQPSPS PGNTTGGPLP GSAASPAHQA SQPLYLNHP
Length:699
Mass (Da):76,007
Last modified:January 1, 1998 - v1
Checksum:i6EBE22386D63868B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030001 Genomic DNA Translation: AAB82014.1
BC013534 mRNA Translation: AAH13534.1
BC052635 mRNA Translation: AAH52635.1
AB010266 Genomic DNA Translation: BAA24435.1
PIRiT09069
UniGeneiMm.4068

Similar proteinsi

Entry informationi

Entry nameiATF6B_MOUSE
AccessioniPrimary (citable) accession number: O35451
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health