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Protein

FK506-binding protein-like

Gene

Fkbpl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein-like
Alternative name(s):
WAF-1/CIP1 stabilizing protein 39
Short name:
WISp39
Gene namesi
Name:Fkbpl
Synonyms:Ng7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1932127. Fkbpl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002898791 – 347FK506-binding protein-likeAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO35450.
PaxDbiO35450.
PeptideAtlasiO35450.
PRIDEiO35450.

PTM databases

iPTMnetiO35450.
PhosphoSitePlusiO35450.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033739.
CleanExiMM_FKBPL.
ExpressionAtlasiO35450. baseline and differential.
GenevisibleiO35450. MM.

Interactioni

Subunit structurei

Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.By similarity

Protein-protein interaction databases

IntActiO35450. 1 interactor.
STRINGi10090.ENSMUSP00000037273.

Structurei

3D structure databases

ProteinModelPortaliO35450.
SMRiO35450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati208 – 241TPR 1Add BLAST34
Repeati250 – 283TPR 2Add BLAST34
Repeati284 – 317TPR 3Add BLAST34

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00680000100108.
HOGENOMiHOG000272638.
HOVERGENiHBG099465.
InParanoidiO35450.
KOiK20097.
OMAiDSWELEA.
OrthoDBiEOG091G0G4G.
PhylomeDBiO35450.
TreeFamiTF105297.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSPISPMN EKNTAQPQQR EENAQQILNT AIPFRQRSPG LLPEALKVGV
60 70 80 90 100
RPDPANQIVE TQEIEHPVAG FEGDSDQFQV STNEMAEHLQ ASDLWYCPDG
110 120 130 140 150
SFVKKIIVPG HGLDKPKLGS KCQVLALGFP FGSGMPEGWT ELTIGIGQWR
160 170 180 190 200
EKMWGELMEK CLESMRQGEE AKIHLPGSSA PLAKLRLDSF TNGRDSWEME
210 220 230 240 250
AMEKEALAKE EHRRGTELFR AGNPQGAARC YGRALRLLLT LPPPGPPERT
260 270 280 290 300
TLYANLAACQ LLLGHPQLAA QSCDRVLERE PGHLKALYRR GVARAALGDL
310 320 330 340
EKATADFKKV LAVDPKNRAA KEELGKVVIQ GRKQDAGLAR GLRKMFS
Length:347
Mass (Da):38,302
Last modified:January 1, 1998 - v1
Checksum:i33C1B20B4CC8FF83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187L → M in BAE26836 (PubMed:16141072).Curated1
Sequence conflicti252L → I in BAE26836 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146018 mRNA. Translation: BAE26836.1.
AF030001 Genomic DNA. Translation: AAB82013.1.
BC046338 mRNA. Translation: AAH46338.1.
CCDSiCCDS28654.1.
PIRiT09068.
RefSeqiNP_063926.1. NM_019873.2.
XP_006524724.1. XM_006524661.3.
XP_006524725.1. XM_006524662.3.
UniGeneiMm.10025.

Genome annotation databases

EnsembliENSMUST00000036720; ENSMUSP00000037273; ENSMUSG00000033739.
GeneIDi56299.
KEGGimmu:56299.
UCSCiuc008cdg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146018 mRNA. Translation: BAE26836.1.
AF030001 Genomic DNA. Translation: AAB82013.1.
BC046338 mRNA. Translation: AAH46338.1.
CCDSiCCDS28654.1.
PIRiT09068.
RefSeqiNP_063926.1. NM_019873.2.
XP_006524724.1. XM_006524661.3.
XP_006524725.1. XM_006524662.3.
UniGeneiMm.10025.

3D structure databases

ProteinModelPortaliO35450.
SMRiO35450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35450. 1 interactor.
STRINGi10090.ENSMUSP00000037273.

PTM databases

iPTMnetiO35450.
PhosphoSitePlusiO35450.

Proteomic databases

MaxQBiO35450.
PaxDbiO35450.
PeptideAtlasiO35450.
PRIDEiO35450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036720; ENSMUSP00000037273; ENSMUSG00000033739.
GeneIDi56299.
KEGGimmu:56299.
UCSCiuc008cdg.1. mouse.

Organism-specific databases

CTDi63943.
MGIiMGI:1932127. Fkbpl.

Phylogenomic databases

eggNOGiKOG1124. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00680000100108.
HOGENOMiHOG000272638.
HOVERGENiHBG099465.
InParanoidiO35450.
KOiK20097.
OMAiDSWELEA.
OrthoDBiEOG091G0G4G.
PhylomeDBiO35450.
TreeFamiTF105297.

Enzyme and pathway databases

ReactomeiR-MMU-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.

Miscellaneous databases

PROiO35450.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033739.
CleanExiMM_FKBPL.
ExpressionAtlasiO35450. baseline and differential.
GenevisibleiO35450. MM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBPL_MOUSE
AccessioniPrimary (citable) accession number: O35450
Secondary accession number(s): Q3UKG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.