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O35450

- FKBPL_MOUSE

UniProt

O35450 - FKBPL_MOUSE

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Protein

FK506-binding protein-like

Gene

Fkbpl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.By similarity

GO - Molecular functioni

  1. FK506 binding Source: RefGenome
  2. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

GO - Biological processi

  1. chaperone-mediated protein folding Source: RefGenome
  2. protein peptidyl-prolyl isomerization Source: RefGenome
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein-like
Alternative name(s):
WAF-1/CIP1 stabilizing protein 39
Short name:
WISp39
Gene namesi
Name:Fkbpl
Synonyms:Ng7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1932127. Fkbpl.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347FK506-binding protein-likePRO_0000289879Add
BLAST

Proteomic databases

MaxQBiO35450.
PaxDbiO35450.
PRIDEiO35450.

PTM databases

PhosphoSiteiO35450.

Expressioni

Gene expression databases

BgeeiO35450.
CleanExiMM_FKBPL.
ExpressionAtlasiO35450. baseline and differential.
GenevestigatoriO35450.

Interactioni

Subunit structurei

Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.By similarity

Protein-protein interaction databases

IntActiO35450. 1 interaction.
STRINGi10090.ENSMUSP00000037273.

Structurei

3D structure databases

ProteinModelPortaliO35450.
SMRiO35450. Positions 99-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati208 – 24134TPR 1Add
BLAST
Repeati250 – 28334TPR 2Add
BLAST
Repeati284 – 31734TPR 3Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG307697.
GeneTreeiENSGT00680000100108.
HOGENOMiHOG000272638.
HOVERGENiHBG099465.
InParanoidiO35450.
OMAiDSWELEA.
OrthoDBiEOG7HTHHD.
PhylomeDBiO35450.
TreeFamiTF105297.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35450-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METSPISPMN EKNTAQPQQR EENAQQILNT AIPFRQRSPG LLPEALKVGV
60 70 80 90 100
RPDPANQIVE TQEIEHPVAG FEGDSDQFQV STNEMAEHLQ ASDLWYCPDG
110 120 130 140 150
SFVKKIIVPG HGLDKPKLGS KCQVLALGFP FGSGMPEGWT ELTIGIGQWR
160 170 180 190 200
EKMWGELMEK CLESMRQGEE AKIHLPGSSA PLAKLRLDSF TNGRDSWEME
210 220 230 240 250
AMEKEALAKE EHRRGTELFR AGNPQGAARC YGRALRLLLT LPPPGPPERT
260 270 280 290 300
TLYANLAACQ LLLGHPQLAA QSCDRVLERE PGHLKALYRR GVARAALGDL
310 320 330 340
EKATADFKKV LAVDPKNRAA KEELGKVVIQ GRKQDAGLAR GLRKMFS
Length:347
Mass (Da):38,302
Last modified:January 1, 1998 - v1
Checksum:i33C1B20B4CC8FF83
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871L → M in BAE26836. (PubMed:16141072)Curated
Sequence conflicti252 – 2521L → I in BAE26836. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK146018 mRNA. Translation: BAE26836.1.
AF030001 Genomic DNA. Translation: AAB82013.1.
BC046338 mRNA. Translation: AAH46338.1.
CCDSiCCDS28654.1.
PIRiT09068.
RefSeqiNP_063926.1. NM_019873.2.
XP_006524721.1. XM_006524658.1.
XP_006524722.1. XM_006524659.1.
XP_006524723.1. XM_006524660.1.
XP_006524724.1. XM_006524661.1.
XP_006524725.1. XM_006524662.1.
XP_006525489.1. XM_006525426.1.
XP_006525490.1. XM_006525427.1.
XP_006525491.1. XM_006525428.1.
XP_006525492.1. XM_006525429.1.
XP_006525493.1. XM_006525430.1.
XP_006536738.1. XM_006536675.1.
XP_006536739.1. XM_006536676.1.
XP_006536740.1. XM_006536677.1.
XP_006536741.1. XM_006536678.1.
XP_006536742.1. XM_006536679.1.
XP_006537469.1. XM_006537406.1.
XP_006537470.1. XM_006537407.1.
XP_006537471.1. XM_006537408.1.
XP_006537472.1. XM_006537409.1.
XP_006537473.1. XM_006537410.1.
UniGeneiMm.10025.

Genome annotation databases

EnsembliENSMUST00000036720; ENSMUSP00000037273; ENSMUSG00000033739.
GeneIDi56299.
KEGGimmu:56299.
UCSCiuc008cdg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK146018 mRNA. Translation: BAE26836.1 .
AF030001 Genomic DNA. Translation: AAB82013.1 .
BC046338 mRNA. Translation: AAH46338.1 .
CCDSi CCDS28654.1.
PIRi T09068.
RefSeqi NP_063926.1. NM_019873.2.
XP_006524721.1. XM_006524658.1.
XP_006524722.1. XM_006524659.1.
XP_006524723.1. XM_006524660.1.
XP_006524724.1. XM_006524661.1.
XP_006524725.1. XM_006524662.1.
XP_006525489.1. XM_006525426.1.
XP_006525490.1. XM_006525427.1.
XP_006525491.1. XM_006525428.1.
XP_006525492.1. XM_006525429.1.
XP_006525493.1. XM_006525430.1.
XP_006536738.1. XM_006536675.1.
XP_006536739.1. XM_006536676.1.
XP_006536740.1. XM_006536677.1.
XP_006536741.1. XM_006536678.1.
XP_006536742.1. XM_006536679.1.
XP_006537469.1. XM_006537406.1.
XP_006537470.1. XM_006537407.1.
XP_006537471.1. XM_006537408.1.
XP_006537472.1. XM_006537409.1.
XP_006537473.1. XM_006537410.1.
UniGenei Mm.10025.

3D structure databases

ProteinModelPortali O35450.
SMRi O35450. Positions 99-346.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O35450. 1 interaction.
STRINGi 10090.ENSMUSP00000037273.

PTM databases

PhosphoSitei O35450.

Proteomic databases

MaxQBi O35450.
PaxDbi O35450.
PRIDEi O35450.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036720 ; ENSMUSP00000037273 ; ENSMUSG00000033739 .
GeneIDi 56299.
KEGGi mmu:56299.
UCSCi uc008cdg.1. mouse.

Organism-specific databases

CTDi 63943.
MGIi MGI:1932127. Fkbpl.

Phylogenomic databases

eggNOGi NOG307697.
GeneTreei ENSGT00680000100108.
HOGENOMi HOG000272638.
HOVERGENi HBG099465.
InParanoidi O35450.
OMAi DSWELEA.
OrthoDBi EOG7HTHHD.
PhylomeDBi O35450.
TreeFami TF105297.

Miscellaneous databases

NextBioi 312232.
PROi O35450.
SOURCEi Search...

Gene expression databases

Bgeei O35450.
CleanExi MM_FKBPL.
ExpressionAtlasi O35450. baseline and differential.
Genevestigatori O35450.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00515. TPR_1. 1 hit.
[Graphical view ]
SMARTi SM00028. TPR. 3 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  2. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiFKBPL_MOUSE
AccessioniPrimary (citable) accession number: O35450
Secondary accession number(s): Q3UKG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3