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Protein

FK506-binding protein-like

Gene

Fkbpl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.By similarity

GO - Molecular functioni

  1. FK506 binding Source: GO_Central
  2. peptidyl-prolyl cis-trans isomerase activity Source: GO_Central

GO - Biological processi

  1. chaperone-mediated protein folding Source: GO_Central
  2. protein peptidyl-prolyl isomerization Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein-like
Alternative name(s):
WAF-1/CIP1 stabilizing protein 39
Short name:
WISp39
Gene namesi
Name:Fkbpl
Synonyms:Ng7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1932127. Fkbpl.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347FK506-binding protein-likePRO_0000289879Add
BLAST

Proteomic databases

MaxQBiO35450.
PaxDbiO35450.
PRIDEiO35450.

PTM databases

PhosphoSiteiO35450.

Expressioni

Gene expression databases

BgeeiO35450.
CleanExiMM_FKBPL.
ExpressionAtlasiO35450. baseline and differential.
GenevestigatoriO35450.

Interactioni

Subunit structurei

Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.By similarity

Protein-protein interaction databases

IntActiO35450. 1 interaction.
STRINGi10090.ENSMUSP00000037273.

Structurei

3D structure databases

ProteinModelPortaliO35450.
SMRiO35450. Positions 99-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati208 – 24134TPR 1Add
BLAST
Repeati250 – 28334TPR 2Add
BLAST
Repeati284 – 31734TPR 3Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG307697.
GeneTreeiENSGT00680000100108.
HOGENOMiHOG000272638.
HOVERGENiHBG099465.
InParanoidiO35450.
OMAiDSWELEA.
OrthoDBiEOG7HTHHD.
PhylomeDBiO35450.
TreeFamiTF105297.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSPISPMN EKNTAQPQQR EENAQQILNT AIPFRQRSPG LLPEALKVGV
60 70 80 90 100
RPDPANQIVE TQEIEHPVAG FEGDSDQFQV STNEMAEHLQ ASDLWYCPDG
110 120 130 140 150
SFVKKIIVPG HGLDKPKLGS KCQVLALGFP FGSGMPEGWT ELTIGIGQWR
160 170 180 190 200
EKMWGELMEK CLESMRQGEE AKIHLPGSSA PLAKLRLDSF TNGRDSWEME
210 220 230 240 250
AMEKEALAKE EHRRGTELFR AGNPQGAARC YGRALRLLLT LPPPGPPERT
260 270 280 290 300
TLYANLAACQ LLLGHPQLAA QSCDRVLERE PGHLKALYRR GVARAALGDL
310 320 330 340
EKATADFKKV LAVDPKNRAA KEELGKVVIQ GRKQDAGLAR GLRKMFS
Length:347
Mass (Da):38,302
Last modified:January 1, 1998 - v1
Checksum:i33C1B20B4CC8FF83
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871L → M in BAE26836 (PubMed:16141072).Curated
Sequence conflicti252 – 2521L → I in BAE26836 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146018 mRNA. Translation: BAE26836.1.
AF030001 Genomic DNA. Translation: AAB82013.1.
BC046338 mRNA. Translation: AAH46338.1.
CCDSiCCDS28654.1.
PIRiT09068.
RefSeqiNP_063926.1. NM_019873.2.
XP_006524721.1. XM_006524658.1.
XP_006524722.1. XM_006524659.1.
XP_006524723.1. XM_006524660.1.
XP_006524724.1. XM_006524661.1.
XP_006524725.1. XM_006524662.1.
XP_006525489.1. XM_006525426.1.
XP_006525490.1. XM_006525427.1.
XP_006525491.1. XM_006525428.1.
XP_006525492.1. XM_006525429.1.
XP_006525493.1. XM_006525430.1.
XP_006536738.1. XM_006536675.1.
XP_006536739.1. XM_006536676.1.
XP_006536740.1. XM_006536677.1.
XP_006536741.1. XM_006536678.1.
XP_006536742.1. XM_006536679.1.
XP_006537469.1. XM_006537406.1.
XP_006537470.1. XM_006537407.1.
XP_006537471.1. XM_006537408.1.
XP_006537472.1. XM_006537409.1.
XP_006537473.1. XM_006537410.1.
UniGeneiMm.10025.

Genome annotation databases

EnsembliENSMUST00000036720; ENSMUSP00000037273; ENSMUSG00000033739.
GeneIDi56299.
KEGGimmu:56299.
UCSCiuc008cdg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146018 mRNA. Translation: BAE26836.1.
AF030001 Genomic DNA. Translation: AAB82013.1.
BC046338 mRNA. Translation: AAH46338.1.
CCDSiCCDS28654.1.
PIRiT09068.
RefSeqiNP_063926.1. NM_019873.2.
XP_006524721.1. XM_006524658.1.
XP_006524722.1. XM_006524659.1.
XP_006524723.1. XM_006524660.1.
XP_006524724.1. XM_006524661.1.
XP_006524725.1. XM_006524662.1.
XP_006525489.1. XM_006525426.1.
XP_006525490.1. XM_006525427.1.
XP_006525491.1. XM_006525428.1.
XP_006525492.1. XM_006525429.1.
XP_006525493.1. XM_006525430.1.
XP_006536738.1. XM_006536675.1.
XP_006536739.1. XM_006536676.1.
XP_006536740.1. XM_006536677.1.
XP_006536741.1. XM_006536678.1.
XP_006536742.1. XM_006536679.1.
XP_006537469.1. XM_006537406.1.
XP_006537470.1. XM_006537407.1.
XP_006537471.1. XM_006537408.1.
XP_006537472.1. XM_006537409.1.
XP_006537473.1. XM_006537410.1.
UniGeneiMm.10025.

3D structure databases

ProteinModelPortaliO35450.
SMRiO35450. Positions 99-346.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35450. 1 interaction.
STRINGi10090.ENSMUSP00000037273.

PTM databases

PhosphoSiteiO35450.

Proteomic databases

MaxQBiO35450.
PaxDbiO35450.
PRIDEiO35450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036720; ENSMUSP00000037273; ENSMUSG00000033739.
GeneIDi56299.
KEGGimmu:56299.
UCSCiuc008cdg.1. mouse.

Organism-specific databases

CTDi63943.
MGIiMGI:1932127. Fkbpl.

Phylogenomic databases

eggNOGiNOG307697.
GeneTreeiENSGT00680000100108.
HOGENOMiHOG000272638.
HOVERGENiHBG099465.
InParanoidiO35450.
OMAiDSWELEA.
OrthoDBiEOG7HTHHD.
PhylomeDBiO35450.
TreeFamiTF105297.

Miscellaneous databases

NextBioi312232.
PROiO35450.
SOURCEiSearch...

Gene expression databases

BgeeiO35450.
CleanExiMM_FKBPL.
ExpressionAtlasiO35450. baseline and differential.
GenevestigatoriO35450.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  2. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiFKBPL_MOUSE
AccessioniPrimary (citable) accession number: O35450
Secondary accession number(s): Q3UKG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 1, 1998
Last modified: February 4, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.