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O35450

- FKBPL_MOUSE

UniProt

O35450 - FKBPL_MOUSE

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Protein
FK506-binding protein-like
Gene
Fkbpl, Ng7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in response to X-ray By similarity. Regulates p21 protein stability by binding to Hsp90 and p21 By similarity.

GO - Molecular functioni

  1. FK506 binding Source: RefGenome
  2. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

GO - Biological processi

  1. peptidyl-proline modification Source: RefGenome
  2. protein peptidyl-prolyl isomerization Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein-like
Alternative name(s):
WAF-1/CIP1 stabilizing protein 39
Short name:
WISp39
Gene namesi
Name:Fkbpl
Synonyms:Ng7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1932127. Fkbpl.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 347347FK506-binding protein-like
PRO_0000289879Add
BLAST

Proteomic databases

PaxDbiO35450.
PRIDEiO35450.

PTM databases

PhosphoSiteiO35450.

Expressioni

Gene expression databases

ArrayExpressiO35450.
BgeeiO35450.
CleanExiMM_FKBPL.
GenevestigatoriO35450.

Interactioni

Subunit structurei

Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90 By similarity.

Protein-protein interaction databases

IntActiO35450. 1 interaction.
STRINGi10090.ENSMUSP00000037273.

Structurei

3D structure databases

ProteinModelPortaliO35450.
SMRiO35450. Positions 99-346.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati208 – 24134TPR 1
Add
BLAST
Repeati250 – 28334TPR 2
Add
BLAST
Repeati284 – 31734TPR 3
Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG307697.
GeneTreeiENSGT00680000100108.
HOGENOMiHOG000272638.
HOVERGENiHBG099465.
InParanoidiO35450.
OMAiDSWELEA.
OrthoDBiEOG7HTHHD.
PhylomeDBiO35450.
TreeFamiTF105297.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35450-1 [UniParc]FASTAAdd to Basket

« Hide

METSPISPMN EKNTAQPQQR EENAQQILNT AIPFRQRSPG LLPEALKVGV    50
RPDPANQIVE TQEIEHPVAG FEGDSDQFQV STNEMAEHLQ ASDLWYCPDG 100
SFVKKIIVPG HGLDKPKLGS KCQVLALGFP FGSGMPEGWT ELTIGIGQWR 150
EKMWGELMEK CLESMRQGEE AKIHLPGSSA PLAKLRLDSF TNGRDSWEME 200
AMEKEALAKE EHRRGTELFR AGNPQGAARC YGRALRLLLT LPPPGPPERT 250
TLYANLAACQ LLLGHPQLAA QSCDRVLERE PGHLKALYRR GVARAALGDL 300
EKATADFKKV LAVDPKNRAA KEELGKVVIQ GRKQDAGLAR GLRKMFS 347
Length:347
Mass (Da):38,302
Last modified:January 1, 1998 - v1
Checksum:i33C1B20B4CC8FF83
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871L → M in BAE26836. 1 Publication
Sequence conflicti252 – 2521L → I in BAE26836. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK146018 mRNA. Translation: BAE26836.1.
AF030001 Genomic DNA. Translation: AAB82013.1.
BC046338 mRNA. Translation: AAH46338.1.
CCDSiCCDS28654.1.
PIRiT09068.
RefSeqiNP_063926.1. NM_019873.2.
XP_006524721.1. XM_006524658.1.
XP_006524722.1. XM_006524659.1.
XP_006524723.1. XM_006524660.1.
XP_006524724.1. XM_006524661.1.
XP_006524725.1. XM_006524662.1.
XP_006525489.1. XM_006525426.1.
XP_006525490.1. XM_006525427.1.
XP_006525491.1. XM_006525428.1.
XP_006525492.1. XM_006525429.1.
XP_006525493.1. XM_006525430.1.
XP_006536738.1. XM_006536675.1.
XP_006536739.1. XM_006536676.1.
XP_006536740.1. XM_006536677.1.
XP_006536741.1. XM_006536678.1.
XP_006536742.1. XM_006536679.1.
XP_006537469.1. XM_006537406.1.
XP_006537470.1. XM_006537407.1.
XP_006537471.1. XM_006537408.1.
XP_006537472.1. XM_006537409.1.
XP_006537473.1. XM_006537410.1.
UniGeneiMm.10025.

Genome annotation databases

EnsembliENSMUST00000036720; ENSMUSP00000037273; ENSMUSG00000033739.
GeneIDi56299.
KEGGimmu:56299.
UCSCiuc008cdg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK146018 mRNA. Translation: BAE26836.1 .
AF030001 Genomic DNA. Translation: AAB82013.1 .
BC046338 mRNA. Translation: AAH46338.1 .
CCDSi CCDS28654.1.
PIRi T09068.
RefSeqi NP_063926.1. NM_019873.2.
XP_006524721.1. XM_006524658.1.
XP_006524722.1. XM_006524659.1.
XP_006524723.1. XM_006524660.1.
XP_006524724.1. XM_006524661.1.
XP_006524725.1. XM_006524662.1.
XP_006525489.1. XM_006525426.1.
XP_006525490.1. XM_006525427.1.
XP_006525491.1. XM_006525428.1.
XP_006525492.1. XM_006525429.1.
XP_006525493.1. XM_006525430.1.
XP_006536738.1. XM_006536675.1.
XP_006536739.1. XM_006536676.1.
XP_006536740.1. XM_006536677.1.
XP_006536741.1. XM_006536678.1.
XP_006536742.1. XM_006536679.1.
XP_006537469.1. XM_006537406.1.
XP_006537470.1. XM_006537407.1.
XP_006537471.1. XM_006537408.1.
XP_006537472.1. XM_006537409.1.
XP_006537473.1. XM_006537410.1.
UniGenei Mm.10025.

3D structure databases

ProteinModelPortali O35450.
SMRi O35450. Positions 99-346.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O35450. 1 interaction.
STRINGi 10090.ENSMUSP00000037273.

PTM databases

PhosphoSitei O35450.

Proteomic databases

PaxDbi O35450.
PRIDEi O35450.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036720 ; ENSMUSP00000037273 ; ENSMUSG00000033739 .
GeneIDi 56299.
KEGGi mmu:56299.
UCSCi uc008cdg.1. mouse.

Organism-specific databases

CTDi 63943.
MGIi MGI:1932127. Fkbpl.

Phylogenomic databases

eggNOGi NOG307697.
GeneTreei ENSGT00680000100108.
HOGENOMi HOG000272638.
HOVERGENi HBG099465.
InParanoidi O35450.
OMAi DSWELEA.
OrthoDBi EOG7HTHHD.
PhylomeDBi O35450.
TreeFami TF105297.

Miscellaneous databases

NextBioi 312232.
PROi O35450.
SOURCEi Search...

Gene expression databases

ArrayExpressi O35450.
Bgeei O35450.
CleanExi MM_FKBPL.
Genevestigatori O35450.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00515. TPR_1. 1 hit.
[Graphical view ]
SMARTi SM00028. TPR. 3 hits.
[Graphical view ]
PROSITEi PS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  2. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiFKBPL_MOUSE
AccessioniPrimary (citable) accession number: O35450
Secondary accession number(s): Q3UKG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi