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O35450

- FKBPL_MOUSE

UniProt

O35450 - FKBPL_MOUSE

Protein

FK506-binding protein-like

Gene

Fkbpl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.By similarity

    GO - Molecular functioni

    1. FK506 binding Source: RefGenome
    2. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

    GO - Biological processi

    1. chaperone-mediated protein folding Source: RefGenome
    2. protein peptidyl-prolyl isomerization Source: RefGenome

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FK506-binding protein-like
    Alternative name(s):
    WAF-1/CIP1 stabilizing protein 39
    Short name:
    WISp39
    Gene namesi
    Name:Fkbpl
    Synonyms:Ng7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1932127. Fkbpl.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 347347FK506-binding protein-likePRO_0000289879Add
    BLAST

    Proteomic databases

    PaxDbiO35450.
    PRIDEiO35450.

    PTM databases

    PhosphoSiteiO35450.

    Expressioni

    Gene expression databases

    ArrayExpressiO35450.
    BgeeiO35450.
    CleanExiMM_FKBPL.
    GenevestigatoriO35450.

    Interactioni

    Subunit structurei

    Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.By similarity

    Protein-protein interaction databases

    IntActiO35450. 1 interaction.
    STRINGi10090.ENSMUSP00000037273.

    Structurei

    3D structure databases

    ProteinModelPortaliO35450.
    SMRiO35450. Positions 99-346.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati208 – 24134TPR 1Add
    BLAST
    Repeati250 – 28334TPR 2Add
    BLAST
    Repeati284 – 31734TPR 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiNOG307697.
    GeneTreeiENSGT00680000100108.
    HOGENOMiHOG000272638.
    HOVERGENiHBG099465.
    InParanoidiO35450.
    OMAiDSWELEA.
    OrthoDBiEOG7HTHHD.
    PhylomeDBiO35450.
    TreeFamiTF105297.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR023566. PPIase_FKBP.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00515. TPR_1. 1 hit.
    [Graphical view]
    SMARTiSM00028. TPR. 3 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35450-1 [UniParc]FASTAAdd to Basket

    « Hide

    METSPISPMN EKNTAQPQQR EENAQQILNT AIPFRQRSPG LLPEALKVGV    50
    RPDPANQIVE TQEIEHPVAG FEGDSDQFQV STNEMAEHLQ ASDLWYCPDG 100
    SFVKKIIVPG HGLDKPKLGS KCQVLALGFP FGSGMPEGWT ELTIGIGQWR 150
    EKMWGELMEK CLESMRQGEE AKIHLPGSSA PLAKLRLDSF TNGRDSWEME 200
    AMEKEALAKE EHRRGTELFR AGNPQGAARC YGRALRLLLT LPPPGPPERT 250
    TLYANLAACQ LLLGHPQLAA QSCDRVLERE PGHLKALYRR GVARAALGDL 300
    EKATADFKKV LAVDPKNRAA KEELGKVVIQ GRKQDAGLAR GLRKMFS 347
    Length:347
    Mass (Da):38,302
    Last modified:January 1, 1998 - v1
    Checksum:i33C1B20B4CC8FF83
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti187 – 1871L → M in BAE26836. (PubMed:16141072)Curated
    Sequence conflicti252 – 2521L → I in BAE26836. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK146018 mRNA. Translation: BAE26836.1.
    AF030001 Genomic DNA. Translation: AAB82013.1.
    BC046338 mRNA. Translation: AAH46338.1.
    CCDSiCCDS28654.1.
    PIRiT09068.
    RefSeqiNP_063926.1. NM_019873.2.
    XP_006524721.1. XM_006524658.1.
    XP_006524722.1. XM_006524659.1.
    XP_006524723.1. XM_006524660.1.
    XP_006524724.1. XM_006524661.1.
    XP_006524725.1. XM_006524662.1.
    XP_006525489.1. XM_006525426.1.
    XP_006525490.1. XM_006525427.1.
    XP_006525491.1. XM_006525428.1.
    XP_006525492.1. XM_006525429.1.
    XP_006525493.1. XM_006525430.1.
    XP_006536738.1. XM_006536675.1.
    XP_006536739.1. XM_006536676.1.
    XP_006536740.1. XM_006536677.1.
    XP_006536741.1. XM_006536678.1.
    XP_006536742.1. XM_006536679.1.
    XP_006537469.1. XM_006537406.1.
    XP_006537470.1. XM_006537407.1.
    XP_006537471.1. XM_006537408.1.
    XP_006537472.1. XM_006537409.1.
    XP_006537473.1. XM_006537410.1.
    UniGeneiMm.10025.

    Genome annotation databases

    EnsembliENSMUST00000036720; ENSMUSP00000037273; ENSMUSG00000033739.
    GeneIDi56299.
    KEGGimmu:56299.
    UCSCiuc008cdg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK146018 mRNA. Translation: BAE26836.1 .
    AF030001 Genomic DNA. Translation: AAB82013.1 .
    BC046338 mRNA. Translation: AAH46338.1 .
    CCDSi CCDS28654.1.
    PIRi T09068.
    RefSeqi NP_063926.1. NM_019873.2.
    XP_006524721.1. XM_006524658.1.
    XP_006524722.1. XM_006524659.1.
    XP_006524723.1. XM_006524660.1.
    XP_006524724.1. XM_006524661.1.
    XP_006524725.1. XM_006524662.1.
    XP_006525489.1. XM_006525426.1.
    XP_006525490.1. XM_006525427.1.
    XP_006525491.1. XM_006525428.1.
    XP_006525492.1. XM_006525429.1.
    XP_006525493.1. XM_006525430.1.
    XP_006536738.1. XM_006536675.1.
    XP_006536739.1. XM_006536676.1.
    XP_006536740.1. XM_006536677.1.
    XP_006536741.1. XM_006536678.1.
    XP_006536742.1. XM_006536679.1.
    XP_006537469.1. XM_006537406.1.
    XP_006537470.1. XM_006537407.1.
    XP_006537471.1. XM_006537408.1.
    XP_006537472.1. XM_006537409.1.
    XP_006537473.1. XM_006537410.1.
    UniGenei Mm.10025.

    3D structure databases

    ProteinModelPortali O35450.
    SMRi O35450. Positions 99-346.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O35450. 1 interaction.
    STRINGi 10090.ENSMUSP00000037273.

    PTM databases

    PhosphoSitei O35450.

    Proteomic databases

    PaxDbi O35450.
    PRIDEi O35450.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036720 ; ENSMUSP00000037273 ; ENSMUSG00000033739 .
    GeneIDi 56299.
    KEGGi mmu:56299.
    UCSCi uc008cdg.1. mouse.

    Organism-specific databases

    CTDi 63943.
    MGIi MGI:1932127. Fkbpl.

    Phylogenomic databases

    eggNOGi NOG307697.
    GeneTreei ENSGT00680000100108.
    HOGENOMi HOG000272638.
    HOVERGENi HBG099465.
    InParanoidi O35450.
    OMAi DSWELEA.
    OrthoDBi EOG7HTHHD.
    PhylomeDBi O35450.
    TreeFami TF105297.

    Miscellaneous databases

    NextBioi 312232.
    PROi O35450.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35450.
    Bgeei O35450.
    CleanExi MM_FKBPL.
    Genevestigatori O35450.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR023566. PPIase_FKBP.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00515. TPR_1. 1 hit.
    [Graphical view ]
    SMARTi SM00028. TPR. 3 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Placenta.
    2. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 129.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiFKBPL_MOUSE
    AccessioniPrimary (citable) accession number: O35450
    Secondary accession number(s): Q3UKG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3