Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O35450 (FKBPL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FK506-binding protein-like
Alternative name(s):
WAF-1/CIP1 stabilizing protein 39
Short name=WISp39
Gene names
Name:Fkbpl
Synonyms:Ng7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in response to X-ray By similarity. Regulates p21 protein stability by binding to Hsp90 and p21 By similarity.

Subunit structure

Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90 By similarity.

Sequence similarities

Contains 3 TPR repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347FK506-binding protein-like
PRO_0000289879

Regions

Repeat208 – 24134TPR 1
Repeat250 – 28334TPR 2
Repeat284 – 31734TPR 3

Experimental info

Sequence conflict1871L → M in BAE26836. Ref.1
Sequence conflict2521L → I in BAE26836. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35450 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 33C1B20B4CC8FF83

FASTA34738,302
        10         20         30         40         50         60 
METSPISPMN EKNTAQPQQR EENAQQILNT AIPFRQRSPG LLPEALKVGV RPDPANQIVE 

        70         80         90        100        110        120 
TQEIEHPVAG FEGDSDQFQV STNEMAEHLQ ASDLWYCPDG SFVKKIIVPG HGLDKPKLGS 

       130        140        150        160        170        180 
KCQVLALGFP FGSGMPEGWT ELTIGIGQWR EKMWGELMEK CLESMRQGEE AKIHLPGSSA 

       190        200        210        220        230        240 
PLAKLRLDSF TNGRDSWEME AMEKEALAKE EHRRGTELFR AGNPQGAARC YGRALRLLLT 

       250        260        270        280        290        300 
LPPPGPPERT TLYANLAACQ LLLGHPQLAA QSCDRVLERE PGHLKALYRR GVARAALGDL 

       310        320        330        340 
EKATADFKKV LAVDPKNRAA KEELGKVVIQ GRKQDAGLAR GLRKMFS 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Placenta.
[2]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 129.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK146018 mRNA. Translation: BAE26836.1.
AF030001 Genomic DNA. Translation: AAB82013.1.
BC046338 mRNA. Translation: AAH46338.1.
CCDSCCDS28654.1.
PIRT09068.
RefSeqNP_063926.1. NM_019873.2.
XP_006524721.1. XM_006524658.1.
XP_006524722.1. XM_006524659.1.
XP_006524723.1. XM_006524660.1.
XP_006524724.1. XM_006524661.1.
XP_006524725.1. XM_006524662.1.
XP_006525489.1. XM_006525426.1.
XP_006525490.1. XM_006525427.1.
XP_006525491.1. XM_006525428.1.
XP_006525492.1. XM_006525429.1.
XP_006525493.1. XM_006525430.1.
XP_006536738.1. XM_006536675.1.
XP_006536739.1. XM_006536676.1.
XP_006536740.1. XM_006536677.1.
XP_006536741.1. XM_006536678.1.
XP_006536742.1. XM_006536679.1.
XP_006537469.1. XM_006537406.1.
XP_006537470.1. XM_006537407.1.
XP_006537471.1. XM_006537408.1.
XP_006537472.1. XM_006537409.1.
XP_006537473.1. XM_006537410.1.
UniGeneMm.10025.

3D structure databases

ProteinModelPortalO35450.
SMRO35450. Positions 99-346.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO35450. 1 interaction.
STRING10090.ENSMUSP00000037273.

PTM databases

PhosphoSiteO35450.

Proteomic databases

PaxDbO35450.
PRIDEO35450.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000036720; ENSMUSP00000037273; ENSMUSG00000033739.
GeneID56299.
KEGGmmu:56299.
UCSCuc008cdg.1. mouse.

Organism-specific databases

CTD63943.
MGIMGI:1932127. Fkbpl.

Phylogenomic databases

eggNOGNOG307697.
GeneTreeENSGT00680000100108.
HOGENOMHOG000272638.
HOVERGENHBG099465.
InParanoidO35450.
OMADSWELEA.
OrthoDBEOG7HTHHD.
PhylomeDBO35450.
TreeFamTF105297.

Gene expression databases

ArrayExpressO35450.
BgeeO35450.
CleanExMM_FKBPL.
GenevestigatorO35450.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR023566. PPIase_FKBP.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00515. TPR_1. 1 hit.
[Graphical view]
SMARTSM00028. TPR. 3 hits.
[Graphical view]
PROSITEPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio312232.
PROO35450.
SOURCESearch...

Entry information

Entry nameFKBPL_MOUSE
AccessionPrimary (citable) accession number: O35450
Secondary accession number(s): Q3UKG5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot