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O35426

- XBP1_MOUSE

UniProt

O35426 - XBP1_MOUSE

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Protein

X-box-binding protein 1

Gene
Xbp1, Treb5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N3[AT]T-3', and also to some TPA response elements (TRE) By similarity. Isoform 2 is involved in controlling the production of interleukin-6.2 Publications

GO - Molecular functioni

  1. RNA polymerase II transcription factor binding Source: MGI
  2. sequence-specific DNA binding Source: Ensembl
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI

GO - Biological processi

  1. cellular response to antibiotic Source: Ensembl
  2. endoplasmic reticulum unfolded protein response Source: Ensembl
  3. epithelial cell maturation Source: MGI
  4. epithelial cell maturation involved in salivary gland development Source: MGI
  5. exocrine pancreas development Source: MGI
  6. glucose homeostasis Source: MGI
  7. positive regulation of endoplasmic reticulum unfolded protein response Source: Ensembl
  8. positive regulation of proteasomal protein catabolic process Source: MGI
  9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  10. response to drug Source: Ensembl
  11. response to electrical stimulus Source: Ensembl
  12. serotonin secretion, neurotransmission Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_106572. XBP1(S) activates chaperone genes.
REACT_32838. ATF6-alpha activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
X-box-binding protein 1
Short name:
XBP-1
Alternative name(s):
Tax-responsive element-binding protein 5 homolog
Gene namesi
Name:Xbp1
Synonyms:Treb5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98970. Xbp1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267X-box-binding protein 1PRO_0000076544Add
BLAST

Proteomic databases

PRIDEiO35426.

PTM databases

PhosphoSiteiO35426.

Expressioni

Inductioni

Up-regulated in response to endoplasmic reticulum stress. Induced by interleukin-4 in plasma cell differentiation.2 Publications

Gene expression databases

ArrayExpressiO35426.
BgeeiO35426.
CleanExiMM_XBP1.
GenevestigatoriO35426.

Interactioni

Protein-protein interaction databases

BioGridi204589. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO35426.
SMRiO35426. Positions 55-120.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 12664bZIPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni65 – 8723Basic motif By similarityAdd
BLAST
Regioni91 – 12636Leucine-zipper By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family.

Phylogenomic databases

eggNOGiNOG285368.
GeneTreeiENSGT00390000017751.
HOGENOMiHOG000007671.
HOVERGENiHBG061457.
KOiK09027.
OMAiNQELRCR.
OrthoDBiEOG74BJVQ.
TreeFamiTF319837.

Family and domain databases

InterProiIPR004827. bZIP.
[Graphical view]
PfamiPF07716. bZIP_2. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O35426-1) [UniParc]FASTAAdd to Basket

Also known as: XBP-1U

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVVVAAAPSA ATAAPKVLLL SGQPASGGRA LPLMVPGPRA AGSEASGTPQ    50
ARKRQRLTHL SPEEKALRRK LKNRVAAQTA RDRKKARMSE LEQQVVDLEE 100
ENHKLQLENQ LLREKTHGLV VENQELRTRL GMDTLDPDEV PEVEAKGSGV 150
RLVAGSAESA ALRLCAPLQQ VQAQLSPPQN IFPWTLTLLP LQILSLISFW 200
AFWTSWTLSC FSNVLPQSLL VWRNSQRSTQ KDLVPYQPPF LCQWGPHQPS 250
WKPLMNSFVL TMYTPSL 267
Length:267
Mass (Da):29,619
Last modified:June 1, 2001 - v2
Checksum:i15009E684F6D426F
GO
Isoform 2 (identifier: O35426-2) [UniParc]FASTAAdd to Basket

Also known as: XBP-1S

The sequence of this isoform differs from the canonical sequence as follows:
     162-267: LRLCAPLQQV...FVLTMYTPSL → GAGPVVTSPE...NELFPQLISV

Note: Potent transcriptional activator. Induced by ERN1 in response to endoplasmic reticulum stress. ERN1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript.

Show »
Length:371
Mass (Da):39,888
Checksum:i6F67EC346DBF3AC8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei162 – 267106LRLCA…YTPSL → GAGPVVTSPEHLPMDSDTVA SSDSESDILLGILDKLDPVM FFKCPSPESASLEELPEVYP EGPSSLPASLSLSVGTSSAK LEAINELIRFDHVYTKPLVL EIPSETESQTNVVVKIEEAP LSSSEEDHPEFIVSVKKEPL EDDFIPELGISNLLSSSHCL RPPSCLLDAHSDCGYEGSPS PFSDMSSPLGTDHSWEDTFA NELFPQLISV in isoform 2. VSP_012937Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271Missing in BAB13793. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB036745 Genomic DNA. Translation: BAB13793.1.
AF443192 mRNA. Translation: AAL60202.1.
AF027963 mRNA. Translation: AAB81862.2.
AL662876 Genomic DNA. Translation: CAI24935.1.
BC008153 mRNA. Translation: AAH08153.1.
BC029197 mRNA. Translation: AAH29197.1.
CCDSiCCDS24400.1. [O35426-1]
PIRiJC7300.
RefSeqiNP_001258659.1. NM_001271730.1. [O35426-2]
NP_038870.2. NM_013842.3. [O35426-1]
UniGeneiMm.469937.

Genome annotation databases

EnsembliENSMUST00000063084; ENSMUSP00000054852; ENSMUSG00000020484. [O35426-1]
GeneIDi22433.
KEGGimmu:22433.
UCSCiuc007hwm.1. mouse. [O35426-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB036745 Genomic DNA. Translation: BAB13793.1 .
AF443192 mRNA. Translation: AAL60202.1 .
AF027963 mRNA. Translation: AAB81862.2 .
AL662876 Genomic DNA. Translation: CAI24935.1 .
BC008153 mRNA. Translation: AAH08153.1 .
BC029197 mRNA. Translation: AAH29197.1 .
CCDSi CCDS24400.1. [O35426-1 ]
PIRi JC7300.
RefSeqi NP_001258659.1. NM_001271730.1. [O35426-2 ]
NP_038870.2. NM_013842.3. [O35426-1 ]
UniGenei Mm.469937.

3D structure databases

ProteinModelPortali O35426.
SMRi O35426. Positions 55-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204589. 1 interaction.

PTM databases

PhosphoSitei O35426.

Proteomic databases

PRIDEi O35426.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063084 ; ENSMUSP00000054852 ; ENSMUSG00000020484 . [O35426-1 ]
GeneIDi 22433.
KEGGi mmu:22433.
UCSCi uc007hwm.1. mouse. [O35426-1 ]

Organism-specific databases

CTDi 7494.
MGIi MGI:98970. Xbp1.

Phylogenomic databases

eggNOGi NOG285368.
GeneTreei ENSGT00390000017751.
HOGENOMi HOG000007671.
HOVERGENi HBG061457.
KOi K09027.
OMAi NQELRCR.
OrthoDBi EOG74BJVQ.
TreeFami TF319837.

Enzyme and pathway databases

Reactomei REACT_106572. XBP1(S) activates chaperone genes.
REACT_32838. ATF6-alpha activates chaperone genes.

Miscellaneous databases

ChiTaRSi XBP1. mouse.
NextBioi 302881.
PROi O35426.
SOURCEi Search...

Gene expression databases

ArrayExpressi O35426.
Bgeei O35426.
CleanExi MM_XBP1.
Genevestigatori O35426.

Family and domain databases

InterProi IPR004827. bZIP.
[Graphical view ]
Pfami PF07716. bZIP_2. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the gene encoding mouse tax-responsive element-binding protein (TREB) 5."
    Masaki T., Noguchi H., Kobayashi M., Yoshida M., Takamatsu K.
    DNA Res. 7:187-193(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA."
    Calfon M., Zeng H., Urano F., Till J.H., Hubbard S.R., Harding H.P., Clark S.G., Ron D.
    Nature 415:92-96(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INDUCTION.
    Strain: 129/SvEv.
  3. "Sequence analysis of murine XBP-1."
    Lee C.M., Reddy E.P.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  6. "XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response."
    Lee A.H., Iwakoshi N.N., Glimcher L.H.
    Mol. Cell. Biol. 23:7448-7459(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1."
    Iwakoshi N.N., Lee A.-H., Vallabhajosyula P., Otipoby K.L., Rajewsky K., Glimcher L.H.
    Nat. Immunol. 4:321-329(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiXBP1_MOUSE
AccessioniPrimary (citable) accession number: O35426
Secondary accession number(s): Q8VHM0, Q922G5, Q9ESS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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