Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O35426

- XBP1_MOUSE

UniProt

O35426 - XBP1_MOUSE

Protein

X-box-binding protein 1

Gene

Xbp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N3[AT]T-3', and also to some TPA response elements (TRE) By similarity. Isoform 2 is involved in controlling the production of interleukin-6.By similarity2 Publications

    GO - Molecular functioni

    1. RNA polymerase II transcription factor binding Source: MGI
    2. sequence-specific DNA binding Source: Ensembl
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI

    GO - Biological processi

    1. cellular response to antibiotic Source: Ensembl
    2. endoplasmic reticulum unfolded protein response Source: Ensembl
    3. epithelial cell maturation Source: MGI
    4. epithelial cell maturation involved in salivary gland development Source: MGI
    5. exocrine pancreas development Source: MGI
    6. glucose homeostasis Source: MGI
    7. positive regulation of endoplasmic reticulum unfolded protein response Source: Ensembl
    8. positive regulation of proteasomal protein catabolic process Source: MGI
    9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    10. response to drug Source: Ensembl
    11. response to electrical stimulus Source: Ensembl
    12. serotonin secretion, neurotransmission Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_106572. XBP1(S) activates chaperone genes.
    REACT_32838. ATF6-alpha activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    X-box-binding protein 1
    Short name:
    XBP-1
    Alternative name(s):
    Tax-responsive element-binding protein 5 homolog
    Gene namesi
    Name:Xbp1
    Synonyms:Treb5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98970. Xbp1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267X-box-binding protein 1PRO_0000076544Add
    BLAST

    Proteomic databases

    PRIDEiO35426.

    PTM databases

    PhosphoSiteiO35426.

    Expressioni

    Inductioni

    Up-regulated in response to endoplasmic reticulum stress. Induced by interleukin-4 in plasma cell differentiation.2 Publications

    Gene expression databases

    ArrayExpressiO35426.
    BgeeiO35426.
    CleanExiMM_XBP1.
    GenevestigatoriO35426.

    Interactioni

    Protein-protein interaction databases

    BioGridi204589. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO35426.
    SMRiO35426. Positions 55-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 12664bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni65 – 8723Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni91 – 12636Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG285368.
    GeneTreeiENSGT00390000017751.
    HOGENOMiHOG000007671.
    HOVERGENiHBG061457.
    KOiK09027.
    OMAiNQELRCR.
    OrthoDBiEOG74BJVQ.
    TreeFamiTF319837.

    Family and domain databases

    InterProiIPR004827. bZIP.
    [Graphical view]
    PfamiPF07716. bZIP_2. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O35426-1) [UniParc]FASTAAdd to Basket

    Also known as: XBP-1U

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVVVAAAPSA ATAAPKVLLL SGQPASGGRA LPLMVPGPRA AGSEASGTPQ    50
    ARKRQRLTHL SPEEKALRRK LKNRVAAQTA RDRKKARMSE LEQQVVDLEE 100
    ENHKLQLENQ LLREKTHGLV VENQELRTRL GMDTLDPDEV PEVEAKGSGV 150
    RLVAGSAESA ALRLCAPLQQ VQAQLSPPQN IFPWTLTLLP LQILSLISFW 200
    AFWTSWTLSC FSNVLPQSLL VWRNSQRSTQ KDLVPYQPPF LCQWGPHQPS 250
    WKPLMNSFVL TMYTPSL 267
    Length:267
    Mass (Da):29,619
    Last modified:June 1, 2001 - v2
    Checksum:i15009E684F6D426F
    GO
    Isoform 2 (identifier: O35426-2) [UniParc]FASTAAdd to Basket

    Also known as: XBP-1S

    The sequence of this isoform differs from the canonical sequence as follows:
         162-267: LRLCAPLQQV...FVLTMYTPSL → GAGPVVTSPE...NELFPQLISV

    Note: Potent transcriptional activator. Induced by ERN1 in response to endoplasmic reticulum stress. ERN1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript.

    Show »
    Length:371
    Mass (Da):39,888
    Checksum:i6F67EC346DBF3AC8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271Missing in BAB13793. (PubMed:10907849)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei162 – 267106LRLCA…YTPSL → GAGPVVTSPEHLPMDSDTVA SSDSESDILLGILDKLDPVM FFKCPSPESASLEELPEVYP EGPSSLPASLSLSVGTSSAK LEAINELIRFDHVYTKPLVL EIPSETESQTNVVVKIEEAP LSSSEEDHPEFIVSVKKEPL EDDFIPELGISNLLSSSHCL RPPSCLLDAHSDCGYEGSPS PFSDMSSPLGTDHSWEDTFA NELFPQLISV in isoform 2. 1 PublicationVSP_012937Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB036745 Genomic DNA. Translation: BAB13793.1.
    AF443192 mRNA. Translation: AAL60202.1.
    AF027963 mRNA. Translation: AAB81862.2.
    AL662876 Genomic DNA. Translation: CAI24935.1.
    BC008153 mRNA. Translation: AAH08153.1.
    BC029197 mRNA. Translation: AAH29197.1.
    CCDSiCCDS24400.1. [O35426-1]
    PIRiJC7300.
    RefSeqiNP_001258659.1. NM_001271730.1. [O35426-2]
    NP_038870.2. NM_013842.3. [O35426-1]
    UniGeneiMm.469937.

    Genome annotation databases

    EnsembliENSMUST00000063084; ENSMUSP00000054852; ENSMUSG00000020484. [O35426-1]
    GeneIDi22433.
    KEGGimmu:22433.
    UCSCiuc007hwm.1. mouse. [O35426-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB036745 Genomic DNA. Translation: BAB13793.1 .
    AF443192 mRNA. Translation: AAL60202.1 .
    AF027963 mRNA. Translation: AAB81862.2 .
    AL662876 Genomic DNA. Translation: CAI24935.1 .
    BC008153 mRNA. Translation: AAH08153.1 .
    BC029197 mRNA. Translation: AAH29197.1 .
    CCDSi CCDS24400.1. [O35426-1 ]
    PIRi JC7300.
    RefSeqi NP_001258659.1. NM_001271730.1. [O35426-2 ]
    NP_038870.2. NM_013842.3. [O35426-1 ]
    UniGenei Mm.469937.

    3D structure databases

    ProteinModelPortali O35426.
    SMRi O35426. Positions 55-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204589. 2 interactions.

    PTM databases

    PhosphoSitei O35426.

    Proteomic databases

    PRIDEi O35426.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063084 ; ENSMUSP00000054852 ; ENSMUSG00000020484 . [O35426-1 ]
    GeneIDi 22433.
    KEGGi mmu:22433.
    UCSCi uc007hwm.1. mouse. [O35426-1 ]

    Organism-specific databases

    CTDi 7494.
    MGIi MGI:98970. Xbp1.

    Phylogenomic databases

    eggNOGi NOG285368.
    GeneTreei ENSGT00390000017751.
    HOGENOMi HOG000007671.
    HOVERGENi HBG061457.
    KOi K09027.
    OMAi NQELRCR.
    OrthoDBi EOG74BJVQ.
    TreeFami TF319837.

    Enzyme and pathway databases

    Reactomei REACT_106572. XBP1(S) activates chaperone genes.
    REACT_32838. ATF6-alpha activates chaperone genes.

    Miscellaneous databases

    ChiTaRSi XBP1. mouse.
    NextBioi 302881.
    PROi O35426.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35426.
    Bgeei O35426.
    CleanExi MM_XBP1.
    Genevestigatori O35426.

    Family and domain databases

    InterProi IPR004827. bZIP.
    [Graphical view ]
    Pfami PF07716. bZIP_2. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the gene encoding mouse tax-responsive element-binding protein (TREB) 5."
      Masaki T., Noguchi H., Kobayashi M., Yoshida M., Takamatsu K.
      DNA Res. 7:187-193(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA."
      Calfon M., Zeng H., Urano F., Till J.H., Hubbard S.R., Harding H.P., Clark S.G., Ron D.
      Nature 415:92-96(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INDUCTION.
      Strain: 129/SvEv.
    3. "Sequence analysis of murine XBP-1."
      Lee C.M., Reddy E.P.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N.
      Tissue: Mammary tumor.
    6. "XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response."
      Lee A.H., Iwakoshi N.N., Glimcher L.H.
      Mol. Cell. Biol. 23:7448-7459(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1."
      Iwakoshi N.N., Lee A.-H., Vallabhajosyula P., Otipoby K.L., Rajewsky K., Glimcher L.H.
      Nat. Immunol. 4:321-329(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.

    Entry informationi

    Entry nameiXBP1_MOUSE
    AccessioniPrimary (citable) accession number: O35426
    Secondary accession number(s): Q8VHM0, Q922G5, Q9ESS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3