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Protein

Proenkephalin-B

Gene

Pdyn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).By similarity
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).By similarity
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.By similarity

GO - Molecular functioni

  1. neuropeptide hormone activity Source: MGI

GO - Biological processi

  1. neuropeptide signaling pathway Source: UniProtKB-KW
  2. synaptic transmission Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Neurotransmitter, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-B
Alternative name(s):
Beta-neoendorphin-dynorphin
Preprodynorphin
Cleaved into the following 9 chains:
Big dynorphin
Short name:
Big Dyn
Dynorphin A(1-17)
Short name:
Dyn-A17
Short name:
Dynorphin A
Alternative name(s):
Dynorphin B
Short name:
Dyn-B
Dynorphin B(1-13)
Alternative name(s):
Dynorphin B-29
Gene namesi
Name:Pdyn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:97535. Pdyn.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 163142PRO_0000008183Add
BLAST
Peptidei166 – 17510Alpha-neoendorphinPRO_0000306353
Peptidei166 – 1749Beta-neoendorphinPRO_0000008184
Peptidei166 – 1705Leu-enkephalinPRO_0000008185
Propeptidei177 – 19923PRO_0000008186Add
BLAST
Peptidei202 – 23332Big dynorphinPRO_0000306354Add
BLAST
Peptidei202 – 21817Dynorphin A(1-17)PRO_0000008187Add
BLAST
Peptidei202 – 21413Dynorphin A(1-13)By similarityPRO_0000306355Add
BLAST
Peptidei202 – 2098Dynorphin A(1-8)By similarityPRO_0000306356
Peptidei202 – 2065Leu-enkephalinPRO_0000008188
Peptidei221 – 24828LeumorphinPRO_0000008189Add
BLAST
Peptidei221 – 23313RimorphinBy similarityPRO_0000306357Add
BLAST
Peptidei221 – 2255Leu-enkephalinPRO_0000008190

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiO35417.
PRIDEiO35417.

PTM databases

PhosphoSiteiO35417.

Miscellaneous databases

PMAP-CutDBO35417.

Expressioni

Gene expression databases

CleanExiMM_PDYN.
GenevestigatoriO35417.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46156.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiO35417.
PhylomeDBiO35417.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWSRLMLAA CLLVMPSNVM ADCLSLCSLC AVRIQDGPRP INPLICSLEC
60 70 80 90 100
QDLVPPSEEW ETCRGFSSFL TLTVSGLRGK DDLEDEVALE EGISAHAKLL
110 120 130 140 150
EPVLKELEKS RLLTSVPEEK FRGLSSSFGN GKESELAGAD RMNDEAAQGR
160 170 180 190 200
TVHFNEEDLR KQAKRYGGFL RKYPKRSSEM ARDEDGGQDG DQVGHEDLYK
210 220 230 240
RYGGFLRRIR PKLKWDNQKR YGGFLRRQFK VVTRSQENPN TYSEDLDV
Length:248
Mass (Da):28,055
Last modified:January 1, 1998 - v1
Checksum:iEDD49766CCD5DA6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026537 mRNA. Translation: AAB82584.1.
CCDSiCCDS38239.1.
UniGeneiMm.6239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026537 mRNA. Translation: AAB82584.1.
CCDSiCCDS38239.1.
UniGeneiMm.6239.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiO35417.

Proteomic databases

PaxDbiO35417.
PRIDEiO35417.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97535. Pdyn.

Phylogenomic databases

eggNOGiNOG46156.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiO35417.
PhylomeDBiO35417.

Miscellaneous databases

PMAP-CutDBO35417.
PROiO35417.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PDYN.
GenevestigatoriO35417.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Glucose stimulation of pancreatic beta-cell lines induces expression and secretion of dynorphin."
    Josefsen K., Buschard K., Sorensen L.R., Wollike M., Ekman R., Birkenbach M.
    Endocrinology 139:4329-4336(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "Dynorphin and neoendorphin peptides decrease dorsal root ganglion neuron calcium-dependent action potential duration."
    Werz M.A., Macdonald R.L.
    J. Pharmacol. Exp. Ther. 234:49-56(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Big dynorphin, a prodynorphin-derived peptide produces NMDA receptor-mediated effects on memory, anxiolytic-like and locomotor behavior in mice."
    Kuzmin A., Madjid N., Terenius L., Ogren S.O., Bakalkin G.
    Neuropsychopharmacology 31:1928-1937(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPDYN_MOUSE
AccessioniPrimary (citable) accession number: O35417
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 1, 1998
Last modified: February 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.