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Protein

Proenkephalin-B

Gene

Pdyn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).By similarity
Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity).By similarity
Leumorphin has a typical opiod activity and may have anti-apoptotic effect.By similarity

GO - Molecular functioni

  • neuropeptide hormone activity Source: MGI
  • opioid receptor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endorphin, Neuropeptide, Neurotransmitter, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Proenkephalin-B
Alternative name(s):
Beta-neoendorphin-dynorphin
Preprodynorphin
Cleaved into the following 9 chains:
Big dynorphin
Short name:
Big Dyn
Dynorphin A(1-17)
Short name:
Dyn-A17
Short name:
Dynorphin A
Alternative name(s):
Dynorphin B
Short name:
Dyn-B
Dynorphin B(1-13)
Alternative name(s):
Dynorphin B-29
Gene namesi
Name:Pdyn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97535. Pdyn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000000818322 – 163Add BLAST142
PeptideiPRO_0000306353166 – 175Alpha-neoendorphin10
PeptideiPRO_0000008184166 – 174Beta-neoendorphin9
PeptideiPRO_0000008185166 – 170Leu-enkephalin5
PropeptideiPRO_0000008186177 – 199Add BLAST23
PeptideiPRO_0000306354202 – 233Big dynorphinAdd BLAST32
PeptideiPRO_0000008187202 – 218Dynorphin A(1-17)Add BLAST17
PeptideiPRO_0000306355202 – 214Dynorphin A(1-13)By similarityAdd BLAST13
PeptideiPRO_0000306356202 – 209Dynorphin A(1-8)By similarity8
PeptideiPRO_0000008188202 – 206Leu-enkephalin5
PeptideiPRO_0000008189221 – 248LeumorphinAdd BLAST28
PeptideiPRO_0000306357221 – 233RimorphinBy similarityAdd BLAST13
PeptideiPRO_0000008190221 – 225Leu-enkephalin5

Post-translational modificationi

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiO35417.
PRIDEiO35417.

PTM databases

PhosphoSitePlusiO35417.

Miscellaneous databases

PMAP-CutDBO35417.

Expressioni

Gene expression databases

CleanExiMM_PDYN.

Interactioni

GO - Molecular functioni

  • neuropeptide hormone activity Source: MGI
  • opioid receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028883.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIMD. Eukaryota.
ENOG4111RTT. LUCA.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiO35417.
PhylomeDBiO35417.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWSRLMLAA CLLVMPSNVM ADCLSLCSLC AVRIQDGPRP INPLICSLEC
60 70 80 90 100
QDLVPPSEEW ETCRGFSSFL TLTVSGLRGK DDLEDEVALE EGISAHAKLL
110 120 130 140 150
EPVLKELEKS RLLTSVPEEK FRGLSSSFGN GKESELAGAD RMNDEAAQGR
160 170 180 190 200
TVHFNEEDLR KQAKRYGGFL RKYPKRSSEM ARDEDGGQDG DQVGHEDLYK
210 220 230 240
RYGGFLRRIR PKLKWDNQKR YGGFLRRQFK VVTRSQENPN TYSEDLDV
Length:248
Mass (Da):28,055
Last modified:January 1, 1998 - v1
Checksum:iEDD49766CCD5DA6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026537 mRNA. Translation: AAB82584.1.
CCDSiCCDS38239.1.
UniGeneiMm.6239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026537 mRNA. Translation: AAB82584.1.
CCDSiCCDS38239.1.
UniGeneiMm.6239.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028883.

PTM databases

PhosphoSitePlusiO35417.

Proteomic databases

PaxDbiO35417.
PRIDEiO35417.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97535. Pdyn.

Phylogenomic databases

eggNOGiENOG410IIMD. Eukaryota.
ENOG4111RTT. LUCA.
HOGENOMiHOG000013003.
HOVERGENiHBG000063.
InParanoidiO35417.
PhylomeDBiO35417.

Miscellaneous databases

PMAP-CutDBO35417.
PROiO35417.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PDYN.

Family and domain databases

InterProiIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERiPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamiPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSiPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDYN_MOUSE
AccessioniPrimary (citable) accession number: O35417
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.