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O35417 (PDYN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proenkephalin-B
Alternative name(s):
Beta-neoendorphin-dynorphin
Preprodynorphin

Cleaved into the following 9 chains:

  1. Alpha-neoendorphin
  2. Beta-neoendorphin
  3. Big dynorphin
    Short name=Big Dyn
  4. Dynorphin A(1-17)
    Short name=Dyn-A17
    Short name=Dynorphin A
  5. Dynorphin A(1-13)
  6. Dynorphin A(1-8)
  7. Leu-enkephalin
  8. Rimorphin
    Alternative name(s):
    Dynorphin B
    Short name=Dyn-B
    Dynorphin B(1-13)
  9. Leumorphin
    Alternative name(s):
    Dynorphin B-29
Gene names
Name:Pdyn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress By similarity. Ref.2 Ref.3

Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin By similarity. Ref.2 Ref.3

Leumorphin has a typical opiod activity and may have anti-apoptotic effect By similarity. Ref.2 Ref.3

Subcellular location

Secreted.

Post-translational modification

The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Sequence similarities

Belongs to the opioid neuropeptide precursor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Propeptide22 – 163142
PRO_0000008183
Peptide166 – 17510Alpha-neoendorphin
PRO_0000306353
Peptide166 – 1749Beta-neoendorphin
PRO_0000008184
Peptide166 – 1705Leu-enkephalin
PRO_0000008185
Propeptide177 – 19923
PRO_0000008186
Peptide202 – 23332Big dynorphin
PRO_0000306354
Peptide202 – 21817Dynorphin A(1-17)
PRO_0000008187
Peptide202 – 21413Dynorphin A(1-13) By similarity
PRO_0000306355
Peptide202 – 2098Dynorphin A(1-8) By similarity
PRO_0000306356
Peptide202 – 2065Leu-enkephalin
PRO_0000008188
Peptide221 – 24828Leumorphin
PRO_0000008189
Peptide221 – 23313Rimorphin By similarity
PRO_0000306357
Peptide221 – 2255Leu-enkephalin
PRO_0000008190

Sequences

Sequence LengthMass (Da)Tools
O35417 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: EDD49766CCD5DA6E

FASTA24828,055
        10         20         30         40         50         60 
MAWSRLMLAA CLLVMPSNVM ADCLSLCSLC AVRIQDGPRP INPLICSLEC QDLVPPSEEW 

        70         80         90        100        110        120 
ETCRGFSSFL TLTVSGLRGK DDLEDEVALE EGISAHAKLL EPVLKELEKS RLLTSVPEEK 

       130        140        150        160        170        180 
FRGLSSSFGN GKESELAGAD RMNDEAAQGR TVHFNEEDLR KQAKRYGGFL RKYPKRSSEM 

       190        200        210        220        230        240 
ARDEDGGQDG DQVGHEDLYK RYGGFLRRIR PKLKWDNQKR YGGFLRRQFK VVTRSQENPN 


TYSEDLDV 

« Hide

References

[1]"Glucose stimulation of pancreatic beta-cell lines induces expression and secretion of dynorphin."
Josefsen K., Buschard K., Sorensen L.R., Wollike M., Ekman R., Birkenbach M.
Endocrinology 139:4329-4336(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"Dynorphin and neoendorphin peptides decrease dorsal root ganglion neuron calcium-dependent action potential duration."
Werz M.A., Macdonald R.L.
J. Pharmacol. Exp. Ther. 234:49-56(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[3]"Big dynorphin, a prodynorphin-derived peptide produces NMDA receptor-mediated effects on memory, anxiolytic-like and locomotor behavior in mice."
Kuzmin A., Madjid N., Terenius L., Ogren S.O., Bakalkin G.
Neuropsychopharmacology 31:1928-1937(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF026537 mRNA. Translation: AAB82584.1.
UniGeneMm.6239.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO35417.

Proteomic databases

PaxDbO35417.
PRIDEO35417.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97535. Pdyn.

Phylogenomic databases

eggNOGNOG46156.
HOGENOMHOG000013003.
HOVERGENHBG000063.
InParanoidO35417.
PhylomeDBO35417.

Gene expression databases

CleanExMM_PDYN.
GenevestigatorO35417.

Family and domain databases

InterProIPR006024. Opioid_neupept.
IPR000750. Proenkphlin_B.
[Graphical view]
PANTHERPTHR11438. PTHR11438. 1 hit.
PTHR11438:SF4. PTHR11438:SF4. 1 hit.
PfamPF01160. Opiods_neuropep. 1 hit.
[Graphical view]
PRINTSPR01028. OPIOIDPRCRSR.
PR01030. PENKBPRCRSR.
PROSITEPS01252. OPIOIDS_PRECURSOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PMAP-CutDBO35417.
PROO35417.
SOURCESearch...

Entry information

Entry namePDYN_MOUSE
AccessionPrimary (citable) accession number: O35417
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot