Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O35417

- PDYN_MOUSE

UniProt

O35417 - PDYN_MOUSE

Protein

Proenkephalin-B

Gene

Pdyn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress By similarity.By similarity
    Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin By similarity.By similarity
    Leumorphin has a typical opiod activity and may have anti-apoptotic effect.By similarity

    GO - Molecular functioni

    1. neuropeptide hormone activity Source: MGI

    GO - Biological processi

    1. neuropeptide signaling pathway Source: UniProtKB-KW
    2. synaptic transmission Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endorphin, Neuropeptide, Neurotransmitter, Opioid peptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proenkephalin-B
    Alternative name(s):
    Beta-neoendorphin-dynorphin
    Preprodynorphin
    Cleaved into the following 9 chains:
    Big dynorphin
    Short name:
    Big Dyn
    Dynorphin A(1-17)
    Short name:
    Dyn-A17
    Short name:
    Dynorphin A
    Alternative name(s):
    Dynorphin B
    Short name:
    Dyn-B
    Dynorphin B(1-13)
    Alternative name(s):
    Dynorphin B-29
    Gene namesi
    Name:Pdyn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:97535. Pdyn.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 163142PRO_0000008183Add
    BLAST
    Peptidei166 – 17510Alpha-neoendorphinPRO_0000306353
    Peptidei166 – 1749Beta-neoendorphinPRO_0000008184
    Peptidei166 – 1705Leu-enkephalinPRO_0000008185
    Propeptidei177 – 19923PRO_0000008186Add
    BLAST
    Peptidei202 – 23332Big dynorphinPRO_0000306354Add
    BLAST
    Peptidei202 – 21817Dynorphin A(1-17)PRO_0000008187Add
    BLAST
    Peptidei202 – 21413Dynorphin A(1-13)By similarityPRO_0000306355Add
    BLAST
    Peptidei202 – 2098Dynorphin A(1-8)By similarityPRO_0000306356
    Peptidei202 – 2065Leu-enkephalinPRO_0000008188
    Peptidei221 – 24828LeumorphinPRO_0000008189Add
    BLAST
    Peptidei221 – 23313RimorphinBy similarityPRO_0000306357Add
    BLAST
    Peptidei221 – 2255Leu-enkephalinPRO_0000008190

    Post-translational modificationi

    The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PaxDbiO35417.
    PRIDEiO35417.

    PTM databases

    PhosphoSiteiO35417.

    Miscellaneous databases

    PMAP-CutDBO35417.

    Expressioni

    Gene expression databases

    CleanExiMM_PDYN.
    GenevestigatoriO35417.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46156.
    HOGENOMiHOG000013003.
    HOVERGENiHBG000063.
    InParanoidiO35417.
    PhylomeDBiO35417.

    Family and domain databases

    InterProiIPR006024. Opioid_neupept.
    IPR000750. Proenkphlin_B.
    [Graphical view]
    PANTHERiPTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF4. PTHR11438:SF4. 1 hit.
    PfamiPF01160. Opiods_neuropep. 1 hit.
    [Graphical view]
    PRINTSiPR01028. OPIOIDPRCRSR.
    PR01030. PENKBPRCRSR.
    PROSITEiPS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35417-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWSRLMLAA CLLVMPSNVM ADCLSLCSLC AVRIQDGPRP INPLICSLEC    50
    QDLVPPSEEW ETCRGFSSFL TLTVSGLRGK DDLEDEVALE EGISAHAKLL 100
    EPVLKELEKS RLLTSVPEEK FRGLSSSFGN GKESELAGAD RMNDEAAQGR 150
    TVHFNEEDLR KQAKRYGGFL RKYPKRSSEM ARDEDGGQDG DQVGHEDLYK 200
    RYGGFLRRIR PKLKWDNQKR YGGFLRRQFK VVTRSQENPN TYSEDLDV 248
    Length:248
    Mass (Da):28,055
    Last modified:January 1, 1998 - v1
    Checksum:iEDD49766CCD5DA6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026537 mRNA. Translation: AAB82584.1.
    CCDSiCCDS38239.1.
    UniGeneiMm.6239.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF026537 mRNA. Translation: AAB82584.1 .
    CCDSi CCDS38239.1.
    UniGenei Mm.6239.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O35417.

    Proteomic databases

    PaxDbi O35417.
    PRIDEi O35417.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97535. Pdyn.

    Phylogenomic databases

    eggNOGi NOG46156.
    HOGENOMi HOG000013003.
    HOVERGENi HBG000063.
    InParanoidi O35417.
    PhylomeDBi O35417.

    Miscellaneous databases

    PMAP-CutDB O35417.
    PROi O35417.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_PDYN.
    Genevestigatori O35417.

    Family and domain databases

    InterProi IPR006024. Opioid_neupept.
    IPR000750. Proenkphlin_B.
    [Graphical view ]
    PANTHERi PTHR11438. PTHR11438. 1 hit.
    PTHR11438:SF4. PTHR11438:SF4. 1 hit.
    Pfami PF01160. Opiods_neuropep. 1 hit.
    [Graphical view ]
    PRINTSi PR01028. OPIOIDPRCRSR.
    PR01030. PENKBPRCRSR.
    PROSITEi PS01252. OPIOIDS_PRECURSOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Glucose stimulation of pancreatic beta-cell lines induces expression and secretion of dynorphin."
      Josefsen K., Buschard K., Sorensen L.R., Wollike M., Ekman R., Birkenbach M.
      Endocrinology 139:4329-4336(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "Dynorphin and neoendorphin peptides decrease dorsal root ganglion neuron calcium-dependent action potential duration."
      Werz M.A., Macdonald R.L.
      J. Pharmacol. Exp. Ther. 234:49-56(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "Big dynorphin, a prodynorphin-derived peptide produces NMDA receptor-mediated effects on memory, anxiolytic-like and locomotor behavior in mice."
      Kuzmin A., Madjid N., Terenius L., Ogren S.O., Bakalkin G.
      Neuropsychopharmacology 31:1928-1937(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiPDYN_MOUSE
    AccessioniPrimary (citable) accession number: O35417
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3