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Protein

Forkhead box protein D2

Gene

Foxd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor involved in embryogenesis and somatogenesis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi129 – 22395Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D2
Alternative name(s):
Mesoderm/mesenchyme forkhead 2
Short name:
MF-2
Gene namesi
Name:Foxd2
Synonyms:Mf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1347471. Foxd2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Forkhead box protein D2PRO_0000091816Add
BLAST

Proteomic databases

PaxDbiO35392.
PRIDEiO35392.

PTM databases

PhosphoSiteiO35392.

Expressioni

Tissue specificityi

Expressed at high levels in the ventral region of newly formed somites, in sclerotomal derivatives, in lateral plate and cephalic mesoderm and in the first and second branchial arches. Other regions of mesodermal expression include the developing tongue, meninges, nose, whiskers, kidney, genital tubercule and limb joints. In the nervous system it is transcribed in restricted regions of the mid- and forebrain.1 Publication

Gene expression databases

BgeeiO35392.
CleanExiMM_FOXD2.
GenevisibleiO35392. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066868.

Structurei

3D structure databases

ProteinModelPortaliO35392.
SMRiO35392. Positions 128-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi229 – 350122Pro-richAdd
BLAST
Compositional biasi249 – 377129Ala-richAdd
BLAST
Compositional biasi393 – 44452Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
InParanoidiO35392.
KOiK09397.
OMAiTGQRPSF.
OrthoDBiEOG7C8GHD.
PhylomeDBiO35392.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLGSCCCEI MSSESSPAAL SEPDADIDVV GGGSGGGELT ARSGPRAPRD
60 70 80 90 100
VLPHGHEPPP EEAEADVAED EEESGGCSDC EPRALAPRGA AAAAGSPGPG
110 120 130 140 150
VQAARGATGP GPGPGPPSGG AATRSPLVKP PYSYIALITM AILQSPKKRL
160 170 180 190 200
TLSEICEFIS GRFPYYREKF PAWQNSIRHN LSLNDCFVKI PREPGNPGKG
210 220 230 240 250
NYWTLDPESA DMFDNGSFLR RRKRFKRQPL PPPHPHPHPH PELLLRGGAA
260 270 280 290 300
AAGDPGAFLS SFAAYGAYGY GYGLALPAYG APPPGPAPHP HPHPHAFAFA
310 320 330 340 350
ATAPCQLSVP PGRAAAPPPG PPTASVFASA ASAPAPAPAP GSGPSPAGLP
360 370 380 390 400
AFLGAELGCA KAFYPASLSP PAAGTAASLS TALLRQGLKT DAGGGAGGGG
410 420 430 440 450
AGTGQRPSFS IDHIMGHGGG GAAPPGSGDG SPGSPFAAAA GPGGQAQVLA
460 470 480 490
MLTAPALTPV AGHIRLSHPG DSLLSSGPSF ASKVAGLSGC HF
Length:492
Mass (Da):48,937
Last modified:January 1, 1998 - v1
Checksum:i7F82440F4C435702
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023915 mRNA. Translation: AAB81275.1.
AL670035 Genomic DNA. Translation: CAM19994.1.
CCDSiCCDS18482.1.
RefSeqiNP_032619.1. NM_008593.3.
UniGeneiMm.7997.

Genome annotation databases

EnsembliENSMUST00000068654; ENSMUSP00000066868; ENSMUSG00000055210.
GeneIDi17301.
KEGGimmu:17301.
UCSCiuc012dix.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023915 mRNA. Translation: AAB81275.1.
AL670035 Genomic DNA. Translation: CAM19994.1.
CCDSiCCDS18482.1.
RefSeqiNP_032619.1. NM_008593.3.
UniGeneiMm.7997.

3D structure databases

ProteinModelPortaliO35392.
SMRiO35392. Positions 128-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066868.

PTM databases

PhosphoSiteiO35392.

Proteomic databases

PaxDbiO35392.
PRIDEiO35392.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068654; ENSMUSP00000066868; ENSMUSG00000055210.
GeneIDi17301.
KEGGimmu:17301.
UCSCiuc012dix.1. mouse.

Organism-specific databases

CTDi2306.
MGIiMGI:1347471. Foxd2.

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
InParanoidiO35392.
KOiK09397.
OMAiTGQRPSF.
OrthoDBiEOG7C8GHD.
PhylomeDBiO35392.
TreeFamiTF316127.

Miscellaneous databases

PROiO35392.
SOURCEiSearch...

Gene expression databases

BgeeiO35392.
CleanExiMM_FOXD2.
GenevisibleiO35392. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis."
    Wu S.C.-Y., Grindley J., Winnier G.E., Hargett L., Hogan B.L.M.
    Mech. Dev. 70:3-13(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Mesenchymal cell.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiFOXD2_MOUSE
AccessioniPrimary (citable) accession number: O35392
Secondary accession number(s): A2AD43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.