HCLS1-associated protein X-1
Reviewed-Annotation score: <p>Annotation score: 5 out of 5</p>
<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome.</p><p><a href='../manual/annotation_score' target='_top'>More...</a></p>Annotation score: 5 out of 5-Experimental evidence at protein leveli
<p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.</p><p><a href='../manual/protein_existence' target='_top'>More...</a></p> Select a section on the left to see content.
<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni
Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools (By similarity).
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi
<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
| <p>Provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.</p><p><a href='../manual/protein_names' target='_top'>More...</a></p>Protein namesi | Recommended name: HCLS1-associated protein X-1Alternative name(s): HS1-associating protein X-1 Short name: HAX-1 HS1-binding protein 1 Short name: HSP1BP-1 |
| <p>Indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.</p><p><a href='../manual/gene_name' target='_top'>More...</a></p>Gene namesi | |
| <p>Provides information on the name(s) of the organism that is the source of the protein sequence.</p><p><a href='../manual/organism-name' target='_top'>More...</a></p>Organismi | Mus musculus (Mouse) |
| <p>Shows the unique identifier assigned by the <span class="caps">NCBI</span> to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.</p><p><a href='../manual/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri | 10090 [NCBI] |
| <p>Contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.</p><p><a href='../manual/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineagei | cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
| <p>Is present for entries that are part of a <a href="/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.</p><p><a href='../manual/proteomes_manual' target='_top'>More...</a></p>Proteomesi | - UP000000589
<p>A UniProt <a href="/manual/proteomes_manual">proteome</a> can consist of several components. <br />The component name refers to the genomic component encoding a set of proteins. <br />These range from a single component such as Viral genomes to several components as in the case of eukaryotic chromosomes. They may also represent different stages in a genome project and include components such as contigs, scaffolds or Whole Genome Shotgun (WGS) master records.</p><p><a href='../manual/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3
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Organism-specific databases
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Mouse genome database (MGD) from Mouse Genome Informatics (MGI)<br/><a href='/database/60'>More..</a>MGIi | MGI:1346319. Hax1.
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<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti
- actin cytoskeleton
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- cytoplasm
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- cytoplasmic, membrane-bounded vesicle
- endoplasmic reticulum
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- lamellipodium
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- mitochondrial intermembrane space
- mitochondrial outer membrane
- mitochondrion
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- nuclear membrane
- sarcoplasmic reticulum
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayi
- transcription factor complex
<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti
Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus, Sarcoplasmic reticulum<p>Provides information on the disease(s) and phenotype(s) associated with a protein.</p><p><a href='../manual/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi
<p>Describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.</p><p><a href='../manual/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei
Mice lacking Hax1 fail to survive longer than 14 weeks, due to a loss of motor coordination and activity, leading to failure to eat and drink. They display extensive apoptosis of neurons in the striatum and cerebellum, and a loss of lymphocytes in spleen, bone marrow and thymus.
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment ini
Cited for: DISRUPTION PHENOTYPE.
<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi
Molecule processing
Amino acid modifications
Sites
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|
| <p>Describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.</p><p><a href='../manual/site' target='_top'>More...</a></p>Sitei | 128 – 129 | 2 | Cleavage; by caspase-3 |   | | |
<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
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Encyclopedia of Proteome Dynamics<br/><a href='/database/205'>More..</a>EPDi | O35387.
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MaxQB - The MaxQuant DataBase<br/><a href='/database/186'>More..</a>MaxQBi | O35387.
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PaxDb, a database of protein abundance averages across all three domains of life<br/><a href='/database/173'>More..</a>PaxDbi | O35387.
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PRoteomics IDEntifications database<br/><a href='/database/130'>More..</a>PRIDEi | O35387.
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PTM databases
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iPTMnet integrated resource for PTMs in systems biology context<br/><a href='/database/200'>More..</a>iPTMneti | O35387.
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Comprehensive resource for the study of human and mouse PTMs<br/><a href='/database/123'>More..</a>PhosphoSitei | O35387.
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<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni
<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’.<br />Examples: <a href="/uniprot/P92958#expression"><span class="caps">P92958</span></a>, <a href="/uniprot/Q8TDN4#expression"><span class="caps">Q8TDN4</span></a>, <a href="/uniprot/O14734#expression"><span class="caps">O14734</span></a></p><p><a href='../manual/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi
Ubiquitous, with highest levels in kidney and liver (at protein level).
<p>Manually curated information for which there is published experimental evidence.</p>
<p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment ini
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Gene expression databases
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Bgee dataBase for Gene Expression Evolution<br/><a href='/database/133'>More..</a>Bgeei | ENSMUSG00000027944.
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CleanEx database of gene expression profiles<br/><a href='/database/8'>More..</a>CleanExi | MM_HAX1.
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ExpressionAtlas, Differential and Baseline Expression<br/><a href='/database/4'>More..</a>ExpressionAtlasi | O35387. baseline.
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Genevisible search portal to normalized and curated expression data from Genevestigator<br/><a href='/database/194'>More..</a>Genevisiblei | O35387. MM.
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<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni
<p>Provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="/help/function_section">‘Function’</a> section).</p><p><a href='../manual/subunit_structure' target='_top'>More...</a></p>Subunit structurei
Directly associates with HCLS1/HS1, through binding to its N-terminal region. Interacts with ABCB1, ABCB4 and ABCB11. Interacts with GNA13. Interacts with CASP9. Interacts with ITGB6. Interacts with PLN and ATP2A2; these interactions are inhibited by calcium. Interacts with GRB7 (By similarity). Interacts with CTTN. Interacts with PKD2. Interacts (via C-terminus) with XIAP/BIRC4 (via BIR 2 domain and BIR 3 domain) and this interaction blocks ubiquitination of XIAP/BIRC4 (By similarity).
<p>Provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.</p><p><a href='../manual/binary_interactions' target='_top'>More...</a></p>Binary interactionsi
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
Protein-protein interaction databases
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The Biological General Repository for Interaction Datasets (BioGrid)<br/><a href='/database/184'>More..</a>BioGridi | 204783. 15 interactions.
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Database of interacting proteins<br/><a href='/database/16'>More..</a>DIPi | DIP-49445N.
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Protein interaction database and analysis system<br/><a href='/database/51'>More..</a>IntActi | O35387. 19 interactions.
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Molecular INTeraction database<br/><a href='/database/158'>More..</a>MINTi | MINT-1592061.
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STRING: functional protein association networks<br/><a href='/database/141'>More..</a>STRINGi | 10090.ENSMUSP00000078661.
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<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei
3D structure databases
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Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase<br/><a href='/database/159'>More..</a>ProteinModelPortali | O35387.
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Database of comparative protein structure models<br/><a href='/database/63'>More..</a>ModBasei | Search...
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MobiDB: a database of protein disorder and mobility annotations<br/><a href='/database/183'>More..</a>MobiDBi | Search...
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<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi
Region
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|
| <p>Describes a region of interest that cannot be described in other subsections.</p><p><a href='../manual/region' target='_top'>More...</a></p>Regioni | 2 – 45 | 44 | Required for localization in mitochondria | | | Add
BLAST |
| <p>Describes a region of interest that cannot be described in other subsections.</p><p><a href='../manual/region' target='_top'>More...</a></p>Regioni | 115 – 280 | 166 | Involved in HCLS1 binding | | | Add
BLAST |
| <p>Describes a region of interest that cannot be described in other subsections.</p><p><a href='../manual/region' target='_top'>More...</a></p>Regioni | 176 – 207 | 32 | Involved in CASP9 binding | | | Add
BLAST |
| <p>Describes a region of interest that cannot be described in other subsections.</p><p><a href='../manual/region' target='_top'>More...</a></p>Regioni | 177 – 248 | 72 | Involved in GNA13 binding | | | Add
BLAST |
| <p>Describes a region of interest that cannot be described in other subsections.</p><p><a href='../manual/region' target='_top'>More...</a></p>Regioni | 184 – 280 | 97 | Required for localization in sarcoplasmic reticulum | | | Add
BLAST |
| <p>Describes a region of interest that cannot be described in other subsections.</p><p><a href='../manual/region' target='_top'>More...</a></p>Regioni | 185 – 280 | 96 | Involved in PKD2 binding | | | Add
BLAST |
| <p>Describes a region of interest that cannot be described in other subsections.</p><p><a href='../manual/region' target='_top'>More...</a></p>Regioni | 204 – 246 | 43 | Involved in ATP2A2 binding | | | Add
BLAST |
| <p>Describes a region of interest that cannot be described in other subsections.</p><p><a href='../manual/region' target='_top'>More...</a></p>Regioni | 204 – 226 | 23 | Involved in PLN binding | | | Add
BLAST |
| <p>Describes a region of interest that cannot be described in other subsections.</p><p><a href='../manual/region' target='_top'>More...</a></p>Regioni | 271 – 280 | 10 | Required for ITGB6 binding | | | |
Compositional bias
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|
| <p>Describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.</p><p><a href='../manual/compbias' target='_top'>More...</a></p>Compositional biasi | 30 – 44 | 15 | Asp/Glu-rich (highly acidic) | | | Add
BLAST |
<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi
Phylogenomic databases
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evolutionary genealogy of genes: Non-supervised Orthologous Groups<br/><a href='/database/152'>More..</a>eggNOGi | ENOG410IJQ0. Eukaryota.
ENOG411211U. LUCA.
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Ensembl GeneTree<br/><a href='/database/162'>More..</a>GeneTreei | ENSGT00390000018324.
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The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms<br/><a href='/database/44'>More..</a>HOGENOMi | HOG000090247.
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The HOVERGEN Database of Homologous Vertebrate Genes<br/><a href='/database/45'>More..</a>HOVERGENi | HBG002991.
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InParanoid: Eukaryotic Ortholog Groups<br/><a href='/database/146'>More..</a>InParanoidi | O35387.
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KEGG Orthology (KO)<br/><a href='/database/164'>More..</a>KOi | K16220.
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Identification of Orthologs from Complete Genome Data<br/><a href='/database/137'>More..</a>OMAi | PKPAPDW.
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Database of Orthologous Groups<br/><a href='/database/143'>More..</a>OrthoDBi | EOG091G0MK9.
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Database for complete collections of gene phylogenies<br/><a href='/database/144'>More..</a>PhylomeDBi | O35387.
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TreeFam database of animal gene trees<br/><a href='/database/185'>More..</a>TreeFami | TF328619.
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Family and domain databases
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Integrated resource of protein families, domains and functional sites<br/><a href='/database/52'>More..</a>InterProi | IPR017248. HAX-1.
[Graphical view] |
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PIRSF; a whole-protein classification database<br/><a href='/database/79'>More..</a>PIRSFi | PIRSF037634. HS1-associating_X-1. 1 hit.
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<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei
<p>Indicates if the <a href="/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.</p><p><a href='../manual/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.
<p>Indicates if the <a href="/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.</p><p><a href='../manual/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.
Sequence databases
Genome annotation databases
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Ensembl eukaryotic genome annotation project<br/><a href='/database/23'>More..</a>Ensembli | ENSMUST00000079724; ENSMUSP00000078661; ENSMUSG00000027944.
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Database of genes from NCBI RefSeq genomes<br/><a href='/database/118'>More..</a>GeneIDi | 23897.
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KEGG: Kyoto Encyclopedia of Genes and Genomes<br/><a href='/database/53'>More..</a>KEGGi | mmu:23897.
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UCSC genome browser<br/><a href='/database/139'>More..</a>UCSCi | uc008qaj.2. mouse.
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<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi
Sequence databases
3D structure databases
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Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase<br/><a href='/database/159'>More..</a>ProteinModelPortali | O35387.
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Database of comparative protein structure models<br/><a href='/database/63'>More..</a>ModBasei | Search...
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MobiDB: a database of protein disorder and mobility annotations<br/><a href='/database/183'>More..</a>MobiDBi | Search...
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Protein-protein interaction databases
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The Biological General Repository for Interaction Datasets (BioGrid)<br/><a href='/database/184'>More..</a>BioGridi | 204783. 15 interactions.
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Database of interacting proteins<br/><a href='/database/16'>More..</a>DIPi | DIP-49445N.
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Protein interaction database and analysis system<br/><a href='/database/51'>More..</a>IntActi | O35387. 19 interactions.
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Molecular INTeraction database<br/><a href='/database/158'>More..</a>MINTi | MINT-1592061.
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STRING: functional protein association networks<br/><a href='/database/141'>More..</a>STRINGi | 10090.ENSMUSP00000078661.
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PTM databases
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iPTMnet integrated resource for PTMs in systems biology context<br/><a href='/database/200'>More..</a>iPTMneti | O35387.
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Comprehensive resource for the study of human and mouse PTMs<br/><a href='/database/123'>More..</a>PhosphoSitei | O35387.
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Proteomic databases
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Encyclopedia of Proteome Dynamics<br/><a href='/database/205'>More..</a>EPDi | O35387.
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MaxQB - The MaxQuant DataBase<br/><a href='/database/186'>More..</a>MaxQBi | O35387.
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PaxDb, a database of protein abundance averages across all three domains of life<br/><a href='/database/173'>More..</a>PaxDbi | O35387.
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PRoteomics IDEntifications database<br/><a href='/database/130'>More..</a>PRIDEi | O35387.
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Protocols and materials databases
Genome annotation databases
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Ensembl eukaryotic genome annotation project<br/><a href='/database/23'>More..</a>Ensembli | ENSMUST00000079724; ENSMUSP00000078661; ENSMUSG00000027944.
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Database of genes from NCBI RefSeq genomes<br/><a href='/database/118'>More..</a>GeneIDi | 23897.
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KEGG: Kyoto Encyclopedia of Genes and Genomes<br/><a href='/database/53'>More..</a>KEGGi | mmu:23897.
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UCSC genome browser<br/><a href='/database/139'>More..</a>UCSCi | uc008qaj.2. mouse.
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Organism-specific databases
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Comparative Toxicogenomics Database<br/><a href='/database/140'>More..</a>CTDi | 10456.
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Mouse genome database (MGD) from Mouse Genome Informatics (MGI)<br/><a href='/database/60'>More..</a>MGIi | MGI:1346319. Hax1.
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Phylogenomic databases
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evolutionary genealogy of genes: Non-supervised Orthologous Groups<br/><a href='/database/152'>More..</a>eggNOGi | ENOG410IJQ0. Eukaryota.
ENOG411211U. LUCA.
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Ensembl GeneTree<br/><a href='/database/162'>More..</a>GeneTreei | ENSGT00390000018324.
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The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms<br/><a href='/database/44'>More..</a>HOGENOMi | HOG000090247.
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The HOVERGEN Database of Homologous Vertebrate Genes<br/><a href='/database/45'>More..</a>HOVERGENi | HBG002991.
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InParanoid: Eukaryotic Ortholog Groups<br/><a href='/database/146'>More..</a>InParanoidi | O35387.
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KEGG Orthology (KO)<br/><a href='/database/164'>More..</a>KOi | K16220.
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Identification of Orthologs from Complete Genome Data<br/><a href='/database/137'>More..</a>OMAi | PKPAPDW.
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Database of Orthologous Groups<br/><a href='/database/143'>More..</a>OrthoDBi | EOG091G0MK9.
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Database for complete collections of gene phylogenies<br/><a href='/database/144'>More..</a>PhylomeDBi | O35387.
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TreeFam database of animal gene trees<br/><a href='/database/185'>More..</a>TreeFami | TF328619.
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Miscellaneous databases
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Protein Ontology<br/><a href='/database/181'>More..</a>PROi | O35387.
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The Stanford Online Universal Resource for Clones and ESTs<br/><a href='/database/99'>More..</a>SOURCEi | Search...
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Gene expression databases
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Bgee dataBase for Gene Expression Evolution<br/><a href='/database/133'>More..</a>Bgeei | ENSMUSG00000027944.
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CleanEx database of gene expression profiles<br/><a href='/database/8'>More..</a>CleanExi | MM_HAX1.
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ExpressionAtlas, Differential and Baseline Expression<br/><a href='/database/4'>More..</a>ExpressionAtlasi | O35387. baseline.
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Genevisible search portal to normalized and curated expression data from Genevestigator<br/><a href='/database/194'>More..</a>Genevisiblei | O35387. MM.
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Family and domain databases
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Integrated resource of protein families, domains and functional sites<br/><a href='/database/52'>More..</a>InterProi | IPR017248. HAX-1.
[Graphical view] |
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PIRSF; a whole-protein classification database<br/><a href='/database/79'>More..</a>PIRSFi | PIRSF037634. HS1-associating_X-1. 1 hit.
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ProtoNet; Automatic hierarchical classification of proteins<br/><a href='/database/85'>More..</a>ProtoNeti | Search...
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<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi
| <p>Provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.</p><p><a href='../manual/entry_name' target='_top'>More...</a></p>Entry namei | HAX1_MOUSE |
| <p>Provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.</p><p><a href='../manual/accession_numbers' target='_top'>More...</a></p>Accessioni | O35387Primary (citable) accession number: O35387
Secondary accession number(s): Q542F8 |
| <p>Shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="help/canonical_and_isoforms">canonical sequence</a> are also displayed.</p><p><a href='../manual/entry_history' target='_top'>More...</a></p>Entry historyi | | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 | | Last sequence update: | January 1, 1998 | | Last modified: | September 7, 2016 | | This is version 133 of the entry and version 1 of the sequence. [Complete history] |
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| <p>Indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).</p><p><a href='../manual/entry_status' target='_top'>More...</a></p>Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
| Annotation program | Chordata Protein Annotation Program |
<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi
<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
- SIMILARITY comments
Index of protein domains and families
<p>Provides links to the UniProt Reference Clusters (<a href="/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.</p><p><a href='../manual/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
