UniProtKB - O35387 (HAX1_MOUSE)
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Protein
HCLS1-associated protein X-1
Gene
Hax1
Organism
Mus musculus (Mouse)
Status
Functioni
Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.By similarity
GO - Molecular functioni
- interleukin-1 binding Source: MGI
- protein N-terminus binding Source: MGI
GO - Biological processi
- cell surface receptor signaling pathway Source: MGI
- cellular response to cytokine stimulus Source: MGI
- negative regulation of apoptotic process Source: MGI
- positive regulation of actin cytoskeleton reorganization Source: MGI
- positive regulation of granulocyte differentiation Source: MGI
- positive regulation of peptidyl-serine phosphorylation Source: MGI
- positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
- positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
- positive regulation of protein kinase B signaling Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of actin filament polymerization Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: HCLS1-associated protein X-1Alternative name(s): HS1-associating protein X-1 Short name: HAX-1 HS1-binding protein 1 Short name: HSP1BP-1 |
Gene namesi | Name:Hax1 Synonyms:Hs1bp1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1346319 Hax1 |
Subcellular locationi
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus, Sarcoplasmic reticulumPathology & Biotechi
Disruption phenotypei
Mice lacking Hax1 fail to survive longer than 14 weeks, due to a loss of motor coordination and activity, leading to failure to eat and drink. They display extensive apoptosis of neurons in the striatum and cerebellum, and a loss of lymphocytes in spleen, bone marrow and thymus.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000083907 | 2 – 280 | HCLS1-associated protein X-1Add BLAST | 279 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 190 | PhosphoserineBy similarity | 1 | |
Modified residuei | 193 | PhosphoserineBy similarity | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 128 – 129 | Cleavage; by caspase-3By similarity | 2 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | O35387 |
MaxQBi | O35387 |
PaxDbi | O35387 |
PRIDEi | O35387 |
PTM databases
iPTMneti | O35387 |
PhosphoSitePlusi | O35387 |
Expressioni
Tissue specificityi
Ubiquitous, with highest levels in kidney and liver (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000027944 |
CleanExi | MM_HAX1 |
ExpressionAtlasi | O35387 baseline and differential |
Genevisiblei | O35387 MM |
Interactioni
Subunit structurei
Interacts with ABCB1, ABCB4 and ABCB11 (By similarity). Directly associates with HCLS1/HS1, through binding to its N-terminal region (By similarity). Interacts with CTTN (PubMed:10760273). Interacts with PKD2(PubMed:10760273). Interacts with GNA13. Interacts with CASP9. Interacts with ITGB6. Interacts with PLN and ATP2A2; these interactions are inhibited by calcium. Interacts with GRB7. Interacts (via C-terminus) with XIAP/BIRC4 (via BIR 2 domain and BIR 3 domain) and this interaction blocks ubiquitination of XIAP/BIRC4. Interacts with TPC2. Interacts with KCNC3 (PubMed:26997484). Interacts with XPO1 (By similarity).By similarity1 Publication
Binary interactionsi
GO - Molecular functioni
- interleukin-1 binding Source: MGI
- protein N-terminus binding Source: MGI
Protein-protein interaction databases
BioGridi | 20478316 interactors. |
CORUMi | O35387 |
DIPi | DIP-49445N |
IntActi | O35387 21 interactors. |
STRINGi | 10090.ENSMUSP00000078661 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 45 | Required for localization in mitochondriaBy similarityAdd BLAST | 44 | |
Regioni | 115 – 280 | Involved in HCLS1 bindingBy similarityAdd BLAST | 166 | |
Regioni | 176 – 207 | Involved in CASP9 bindingBy similarityAdd BLAST | 32 | |
Regioni | 177 – 248 | Involved in GNA13 bindingBy similarityAdd BLAST | 72 | |
Regioni | 184 – 280 | Required for localization in sarcoplasmic reticulumBy similarityAdd BLAST | 97 | |
Regioni | 185 – 280 | Involved in PKD2 bindingAdd BLAST | 96 | |
Regioni | 204 – 246 | Involved in ATP2A2 bindingBy similarityAdd BLAST | 43 | |
Regioni | 204 – 226 | Involved in PLN bindingBy similarityAdd BLAST | 23 | |
Regioni | 271 – 280 | Required for ITGB6 bindingBy similarity | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 30 – 44 | Asp/Glu-rich (highly acidic)Add BLAST | 15 |
Sequence similaritiesi
Belongs to the HAX1 family.Curated
Phylogenomic databases
eggNOGi | ENOG410IJQ0 Eukaryota ENOG411211U LUCA |
GeneTreei | ENSGT00390000018324 |
HOGENOMi | HOG000090247 |
HOVERGENi | HBG002991 |
InParanoidi | O35387 |
KOi | K16220 |
OMAi | PKPAPDW |
OrthoDBi | EOG091G0MK9 |
PhylomeDBi | O35387 |
TreeFami | TF328619 |
Family and domain databases
InterProi | View protein in InterPro IPR017248 HAX-1 |
PIRSFi | PIRSF037634 HS1-associating_X-1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O35387-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVFDLFRGF FGFPGPRSHR DPFFGGMTRD DDDDDDDDDE AEEDRGAWGR
60 70 80 90 100
ESYAFDGSQP PEEFGFSFSP RGGMRFHGNF GFDDLVRDFN SIFSEMGAWT
110 120 130 140 150
LPSHSPELPG PESETPGERL REGQTLRDSM LKYPDSHQPR IFEGVLESHA
160 170 180 190 200
KPESPKPAPD WGSQGPFHRL DDTWPVSPHS RAKEDKDLDS QVSQEGLGPL
210 220 230 240 250
LQPQPKSYFK SISVTKITKP DGTVEERRTV VDSEGRRETT VTHQEAHDSS
260 270 280
RSDPDSQRSS ALDDPFSILD LLLGRWFRSR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF023482 mRNA Translation: AAB81081.1 AK002256 mRNA Translation: BAB21969.1 AK010633 mRNA Translation: BAB27077.1 AK088746 mRNA Translation: BAC40544.1 BC006688 mRNA Translation: AAH06688.1 BC098225 mRNA Translation: AAH98225.1 |
CCDSi | CCDS17519.1 |
RefSeqi | NP_035956.1, NM_011826.4 |
UniGenei | Mm.256035 Mm.416677 |
Genome annotation databases
Ensembli | ENSMUST00000079724; ENSMUSP00000078661; ENSMUSG00000027944 |
GeneIDi | 23897 |
KEGGi | mmu:23897 |
UCSCi | uc008qaj.2 mouse |
Similar proteinsi
Entry informationi
Entry namei | HAX1_MOUSE | |
Accessioni | O35387Primary (citable) accession number: O35387 Secondary accession number(s): Q542F8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | March 28, 2018 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |