Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O35382 (EXOC4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exocyst complex component 4
Alternative name(s):
Exocyst complex component Sec8
Gene names
Name:Exoc4
Synonyms:Sec8, Sec8l1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length975 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Subunit structure

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 By similarity. Interacts with BIRC6/bruce By similarity. Interacts with MYRIP. Ref.3

Sequence similarities

Belongs to the SEC8 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Exoc7O352502EBI-772648,EBI-775332

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 975974Exocyst complex component 4
PRO_0000118935

Regions

Coiled coil32 – 11483 Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue91N6-acetyllysine By similarity
Modified residue2381Phosphothreonine By similarity

Experimental info

Sequence conflict6921G → A in AAB86537. Ref.1
Sequence conflict7171S → R in AAB86537. Ref.1
Sequence conflict8321S → T in AAB86537. Ref.1
Sequence conflict949 – 97527RLQRL…KITTV → SCRDSRRSSVSRLPSSKPPR TRK in AAB86537. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35382 [UniParc].

Last modified October 25, 2002. Version 2.
Checksum: 8DB5E154FA44E52A

FASTA975110,545
        10         20         30         40         50         60 
MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA YEKCDRDLDE 

        70         80         90        100        110        120 
LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC KMLLHCKRDE LRKLWIEGIE 

       130        140        150        160        170        180 
HKHVLNLLDE IENIKQVPQK LEQCMASKHY LSATDMLVSA VESLEGPLLQ VEGLSDLRLE 

       190        200        210        220        230        240 
LHSKKMNLHL VLIEELHRHL YIKSTSRVVQ RNKEKGKMSS HGKDPSPGPL IDVSNIPTPR 

       250        260        270        280        290        300 
KFLDASQYSA AGGSSVREMN LQDVKEDLEC DPEENSTLFM GILIQGLARL KKIPETVKAI 

       310        320        330        340        350        360 
KERLEQELKQ IVKRSTTQVA DSAYQRGESL TVDNQPRLLL ELLELLFDKF NAVATAHSVV 

       370        380        390        400        410        420 
LGYLQDSVGT QLTQQEEIKL YDMADVWVKI QDVLQMLLTE YLDMKNTRTA SEPSAQLSYA 

       430        440        450        460        470        480 
STGREFAAFF AKKKPQRPKN SLFKFESSSH AISMSAYLRE QRRELYSRSG ELQGGPDDNL 

       490        500        510        520        530        540 
IEGGGTKFVC KPGARNITVI FHPLLRFIQE IEHALGLGPA KQCPLREFLT VYIKSIFLNQ 

       550        560        570        580        590        600 
VLAEINKEIE GVTKTSDPLK ILANADTMKV LGVQRPLLQS TIIVEKTVQD LMNLMHDLSA 

       610        620        630        640        650        660 
YSDQFLNMVC VKLQEYKDTC STAYRGIVQS EEKLVISASW AKDDDISRLL KSLPNWTNMA 

       670        680        690        700        710        720 
QPKQLRPKRE EEEDFIRAAF GKESEVLIGN LGDKLIPPQD ILRDVSDLKA LANMHESLEW 

       730        740        750        760        770        780 
LAGRTKSAFS NLSTSQMLSP AQESHVNMDL PPVSEQIMQT LSELAKTFQD MADRCLLVLH 

       790        800        810        820        830        840 
LEVRVHCFHY LIPLAKEGNY AIVANVESMD YDPLVVKLNK DISAMEEAMS ASLQQHKFQY 

       850        860        870        880        890        900 
IFEGLGHLIS CILINGAQYF RRISESGIKK MCRNIFVLQQ NLTNITMSRE ADLDFARQYY 

       910        920        930        940        950        960 
EMLYNTADEL LNLVVDQGVK YTELEYIHAL TLLHRSQTGV GDQTTQNTRL QRLKEIICEQ 

       970 
AAIKQATKDK KITTV 

« Hide

References

« Hide 'large scale' references
[1]"The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse."
Friedrich G.A., Hildebrand J.D., Soriano P.
Dev. Biol. 192:364-374(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/Sv.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
[3]"MyRIP anchors protein kinase A to the exocyst complex."
Goehring A.S., Pedroja B.S., Hinke S.A., Langeberg L.K., Scott J.D.
J. Biol. Chem. 282:33155-33167(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MYRIP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF022962 mRNA. Translation: AAB86537.1.
BC034644 mRNA. Translation: AAH34644.1.
CCDSCCDS19987.1.
RefSeqNP_033174.2. NM_009148.3.
UniGeneMm.265512.

3D structure databases

ProteinModelPortalO35382.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203152. 2 interactions.
DIPDIP-32368N.
IntActO35382. 10 interactions.
MINTMINT-1897858.

PTM databases

PhosphoSiteO35382.

Proteomic databases

MaxQBO35382.
PaxDbO35382.
PRIDEO35382.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052266; ENSMUSP00000051965; ENSMUSG00000029763.
GeneID20336.
KEGGmmu:20336.
UCSCuc009bgs.1. mouse.

Organism-specific databases

CTD60412.
MGIMGI:1096376. Exoc4.

Phylogenomic databases

eggNOGNOG270077.
GeneTreeENSGT00390000001439.
HOVERGENHBG036151.
InParanoidO35382.
KOK06111.
OMAMQLNILV.
OrthoDBEOG72NRRP.
TreeFamTF313954.

Enzyme and pathway databases

ReactomeREACT_147847. Translocation of Glut4 to the Plasma Membrane.
REACT_209837. Membrane Trafficking.

Gene expression databases

ArrayExpressO35382.
BgeeO35382.
CleanExMM_EXOC4.
GenevestigatorO35382.

Family and domain databases

InterProIPR007191. Sec8_exocyst.
[Graphical view]
PfamPF04048. Sec8_exocyst. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298147.
PROO35382.
SOURCESearch...

Entry information

Entry nameEXOC4_MOUSE
AccessionPrimary (citable) accession number: O35382
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: July 9, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot