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Protein

Exocyst complex component 4

Gene

Exoc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

  1. PDZ domain binding Source: UniProtKB
  2. protein N-terminus binding Source: MGI
  3. Ral GTPase binding Source: MGI

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. vesicle docking involved in exocytosis Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_298481. Insulin processing.
REACT_302653. Translocation of GLUT4 to the plasma membrane.
REACT_315493. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 4
Alternative name(s):
Exocyst complex component Sec8
Gene namesi
Name:Exoc4
Synonyms:Sec8, Sec8l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1096376. Exoc4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. exocyst Source: InterPro
  3. growth cone membrane Source: MGI
  4. membrane Source: MGI
  5. myelin sheath abaxonal region Source: BHF-UCL
  6. plasma membrane Source: Reactome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 975974Exocyst complex component 4PRO_0000118935Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei9 – 91N6-acetyllysineBy similarity
Modified residuei226 – 2261PhosphoserineBy similarity
Modified residuei238 – 2381PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO35382.
PaxDbiO35382.
PRIDEiO35382.

PTM databases

PhosphoSiteiO35382.

Expressioni

Gene expression databases

BgeeiO35382.
CleanExiMM_EXOC4.
ExpressionAtlasiO35382. baseline and differential.
GenevestigatoriO35382.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Exoc7O352502EBI-772648,EBI-775332

Protein-protein interaction databases

BioGridi203152. 2 interactions.
DIPiDIP-32368N.
IntActiO35382. 10 interactions.
MINTiMINT-1897858.

Structurei

3D structure databases

ProteinModelPortaliO35382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili32 – 11483Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SEC8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG270077.
GeneTreeiENSGT00390000001439.
HOVERGENiHBG036151.
InParanoidiO35382.
KOiK06111.
OMAiKEICNTA.
OrthoDBiEOG72NRRP.
TreeFamiTF313954.

Family and domain databases

InterProiIPR007191. Sec8_exocyst.
[Graphical view]
PfamiPF04048. Sec8_exocyst. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA
60 70 80 90 100
YEKCDRDLDE LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC
110 120 130 140 150
KMLLHCKRDE LRKLWIEGIE HKHVLNLLDE IENIKQVPQK LEQCMASKHY
160 170 180 190 200
LSATDMLVSA VESLEGPLLQ VEGLSDLRLE LHSKKMNLHL VLIEELHRHL
210 220 230 240 250
YIKSTSRVVQ RNKEKGKMSS HGKDPSPGPL IDVSNIPTPR KFLDASQYSA
260 270 280 290 300
AGGSSVREMN LQDVKEDLEC DPEENSTLFM GILIQGLARL KKIPETVKAI
310 320 330 340 350
KERLEQELKQ IVKRSTTQVA DSAYQRGESL TVDNQPRLLL ELLELLFDKF
360 370 380 390 400
NAVATAHSVV LGYLQDSVGT QLTQQEEIKL YDMADVWVKI QDVLQMLLTE
410 420 430 440 450
YLDMKNTRTA SEPSAQLSYA STGREFAAFF AKKKPQRPKN SLFKFESSSH
460 470 480 490 500
AISMSAYLRE QRRELYSRSG ELQGGPDDNL IEGGGTKFVC KPGARNITVI
510 520 530 540 550
FHPLLRFIQE IEHALGLGPA KQCPLREFLT VYIKSIFLNQ VLAEINKEIE
560 570 580 590 600
GVTKTSDPLK ILANADTMKV LGVQRPLLQS TIIVEKTVQD LMNLMHDLSA
610 620 630 640 650
YSDQFLNMVC VKLQEYKDTC STAYRGIVQS EEKLVISASW AKDDDISRLL
660 670 680 690 700
KSLPNWTNMA QPKQLRPKRE EEEDFIRAAF GKESEVLIGN LGDKLIPPQD
710 720 730 740 750
ILRDVSDLKA LANMHESLEW LAGRTKSAFS NLSTSQMLSP AQESHVNMDL
760 770 780 790 800
PPVSEQIMQT LSELAKTFQD MADRCLLVLH LEVRVHCFHY LIPLAKEGNY
810 820 830 840 850
AIVANVESMD YDPLVVKLNK DISAMEEAMS ASLQQHKFQY IFEGLGHLIS
860 870 880 890 900
CILINGAQYF RRISESGIKK MCRNIFVLQQ NLTNITMSRE ADLDFARQYY
910 920 930 940 950
EMLYNTADEL LNLVVDQGVK YTELEYIHAL TLLHRSQTGV GDQTTQNTRL
960 970
QRLKEIICEQ AAIKQATKDK KITTV
Length:975
Mass (Da):110,545
Last modified:October 25, 2002 - v2
Checksum:i8DB5E154FA44E52A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti692 – 6921G → A in AAB86537 (PubMed:9441674).Curated
Sequence conflicti717 – 7171S → R in AAB86537 (PubMed:9441674).Curated
Sequence conflicti832 – 8321S → T in AAB86537 (PubMed:9441674).Curated
Sequence conflicti949 – 97527RLQRL…KITTV → SCRDSRRSSVSRLPSSKPPR TRK in AAB86537 (PubMed:9441674).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022962 mRNA. Translation: AAB86537.1.
BC034644 mRNA. Translation: AAH34644.1.
CCDSiCCDS19987.1.
RefSeqiNP_033174.2. NM_009148.3.
UniGeneiMm.265512.

Genome annotation databases

EnsembliENSMUST00000052266; ENSMUSP00000051965; ENSMUSG00000029763.
GeneIDi20336.
KEGGimmu:20336.
UCSCiuc009bgs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022962 mRNA. Translation: AAB86537.1.
BC034644 mRNA. Translation: AAH34644.1.
CCDSiCCDS19987.1.
RefSeqiNP_033174.2. NM_009148.3.
UniGeneiMm.265512.

3D structure databases

ProteinModelPortaliO35382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203152. 2 interactions.
DIPiDIP-32368N.
IntActiO35382. 10 interactions.
MINTiMINT-1897858.

PTM databases

PhosphoSiteiO35382.

Proteomic databases

MaxQBiO35382.
PaxDbiO35382.
PRIDEiO35382.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052266; ENSMUSP00000051965; ENSMUSG00000029763.
GeneIDi20336.
KEGGimmu:20336.
UCSCiuc009bgs.1. mouse.

Organism-specific databases

CTDi60412.
MGIiMGI:1096376. Exoc4.

Phylogenomic databases

eggNOGiNOG270077.
GeneTreeiENSGT00390000001439.
HOVERGENiHBG036151.
InParanoidiO35382.
KOiK06111.
OMAiKEICNTA.
OrthoDBiEOG72NRRP.
TreeFamiTF313954.

Enzyme and pathway databases

ReactomeiREACT_298481. Insulin processing.
REACT_302653. Translocation of GLUT4 to the plasma membrane.
REACT_315493. VxPx cargo-targeting to cilium.

Miscellaneous databases

ChiTaRSiExoc4. mouse.
NextBioi298147.
PROiO35382.
SOURCEiSearch...

Gene expression databases

BgeeiO35382.
CleanExiMM_EXOC4.
ExpressionAtlasiO35382. baseline and differential.
GenevestigatoriO35382.

Family and domain databases

InterProiIPR007191. Sec8_exocyst.
[Graphical view]
PfamiPF04048. Sec8_exocyst. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse."
    Friedrich G.A., Hildebrand J.D., Soriano P.
    Dev. Biol. 192:364-374(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
  3. Cited for: INTERACTION WITH MYRIP.

Entry informationi

Entry nameiEXOC4_MOUSE
AccessioniPrimary (citable) accession number: O35382
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: April 1, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.