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Protein

Exocyst complex component 4

Gene

Exoc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

  • PDZ domain binding Source: UniProtKB
  • protein N-terminus binding Source: MGI
  • Ral GTPase binding Source: MGI

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-264876. Insulin processing.
R-MMU-5620916. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 4
Alternative name(s):
Exocyst complex component Sec8
Gene namesi
Name:Exoc4
Synonyms:Sec8, Sec8l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1096376. Exoc4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001189352 – 975Exocyst complex component 4Add BLAST974

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei9N6-acetyllysineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei238PhosphothreonineBy similarity1
Modified residuei469PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO35382.
MaxQBiO35382.
PaxDbiO35382.
PeptideAtlasiO35382.
PRIDEiO35382.

PTM databases

iPTMnetiO35382.
PhosphoSitePlusiO35382.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029763.
CleanExiMM_EXOC4.
ExpressionAtlasiO35382. baseline and differential.
GenevisibleiO35382. MM.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP. Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Exoc7O352502EBI-772648,EBI-775332

GO - Molecular functioni

  • PDZ domain binding Source: UniProtKB
  • protein N-terminus binding Source: MGI
  • Ral GTPase binding Source: MGI

Protein-protein interaction databases

BioGridi203152. 3 interactors.
DIPiDIP-32368N.
IntActiO35382. 11 interactors.
MINTiMINT-1897858.
STRINGi10090.ENSMUSP00000051965.

Structurei

3D structure databases

ProteinModelPortaliO35382.
SMRiO35382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 114Sequence analysisAdd BLAST83

Sequence similaritiesi

Belongs to the SEC8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3691. Eukaryota.
ENOG410Z8N0. LUCA.
GeneTreeiENSGT00390000001439.
HOVERGENiHBG036151.
InParanoidiO35382.
OMAiKEHRRNA.
OrthoDBiEOG091G0QUY.
TreeFamiTF313954.

Family and domain databases

InterProiView protein in InterPro
IPR007191. Sec8_exocyst.
PfamiView protein in Pfam
PF04048. Sec8_exocyst. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA
60 70 80 90 100
YEKCDRDLDE LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC
110 120 130 140 150
KMLLHCKRDE LRKLWIEGIE HKHVLNLLDE IENIKQVPQK LEQCMASKHY
160 170 180 190 200
LSATDMLVSA VESLEGPLLQ VEGLSDLRLE LHSKKMNLHL VLIEELHRHL
210 220 230 240 250
YIKSTSRVVQ RNKEKGKMSS HGKDPSPGPL IDVSNIPTPR KFLDASQYSA
260 270 280 290 300
AGGSSVREMN LQDVKEDLEC DPEENSTLFM GILIQGLARL KKIPETVKAI
310 320 330 340 350
KERLEQELKQ IVKRSTTQVA DSAYQRGESL TVDNQPRLLL ELLELLFDKF
360 370 380 390 400
NAVATAHSVV LGYLQDSVGT QLTQQEEIKL YDMADVWVKI QDVLQMLLTE
410 420 430 440 450
YLDMKNTRTA SEPSAQLSYA STGREFAAFF AKKKPQRPKN SLFKFESSSH
460 470 480 490 500
AISMSAYLRE QRRELYSRSG ELQGGPDDNL IEGGGTKFVC KPGARNITVI
510 520 530 540 550
FHPLLRFIQE IEHALGLGPA KQCPLREFLT VYIKSIFLNQ VLAEINKEIE
560 570 580 590 600
GVTKTSDPLK ILANADTMKV LGVQRPLLQS TIIVEKTVQD LMNLMHDLSA
610 620 630 640 650
YSDQFLNMVC VKLQEYKDTC STAYRGIVQS EEKLVISASW AKDDDISRLL
660 670 680 690 700
KSLPNWTNMA QPKQLRPKRE EEEDFIRAAF GKESEVLIGN LGDKLIPPQD
710 720 730 740 750
ILRDVSDLKA LANMHESLEW LAGRTKSAFS NLSTSQMLSP AQESHVNMDL
760 770 780 790 800
PPVSEQIMQT LSELAKTFQD MADRCLLVLH LEVRVHCFHY LIPLAKEGNY
810 820 830 840 850
AIVANVESMD YDPLVVKLNK DISAMEEAMS ASLQQHKFQY IFEGLGHLIS
860 870 880 890 900
CILINGAQYF RRISESGIKK MCRNIFVLQQ NLTNITMSRE ADLDFARQYY
910 920 930 940 950
EMLYNTADEL LNLVVDQGVK YTELEYIHAL TLLHRSQTGV GDQTTQNTRL
960 970
QRLKEIICEQ AAIKQATKDK KITTV
Length:975
Mass (Da):110,545
Last modified:October 25, 2002 - v2
Checksum:i8DB5E154FA44E52A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti692G → A in AAB86537 (PubMed:9441674).Curated1
Sequence conflicti717S → R in AAB86537 (PubMed:9441674).Curated1
Sequence conflicti832S → T in AAB86537 (PubMed:9441674).Curated1
Sequence conflicti949 – 975RLQRL…KITTV → SCRDSRRSSVSRLPSSKPPR TRK in AAB86537 (PubMed:9441674).CuratedAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022962 mRNA. Translation: AAB86537.1.
BC034644 mRNA. Translation: AAH34644.1.
CCDSiCCDS19987.1.
RefSeqiNP_033174.2. NM_009148.3.
UniGeneiMm.265512.

Genome annotation databases

EnsembliENSMUST00000052266; ENSMUSP00000051965; ENSMUSG00000029763.
GeneIDi20336.
UCSCiuc009bgs.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiEXOC4_MOUSE
AccessioniPrimary (citable) accession number: O35382
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: November 22, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families