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O35382

- EXOC4_MOUSE

UniProt

O35382 - EXOC4_MOUSE

Protein

Exocyst complex component 4

Gene

Exoc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (25 Oct 2002)
      Previous versions | rss
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    Functioni

    Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

    GO - Molecular functioni

    1. PDZ domain binding Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. vesicle docking involved in exocytosis Source: InterPro

    Keywords - Biological processi

    Exocytosis, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_199054. Translocation of GLUT4 to the plasma membrane.
    REACT_207837. Insulin processing.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exocyst complex component 4
    Alternative name(s):
    Exocyst complex component Sec8
    Gene namesi
    Name:Exoc4
    Synonyms:Sec8, Sec8l1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1096376. Exoc4.

    Subcellular locationi

    GO - Cellular componenti

    1. exocyst Source: InterPro
    2. growth cone membrane Source: MGI
    3. myelin sheath abaxonal region Source: BHF-UCL
    4. plasma membrane Source: Reactome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 975974Exocyst complex component 4PRO_0000118935Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei9 – 91N6-acetyllysineBy similarity
    Modified residuei238 – 2381PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO35382.
    PaxDbiO35382.
    PRIDEiO35382.

    PTM databases

    PhosphoSiteiO35382.

    Expressioni

    Gene expression databases

    ArrayExpressiO35382.
    BgeeiO35382.
    CleanExiMM_EXOC4.
    GenevestigatoriO35382.

    Interactioni

    Subunit structurei

    The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 By similarity. Interacts with BIRC6/bruce By similarity. Interacts with MYRIP.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Exoc7O352502EBI-772648,EBI-775332

    Protein-protein interaction databases

    BioGridi203152. 2 interactions.
    DIPiDIP-32368N.
    IntActiO35382. 10 interactions.
    MINTiMINT-1897858.

    Structurei

    3D structure databases

    ProteinModelPortaliO35382.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili32 – 11483Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SEC8 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG270077.
    GeneTreeiENSGT00390000001439.
    HOVERGENiHBG036151.
    InParanoidiO35382.
    KOiK06111.
    OMAiMQLNILV.
    OrthoDBiEOG72NRRP.
    TreeFamiTF313954.

    Family and domain databases

    InterProiIPR007191. Sec8_exocyst.
    [Graphical view]
    PfamiPF04048. Sec8_exocyst. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35382-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAEAAGGKY RSTVSKSKDP SGLLISVIRT LSTSDDVEDR ENEKGRLEEA    50
    YEKCDRDLDE LIVQHYTELT TAIRTYQSIT ERITNSRNKI KQVKENLLSC 100
    KMLLHCKRDE LRKLWIEGIE HKHVLNLLDE IENIKQVPQK LEQCMASKHY 150
    LSATDMLVSA VESLEGPLLQ VEGLSDLRLE LHSKKMNLHL VLIEELHRHL 200
    YIKSTSRVVQ RNKEKGKMSS HGKDPSPGPL IDVSNIPTPR KFLDASQYSA 250
    AGGSSVREMN LQDVKEDLEC DPEENSTLFM GILIQGLARL KKIPETVKAI 300
    KERLEQELKQ IVKRSTTQVA DSAYQRGESL TVDNQPRLLL ELLELLFDKF 350
    NAVATAHSVV LGYLQDSVGT QLTQQEEIKL YDMADVWVKI QDVLQMLLTE 400
    YLDMKNTRTA SEPSAQLSYA STGREFAAFF AKKKPQRPKN SLFKFESSSH 450
    AISMSAYLRE QRRELYSRSG ELQGGPDDNL IEGGGTKFVC KPGARNITVI 500
    FHPLLRFIQE IEHALGLGPA KQCPLREFLT VYIKSIFLNQ VLAEINKEIE 550
    GVTKTSDPLK ILANADTMKV LGVQRPLLQS TIIVEKTVQD LMNLMHDLSA 600
    YSDQFLNMVC VKLQEYKDTC STAYRGIVQS EEKLVISASW AKDDDISRLL 650
    KSLPNWTNMA QPKQLRPKRE EEEDFIRAAF GKESEVLIGN LGDKLIPPQD 700
    ILRDVSDLKA LANMHESLEW LAGRTKSAFS NLSTSQMLSP AQESHVNMDL 750
    PPVSEQIMQT LSELAKTFQD MADRCLLVLH LEVRVHCFHY LIPLAKEGNY 800
    AIVANVESMD YDPLVVKLNK DISAMEEAMS ASLQQHKFQY IFEGLGHLIS 850
    CILINGAQYF RRISESGIKK MCRNIFVLQQ NLTNITMSRE ADLDFARQYY 900
    EMLYNTADEL LNLVVDQGVK YTELEYIHAL TLLHRSQTGV GDQTTQNTRL 950
    QRLKEIICEQ AAIKQATKDK KITTV 975
    Length:975
    Mass (Da):110,545
    Last modified:October 25, 2002 - v2
    Checksum:i8DB5E154FA44E52A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti692 – 6921G → A in AAB86537. (PubMed:9441674)Curated
    Sequence conflicti717 – 7171S → R in AAB86537. (PubMed:9441674)Curated
    Sequence conflicti832 – 8321S → T in AAB86537. (PubMed:9441674)Curated
    Sequence conflicti949 – 97527RLQRL…KITTV → SCRDSRRSSVSRLPSSKPPR TRK in AAB86537. (PubMed:9441674)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022962 mRNA. Translation: AAB86537.1.
    BC034644 mRNA. Translation: AAH34644.1.
    CCDSiCCDS19987.1.
    RefSeqiNP_033174.2. NM_009148.3.
    UniGeneiMm.265512.

    Genome annotation databases

    EnsembliENSMUST00000052266; ENSMUSP00000051965; ENSMUSG00000029763.
    GeneIDi20336.
    KEGGimmu:20336.
    UCSCiuc009bgs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022962 mRNA. Translation: AAB86537.1 .
    BC034644 mRNA. Translation: AAH34644.1 .
    CCDSi CCDS19987.1.
    RefSeqi NP_033174.2. NM_009148.3.
    UniGenei Mm.265512.

    3D structure databases

    ProteinModelPortali O35382.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203152. 2 interactions.
    DIPi DIP-32368N.
    IntActi O35382. 10 interactions.
    MINTi MINT-1897858.

    PTM databases

    PhosphoSitei O35382.

    Proteomic databases

    MaxQBi O35382.
    PaxDbi O35382.
    PRIDEi O35382.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052266 ; ENSMUSP00000051965 ; ENSMUSG00000029763 .
    GeneIDi 20336.
    KEGGi mmu:20336.
    UCSCi uc009bgs.1. mouse.

    Organism-specific databases

    CTDi 60412.
    MGIi MGI:1096376. Exoc4.

    Phylogenomic databases

    eggNOGi NOG270077.
    GeneTreei ENSGT00390000001439.
    HOVERGENi HBG036151.
    InParanoidi O35382.
    KOi K06111.
    OMAi MQLNILV.
    OrthoDBi EOG72NRRP.
    TreeFami TF313954.

    Enzyme and pathway databases

    Reactomei REACT_199054. Translocation of GLUT4 to the plasma membrane.
    REACT_207837. Insulin processing.

    Miscellaneous databases

    NextBioi 298147.
    PROi O35382.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35382.
    Bgeei O35382.
    CleanExi MM_EXOC4.
    Genevestigatori O35382.

    Family and domain databases

    InterProi IPR007191. Sec8_exocyst.
    [Graphical view ]
    Pfami PF04048. Sec8_exocyst. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse."
      Friedrich G.A., Hildebrand J.D., Soriano P.
      Dev. Biol. 192:364-374(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
    3. Cited for: INTERACTION WITH MYRIP.

    Entry informationi

    Entry nameiEXOC4_MOUSE
    AccessioniPrimary (citable) accession number: O35382
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: October 25, 2002
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3