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O35379

- MRP1_MOUSE

UniProt

O35379 - MRP1_MOUSE

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Protein

Multidrug resistance-associated protein 1

Gene

Abcc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi678 – 6858ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1324 – 13318ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_189118. Cobalamin (Cbl, vitamin B12) transport and metabolism.
REACT_215561. Synthesis of Leukotrienes (LT) and Eoxins (EX).
REACT_237882. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 1
Alternative name(s):
ATP-binding cassette sub-family C member 1
Leukotriene C(4) transporter
Short name:
LTC4 transporter
Gene namesi
Name:Abcc1
Synonyms:Abcc1a, Abcc1b, Mdrap, Mrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:102676. Abcc1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularBy similarityAdd
BLAST
Transmembranei34 – 5421Helical; Name=1PROSITE-ProRule annotationAdd
BLAST
Topological domaini55 – 7420CytoplasmicBy similarityAdd
BLAST
Transmembranei75 – 9521Helical; Name=2PROSITE-ProRule annotationAdd
BLAST
Topological domaini96 – 1005ExtracellularBy similarity
Transmembranei101 – 12121Helical; Name=3PROSITE-ProRule annotationAdd
BLAST
Topological domaini122 – 13312CytoplasmicBy similarityAdd
BLAST
Transmembranei134 – 15421Helical; Name=4PROSITE-ProRule annotationAdd
BLAST
Topological domaini155 – 17218ExtracellularBy similarityAdd
BLAST
Transmembranei173 – 19321Helical; Name=5PROSITE-ProRule annotationAdd
BLAST
Topological domaini194 – 317124CytoplasmicBy similarityAdd
BLAST
Transmembranei318 – 33821Helical; Name=6PROSITE-ProRule annotationAdd
BLAST
Topological domaini339 – 36426ExtracellularBy similarityAdd
BLAST
Transmembranei365 – 38521Helical; Name=7PROSITE-ProRule annotationAdd
BLAST
Topological domaini386 – 44156CytoplasmicBy similarityAdd
BLAST
Transmembranei442 – 46221Helical; Name=8PROSITE-ProRule annotationAdd
BLAST
Topological domaini463 – 4653ExtracellularBy similarity
Transmembranei466 – 48621Helical; Name=9PROSITE-ProRule annotationAdd
BLAST
Topological domaini487 – 54862CytoplasmicBy similarityAdd
BLAST
Transmembranei549 – 56921Helical; Name=10PROSITE-ProRule annotationAdd
BLAST
Topological domaini570 – 59122ExtracellularBy similarityAdd
BLAST
Transmembranei592 – 61221Helical; Name=11PROSITE-ProRule annotationAdd
BLAST
Topological domaini613 – 963351CytoplasmicBy similarityAdd
BLAST
Transmembranei964 – 98421Helical; Name=12PROSITE-ProRule annotationAdd
BLAST
Topological domaini985 – 102238ExtracellularBy similarityAdd
BLAST
Transmembranei1023 – 104321Helical; Name=13PROSITE-ProRule annotationAdd
BLAST
Topological domaini1044 – 108643CytoplasmicBy similarityAdd
BLAST
Transmembranei1087 – 110721Helical; Name=14PROSITE-ProRule annotationAdd
BLAST
Topological domaini1108 – 11081ExtracellularBy similarity
Transmembranei1109 – 112921Helical; Name=15PROSITE-ProRule annotationAdd
BLAST
Topological domaini1130 – 120071CytoplasmicBy similarityAdd
BLAST
Transmembranei1201 – 122121Helical; Name=16PROSITE-ProRule annotationAdd
BLAST
Topological domaini1222 – 12232ExtracellularBy similarity
Transmembranei1224 – 124421Helical; Name=17PROSITE-ProRule annotationAdd
BLAST
Topological domaini1245 – 1528284CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15281528Multidrug resistance-associated protein 1PRO_0000093353Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Modified residuei504 – 5041N6-succinyllysine1 Publication
Modified residuei878 – 8781Phosphoserine1 Publication
Modified residuei882 – 8821Phosphoserine1 Publication
Modified residuei912 – 9121PhosphoserineBy similarity
Modified residuei927 – 9271PhosphoserineBy similarity
Glycosylationi1003 – 10031N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO35379.
PaxDbiO35379.
PRIDEiO35379.

PTM databases

PhosphoSiteiO35379.

Expressioni

Gene expression databases

BgeeiO35379.
ExpressionAtlasiO35379. baseline and differential.
GenevestigatoriO35379.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097743.

Structurei

3D structure databases

ProteinModelPortaliO35379.
SMRiO35379. Positions 418-905, 955-1525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini326 – 609284ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini644 – 868225ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini971 – 1253283ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1290 – 1524235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00770000120479.
HOVERGENiHBG108314.
InParanoidiO35379.
KOiK05665.
OMAiLIQCERR.
OrthoDBiEOG7MWGW0.
PhylomeDBiO35379.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35379-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALRSFCSAD GSDPLWDWNV TWHTSNPDFT KCFQNTVLTW VPCFYLWSCF
60 70 80 90 100
PLYFFYLSRH DRGYIQMTHL NKTKTALGFF LWIICWADLF YSFWERSQGV
110 120 130 140 150
LRAPVLLVSP TLLGITMLLA TFLIQLERRK GVQSSGIMLT FWLVALLCAL
160 170 180 190 200
AILRSKIISA LKKDAHVDVF RDSTFYLYFT LVLVQLVLSC FSDCSPLFSE
210 220 230 240 250
TVHDRNPCPE SSASFLSRIT FWWITGMMVH GYRQPLESSD LWSLNKEDTS
260 270 280 290 300
EEVVPVLVNN WKKECDKSRK QPVRIVYAPP KDPSKPKGSS QLDVNEEVEA
310 320 330 340 350
LIVKSPHKDR EPSLFKVLYK TFGPYFLMSF LYKALHDLMM FAGPKILELI
360 370 380 390 400
INFVNDREAP DWQGYFYTAL LFVSACLQTL ALHQYFHICF VSGMRIKTAV
410 420 430 440 450
VGAVYRKALL ITNAARKSST VGEIVNLMSV DAQRFMDLAT YINMIWSAPL
460 470 480 490 500
QVILALYFLW LSLGPSVLAG VAVMILMVPL NAVMAMKTKT YQVAHMKSKD
510 520 530 540 550
NRIKLMNEIL NGIKVLKLYA WELAFQDKVM SIRQEELKVL KKSAYLAAVG
560 570 580 590 600
TFTWVCTPFL VALSTFAVFV TVDERNILDA KKAFVSLALF NILRFPLNIL
610 620 630 640 650
PMVISSIVQA SVSLKRLRIF LSHEELEPDS IERRSIKSGE GNSITVKNAT
660 670 680 690 700
FTWARGEPPT LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG
710 720 730 740 750
HVTLKGSVAY VPQQAWIQND SLRENILFGH PLQENYYKAV MEACALLPDL
760 770 780 790 800
EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYSNSDIYL FDDPLSAVDA
810 820 830 840 850
HVGKHIFEKV VGPMGLLKNK TRILVTHGIS YLPQVDVIIV MSGGKISEMG
860 870 880 890 900
SYQELLDRDG AFAEFLRTYA NAEQDLASED DSVSGSGKES KPVENGMLVT
910 920 930 940 950
DTVGKHLQRH LSNSSSHSGD TSQQHSSIAE LQKAGAKEET WKLMEADKAQ
960 970 980 990 1000
TGQVQLSVYW NYMKAIGLFI TFLSIFLFLC NHVSALASNY WLSLWTDDPP
1010 1020 1030 1040 1050
VVNGTQANRN FRLSVYGALG ILQGAAIFGY SMAVSIGGIF ASRRLHLDLL
1060 1070 1080 1090 1100
YNVLRSPMSF FERTPSGNLV NRFSKELDTV DSMIPQVIKM FMGSLFSVIG
1110 1120 1130 1140 1150
AVIIILLATP IAAVIIPPLG LVYFFVQRFY VASSRQLKRL ESVSRSPVYS
1160 1170 1180 1190 1200
HFNETLLGVS VIRAFEEQER FIHQSDLKVD ENQKAYYPSI VANRWLAVRL
1210 1220 1230 1240 1250
ECVGNCIVLF AALFAVISRH SLSAGLVGLS VSYSLQITAY LNWLVRMSSE
1260 1270 1280 1290 1300
METNIVAVER LKEYSETEKE APWQIQETAP PSTWPHSGRV EFRDYCLRYR
1310 1320 1330 1340 1350
EDLDLVLKHI NVTIEGGEKV GIVGRTGAGK SSLTLGLFRI NESAEGEIII
1360 1370 1380 1390 1400
DGVNIAKIGL HNLRFKITII PQDPVLFSGS LRMNLDPFSQ YSDEEVWMAL
1410 1420 1430 1440 1450
ELAHLKGFVS ALPDKLNHEC AEGGENLSVG QRQLVCLARA LLRKTKILVL
1460 1470 1480 1490 1500
DEATAAVDLE TDNLIQSTIR TQFEDCTVLT IAHRLNTIMD YTRVIVLDKG
1510 1520
EVRECGAPSE LLQQRGIFYS MAKDAGLV
Length:1,528
Mass (Da):171,185
Last modified:January 1, 1998 - v1
Checksum:i68FD13667D61DBBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022908 mRNA. Translation: AAB80938.1.
AK029876 mRNA. Translation: BAC26654.1.
CCDSiCCDS37264.1.
RefSeqiNP_032602.1. NM_008576.3.
UniGeneiMm.196634.

Genome annotation databases

EnsembliENSMUST00000100167; ENSMUSP00000097743; ENSMUSG00000023088.
GeneIDi17250.
KEGGimmu:17250.
UCSCiuc007yhj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022908 mRNA. Translation: AAB80938.1 .
AK029876 mRNA. Translation: BAC26654.1 .
CCDSi CCDS37264.1.
RefSeqi NP_032602.1. NM_008576.3.
UniGenei Mm.196634.

3D structure databases

ProteinModelPortali O35379.
SMRi O35379. Positions 418-905, 955-1525.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000097743.

Chemistry

BindingDBi O35379.
ChEMBLi CHEMBL2532.

PTM databases

PhosphoSitei O35379.

Proteomic databases

MaxQBi O35379.
PaxDbi O35379.
PRIDEi O35379.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000100167 ; ENSMUSP00000097743 ; ENSMUSG00000023088 .
GeneIDi 17250.
KEGGi mmu:17250.
UCSCi uc007yhj.2. mouse.

Organism-specific databases

CTDi 4363.
MGIi MGI:102676. Abcc1.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00770000120479.
HOVERGENi HBG108314.
InParanoidi O35379.
KOi K05665.
OMAi LIQCERR.
OrthoDBi EOG7MWGW0.
PhylomeDBi O35379.
TreeFami TF105199.

Enzyme and pathway databases

Reactomei REACT_189118. Cobalamin (Cbl, vitamin B12) transport and metabolism.
REACT_215561. Synthesis of Leukotrienes (LT) and Eoxins (EX).
REACT_237882. ABC-family proteins mediated transport.

Miscellaneous databases

NextBioi 291714.
PROi O35379.
SOURCEi Search...

Gene expression databases

Bgeei O35379.
ExpressionAtlasi O35379. baseline and differential.
Genevestigatori O35379.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter."
    Stride B.D., Valdimarsson G., Gerlach J.H., Wilson G.M., Cole S.P.C., Deeley R.G.
    Mol. Pharmacol. 49:962-971(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Muscle.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells."
    Stride B.D., Grant C.E., Loe D.W., Hipfner D.R., Cole S.P.C., Deeley R.G.
    Mol. Pharmacol. 52:344-353(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-878 AND SER-882, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-504, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMRP1_MOUSE
AccessioniPrimary (citable) accession number: O35379
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3