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O35379

- MRP1_MOUSE

UniProt

O35379 - MRP1_MOUSE

Protein

Multidrug resistance-associated protein 1

Gene

Abcc1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi678 – 6858ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1324 – 13318ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_189118. Cobalamin (Cbl, vitamin B12) transport and metabolism.
    REACT_215561. Synthesis of Leukotrienes (LT) and Eoxins (EX).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug resistance-associated protein 1
    Alternative name(s):
    ATP-binding cassette sub-family C member 1
    Leukotriene C(4) transporter
    Short name:
    LTC4 transporter
    Gene namesi
    Name:Abcc1
    Synonyms:Abcc1a, Abcc1b, Mdrap, Mrp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:102676. Abcc1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. integral component of plasma membrane Source: MGI
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15281528Multidrug resistance-associated protein 1PRO_0000093353Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Modified residuei504 – 5041N6-succinyllysine1 Publication
    Modified residuei878 – 8781Phosphoserine1 Publication
    Modified residuei882 – 8821Phosphoserine1 Publication
    Modified residuei912 – 9121PhosphoserineBy similarity
    Modified residuei927 – 9271PhosphoserineBy similarity
    Glycosylationi1003 – 10031N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO35379.
    PaxDbiO35379.
    PRIDEiO35379.

    PTM databases

    PhosphoSiteiO35379.

    Expressioni

    Gene expression databases

    ArrayExpressiO35379.
    BgeeiO35379.
    GenevestigatoriO35379.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000097743.

    Structurei

    3D structure databases

    ProteinModelPortaliO35379.
    SMRiO35379. Positions 418-905, 969-1525.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularBy similarityAdd
    BLAST
    Topological domaini55 – 7420CytoplasmicBy similarityAdd
    BLAST
    Topological domaini96 – 1005ExtracellularBy similarity
    Topological domaini122 – 13312CytoplasmicBy similarityAdd
    BLAST
    Topological domaini155 – 17218ExtracellularBy similarityAdd
    BLAST
    Topological domaini194 – 317124CytoplasmicBy similarityAdd
    BLAST
    Topological domaini339 – 36426ExtracellularBy similarityAdd
    BLAST
    Topological domaini386 – 44156CytoplasmicBy similarityAdd
    BLAST
    Topological domaini463 – 4653ExtracellularBy similarity
    Topological domaini487 – 54862CytoplasmicBy similarityAdd
    BLAST
    Topological domaini570 – 59122ExtracellularBy similarityAdd
    BLAST
    Topological domaini613 – 963351CytoplasmicBy similarityAdd
    BLAST
    Topological domaini985 – 102238ExtracellularBy similarityAdd
    BLAST
    Topological domaini1044 – 108643CytoplasmicBy similarityAdd
    BLAST
    Topological domaini1108 – 11081ExtracellularBy similarity
    Topological domaini1130 – 120071CytoplasmicBy similarityAdd
    BLAST
    Topological domaini1222 – 12232ExtracellularBy similarity
    Topological domaini1245 – 1528284CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421Helical; Name=1PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei75 – 9521Helical; Name=2PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei134 – 15421Helical; Name=4PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei173 – 19321Helical; Name=5PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei318 – 33821Helical; Name=6PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei365 – 38521Helical; Name=7PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei442 – 46221Helical; Name=8PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei466 – 48621Helical; Name=9PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei549 – 56921Helical; Name=10PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei592 – 61221Helical; Name=11PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei964 – 98421Helical; Name=12PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1023 – 104321Helical; Name=13PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1087 – 110721Helical; Name=14PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1109 – 112921Helical; Name=15PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1201 – 122121Helical; Name=16PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1224 – 124421Helical; Name=17PROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini326 – 609284ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini644 – 868225ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini971 – 1253283ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1290 – 1524235ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    GeneTreeiENSGT00750000117309.
    HOVERGENiHBG108314.
    InParanoidiO35379.
    KOiK05665.
    OMAiLIQCERR.
    OrthoDBiEOG7MWGW0.
    PhylomeDBiO35379.
    TreeFamiTF105199.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005292. Multidrug-R_assoc.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35379-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALRSFCSAD GSDPLWDWNV TWHTSNPDFT KCFQNTVLTW VPCFYLWSCF     50
    PLYFFYLSRH DRGYIQMTHL NKTKTALGFF LWIICWADLF YSFWERSQGV 100
    LRAPVLLVSP TLLGITMLLA TFLIQLERRK GVQSSGIMLT FWLVALLCAL 150
    AILRSKIISA LKKDAHVDVF RDSTFYLYFT LVLVQLVLSC FSDCSPLFSE 200
    TVHDRNPCPE SSASFLSRIT FWWITGMMVH GYRQPLESSD LWSLNKEDTS 250
    EEVVPVLVNN WKKECDKSRK QPVRIVYAPP KDPSKPKGSS QLDVNEEVEA 300
    LIVKSPHKDR EPSLFKVLYK TFGPYFLMSF LYKALHDLMM FAGPKILELI 350
    INFVNDREAP DWQGYFYTAL LFVSACLQTL ALHQYFHICF VSGMRIKTAV 400
    VGAVYRKALL ITNAARKSST VGEIVNLMSV DAQRFMDLAT YINMIWSAPL 450
    QVILALYFLW LSLGPSVLAG VAVMILMVPL NAVMAMKTKT YQVAHMKSKD 500
    NRIKLMNEIL NGIKVLKLYA WELAFQDKVM SIRQEELKVL KKSAYLAAVG 550
    TFTWVCTPFL VALSTFAVFV TVDERNILDA KKAFVSLALF NILRFPLNIL 600
    PMVISSIVQA SVSLKRLRIF LSHEELEPDS IERRSIKSGE GNSITVKNAT 650
    FTWARGEPPT LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG 700
    HVTLKGSVAY VPQQAWIQND SLRENILFGH PLQENYYKAV MEACALLPDL 750
    EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYSNSDIYL FDDPLSAVDA 800
    HVGKHIFEKV VGPMGLLKNK TRILVTHGIS YLPQVDVIIV MSGGKISEMG 850
    SYQELLDRDG AFAEFLRTYA NAEQDLASED DSVSGSGKES KPVENGMLVT 900
    DTVGKHLQRH LSNSSSHSGD TSQQHSSIAE LQKAGAKEET WKLMEADKAQ 950
    TGQVQLSVYW NYMKAIGLFI TFLSIFLFLC NHVSALASNY WLSLWTDDPP 1000
    VVNGTQANRN FRLSVYGALG ILQGAAIFGY SMAVSIGGIF ASRRLHLDLL 1050
    YNVLRSPMSF FERTPSGNLV NRFSKELDTV DSMIPQVIKM FMGSLFSVIG 1100
    AVIIILLATP IAAVIIPPLG LVYFFVQRFY VASSRQLKRL ESVSRSPVYS 1150
    HFNETLLGVS VIRAFEEQER FIHQSDLKVD ENQKAYYPSI VANRWLAVRL 1200
    ECVGNCIVLF AALFAVISRH SLSAGLVGLS VSYSLQITAY LNWLVRMSSE 1250
    METNIVAVER LKEYSETEKE APWQIQETAP PSTWPHSGRV EFRDYCLRYR 1300
    EDLDLVLKHI NVTIEGGEKV GIVGRTGAGK SSLTLGLFRI NESAEGEIII 1350
    DGVNIAKIGL HNLRFKITII PQDPVLFSGS LRMNLDPFSQ YSDEEVWMAL 1400
    ELAHLKGFVS ALPDKLNHEC AEGGENLSVG QRQLVCLARA LLRKTKILVL 1450
    DEATAAVDLE TDNLIQSTIR TQFEDCTVLT IAHRLNTIMD YTRVIVLDKG 1500
    EVRECGAPSE LLQQRGIFYS MAKDAGLV 1528
    Length:1,528
    Mass (Da):171,185
    Last modified:January 1, 1998 - v1
    Checksum:i68FD13667D61DBBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022908 mRNA. Translation: AAB80938.1.
    AK029876 mRNA. Translation: BAC26654.1.
    CCDSiCCDS37264.1.
    RefSeqiNP_032602.1. NM_008576.3.
    UniGeneiMm.196634.

    Genome annotation databases

    EnsembliENSMUST00000100167; ENSMUSP00000097743; ENSMUSG00000023088.
    GeneIDi17250.
    KEGGimmu:17250.
    UCSCiuc007yhj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022908 mRNA. Translation: AAB80938.1 .
    AK029876 mRNA. Translation: BAC26654.1 .
    CCDSi CCDS37264.1.
    RefSeqi NP_032602.1. NM_008576.3.
    UniGenei Mm.196634.

    3D structure databases

    ProteinModelPortali O35379.
    SMRi O35379. Positions 418-905, 969-1525.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000097743.

    Chemistry

    BindingDBi O35379.
    ChEMBLi CHEMBL2532.

    PTM databases

    PhosphoSitei O35379.

    Proteomic databases

    MaxQBi O35379.
    PaxDbi O35379.
    PRIDEi O35379.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000100167 ; ENSMUSP00000097743 ; ENSMUSG00000023088 .
    GeneIDi 17250.
    KEGGi mmu:17250.
    UCSCi uc007yhj.2. mouse.

    Organism-specific databases

    CTDi 4363.
    MGIi MGI:102676. Abcc1.

    Phylogenomic databases

    eggNOGi COG1132.
    GeneTreei ENSGT00750000117309.
    HOVERGENi HBG108314.
    InParanoidi O35379.
    KOi K05665.
    OMAi LIQCERR.
    OrthoDBi EOG7MWGW0.
    PhylomeDBi O35379.
    TreeFami TF105199.

    Enzyme and pathway databases

    Reactomei REACT_189118. Cobalamin (Cbl, vitamin B12) transport and metabolism.
    REACT_215561. Synthesis of Leukotrienes (LT) and Eoxins (EX).

    Miscellaneous databases

    NextBioi 291714.
    PROi O35379.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35379.
    Bgeei O35379.
    Genevestigatori O35379.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005292. Multidrug-R_assoc.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter."
      Stride B.D., Valdimarsson G., Gerlach J.H., Wilson G.M., Cole S.P.C., Deeley R.G.
      Mol. Pharmacol. 49:962-971(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Muscle.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells."
      Stride B.D., Grant C.E., Loe D.W., Hipfner D.R., Cole S.P.C., Deeley R.G.
      Mol. Pharmacol. 52:344-353(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-878 AND SER-882, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-504, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiMRP1_MOUSE
    AccessioniPrimary (citable) accession number: O35379
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3