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Protein

Multidrug resistance-associated protein 1

Gene

Abcc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi678 – 685ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1324 – 1331ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.
R-MMU-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX).
R-MMU-382556. ABC-family proteins mediated transport.

Chemistry databases

SwissLipidsiSLP:000000463.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 1
Alternative name(s):
ATP-binding cassette sub-family C member 1
Leukotriene C(4) transporter
Short name:
LTC4 transporter
Gene namesi
Name:Abcc1
Synonyms:Abcc1a, Abcc1b, Mdrap, Mrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:102676. Abcc1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
Transmembranei34 – 54Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini55 – 74CytoplasmicBy similarityAdd BLAST20
Transmembranei75 – 95Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini96 – 100ExtracellularBy similarity5
Transmembranei101 – 121Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini122 – 133CytoplasmicBy similarityAdd BLAST12
Transmembranei134 – 154Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini155 – 172ExtracellularBy similarityAdd BLAST18
Transmembranei173 – 193Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini194 – 317CytoplasmicBy similarityAdd BLAST124
Transmembranei318 – 338Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini339 – 364ExtracellularBy similarityAdd BLAST26
Transmembranei365 – 385Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini386 – 441CytoplasmicBy similarityAdd BLAST56
Transmembranei442 – 462Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini463 – 465ExtracellularBy similarity3
Transmembranei466 – 486Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini487 – 548CytoplasmicBy similarityAdd BLAST62
Transmembranei549 – 569Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini570 – 591ExtracellularBy similarityAdd BLAST22
Transmembranei592 – 612Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini613 – 963CytoplasmicBy similarityAdd BLAST351
Transmembranei964 – 984Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini985 – 1022ExtracellularBy similarityAdd BLAST38
Transmembranei1023 – 1043Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1044 – 1086CytoplasmicBy similarityAdd BLAST43
Transmembranei1087 – 1107Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1108ExtracellularBy similarity1
Transmembranei1109 – 1129Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1130 – 1200CytoplasmicBy similarityAdd BLAST71
Transmembranei1201 – 1221Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1222 – 1223ExtracellularBy similarity2
Transmembranei1224 – 1244Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1245 – 1528CytoplasmicBy similarityAdd BLAST284

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2532.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933531 – 1528Multidrug resistance-associated protein 1Add BLAST1528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Modified residuei277PhosphotyrosineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei504N6-succinyllysineCombined sources1
Modified residuei878PhosphoserineCombined sources1
Modified residuei882PhosphoserineCombined sources1
Modified residuei912PhosphoserineBy similarity1
Modified residuei927PhosphoserineBy similarity1
Glycosylationi1003N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO35379.
MaxQBiO35379.
PaxDbiO35379.
PRIDEiO35379.

PTM databases

iPTMnetiO35379.
PhosphoSitePlusiO35379.
SwissPalmiO35379.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023088.
ExpressionAtlasiO35379. baseline and differential.
GenevisibleiO35379. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097743.

Structurei

3D structure databases

ProteinModelPortaliO35379.
SMRiO35379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini326 – 609ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini644 – 868ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini971 – 1253ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST283
Domaini1290 – 1524ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG108314.
InParanoidiO35379.
KOiK05665.
OMAiVELILCC.
OrthoDBiEOG091G00IN.
PhylomeDBiO35379.
TreeFamiTF105199.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030241. ABCC1.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF241. PTHR24223:SF241. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRSFCSAD GSDPLWDWNV TWHTSNPDFT KCFQNTVLTW VPCFYLWSCF
60 70 80 90 100
PLYFFYLSRH DRGYIQMTHL NKTKTALGFF LWIICWADLF YSFWERSQGV
110 120 130 140 150
LRAPVLLVSP TLLGITMLLA TFLIQLERRK GVQSSGIMLT FWLVALLCAL
160 170 180 190 200
AILRSKIISA LKKDAHVDVF RDSTFYLYFT LVLVQLVLSC FSDCSPLFSE
210 220 230 240 250
TVHDRNPCPE SSASFLSRIT FWWITGMMVH GYRQPLESSD LWSLNKEDTS
260 270 280 290 300
EEVVPVLVNN WKKECDKSRK QPVRIVYAPP KDPSKPKGSS QLDVNEEVEA
310 320 330 340 350
LIVKSPHKDR EPSLFKVLYK TFGPYFLMSF LYKALHDLMM FAGPKILELI
360 370 380 390 400
INFVNDREAP DWQGYFYTAL LFVSACLQTL ALHQYFHICF VSGMRIKTAV
410 420 430 440 450
VGAVYRKALL ITNAARKSST VGEIVNLMSV DAQRFMDLAT YINMIWSAPL
460 470 480 490 500
QVILALYFLW LSLGPSVLAG VAVMILMVPL NAVMAMKTKT YQVAHMKSKD
510 520 530 540 550
NRIKLMNEIL NGIKVLKLYA WELAFQDKVM SIRQEELKVL KKSAYLAAVG
560 570 580 590 600
TFTWVCTPFL VALSTFAVFV TVDERNILDA KKAFVSLALF NILRFPLNIL
610 620 630 640 650
PMVISSIVQA SVSLKRLRIF LSHEELEPDS IERRSIKSGE GNSITVKNAT
660 670 680 690 700
FTWARGEPPT LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG
710 720 730 740 750
HVTLKGSVAY VPQQAWIQND SLRENILFGH PLQENYYKAV MEACALLPDL
760 770 780 790 800
EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYSNSDIYL FDDPLSAVDA
810 820 830 840 850
HVGKHIFEKV VGPMGLLKNK TRILVTHGIS YLPQVDVIIV MSGGKISEMG
860 870 880 890 900
SYQELLDRDG AFAEFLRTYA NAEQDLASED DSVSGSGKES KPVENGMLVT
910 920 930 940 950
DTVGKHLQRH LSNSSSHSGD TSQQHSSIAE LQKAGAKEET WKLMEADKAQ
960 970 980 990 1000
TGQVQLSVYW NYMKAIGLFI TFLSIFLFLC NHVSALASNY WLSLWTDDPP
1010 1020 1030 1040 1050
VVNGTQANRN FRLSVYGALG ILQGAAIFGY SMAVSIGGIF ASRRLHLDLL
1060 1070 1080 1090 1100
YNVLRSPMSF FERTPSGNLV NRFSKELDTV DSMIPQVIKM FMGSLFSVIG
1110 1120 1130 1140 1150
AVIIILLATP IAAVIIPPLG LVYFFVQRFY VASSRQLKRL ESVSRSPVYS
1160 1170 1180 1190 1200
HFNETLLGVS VIRAFEEQER FIHQSDLKVD ENQKAYYPSI VANRWLAVRL
1210 1220 1230 1240 1250
ECVGNCIVLF AALFAVISRH SLSAGLVGLS VSYSLQITAY LNWLVRMSSE
1260 1270 1280 1290 1300
METNIVAVER LKEYSETEKE APWQIQETAP PSTWPHSGRV EFRDYCLRYR
1310 1320 1330 1340 1350
EDLDLVLKHI NVTIEGGEKV GIVGRTGAGK SSLTLGLFRI NESAEGEIII
1360 1370 1380 1390 1400
DGVNIAKIGL HNLRFKITII PQDPVLFSGS LRMNLDPFSQ YSDEEVWMAL
1410 1420 1430 1440 1450
ELAHLKGFVS ALPDKLNHEC AEGGENLSVG QRQLVCLARA LLRKTKILVL
1460 1470 1480 1490 1500
DEATAAVDLE TDNLIQSTIR TQFEDCTVLT IAHRLNTIMD YTRVIVLDKG
1510 1520
EVRECGAPSE LLQQRGIFYS MAKDAGLV
Length:1,528
Mass (Da):171,185
Last modified:January 1, 1998 - v1
Checksum:i68FD13667D61DBBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022908 mRNA. Translation: AAB80938.1.
AK029876 mRNA. Translation: BAC26654.1.
CCDSiCCDS37264.1.
RefSeqiNP_032602.1. NM_008576.3.
UniGeneiMm.196634.

Genome annotation databases

EnsembliENSMUST00000100167; ENSMUSP00000097743; ENSMUSG00000023088.
GeneIDi17250.
KEGGimmu:17250.
UCSCiuc007yhj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022908 mRNA. Translation: AAB80938.1.
AK029876 mRNA. Translation: BAC26654.1.
CCDSiCCDS37264.1.
RefSeqiNP_032602.1. NM_008576.3.
UniGeneiMm.196634.

3D structure databases

ProteinModelPortaliO35379.
SMRiO35379.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097743.

Chemistry databases

ChEMBLiCHEMBL2532.
SwissLipidsiSLP:000000463.

PTM databases

iPTMnetiO35379.
PhosphoSitePlusiO35379.
SwissPalmiO35379.

Proteomic databases

EPDiO35379.
MaxQBiO35379.
PaxDbiO35379.
PRIDEiO35379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100167; ENSMUSP00000097743; ENSMUSG00000023088.
GeneIDi17250.
KEGGimmu:17250.
UCSCiuc007yhj.2. mouse.

Organism-specific databases

CTDi4363.
MGIiMGI:102676. Abcc1.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG108314.
InParanoidiO35379.
KOiK05665.
OMAiVELILCC.
OrthoDBiEOG091G00IN.
PhylomeDBiO35379.
TreeFamiTF105199.

Enzyme and pathway databases

ReactomeiR-MMU-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.
R-MMU-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX).
R-MMU-382556. ABC-family proteins mediated transport.

Miscellaneous databases

PROiO35379.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023088.
ExpressionAtlasiO35379. baseline and differential.
GenevisibleiO35379. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030241. ABCC1.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF241. PTHR24223:SF241. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP1_MOUSE
AccessioniPrimary (citable) accession number: O35379
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.