O35375 (NRP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuropilin-2

Alternative name(s):
Vascular endothelial cell growth factor 165 receptor 2

Gene names

Name:

Nrp2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	931 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
Subunit structure	Heterodimer with NRP1. Binds PLXNB1 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed in developing CNS, PNS and in some nonneural tissues including limb buds, developing bones, muscles, intestinal epithelium, kidney, lung and submandibular gland.
Developmental stage	The expression pattern is very dynamic and is developmentally regulated.
Domain	The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding By similarity.
Sequence similarities	Belongs to the neuropilin family. Contains 2 CUB domains. Contains 2 F5/8 type C domains. Contains 1 MAM domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Heparin-binding Metal-binding
Molecular function	Developmental protein Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	axon guidance Inferred from mutant phenotype. Source: MGI cell adhesion Inferred from electronic annotation. Source: InterPro heart development Inferred from genetic interaction. Source: MGI negative chemotaxis Inferred from mutant phenotype. Source: MGI neural crest cell migration Inferred from mutant phenotype. Source: MGI
Cellular component	axon Inferred from direct assay. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred by curator. Source: MGI
Molecular function	heparin binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: MGI semaphorin receptor activity Inferred from physical interaction. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform A22 (identifier: O35375-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A0 (identifier: O35375-2)

The sequence of this isoform differs from the canonical sequence as follows:
     809-830: Missing.

Isoform A5 (identifier: O35375-3)

The sequence of this isoform differs from the canonical sequence as follows:
     814-830: Missing.

Isoform A17 (identifier: O35375-4)

The sequence of this isoform differs from the canonical sequence as follows:
     809-813: Missing.

Isoform B0 (identifier: O35375-5)

The sequence of this isoform differs from the canonical sequence as follows:
     810-931: EDFKVDIPET...INHQKCCSEA → GTLPPGTEPT...KLEQERGSHC

Isoform B5 (identifier: O35375-6)

The sequence of this isoform differs from the canonical sequence as follows:
     814-931: VDIPETHGGE...INHQKCCSEA → GGTLPPGTEP...KLEQERGSHC

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 931	911	Neuropilin-2		PRO_0000021864
Regions
	Topological domain	21 – 864	844	Extracellular Potential
	Transmembrane	865 – 889	25	Helical; Potential
	Topological domain	890 – 931	42	Cytoplasmic Potential
	Domain	28 – 142	115	CUB 1
	Domain	149 – 267	119	CUB 2
	Domain	277 – 427	151	F5/8 type C 1
	Domain	434 – 592	159	F5/8 type C 2
	Domain	642 – 802	161	MAM
	Compositional bias	838 – 845	8	Poly-Ser
Sites
	Metal binding	197	1	Calcium By similarity
	Metal binding	211	1	Calcium By similarity
	Metal binding	252	1	Calcium By similarity
Amino acid modifications
	Glycosylation	152	1	N-linked (GlcNAc...) Potential
	Glycosylation	157	1	N-linked (GlcNAc...) Potential
	Glycosylation	629	1	N-linked (GlcNAc...) Potential
	Glycosylation	839	1	N-linked (GlcNAc...) Potential
	Disulfide bond	28 ↔ 55		By similarity
	Disulfide bond	83 ↔ 105		By similarity
	Disulfide bond	149 ↔ 175		By similarity
	Disulfide bond	208 ↔ 230		By similarity
	Disulfide bond	277 ↔ 427		By similarity
	Disulfide bond	434 ↔ 592		By similarity
Natural variations
	Alternative sequence	809 – 830	22	Missing in isoform A0.		VSP_004344
	Alternative sequence	809 – 813	5	Missing in isoform A17.		VSP_004343
	Alternative sequence	810 – 931	122	EDFKV…CCSEA → GTLPPGTEPTVDTVPVQPIP AYWYYVMAAGGAVLVLASVV LALVLHYHRFRYAAKKTDHS ITYKTSHYTNGAPLAVEPTL TIKLEQERGSHC in isoform B0.		VSP_004346
	Alternative sequence	814 – 931	118	VDIPE…CCSEA → GGTLPPGTEPTVDTVPVQPI PAYWYYVMAAGGAVLVLASV VLALVLHYHRFRYAAKKTDH SITYKTSHYTNGAPLAVEPT LTIKLEQERGSHC in isoform B5.		VSP_004347
	Alternative sequence	814 – 830	17	Missing in isoform A5.		VSP_004345
Experimental info
	Sequence conflict	32	1	L → P in AAC53377. Ref.1
	Sequence conflict	32	1	L → P in AAC53378. Ref.1
	Sequence conflict	32	1	L → P in AAC53379. Ref.1
	Sequence conflict	32	1	L → P in AAC53380. Ref.1
	Sequence conflict	32	1	L → P in AAC53381. Ref.1
	Sequence conflict	32	1	L → P in AAC53382. Ref.1
	Sequence conflict	786	1	I → G in AAC53377. Ref.1
	Sequence conflict	786	1	I → G in AAC53378. Ref.1
	Sequence conflict	786	1	I → G in AAC53382. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform A22 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 08AA821E696A2885	FASTA	931	104,631
	10 20 30 40 50 60 MDMFPLTWVF LALYFSGHEV RSQQDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY 70 80 90 100 110 120 APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSVL 130 140 150 160 170 180 YIKFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL 190 200 210 220 230 240 AKPRMEIILQ FLTFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSKLRS 250 260 270 280 290 300 STGILSLTFH TDMAVAKDGF SARYYLIHQE PPENFQCNVP LGMESGRIAN EQISASSTFS 310 320 330 340 350 360 DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQKGYYVKS 370 380 390 400 410 420 YKLEVSTNGE DWMVYRHGKN HKIFQANNDA TEVVLNKLHM PLLTRFIRIR PQTWHLGIAL 430 440 450 460 470 480 RLELFGCRVT DAPCSNMLGM LSGLIADTQI SASSTREYLW SPSAARLVSS RSGWFPRNPQ 490 500 510 520 530 540 AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD 550 560 570 580 590 600 PRTQQTKLFE GNMHYDTPDI RRFDPVPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT 610 620 630 640 650 660 VETLGPTVKS EETTTPYPMD EDATECGENC SFEDDKDLQL PSGFNCNFDF PEETCGWVYD 670 680 690 700 710 720 HAKWLRSTWI SSANPNDRTF PDDKNFLKLQ SDGRREGQYG RLISPPVHLP RSPVCMEFQY 730 740 750 760 770 780 QAMGGHGVAL QVVREASQES KLLWVIREDQ GSEWKHGRII LPSYDMEYQI VFEGVIGKGR 790 800 810 820 830 840 SGEISIDDIR ISTDVPLENC MEPISAFAGE DFKVDIPETH GGEGYEDEID DEYEGDWSNS 850 860 870 880 890 900 SSSTSGAGDP SSGKEKSWLY TLDPILITII AMSSLGVLLG ATCAGLLLYC TCSYSGLSSR 910 920 930 SCTTLENYNF ELYDGLKHKV KINHQKCCSE A
	Isoform A0 [UniParc]. Checksum: A34352A52526A136	FASTA	909	102,198
	10 20 30 40 50 60 MDMFPLTWVF LALYFSGHEV RSQQDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY 70 80 90 100 110 120 APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSVL 130 140 150 160 170 180 YIKFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL 190 200 210 220 230 240 AKPRMEIILQ FLTFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSKLRS 250 260 270 280 290 300 STGILSLTFH TDMAVAKDGF SARYYLIHQE PPENFQCNVP LGMESGRIAN EQISASSTFS 310 320 330 340 350 360 DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQKGYYVKS 370 380 390 400 410 420 YKLEVSTNGE DWMVYRHGKN HKIFQANNDA TEVVLNKLHM PLLTRFIRIR PQTWHLGIAL 430 440 450 460 470 480 RLELFGCRVT DAPCSNMLGM LSGLIADTQI SASSTREYLW SPSAARLVSS RSGWFPRNPQ 490 500 510 520 530 540 AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD 550 560 570 580 590 600 PRTQQTKLFE GNMHYDTPDI RRFDPVPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT 610 620 630 640 650 660 VETLGPTVKS EETTTPYPMD EDATECGENC SFEDDKDLQL PSGFNCNFDF PEETCGWVYD 670 680 690 700 710 720 HAKWLRSTWI SSANPNDRTF PDDKNFLKLQ SDGRREGQYG RLISPPVHLP RSPVCMEFQY 730 740 750 760 770 780 QAMGGHGVAL QVVREASQES KLLWVIREDQ GSEWKHGRII LPSYDMEYQI VFEGVIGKGR 790 800 810 820 830 840 SGEISIDDIR ISTDVPLENC MEPISAFADE YEGDWSNSSS STSGAGDPSS GKEKSWLYTL 850 860 870 880 890 900 DPILITIIAM SSLGVLLGAT CAGLLLYCTC SYSGLSSRSC TTLENYNFEL YDGLKHKVKI NHQKCCSEA
	Isoform A5 [UniParc]. Checksum: 6EA486DAB152F20B	FASTA	914	102,775
	10 20 30 40 50 60 MDMFPLTWVF LALYFSGHEV RSQQDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY 70 80 90 100 110 120 APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSVL 130 140 150 160 170 180 YIKFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL 190 200 210 220 230 240 AKPRMEIILQ FLTFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSKLRS 250 260 270 280 290 300 STGILSLTFH TDMAVAKDGF SARYYLIHQE PPENFQCNVP LGMESGRIAN EQISASSTFS 310 320 330 340 350 360 DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQKGYYVKS 370 380 390 400 410 420 YKLEVSTNGE DWMVYRHGKN HKIFQANNDA TEVVLNKLHM PLLTRFIRIR PQTWHLGIAL 430 440 450 460 470 480 RLELFGCRVT DAPCSNMLGM LSGLIADTQI SASSTREYLW SPSAARLVSS RSGWFPRNPQ 490 500 510 520 530 540 AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD 550 560 570 580 590 600 PRTQQTKLFE GNMHYDTPDI RRFDPVPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT 610 620 630 640 650 660 VETLGPTVKS EETTTPYPMD EDATECGENC SFEDDKDLQL PSGFNCNFDF PEETCGWVYD 670 680 690 700 710 720 HAKWLRSTWI SSANPNDRTF PDDKNFLKLQ SDGRREGQYG RLISPPVHLP RSPVCMEFQY 730 740 750 760 770 780 QAMGGHGVAL QVVREASQES KLLWVIREDQ GSEWKHGRII LPSYDMEYQI VFEGVIGKGR 790 800 810 820 830 840 SGEISIDDIR ISTDVPLENC MEPISAFAGE DFKDEYEGDW SNSSSSTSGA GDPSSGKEKS 850 860 870 880 890 900 WLYTLDPILI TIIAMSSLGV LLGATCAGLL LYCTCSYSGL SSRSCTTLEN YNFELYDGLK 910 HKVKINHQKC CSEA
	Isoform A17 [UniParc]. Checksum: 8073D6478C9A8467	FASTA	926	104,055
	10 20 30 40 50 60 MDMFPLTWVF LALYFSGHEV RSQQDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY 70 80 90 100 110 120 APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSVL 130 140 150 160 170 180 YIKFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL 190 200 210 220 230 240 AKPRMEIILQ FLTFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSKLRS 250 260 270 280 290 300 STGILSLTFH TDMAVAKDGF SARYYLIHQE PPENFQCNVP LGMESGRIAN EQISASSTFS 310 320 330 340 350 360 DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQKGYYVKS 370 380 390 400 410 420 YKLEVSTNGE DWMVYRHGKN HKIFQANNDA TEVVLNKLHM PLLTRFIRIR PQTWHLGIAL 430 440 450 460 470 480 RLELFGCRVT DAPCSNMLGM LSGLIADTQI SASSTREYLW SPSAARLVSS RSGWFPRNPQ 490 500 510 520 530 540 AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD 550 560 570 580 590 600 PRTQQTKLFE GNMHYDTPDI RRFDPVPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT 610 620 630 640 650 660 VETLGPTVKS EETTTPYPMD EDATECGENC SFEDDKDLQL PSGFNCNFDF PEETCGWVYD 670 680 690 700 710 720 HAKWLRSTWI SSANPNDRTF PDDKNFLKLQ SDGRREGQYG RLISPPVHLP RSPVCMEFQY 730 740 750 760 770 780 QAMGGHGVAL QVVREASQES KLLWVIREDQ GSEWKHGRII LPSYDMEYQI VFEGVIGKGR 790 800 810 820 830 840 SGEISIDDIR ISTDVPLENC MEPISAFAVD IPETHGGEGY EDEIDDEYEG DWSNSSSSTS 850 860 870 880 890 900 GAGDPSSGKE KSWLYTLDPI LITIIAMSSL GVLLGATCAG LLLYCTCSYS GLSSRSCTTL 910 920 ENYNFELYDG LKHKVKINHQ KCCSEA
	Isoform B0 [UniParc]. Checksum: F763734C2A09F52F	FASTA	901	101,418
	10 20 30 40 50 60 MDMFPLTWVF LALYFSGHEV RSQQDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY 70 80 90 100 110 120 APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSVL 130 140 150 160 170 180 YIKFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL 190 200 210 220 230 240 AKPRMEIILQ FLTFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSKLRS 250 260 270 280 290 300 STGILSLTFH TDMAVAKDGF SARYYLIHQE PPENFQCNVP LGMESGRIAN EQISASSTFS 310 320 330 340 350 360 DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQKGYYVKS 370 380 390 400 410 420 YKLEVSTNGE DWMVYRHGKN HKIFQANNDA TEVVLNKLHM PLLTRFIRIR PQTWHLGIAL 430 440 450 460 470 480 RLELFGCRVT DAPCSNMLGM LSGLIADTQI SASSTREYLW SPSAARLVSS RSGWFPRNPQ 490 500 510 520 530 540 AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD 550 560 570 580 590 600 PRTQQTKLFE GNMHYDTPDI RRFDPVPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT 610 620 630 640 650 660 VETLGPTVKS EETTTPYPMD EDATECGENC SFEDDKDLQL PSGFNCNFDF PEETCGWVYD 670 680 690 700 710 720 HAKWLRSTWI SSANPNDRTF PDDKNFLKLQ SDGRREGQYG RLISPPVHLP RSPVCMEFQY 730 740 750 760 770 780 QAMGGHGVAL QVVREASQES KLLWVIREDQ GSEWKHGRII LPSYDMEYQI VFEGVIGKGR 790 800 810 820 830 840 SGEISIDDIR ISTDVPLENC MEPISAFAGG TLPPGTEPTV DTVPVQPIPA YWYYVMAAGG 850 860 870 880 890 900 AVLVLASVVL ALVLHYHRFR YAAKKTDHSI TYKTSHYTNG APLAVEPTLT IKLEQERGSH C
	Isoform B5 [UniParc]. Checksum: 6D66AF632D47A21F	FASTA	906	101,995
	10 20 30 40 50 60 MDMFPLTWVF LALYFSGHEV RSQQDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY 70 80 90 100 110 120 APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSVL 130 140 150 160 170 180 YIKFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL 190 200 210 220 230 240 AKPRMEIILQ FLTFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSKLRS 250 260 270 280 290 300 STGILSLTFH TDMAVAKDGF SARYYLIHQE PPENFQCNVP LGMESGRIAN EQISASSTFS 310 320 330 340 350 360 DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQKGYYVKS 370 380 390 400 410 420 YKLEVSTNGE DWMVYRHGKN HKIFQANNDA TEVVLNKLHM PLLTRFIRIR PQTWHLGIAL 430 440 450 460 470 480 RLELFGCRVT DAPCSNMLGM LSGLIADTQI SASSTREYLW SPSAARLVSS RSGWFPRNPQ 490 500 510 520 530 540 AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD 550 560 570 580 590 600 PRTQQTKLFE GNMHYDTPDI RRFDPVPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT 610 620 630 640 650 660 VETLGPTVKS EETTTPYPMD EDATECGENC SFEDDKDLQL PSGFNCNFDF PEETCGWVYD 670 680 690 700 710 720 HAKWLRSTWI SSANPNDRTF PDDKNFLKLQ SDGRREGQYG RLISPPVHLP RSPVCMEFQY 730 740 750 760 770 780 QAMGGHGVAL QVVREASQES KLLWVIREDQ GSEWKHGRII LPSYDMEYQI VFEGVIGKGR 790 800 810 820 830 840 SGEISIDDIR ISTDVPLENC MEPISAFAGE DFKGGTLPPG TEPTVDTVPV QPIPAYWYYV 850 860 870 880 890 900 MAAGGAVLVL ASVVLALVLH YHRFRYAAKK TDHSITYKTS HYTNGAPLAV EPTLTIKLEQ ERGSHC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III." Chen H., Chedotal A., He Z.-G., Goodman C.S., Tessier-Lavigne M. Neuron 19:547-559(1997) [PubMed: 9331348] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A0; A17; A22; A5; B0 AND B5). Strain: BALB/c.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF022856 mRNA. Translation: AAC53379.1. AF022854 mRNA. Translation: AAC53377.1. AF022855 mRNA. Translation: AAC53378.1. AF022857 mRNA. Translation: AAC53380.1. AF022858 mRNA. Translation: AAC53381.1. AF022861 mRNA. Translation: AAC53382.1. AL671560, AL645727 Genomic DNA. Translation: CAI24156.1. AL645727, AL671560 Genomic DNA. Translation: CAI24511.1.
IPI	IPI00129911. IPI00227582. IPI00227583. IPI00227584. IPI00755777. IPI00876020.
RefSeq	NP_001070871.1. NM_001077403.1.
UniGene	Mm.266341.
3D structure databases
ProteinModelPortal	O35375.
SMR	O35375. Positions 26-595.
ModBase	Search...
Protein-protein interaction databases
STRING	O35375.
Proteomic databases
PRIDE	O35375.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027112; ENSMUSP00000027112; ENSMUSG00000025969. ENSMUST00000063594; ENSMUSP00000069379; ENSMUSG00000025969. ENSMUST00000075144; ENSMUSP00000074642; ENSMUSG00000025969. ENSMUST00000102822; ENSMUSP00000099886; ENSMUSG00000025969. ENSMUST00000114155; ENSMUSP00000109792; ENSMUSG00000025969. ENSMUST00000114157; ENSMUSP00000109794; ENSMUSG00000025969.
GeneID	18187.
KEGG	mmu:18187.
Organism-specific databases
CTD	8828.
MGI	MGI:1100492. Nrp2.
Phylogenomic databases
eggNOG	roNOG04879.
HOGENOM	HBG714573.
HOVERGEN	HBG000502.
InParanoid	O35375.
Enzyme and pathway databases
Reactome	REACT_115492. Developmental Biology.
Gene expression databases
ArrayExpress	O35375.
Bgee	O35375.
CleanEx	MM_NRP2.
Genevestigator	O35375.
GermOnline	ENSMUSG00000025969. Mus musculus.
Family and domain databases
InterPro	IPR000421. Coagulation_fac_5/8-C_type_dom. IPR008985. ConA-like_lec_gl. IPR000859. CUB. IPR008979. Galactose-bd-like. IPR000998. MAM_dom. IPR014648. Neuropilin. IPR022579. Neuropilin1_C. [Graphical view]
Gene3D	G3DSA:2.60.120.290. CUB. 2 hits.
KO	K06819.
Pfam	PF00431. CUB. 2 hits. PF11980. DUF3481. 1 hit. PF00754. F5_F8_type_C. 2 hits. PF00629. MAM. 1 hit. [Graphical view]
PIRSF	PIRSF036960. Neuropilin. 1 hit.
PRINTS	PR00020. MAMDOMAIN.
SMART	SM00042. CUB. 2 hits. SM00231. FA58C. 2 hits. SM00137. MAM. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit. SSF49854. CUB. 2 hits. SSF49785. Gal_bind_like. 2 hits.
PROSITE	PS01180. CUB. 2 hits. PS01285. FA58C_1. 2 hits. PS01286. FA58C_2. 2 hits. PS50022. FA58C_3. 2 hits. PS50060. MAM_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

NRP2_MOUSE

Accession

Primary (citable) accession number: O35375
Secondary accession number(s): B1AT44 , O35373, O35374, O35376, O35377, O35378

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	July 27, 2011
Last modified:	December 14, 2011
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program